Details of the Drug

General Information of Drug (ID: DM4ZP3W)

• Drug Name: Heparin
• Synonyms: enoxaparin; Ardeparin; Bemiparin; SEMULOPARIN; Lovenox; LMWH; Nadroparin; Nadroparine; Reviparin; Clivarin; Sublingula; Sandoparin; Parvoparin; Parnaparin; Novoheparin; Adomiparin; Tinzaparin; Multiparin; Hepathrom; Heparina; Triofiban; Pularin; Liquemin; Heparinum; Subeparin; PK-10169; Pabyrin; Octaparin; Liquaemin; Heparine; Vetren; Fluxum; Hed-heparin; Depo-Heparin; Lipo-hepin; Fragmin A; Fragmin B; Vitrum AB; Heparin [BAN]; Eparina [DCIT]; CY 216; Adomiparin [USAN]; FR 860; Heparin CY 216; Heparine [INN-French]

Indication

Disease Entry	ICD 11	Status	REF
Aplastic anemia	3A70	Approved	[1]
Bacteremia	1A73	Approved	[1]
Burns	N.A.	Approved	[1]
Coronary heart disease	BA80.Z	Approved	[1]
Deep vein thrombosis	BD71	Approved	[1]
Disseminated intravascular coagulation	3B20	Approved	[1]
Metabolic disorder	5C50-5D2Z	Approved	[1]
Pneumonia	CA40	Approved	[1]
Pulmonary embolism	BB00	Approved	[1]
Venous thrombosis	BA43	Approved	[2]
Coronavirus Disease 2019 (COVID-19)	1D6Y	Investigative	[3]
Diabetic angiopathy	BD53.Y	Investigative	[1]

• Affected Organisms: Humans and other mammals
• ATC Code:
  B01AB01: Heparin
  B01AB: Heparin group
  B01A: ANTITHROMBOTIC AGENTS
  B01: ANTITHROMBOTIC AGENTS
  B: BLOOD AND BLOOD FORMING ORGANS
  B01AB05: Heparin
  B01AB: Heparin group
  B01A: ANTITHROMBOTIC AGENTS
  B01: ANTITHROMBOTIC AGENTS
  B: BLOOD AND BLOOD FORMING ORGANS
  B01AB06: Heparin
  B01AB: Heparin group
  B01A: ANTITHROMBOTIC AGENTS
  B01: ANTITHROMBOTIC AGENTS
  B: BLOOD AND BLOOD FORMING ORGANS
  B01AB07: Heparin
  B01AB: Heparin group
  B01A: ANTITHROMBOTIC AGENTS
  B01: ANTITHROMBOTIC AGENTS
  B: BLOOD AND BLOOD FORMING ORGANS
  B01AB08: Heparin
  B01AB: Heparin group
  B01A: ANTITHROMBOTIC AGENTS
  B01: ANTITHROMBOTIC AGENTS
  B: BLOOD AND BLOOD FORMING ORGANS
  B01AB10: Heparin
  B01AB: Heparin group
  B01A: ANTITHROMBOTIC AGENTS
  B01: ANTITHROMBOTIC AGENTS
  B: BLOOD AND BLOOD FORMING ORGANS
  B01AB12: Heparin
  B01AB: Heparin group
  B01A: ANTITHROMBOTIC AGENTS
  B01: ANTITHROMBOTIC AGENTS
  B: BLOOD AND BLOOD FORMING ORGANS
  C05BA03: Heparin
  C05BA: Heparins or heparinoids for topical use
  C05B: ANTIVARICOSE THERAPY
  C05: VASOPROTECTIVES
  C: CARDIOVASCULAR SYSTEM
  S01XA14: Heparin
  S01XA: Other ophthalmologicals
  S01X: OTHER OPHTHALMOLOGICALS
  S01: OPHTHALMOLOGICALS
  S: SENSORY ORGANS
• Drug Type: Small molecular drug
• Chemical Identifiers:
  Formula: C26H42N2O37S5
  Canonical SMILES: CC(=O)NC1C(C(C(OC1O)COS(=O)(=O)O)OC2C(C(C(C(O2)C(=O)O)OC3C(C(C(C(O3)CO)OC4C(C(C(C(O4)C(=O)O)O)O)OS(=O)(=O)O)OS(=O)(=O)O)NS(=O)(=O)O)O)OS(=O)(=O)O)O
  InChI: InChI=1S/C26H42N2O37S5/c1-4(30)27-7-9(31)13(6(56-23(7)39)3-55-67(43,44)45)58-26-19(65-70(52,53)54)12(34)16(20(62-26)22(37)38)60-24-8(28-66(40,41)42)15(63-68(46,47)48)14(5(2-29)57-24)59-25-18(64-69(49,50)51)11(33)10(32)17(61-25)21(35)36/h5-20,23-26,28-29,31-34,39H,2-3H2,1H3,(H,27,30)(H,35,36)(H,37,38)(H,40,41,42)(H,43,44,45)(H,46,47,48)(H,49,50,51)(H,52,53,54)
  InChIKey: HTTJABKRGRZYRN-UHFFFAOYSA-N
• Cross-matching ID:
  PubChem CID: 772
  CAS Number: 9005-49-6
  UNII: VL0L558GCB
  DrugBank ID: DB00407
  TTD ID: D0A7CO
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References

• [1] Heparin FDA Label
• [2] FDA Approved Drug Products from FDA Official Website. 2019. Application Number: (ANDA) 090809.
• [3] Hypothesis for potential pathogenesis of SARS-CoV-2 infection-a review of immune changes in patients with viral pneumonia. Emerg Microbes Infect. 2020 Dec;9(1):727-732.