Details of the Drug Combination

General Information of Drug Combination (ID: DC53XKB)

Drug Combination Name
ABIRATERONE Amonafide
Indication
Disease Entry Status REF
Carcinoma Investigative [1]
Component Drugs ABIRATERONE   DM8V75C Amonafide   DMAH59S
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL
High-throughput Screening Result Testing Cell Line: MCF7
Zero Interaction Potency (ZIP) Score: 2.87
Bliss Independence Score: 4.06
Loewe Additivity Score: 2.64
LHighest Single Agent (HSA) Score: 5.93

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of ABIRATERONE
Disease Entry ICD 11 Status REF
Prostate cancer 2C82.0 Approved [2]
ABIRATERONE Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Steroid 17-alpha-monooxygenase (S17AH) TTRA5BZ CP17A_HUMAN Modulator [4]
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Indication(s) of Amonafide
Disease Entry ICD 11 Status REF
Breast cancer 2C60-2C65 Phase 3 [3]
Ovarian cancer 2C73 Phase 3 [3]
Prostate cancer 2C82.0 Phase 3 [3]

Test Results of This Drug Combination in Other Disease Systems

Indication DrugCom ID Cell Line Status REF
Astrocytoma DCTIBIN SNB-19 Investigative [5]
Clear cell renal cell carcinoma DCVF2O6 786-0 Investigative [5]
Adenocarcinoma DCYN3JC HT29 Investigative [6]
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References

1 CheMBL Affinity Phenotypic Cellular Interaction Assay ID: CHEMBL1126165
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6745).
3 ClinicalTrials.gov (NCT00715637) Phase III Randomized Study of Amonafide (AS1413) and Cytarabine Versus Daunorubicin and Cytarabine in Patients With Secondary Acute Myeloid Leukemia (AML)- the ACCEDEStudy. U.S. National Institutes of Health.
4 2011 FDA drug approvals. Nat Rev Drug Discov. 2012 Feb 1;11(2):91-4.
5 CheMBL Affinity Phenotypic Cellular Interaction Assay ID: CHEMBL1125966
6 CheMBL Affinity Phenotypic Cellular Interaction Assay ID: CHEMBL1125976