Details of the Drug Combination

General Information of Drug Combination (ID: DCAWCKJ)

• Drug Combination Name: Sorafenib + Cytarabine
• Indication: Chronic myelogenous leukemia; Status: Investigative [1]
• Component Drugs:
  Sorafenib (DMS8IFC): Small molecular drug
  Cytarabine (DMZD5QR): Small molecular drug
• High-throughput Screening Result:
  Testing Cell Line: KBM-7
  Zero Interaction Potency (ZIP) Score: 2.21
  Bliss Independence Score: 2.21
  Loewe Additivity Score: 2.64
  LHighest Single Agent (HSA) Score: 2.67

Molecular Interaction Atlas of This Drug Combination

Indication(s) of Sorafenib

Disease Entry	ICD 11	Status	REF
Adenocarcinoma	2D40	Approved	[2]
Carcinoma	2A00-2F9Z	Approved	[2]
Clear cell renal carcinoma	N.A.	Approved	[2]
Lung cancer	2C25.0	Approved	[2]
Medullary thyroid gland carcinoma	N.A.	Approved	[2]
Non-small-cell lung cancer	2C25.Y	Approved	[2]
Renal cell carcinoma	2C90	Approved	[3]
Thyroid cancer	2D10	Approved	[2]
Hepatocellular carcinoma	2C12.02	Phase 3	[3]
Myelodysplastic syndrome	2A37	Phase 2	[3]

Sorafenib Interacts with 4 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Tyrosine-protein kinase Kit (KIT)	TTX41N9	KIT_HUMAN	Modulator	[11]
Platelet-derived growth factor receptor beta (PDGFRB)	TTI7421	PGFRB_HUMAN	Modulator	[11]
Epidermal growth factor receptor (EGFR)	TTGKNB4	EGFR_HUMAN	Inhibitor	[12]
Vascular endothelial growth factor receptor 2 (KDR)	TTUTJGQ	VGFR2_HUMAN	Modulator	[11]

Sorafenib Interacts with 7 DTP Molecule(s)

DTP Name	DTP ID	UniProt ID	Mode of Action	REF
Multidrug resistance-associated protein 2 (ABCC2)	DTFI42L	MRP2_HUMAN	Substrate	[13]
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[14]
Breast cancer resistance protein (ABCG2)	DTI7UX6	ABCG2_HUMAN	Substrate	[15]
Organic anion transporting polypeptide 1B1 (SLCO1B1)	DT3D8F0	SO1B1_HUMAN	Substrate	[16]
Organic cation transporter 1 (SLC22A1)	DTT79CX	S22A1_HUMAN	Substrate	[17]
Organic anion transporting polypeptide 1B3 (SLCO1B3)	DT9C1TS	SO1B3_HUMAN	Substrate	[16]
RalBP1-associated Eps domain-containing protein 2 (RALBP1)	DTYEM9B	REPS2_HUMAN	Substrate	[18]

Sorafenib Interacts with 6 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Metabolism	[19]
Cytochrome P450 1A2 (CYP1A2)	DEJGDUW	CP1A2_HUMAN	Metabolism	[20]
Cytochrome P450 3A5 (CYP3A5)	DEIBDNY	CP3A5_HUMAN	Metabolism	[21]
Cytochrome P450 3A7 (CYP3A7)	DERD86B	CP3A7_HUMAN	Metabolism	[21]
Cytochrome P450 2C8 (CYP2C8)	DES5XRU	CP2C8_HUMAN	Metabolism	[19]
UDP-glucuronosyltransferase 1A9 (UGT1A9)	DE85D2P	UD19_HUMAN	Metabolism	[22]

Sorafenib Interacts with 112 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
Cytochrome P450 2C8 (CYP2C8)	OTHCWT42	CP2C8_HUMAN	Decreases Activity	[23]
ATP-binding cassette sub-family C member 2 (ABCC2)	OTJSIGV5	MRP2_HUMAN	Affects Response To Substance	[24]
Mast/stem cell growth factor receptor Kit (KIT)	OTHUY3VZ	KIT_HUMAN	Decreases Phosphorylation	[25]
NF-kappa-B inhibitor alpha (NFKBIA)	OTFT924M	IKBA_HUMAN	Increases Expression	[26]
DNA damage-inducible transcript 3 protein (DDIT3)	OTI8YKKE	DDIT3_HUMAN	Increases Expression	[27]
DNA damage-inducible transcript 4 protein (DDIT4)	OTHY8SY4	DDIT4_HUMAN	Increases Expression	[27]
Bile salt export pump (ABCB11)	OTRU7THO	ABCBB_HUMAN	Decreases Activity	[28]
Mitogen-activated protein kinase 3 (MAPK3)	OTCYKGKO	MK03_HUMAN	Decreases Activity	[29]
Mitogen-activated protein kinase 1 (MAPK1)	OTH85PI5	MK01_HUMAN	Decreases Activity	[29]
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (PIK3C2A)	OTFBU4GD	P3C2A_HUMAN	Decreases Expression	[6]
Baculoviral IAP repeat-containing protein 5 (BIRC5)	OTILXZYL	BIRC5_HUMAN	Decreases Expression	[6]
Epidermal growth factor receptor (EGFR)	OTAPLO1S	EGFR_HUMAN	Decreases Expression	[6]
GTPase NRas (NRAS)	OTVQ1DG3	RASN_HUMAN	Decreases Expression	[6]
Insulin-like growth factor 1 receptor (IGF1R)	OTXJIF13	IGF1R_HUMAN	Decreases Expression	[6]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Decreases Expression	[6]
Protein kinase C alpha type (PRKCA)	OT5UWNRD	KPCA_HUMAN	Decreases Expression	[6]
Cyclin-dependent kinase 2 (CDK2)	OTB5DYYZ	CDK2_HUMAN	Decreases Expression	[6]
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA)	OTTOMI8J	PK3CA_HUMAN	Decreases Expression	[6]
Serine/threonine-protein kinase mTOR (MTOR)	OTHH8KU7	MTOR_HUMAN	Decreases Expression	[6]
Cyclin-dependent kinase 9 (CDK9)	OT2B7OGB	CDK9_HUMAN	Decreases Expression	[6]
Growth factor receptor-bound protein 2 (GRB2)	OTOP7LTE	GRB2_HUMAN	Decreases Expression	[6]
E3 ubiquitin-protein ligase Mdm2 (MDM2)	OTOVXARF	MDM2_HUMAN	Increases Expression	[6]
Interferon regulatory factor 5 (IRF5)	OT8SIIAP	IRF5_HUMAN	Increases Expression	[6]
Hypoxia-inducible factor 1-alpha (HIF1A)	OTADSC03	HIF1A_HUMAN	Decreases Expression	[6]
Serine/threonine-protein kinase PLK3 (PLK3)	OT19CT2Z	PLK3_HUMAN	Increases Expression	[6]
Serine/threonine-protein kinase PLK2 (PLK2)	OTKMJXJ8	PLK2_HUMAN	Increases Expression	[6]
Histone deacetylase 6 (HDAC6)	OT9W9MXQ	HDAC6_HUMAN	Decreases Expression	[6]
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)	OTA1CPBV	TR10B_HUMAN	Increases Expression	[27]
CASP8 and FADD-like apoptosis regulator (CFLAR)	OTX14BAS	CFLAR_HUMAN	Decreases Expression	[30]
Bcl-2-like protein 11 (BCL2L11)	OTNQQWFJ	B2L11_HUMAN	Decreases Expression	[31]
Zinc finger protein SNAI2 (SNAI2)	OT7Y8EJ2	SNAI2_HUMAN	Decreases Expression	[7]
E3 ubiquitin-protein ligase parkin (PRKN)	OTJBN41W	PRKN_HUMAN	Increases Ubiquitination	[32]
Growth arrest and DNA damage-inducible protein GADD45 beta (GADD45B)	OTL9I7LO	GA45B_HUMAN	Increases Expression	[33]
Protein phosphatase 1 regulatory subunit 15A (PPP1R15A)	OTYG179K	PR15A_HUMAN	Increases Expression	[8]
Growth arrest and DNA damage-inducible protein GADD45 gamma (GADD45G)	OT8V1J4M	GA45G_HUMAN	Increases Expression	[34]
Apoptosis-inducing factor 1, mitochondrial (AIFM1)	OTKPWB7Q	AIFM1_HUMAN	Affects Localization	[31]
Tyrosine-protein kinase ABL1 (ABL1)	OT09YVXH	ABL1_HUMAN	Decreases Activity	[35]
Urokinase-type plasminogen activator (PLAU)	OTX0QGKK	UROK_HUMAN	Decreases Expression	[36]
Transforming growth factor beta-1 proprotein (TGFB1)	OTV5XHVH	TGFB1_HUMAN	Decreases Activity	[37]
Interleukin-1 beta (IL1B)	OT0DWXXB	IL1B_HUMAN	Increases Secretion	[38]
RAF proto-oncogene serine/threonine-protein kinase (RAF1)	OT51LSFO	RAF1_HUMAN	Decreases Activity	[25]
Cytochrome P450 1A1 (CYP1A1)	OTE4EFH8	CP1A1_HUMAN	Decreases Expression	[39]
Transcription factor Jun (JUN)	OTCYBO6X	JUN_HUMAN	Increases Expression	[33]
Tyrosine-protein kinase Lck (LCK)	OT883FG9	LCK_HUMAN	Decreases Phosphorylation	[40]
Retinoblastoma-associated protein (RB1)	OTQJUJMZ	RB_HUMAN	Decreases Expression	[41]
Eukaryotic translation initiation factor 4E (EIF4E)	OTDAWNLA	IF4E_HUMAN	Decreases Phosphorylation	[31]
Proto-oncogene tyrosine-protein kinase receptor Ret (RET)	OTLU040A	RET_HUMAN	Decreases Activity	[42]
High mobility group protein B1 (HMGB1)	OT4B7CPF	HMGB1_HUMAN	Increases Expression	[38]
Poly polymerase 1 (PARP1)	OT310QSG	PARP1_HUMAN	Increases Cleavage	[43]
Breakpoint cluster region protein (BCR)	OTCN76C1	BCR_HUMAN	Decreases Activity	[35]
Cytochrome P450 2C9 (CYP2C9)	OTGLBN29	CP2C9_HUMAN	Decreases Activity	[23]
Cyclin-dependent kinase 4 (CDK4)	OT7EP05T	CDK4_HUMAN	Decreases Expression	[44]
Cadherin-1 (CDH1)	OTFJMXPM	CADH1_HUMAN	Increases Expression	[7]
Proto-oncogene tyrosine-protein kinase Src (SRC)	OTETYX40	SRC_HUMAN	Decreases Activity	[45]
Serine/threonine-protein kinase B-raf (BRAF)	OT7S81XQ	BRAF_HUMAN	Decreases Activity	[46]
Platelet-derived growth factor receptor alpha (PDGFRA)	OTDJXUCN	PGFRA_HUMAN	Decreases Phosphorylation	[47]
Cyclic AMP-dependent transcription factor ATF-4 (ATF4)	OTRFV19J	ATF4_HUMAN	Increases Expression	[27]
Ribosomal protein S6 kinase beta-1 (RPS6KB1)	OTAELNGX	KS6B1_HUMAN	Decreases Phosphorylation	[48]
Alanine aminotransferase 1 (GPT)	OTOXOA0Q	ALAT1_HUMAN	Increases Secretion	[49]
G1/S-specific cyclin-D1 (CCND1)	OT8HPTKJ	CCND1_HUMAN	Decreases Expression	[50]
G1/S-specific cyclin-D2 (CCND2)	OTDULQF9	CCND2_HUMAN	Decreases Expression	[50]
G1/S-specific cyclin-D3 (CCND3)	OTNKPQ22	CCND3_HUMAN	Decreases Expression	[44]
RAC-alpha serine/threonine-protein kinase (AKT1)	OT8H2YY7	AKT1_HUMAN	Decreases Expression	[51]
Vascular endothelial growth factor receptor 2 (KDR)	OT15797V	VGFR2_HUMAN	Decreases Phosphorylation	[25]
Dual specificity mitogen-activated protein kinase kinase 2 (MAP2K2)	OTUE7Z91	MP2K2_HUMAN	Decreases Phosphorylation	[46]
Signal transducer and activator of transcription 3 (STAT3)	OTAAGKYZ	STAT3_HUMAN	Decreases Phosphorylation	[52]
Signal transducer and activator of transcription 5A (STAT5A)	OTBSJGN3	STA5A_HUMAN	Decreases Activity	[53]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Decreases Expression	[54]
Mitogen-activated protein kinase 8 (MAPK8)	OTEREYS5	MK08_HUMAN	Decreases Phosphorylation	[36]
Mitogen-activated protein kinase 9 (MAPK9)	OTCEVJ9E	MK09_HUMAN	Decreases Phosphorylation	[36]
Dual specificity mitogen-activated protein kinase kinase 4 (MAP2K4)	OTZPZX11	MP2K4_HUMAN	Decreases Phosphorylation	[36]
Crk-like protein (CRKL)	OTOYSD1R	CRKL_HUMAN	Decreases Phosphorylation	[35]
Cyclin-dependent kinase inhibitor 1B (CDKN1B)	OTNY5LLZ	CDN1B_HUMAN	Increases Expression	[55]
CCAAT/enhancer-binding protein delta (CEBPD)	OTNBIPMY	CEBPD_HUMAN	Increases Expression	[34]
Glycogen synthase kinase-3 beta (GSK3B)	OTL3L14B	GSK3B_HUMAN	Increases Phosphorylation	[54]
Tumor necrosis factor ligand superfamily member 10 (TNFSF10)	OT4PXBTA	TNF10_HUMAN	Increases Response To Substance	[56]
Stanniocalcin-1 (STC1)	OTGVVXYF	STC1_HUMAN	Decreases Expression	[57]
Caspase-7 (CASP7)	OTAPJ040	CASP7_HUMAN	Increases Activity	[58]
Caspase-9 (CASP9)	OTD4RFFG	CASP9_HUMAN	Increases Activity	[40]
Gasdermin-D (GSDMD)	OTH39BKI	GSDMD_HUMAN	Increases Expression	[38]
Sestrin-2 (SESN2)	OT889IXY	SESN2_HUMAN	Increases Expression	[59]
Small ribosomal subunit protein eS6 (RPS6)	OTT4D1LN	RS6_HUMAN	Decreases Phosphorylation	[60]
Cytochrome c (CYCS)	OTBFALJD	CYC_HUMAN	Affects Localization	[61]
Cyclin-dependent kinase 6 (CDK6)	OTR95N0X	CDK6_HUMAN	Decreases Expression	[44]
Dual specificity mitogen-activated protein kinase kinase 1 (MAP2K1)	OT4Y9NQI	MP2K1_HUMAN	Decreases Phosphorylation	[46]
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Increases Cleavage	[31]
Bcl-2-like protein 1 (BCL2L1)	OTRC5K9O	B2CL1_HUMAN	Decreases Expression	[31]
Potassium voltage-gated channel subfamily H member 2 (KCNH2)	OTZX881H	KCNH2_HUMAN	Decreases Activity	[62]
Baculoviral IAP repeat-containing protein 3 (BIRC3)	OT3E95KB	BIRC3_HUMAN	Decreases Expression	[63]
Sequestosome-1 (SQSTM1)	OTGY5D5J	SQSTM_HUMAN	Decreases Expression	[48]
Eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1)	OTHBQVD5	4EBP1_HUMAN	Decreases Phosphorylation	[64]
Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1)	OTXEE550	APR_HUMAN	Decreases Expression	[65]
Caspase-8 (CASP8)	OTA8TVI8	CASP8_HUMAN	Increases Cleavage	[9]
Mitogen-activated protein kinase 14 (MAPK14)	OT5TCO3O	MK14_HUMAN	Decreases Expression	[66]
Bcl-2 homologous antagonist/killer (BAK1)	OTDP6ILW	BAK_HUMAN	Decreases Expression	[31]
Cytochrome P450 1B1 (CYP1B1)	OTYXFLSD	CP1B1_HUMAN	Decreases Activity	[67]
Bcl2-associated agonist of cell death (BAD)	OT63ERYM	BAD_HUMAN	Increases Expression	[9]
Docking protein 1 (DOK1)	OTGVRLW6	DOK1_HUMAN	Decreases Phosphorylation	[35]
Serine/threonine-protein kinase PINK1, mitochondrial (PINK1)	OT50NR57	PINK1_HUMAN	Increases Expression	[32]
Eukaryotic translation initiation factor 2A (EIF2A)	OTWXELQP	EIF2A_HUMAN	Increases Phosphorylation	[8]
Autophagy protein 5 (ATG5)	OT4T5SMS	ATG5_HUMAN	Increases Expression	[68]
Transcription factor SOX-17 (SOX17)	OT9H4WWE	SOX17_HUMAN	Decreases Localization	[69]
Ubiquitin carboxyl-terminal hydrolase CYLD (CYLD)	OT37FKH0	CYLD_HUMAN	Increases Expression	[26]
Diablo IAP-binding mitochondrial protein (DIABLO)	OTHJ9MCZ	DBLOH_HUMAN	Affects Localization	[65]
Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3)	OT0DZGY4	E2AK3_HUMAN	Increases Phosphorylation	[8]
E3 ubiquitin-protein ligase TRIM62 (TRIM62)	OT15YO6N	TRI62_HUMAN	Affects Response To Substance	[70]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)	OT2YYI1A	MCL1_HUMAN	Decreases Response To Substance	[31]
ATP-binding cassette sub-family C member 3 (ABCC3)	OTC3IJV4	MRP3_HUMAN	Affects Response To Substance	[24]
Hepatocyte growth factor (HGF)	OTGHUA23	HGF_HUMAN	Decreases Response To Substance	[71]
Multidrug resistance-associated protein 1 (ABCC1)	OTGUN89S	MRP1_HUMAN	Affects Response To Substance	[24]
Receptor-type tyrosine-protein kinase FLT3 (FLT3)	OTMSRYMK	FLT3_HUMAN	Increases Response To Substance	[60]
Na(+)/citrate cotransporter (SLC13A5)	OTPH1TA7	S13A5_HUMAN	Decreases Response To Substance	[72]

Indication(s) of Cytarabine

Disease Entry	ICD 11	Status	REF
Acute lymphoblastic leukaemia	2A85	Approved	[4]
Acute myelogenous leukaemia	2A41	Approved	[5]
Adult acute monocytic leukemia	N.A.	Approved	[5]
Childhood acute megakaryoblastic leukemia	N.A.	Approved	[5]
Plasma cell myeloma	2A83.1	Approved	[5]
Neoplastic meningitis	N.A.	Investigative	[5]

Cytarabine Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Herpes simplex virus DNA polymerase UL30 (HSV UL30)	TTIU7X1	DPOL_HHV11	Inhibitor	[80]

Cytarabine Interacts with 6 DTP Molecule(s)

DTP Name	DTP ID	UniProt ID	Mode of Action	REF
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[81]
Organic cation transporter 1 (SLC22A1)	DTT79CX	S22A1_HUMAN	Substrate	[82]
Organic cation/carnitine transporter 1 (SLC22A4)	DT2EG60	S22A4_HUMAN	Substrate	[83]
Concentrative nucleoside transporter 1 (SLC28A1)	DT0EQPW	S28A1_HUMAN	Substrate	[84]
Equilibrative nucleoside transporter 1 (SLC29A1)	DTXD1TQ	S29A1_HUMAN	Substrate	[84]
Equilibrative nucleoside transporter 2 (SLC29A2)	DTW78DQ	S29A2_HUMAN	Substrate	[84]

Cytarabine Interacts with 5 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Metabolism	[85]
Cytidine aminohydrolase (CDA)	DEKEDRC	CDD_HUMAN	Metabolism	[86]
Ecto-5'-nucleotidase (NT5E)	DE3Z9HM	5NTD_HUMAN	Metabolism	[86]
Deoxycytidylate deaminase (DCTD)	DEXL3P2	DCTD_HUMAN	Metabolism	[86]
Cytidine deaminase (cdd)	DEYILK4	E0TLJ6_MYCHH	Metabolism	[87]

Cytarabine Interacts with 549 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Increases Expression	[88]
Equilibrative nucleoside transporter 1 (SLC29A1)	OTLOOZZS	S29A1_HUMAN	Decreases Response To Substance	[89]
GTP-binding protein 1 (GTPBP1)	OTA9KV6C	GTPB1_HUMAN	Increases Expression	[73]
Kinetochore protein NDC80 homolog (NDC80)	OTS7D306	NDC80_HUMAN	Increases Expression	[73]
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (PDE6D)	OTIFVXWD	PDE6D_HUMAN	Decreases Expression	[73]
Lymphocyte antigen 75 (LY75)	OTDHBU0N	LY75_HUMAN	Increases Expression	[73]
ATP-dependent DNA helicase Q5 (RECQL5)	OTVZMP1Q	RECQ5_HUMAN	Decreases Expression	[73]
SLIT and NTRK-like protein 5 (SLITRK5)	OTTSUSB8	SLIK5_HUMAN	Decreases Expression	[73]
Dihydrofolate reductase (DHFR)	OT3DVIGM	DYR_HUMAN	Increases Expression	[73]
Alpha-1-antitrypsin (SERPINA1)	OTACYW9J	A1AT_HUMAN	Increases Expression	[73]
T-cell surface glycoprotein CD8 alpha chain (CD8A)	OTDWQJXK	CD8A_HUMAN	Increases Expression	[73]
Thy-1 membrane glycoprotein (THY1)	OTVONVTB	THY1_HUMAN	Decreases Expression	[73]
Serglycin (SRGN)	OTFAVSX0	SRGN_HUMAN	Increases Expression	[73]
Non-secretory ribonuclease (RNASE2)	OT8Z4FNE	RNAS2_HUMAN	Increases Expression	[73]
Low affinity immunoglobulin gamma Fc region receptor II-a (FCGR2A)	OT0OUDUT	FCG2A_HUMAN	Increases Expression	[73]
Heat shock 70 kDa protein 6 (HSPA6)	OTH4S7WB	HSP76_HUMAN	Increases Expression	[73]
Transcription factor E3 (TFE3)	OTM99ZWH	TFE3_HUMAN	Increases Expression	[73]
Protein S100-P (S100P)	OTJCXNJG	S100P_HUMAN	Increases Expression	[73]
Ribonucleoside-diphosphate reductase subunit M2 (RRM2)	OTOB6J6R	RIR2_HUMAN	Increases Expression	[73]
Low affinity immunoglobulin gamma Fc region receptor II-c (FCGR2C)	OTNLMNYB	FCG2C_HUMAN	Increases Expression	[73]
G protein-coupled receptor kinase 5 (GRK5)	OTJK79EK	GRK5_HUMAN	Increases Expression	[73]
RNA-binding protein 34 (RBM34)	OTX3LUGI	RBM34_HUMAN	Decreases Expression	[73]
Ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1)	OT6E2OW6	ENTP1_HUMAN	Increases Expression	[73]
Tumor necrosis factor ligand superfamily member 10 (TNFSF10)	OT4PXBTA	TNF10_HUMAN	Increases Expression	[73]
Breast cancer type 2 susceptibility protein (BRCA2)	OTF1XSV1	BRCA2_HUMAN	Increases Expression	[73]
Geranylgeranyl transferase type-2 subunit beta (RABGGTB)	OTZ25I2W	PGTB2_HUMAN	Decreases Expression	[73]
UV excision repair protein RAD23 homolog A (RAD23A)	OTBPAWHX	RD23A_HUMAN	Decreases Expression	[73]
Ras-related protein Rab-5B (RAB5B)	OT06PN42	RAB5B_HUMAN	Increases Expression	[73]
C-X-C chemokine receptor type 4 (CXCR4)	OTUFSBX2	CXCR4_HUMAN	Increases Expression	[73]
Lysozyme C (LYZ)	OTD7H0G6	LYSC_HUMAN	Increases Expression	[73]
Histone H4 (H4C1)	OTB71W46	H4_HUMAN	Decreases Expression	[73]
DNA repair protein RAD51 homolog 1 (RAD51)	OTNVWGC1	RAD51_HUMAN	Increases Expression	[73]
Dual specificity protein phosphatase 4 (DUSP4)	OT6WAO12	DUS4_HUMAN	Decreases Expression	[73]
Src-like-adapter (SLA)	OTV17DY2	SLAP1_HUMAN	Increases Expression	[73]
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 (ACAP1)	OTPFQ2QC	ACAP1_HUMAN	Increases Expression	[73]
Cytohesin-1 (CYTH1)	OTYH9NRJ	CYH1_HUMAN	Increases Expression	[73]
C3a anaphylatoxin chemotactic receptor (C3AR1)	OT8J0TF8	C3AR_HUMAN	Increases Expression	[73]
Drebrin (DBN1)	OTZVKG8A	DREB_HUMAN	Decreases Expression	[73]
DALR anticodon-binding domain-containing protein 3 (DALRD3)	OTU79VIP	DALD3_HUMAN	Decreases Expression	[73]
Equilibrative nucleobase transporter 1 (SLC43A3)	OTR60ZLA	S43A3_HUMAN	Increases Expression	[73]
Glutathione S-transferase C-terminal domain-containing protein (GSTCD)	OTIIINMT	GSTCD_HUMAN	Increases Expression	[73]
DENN domain-containing protein 1A (DENND1A)	OTONDAA0	DEN1A_HUMAN	Increases Expression	[73]
Serine protease FAM111A (FAM111A)	OTVLARLG	F111A_HUMAN	Increases Expression	[73]
Proline-serine-threonine phosphatase-interacting protein 2 (PSTPIP2)	OTG6F93V	PPIP2_HUMAN	Decreases Expression	[73]
Partitioning defective 6 homolog alpha (PARD6A)	OTWLV3X1	PAR6A_HUMAN	Decreases Expression	[73]
Mediator of RNA polymerase II transcription subunit 9 (MED9)	OT59OKEJ	MED9_HUMAN	Decreases Expression	[73]
Phospholipid-transporting ATPase VD (ATP10D)	OT3JPE4H	AT10D_HUMAN	Increases Expression	[73]
Bridging integrator 2 (BIN2)	OT4S45WJ	BIN2_HUMAN	Increases Expression	[73]
DNA dC->dU-editing enzyme APOBEC-3B (APOBEC3B)	OTHLNI51	ABC3B_HUMAN	Increases Expression	[73]
Protein PRRC2C (PRRC2C)	OTBX3MXM	PRC2C_HUMAN	Decreases Expression	[73]
Odontogenic ameloblast-associated protein (ODAM)	OTT666SJ	ODAM_HUMAN	Decreases Expression	[74]
Pleckstrin homology domain-containing family G member 3 (PLEKHG3)	OTF6I8RV	PKHG3_HUMAN	Decreases Expression	[74]
Aldo-keto reductase family 1 member B15 (AKR1B15)	OTUEXSWH	AK1BF_HUMAN	Decreases Expression	[74]
Alternative prion protein (PRNP)	OTE85L1Q	APRIO_HUMAN	Decreases Expression	[74]
Matrilin-2 (MATN2)	OTVDR68G	MATN2_HUMAN	Decreases Expression	[74]
Homeobox protein Meis1 (MEIS1)	OTH9DKAD	MEIS1_HUMAN	Increases Expression	[74]
Gamma-aminobutyric acid receptor subunit pi (GABRP)	OTGKA8WS	GBRP_HUMAN	Increases Expression	[74]
Podocalyxin (PODXL)	OTPNQXF3	PODXL_HUMAN	Decreases Expression	[74]
Sarcolipin (SLN)	OTERIU75	SARCO_HUMAN	Decreases Expression	[74]
Nuclear factor 1 B-type (NFIB)	OTX94PD0	NFIB_HUMAN	Increases Expression	[74]
Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (NHERF1)	OTFK8KDP	NHRF1_HUMAN	Decreases Expression	[74]
Heparan sulfate glucosamine 3-O-sulfotransferase 1 (HS3ST1)	OT5DVN9P	HS3S1_HUMAN	Decreases Expression	[74]
Tetraspanin-4 (TSPAN4)	OTKFK57F	TSN4_HUMAN	Decreases Expression	[74]
Regulator of G-protein signaling 13 (RGS13)	OTPAMQ18	RGS13_HUMAN	Decreases Expression	[74]
Surfeit locus protein 4 (SURF4)	OTCSXJ9C	SURF4_HUMAN	Decreases Expression	[74]
Monocarboxylate transporter 4 (SLC16A3)	OTDIXEXY	MOT4_HUMAN	Decreases Expression	[74]
Prolyl 4-hydroxylase subunit alpha-2 (P4HA2)	OTP45YKX	P4HA2_HUMAN	Decreases Expression	[74]
Glycogenin-2 (GYG2)	OTAJ7YEW	GLYG2_HUMAN	Decreases Expression	[74]
Fatty acid-binding protein, brain (FABP7)	OTRE2H4G	FABP7_HUMAN	Increases Expression	[74]
Leucine-rich repeat transmembrane protein FLRT2 (FLRT2)	OTGD8TID	FLRT2_HUMAN	Decreases Expression	[74]
SLIT-ROBO Rho GTPase-activating protein 3 (SRGAP3)	OT9ZS72C	SRGP3_HUMAN	Increases Expression	[74]
Homeobox protein Hox-A2 (HOXA2)	OT6G6ZIK	HXA2_HUMAN	Increases Expression	[74]
Mothers against decapentaplegic homolog 6 (SMAD6)	OTUZZWUD	SMAD6_HUMAN	Decreases Expression	[74]
Carbonic anhydrase 12 (CA12)	OT6WNFU8	CAH12_HUMAN	Decreases Expression	[74]
Zinc finger protein SNAI2 (SNAI2)	OT7Y8EJ2	SNAI2_HUMAN	Decreases Expression	[74]
Transcription factor 21 (TCF21)	OT393IMA	TCF21_HUMAN	Decreases Expression	[74]
ER lumen protein-retaining receptor 3 (KDELR3)	OTW8C1V0	ERD23_HUMAN	Decreases Expression	[74]
Adhesion G protein-coupled receptor B3 (ADGRB3)	OT1EWGRW	AGRB3_HUMAN	Increases Expression	[74]
Protocadherin-7 (PCDH7)	OTP091X8	PCDH7_HUMAN	Decreases Expression	[74]
Suppression of tumorigenicity 18 protein (ST18)	OTPRIMTA	ST18_HUMAN	Increases Expression	[74]
TBC1 domain family member 4 (TBC1D4)	OTK66C40	TBCD4_HUMAN	Decreases Expression	[74]
Protein-tyrosine sulfotransferase 1 (TPST1)	OTDPQKEA	TPST1_HUMAN	Decreases Expression	[74]
Clathrin coat assembly protein AP180 (SNAP91)	OTE3EXWZ	AP180_HUMAN	Increases Expression	[74]
Kelch-like protein 41 (KLHL41)	OTLABE56	KLH41_HUMAN	Decreases Expression	[74]
Perilipin-3 (PLIN3)	OT9ZA7MR	PLIN3_HUMAN	Decreases Expression	[74]
P antigen family member 4 (PAGE4)	OT2VLWT0	PAGE4_HUMAN	Decreases Expression	[74]
Receptor activity-modifying protein 1 (RAMP1)	OT7UT2XB	RAMP1_HUMAN	Decreases Expression	[74]
Phosphatase and actin regulator 2 (PHACTR2)	OTWMX2A8	PHAR2_HUMAN	Decreases Expression	[74]
Leucine-rich repeat neuronal protein 2 (LRRN2)	OTGP2DCY	LRRN2_HUMAN	Decreases Expression	[74]
Cartilage-associated protein (CRTAP)	OT53H5U6	CRTAP_HUMAN	Decreases Expression	[74]
Breast cancer anti-estrogen resistance protein 3 (BCAR3)	OTPJ17M8	BCAR3_HUMAN	Decreases Expression	[74]
Matrix metalloproteinase-23 (MMP23B)	OT2OR6TS	MMP23_HUMAN	Decreases Expression	[74]
Regulator of G-protein signaling 20 (RGS20)	OT6CGYHW	RGS20_HUMAN	Increases Expression	[74]
Lymphocyte antigen 6H (LY6H)	OTTFGUD2	LY6H_HUMAN	Decreases Expression	[74]
Slit homolog 2 protein (SLIT2)	OTLS2RJ4	SLIT2_HUMAN	Decreases Expression	[74]
Sorbin and SH3 domain-containing protein 2 (SORBS2)	OTJSX44Y	SRBS2_HUMAN	Increases Expression	[74]
Glutaminase kidney isoform, mitochondrial (GLS)	OTGOZG2M	GLSK_HUMAN	Decreases Expression	[74]
SLIT and NTRK-like protein 3 (SLITRK3)	OT018P93	SLIK3_HUMAN	Decreases Expression	[74]
Myelin protein zero-like protein 1 (MPZL1)	OTJSUUHR	MPZL1_HUMAN	Decreases Expression	[74]
BAG family molecular chaperone regulator 3 (BAG3)	OTVXYUDQ	BAG3_HUMAN	Decreases Expression	[74]
EGF-containing fibulin-like extracellular matrix protein 2 (EFEMP2)	OT0I2B4J	FBLN4_HUMAN	Decreases Expression	[74]
Heart- and neural crest derivatives-expressed protein 1 (HAND1)	OTN4IPVV	HAND1_HUMAN	Decreases Expression	[74]
G1/S-specific cyclin-E2 (CCNE2)	OTBBUKQQ	CCNE2_HUMAN	Increases Expression	[74]
Cytochrome b5 (CYB5A)	OT6SN4RM	CYB5_HUMAN	Decreases Expression	[74]
Tissue-type plasminogen activator (PLAT)	OTQPDNAB	TPA_HUMAN	Decreases Expression	[74]
Serine protease inhibitor Kazal-type 1 (SPINK1)	OTSUVAL2	ISK1_HUMAN	Increases Expression	[74]
Metalloproteinase inhibitor 1 (TIMP1)	OTOXC51H	TIMP1_HUMAN	Decreases Expression	[74]
Pro-neuropeptide Y (NPY)	OT4ICV3P	NPY_HUMAN	Decreases Expression	[74]
Collagen alpha-1(I) chain (COL1A1)	OTI31178	CO1A1_HUMAN	Decreases Expression	[74]
Collagen alpha-1(III) chain (COL3A1)	OTT1EMLM	CO3A1_HUMAN	Decreases Expression	[74]
Alpha-crystallin B chain (CRYAB)	OTY4JGYU	CRYAB_HUMAN	Decreases Expression	[74]
Metallothionein-2 (MT2A)	OTHOACHD	MT2_HUMAN	Decreases Expression	[74]
Metallothionein-1A (MT1A)	OTKBH52X	MT1A_HUMAN	Decreases Expression	[74]
Metallothionein-1E (MT1E)	OTXJKU4Y	MT1E_HUMAN	Decreases Expression	[74]
Sodium/potassium-transporting ATPase subunit beta-1 (ATP1B1)	OTTO6ZP4	AT1B1_HUMAN	Decreases Expression	[74]
Keratin, type II cytoskeletal 8 (KRT8)	OTTM4X11	K2C8_HUMAN	Decreases Expression	[74]
Collagen alpha-2(V) chain (COL5A2)	OT5VOSQE	CO5A2_HUMAN	Decreases Expression	[74]
Tyrosine-protein kinase Fyn (FYN)	OTLSLVZS	FYN_HUMAN	Increases Expression	[74]
Tyrosine 3-monooxygenase (TH)	OT6ZORKP	TY3H_HUMAN	Decreases Expression	[74]
Annexin A2 (ANXA2)	OTFNS0CC	ANXA2_HUMAN	Decreases Expression	[74]
Calpain-1 catalytic subunit (CAPN1)	OTK6OQZR	CAN1_HUMAN	Decreases Expression	[74]
Decorin (DCN)	OTWLJL7K	PGS2_HUMAN	Decreases Expression	[74]
Procathepsin L (CTSL)	OTYTUW29	CATL1_HUMAN	Decreases Expression	[74]
Tyrosine-protein kinase Lyn (LYN)	OTP686K2	LYN_HUMAN	Decreases Expression	[74]
Thrombospondin-1 (THBS1)	OT0ECWK3	TSP1_HUMAN	Increases Expression	[74]
Collagen alpha-2(I) chain (COL1A2)	OTY7G382	CO1A2_HUMAN	Decreases Expression	[74]
Annexin A6 (ANXA6)	OT9KIQ0Y	ANXA6_HUMAN	Decreases Expression	[74]
Rho-related GTP-binding protein RhoC (RHOC)	OTOLE1FT	RHOC_HUMAN	Decreases Expression	[74]
Matrix Gla protein (MGP)	OTZWU3FU	MGP_HUMAN	Decreases Expression	[74]
Keratin, type I cytoskeletal 19 (KRT19)	OTDGDQ75	K1C19_HUMAN	Decreases Expression	[74]
SPARC (SPARC)	OTPN90H0	SPRC_HUMAN	Decreases Expression	[74]
Platelet-derived growth factor receptor beta (PDGFRB)	OTYSNK9Q	PGFRB_HUMAN	Decreases Expression	[74]
Homeobox protein Hox-C6 (HOXC6)	OTBCRAZV	HXC6_HUMAN	Decreases Expression	[74]
Pro-cathepsin H (CTSH)	OTLFL0DG	CATH_HUMAN	Decreases Expression	[74]
Interferon-induced protein with tetratricopeptide repeats 1 (IFIT1)	OTXOQDSG	IFIT1_HUMAN	Decreases Expression	[74]
Thymosin beta-15A (TMSB15A)	OTSBWCES	TB15A_HUMAN	Increases Expression	[74]
Ras-related protein R-Ras (RRAS)	OTBBF28C	RRAS_HUMAN	Decreases Expression	[74]
Tissue factor pathway inhibitor (TFPI)	OTA0FX16	TFPI1_HUMAN	Decreases Expression	[74]
Growth hormone receptor (GHR)	OT8WUWMU	GHR_HUMAN	Decreases Expression	[74]
Hyaluronan and proteoglycan link protein 1 (HAPLN1)	OTXWR9TJ	HPLN1_HUMAN	Decreases Expression	[74]
Microtubule-associated protein 2 (MAP2)	OT6UYT3X	MTAP2_HUMAN	Increases Expression	[74]
Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1)	OTA675TJ	GTR1_HUMAN	Decreases Expression	[74]
Collagen alpha-2(VI) chain (COL6A2)	OTQC6PPO	CO6A2_HUMAN	Decreases Expression	[74]
Collagen alpha-3(VI) chain (COL6A3)	OTAS6R6I	CO6A3_HUMAN	Decreases Expression	[74]
Creatine kinase B-type (CKB)	OTUCKOTT	KCRB_HUMAN	Increases Expression	[74]
Bone morphogenetic protein 4 (BMP4)	OTPZMDFH	BMP4_HUMAN	Decreases Expression	[74]
Myosin light chain 4 (MYL4)	OTURFCSE	MYL4_HUMAN	Decreases Expression	[74]
Cytochrome b-245 light chain (CYBA)	OT16N9ZO	CY24A_HUMAN	Decreases Expression	[74]
Elongation factor 2 (EEF2)	OTZ7SZ39	EF2_HUMAN	Decreases Expression	[74]
Annexin A8 (ANXA8)	OTLSSQCY	ANXA8_HUMAN	Decreases Expression	[74]
Beta-enolase (ENO3)	OT3HYKYI	ENOB_HUMAN	Decreases Expression	[74]
Ezrin (EZR)	OTHBPF1Z	EZRI_HUMAN	Decreases Expression	[74]
N-chimaerin (CHN1)	OTM196M3	CHIN_HUMAN	Decreases Expression	[74]
CD44 antigen (CD44)	OT9TTJ41	CD44_HUMAN	Decreases Expression	[74]
Histone H1.2 (H1-2)	OT0AVI4M	H12_HUMAN	Decreases Expression	[74]
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 (GNB3)	OTA6HYBA	GBB3_HUMAN	Decreases Expression	[74]
Natriuretic peptides B (NPPB)	OTSN2IPY	ANFB_HUMAN	Increases Expression	[74]
Homeobox protein Hox-B8 (HOXB8)	OTKHOD17	HXB8_HUMAN	Decreases Expression	[74]
Homeobox protein Hox-B4 (HOXB4)	OTH1HRW5	HXB4_HUMAN	Decreases Expression	[74]
Homeobox protein Hox-B6 (HOXB6)	OT3TFQ0U	HXB6_HUMAN	Decreases Expression	[74]
Neuromodulin (GAP43)	OT2OTGGV	NEUM_HUMAN	Increases Expression	[74]
Insulin-like growth factor-binding protein 3 (IGFBP3)	OTIX63TX	IBP3_HUMAN	Decreases Expression	[74]
Integrin beta-5 (ITGB5)	OT21MF51	ITB5_HUMAN	Decreases Expression	[74]
Cyclic AMP-dependent transcription factor ATF-3 (ATF3)	OTC1UOHP	ATF3_HUMAN	Decreases Expression	[74]
Protachykinin-1 (TAC1)	OTM842YW	TKN1_HUMAN	Increases Expression	[74]
Homeobox protein Hox-A5 (HOXA5)	OTLWGPQD	HXA5_HUMAN	Increases Expression	[74]
Ephrin-A1 (EFNA1)	OTU2NUA2	EFNA1_HUMAN	Decreases Expression	[74]
Collagen alpha-1(IX) chain (COL9A1)	OTWBR27Y	CO9A1_HUMAN	Increases Expression	[74]
Collagen alpha-1(V) chain (COL5A1)	OT24078H	CO5A1_HUMAN	Decreases Expression	[74]
Cannabinoid receptor 1 (CNR1)	OTEALO6G	CNR1_HUMAN	Increases Expression	[74]
Tumor necrosis factor alpha-induced protein 3 (TNFAIP3)	OTVLI4DD	TNAP3_HUMAN	Decreases Expression	[74]
Midkine (MDK)	OTF24HKC	MK_HUMAN	Decreases Expression	[74]
Bone morphogenetic protein 5 (BMP5)	OTC0Y6E0	BMP5_HUMAN	Decreases Expression	[74]
Cadherin-3 (CDH3)	OTKNLQU7	CADH3_HUMAN	Decreases Expression	[74]
Calretinin (CALB2)	OTSNMCG9	CALB2_HUMAN	Decreases Expression	[74]
Fibulin-1 (FBLN1)	OT5MHHOP	FBLN1_HUMAN	Decreases Expression	[74]
Receptor-type tyrosine-protein phosphatase zeta (PTPRZ1)	OT2NRISU	PTPRZ_HUMAN	Increases Expression	[74]
Insulin-like growth factor-binding protein 5 (IGFBP5)	OTRE5V0C	IBP5_HUMAN	Decreases Expression	[74]
Paired box protein Pax-6 (PAX6)	OTOC9876	PAX6_HUMAN	Increases Expression	[74]
Protein S100-A4 (S100A4)	OTLRGFSQ	S10A4_HUMAN	Decreases Expression	[74]
Ciliary neurotrophic factor receptor subunit alpha (CNTFR)	OT3B1RGG	CNTFR_HUMAN	Increases Expression	[74]
Stomatin (STOM)	OTC8R6EH	STOM_HUMAN	Decreases Expression	[74]
Protein-lysine 6-oxidase (LOX)	OT1C2HIU	LYOX_HUMAN	Decreases Expression	[74]
Homeobox protein MSX-1 (MSX1)	OT5U41ZP	MSX1_HUMAN	Decreases Expression	[74]
Grancalcin (GCA)	OTAJ7ZHG	GRAN_HUMAN	Decreases Expression	[74]
Cellular retinoic acid-binding protein 1 (CRABP1)	OTISDG5X	RABP1_HUMAN	Increases Expression	[74]
Aquaporin-1 (AQP1)	OTX5MYX9	AQP1_HUMAN	Decreases Expression	[74]
G1/S-specific cyclin-D3 (CCND3)	OTNKPQ22	CCND3_HUMAN	Decreases Expression	[74]
Tyrosine-protein kinase receptor UFO (AXL)	OTKA2SUX	UFO_HUMAN	Decreases Expression	[74]
Translocator protein (TSPO)	OTSU7ESK	TSPO_HUMAN	Decreases Expression	[74]
Gastrin-releasing peptide receptor (GRPR)	OTBQGYJT	GRPR_HUMAN	Decreases Expression	[74]
Homeobox protein Hox-C8 (HOXC8)	OTJUYU8J	HXC8_HUMAN	Decreases Expression	[74]
Syndecan-4 (SDC4)	OTKUVUGZ	SDC4_HUMAN	Decreases Expression	[74]
Dimethylaniline monooxygenase 4 (FMO4)	OT5UYZL7	FMO4_HUMAN	Decreases Expression	[74]
Gastrin/cholecystokinin type B receptor (CCKBR)	OTQSNXOI	GASR_HUMAN	Decreases Expression	[74]
Serpin B6 (SERPINB6)	OT7G55IK	SPB6_HUMAN	Decreases Expression	[74]
Apelin receptor (APLNR)	OT8585HU	APJ_HUMAN	Decreases Expression	[74]
Copper-transporting ATPase 2 (ATP7B)	OTPWLNCO	ATP7B_HUMAN	Decreases Expression	[74]
Collagen alpha-1(XVIII) chain (COL18A1)	OTJFUH6O	COIA1_HUMAN	Decreases Expression	[74]
Melanocyte protein PMEL (PMEL)	OTCDDHHM	PMEL_HUMAN	Increases Expression	[74]
Peripherin (PRPH)	OT6VUH78	PERI_HUMAN	Decreases Expression	[74]
Transcription factor SOX-3 (SOX3)	OT1CRCOB	SOX3_HUMAN	Increases Expression	[74]
Glutamate receptor 2 (GRIA2)	OT5N1WB7	GRIA2_HUMAN	Increases Expression	[74]
Troponin T, cardiac muscle (TNNT2)	OT80NN7R	TNNT2_HUMAN	Decreases Expression	[74]
Peptidyl-prolyl cis-trans isomerase C (PPIC)	OTY5Q42N	PPIC_HUMAN	Decreases Expression	[74]
Leptin receptor (LEPR)	OT9H7G0C	LEPR_HUMAN	Decreases Expression	[74]
Neuromedin-U (NMU)	OTW9X7BQ	NMU_HUMAN	Increases Expression	[74]
Nestin (NES)	OTZ9PZ14	NEST_HUMAN	Increases Expression	[74]
Casein kinase I isoform delta (CSNK1D)	OTNF4S77	KC1D_HUMAN	Decreases Expression	[74]
CCAAT/enhancer-binding protein delta (CEBPD)	OTNBIPMY	CEBPD_HUMAN	Decreases Expression	[74]
Regulator of G-protein signaling 4 (RGS4)	OTG94HHL	RGS4_HUMAN	Decreases Expression	[74]
Cyclin-dependent kinase inhibitor 1C (CDKN1C)	OTASTJ3Q	CDN1C_HUMAN	Decreases Expression	[74]
Serpin B9 (SERPINB9)	OTJ811IF	SPB9_HUMAN	Decreases Expression	[74]
Serpin H1 (SERPINH1)	OTKGI7BS	SERPH_HUMAN	Decreases Expression	[74]
Ras association domain-containing protein 2 (RASSF2)	OT2JHDO4	RASF2_HUMAN	Increases Expression	[74]
Lipopolysaccharide-responsive and beige-like anchor protein (LRBA)	OTOUZN9G	LRBA_HUMAN	Decreases Expression	[74]
RNA-binding protein Nova-1 (NOVA1)	OT6A9KHY	NOVA1_HUMAN	Increases Expression	[74]
Neuronal membrane glycoprotein M6-a (GPM6A)	OT8G13EG	GPM6A_HUMAN	Increases Expression	[74]
Lumican (LUM)	OTSRC874	LUM_HUMAN	Decreases Expression	[74]
Heterogeneous nuclear ribonucleoprotein A3 (HNRNPA3)	OT4O4NFS	ROA3_HUMAN	Decreases Expression	[74]
Rho GDP-dissociation inhibitor 2 (ARHGDIB)	OT9PD6CS	GDIR2_HUMAN	Decreases Expression	[74]
Cationic amino acid transporter 2 (SLC7A2)	OTAMWBVM	CTR2_HUMAN	Decreases Expression	[74]
Atrophin-1 (ATN1)	OTNZFLKY	ATN1_HUMAN	Increases Expression	[74]
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (PDE1A)	OTU7J3F7	PDE1A_HUMAN	Increases Expression	[74]
Hydroxymethylglutaryl-CoA synthase, mitochondrial (HMGCS2)	OTC3RUN9	HMCS2_HUMAN	Decreases Expression	[74]
Phospholipid transfer protein (PLTP)	OTVJJO5Z	PLTP_HUMAN	Decreases Expression	[74]
Microfibril-associated glycoprotein 4 (MFAP4)	OT5W64QY	MFAP4_HUMAN	Decreases Expression	[74]
Cadherin-11 (CDH11)	OTIZKPTF	CAD11_HUMAN	Decreases Expression	[74]
Claudin-15 (CLDN15)	OT9K0KI7	CLD15_HUMAN	Decreases Expression	[74]
Junctional adhesion molecule B (JAM2)	OTHVJJRJ	JAM2_HUMAN	Increases Expression	[74]
Myelin proteolipid protein (PLP1)	OT8CM9CX	MYPR_HUMAN	Increases Expression	[74]
Protein S100-A10 (S100A10)	OTI71243	S10AA_HUMAN	Decreases Expression	[74]
Heart- and neural crest derivatives-expressed protein 2 (HAND2)	OTCXYW4Y	HAND2_HUMAN	Decreases Expression	[74]
Neurocalcin-delta (NCALD)	OTJZ8UEL	NCALD_HUMAN	Increases Expression	[74]
cAMP-dependent protein kinase inhibitor alpha (PKIA)	OT8M5GVO	IPKA_HUMAN	Decreases Expression	[74]
Actin, alpha cardiac muscle 1 (ACTC1)	OTJU04B1	ACTC_HUMAN	Decreases Expression	[74]
Actin, alpha skeletal muscle (ACTA1)	OTOVGLPG	ACTS_HUMAN	Increases Expression	[74]
Pituitary homeobox 1 (PITX1)	OTA0UN4C	PITX1_HUMAN	Decreases Expression	[74]
Oxidized low-density lipoprotein receptor 1 (OLR1)	OTS44RIC	OLR1_HUMAN	Decreases Expression	[74]
Iroquois-class homeodomain protein IRX-5 (IRX5)	OT05J514	IRX5_HUMAN	Increases Expression	[74]
Reelin (RELN)	OTLKMW1O	RELN_HUMAN	Decreases Expression	[74]
Arginase-2, mitochondrial (ARG2)	OTCPI0E8	ARGI2_HUMAN	Decreases Expression	[74]
Metallothionein-1X (MT1X)	OT9AKFVS	MT1X_HUMAN	Decreases Expression	[74]
Matrix-remodeling-associated protein 7 (MXRA7)	OTVQLYIY	MXRA7_HUMAN	Decreases Expression	[74]
Disabled homolog 2 (DAB2)	OTRMQTMZ	DAB2_HUMAN	Decreases Expression	[74]
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (PDE1B)	OT9NPJCR	PDE1B_HUMAN	Increases Expression	[74]
Myosin regulatory light chain 2, atrial isoform (MYL7)	OT7ZNDP4	MLRA_HUMAN	Decreases Expression	[74]
Peripheral myelin protein 22 (PMP22)	OTXWYWCZ	PMP22_HUMAN	Decreases Expression	[74]
Flavin-containing monooxygenase 1 (FMO1)	OTTHSQKP	FMO1_HUMAN	Decreases Expression	[74]
ATP-dependent 6-phosphofructokinase, platelet type (PFKP)	OTFP7AA8	PFKAP_HUMAN	Decreases Expression	[74]
Zinc finger protein basonuclin-1 (BNC1)	OTGJ5WUF	BNC1_HUMAN	Decreases Expression	[74]
Transgelin (TAGLN)	OTAEZ0KP	TAGL_HUMAN	Increases Expression	[74]
Guanylate cyclase soluble subunit alpha-1 (GUCY1A1)	OTPTCBUN	GCYA1_HUMAN	Decreases Expression	[74]
Sterol 26-hydroxylase, mitochondrial (CYP27A1)	OT649C01	CP27A_HUMAN	Decreases Expression	[74]
Desmocollin-2 (DSC2)	OTODVH8K	DSC2_HUMAN	Decreases Expression	[74]
Angiopoietin-1 receptor (TEK)	OT78YN57	TIE2_HUMAN	Decreases Expression	[74]
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 (PLOD1)	OT3ZIANF	PLOD1_HUMAN	Decreases Expression	[74]
Transforming growth factor beta receptor type 3 (TGFBR3)	OTQOOUC4	TGBR3_HUMAN	Decreases Expression	[74]
Parathyroid hormone/parathyroid hormone-related peptide receptor (PTH1R)	OTQF5ZAK	PTH1R_HUMAN	Decreases Expression	[74]
MBT domain-containing protein 1 (MBTD1)	OT2P6943	MBTD1_HUMAN	Increases Expression	[74]
3',5'-cyclic-AMP phosphodiesterase 4B (PDE4B)	OTOA8WU2	PDE4B_HUMAN	Increases Expression	[74]
Trefoil factor 3 (TFF3)	OTJJDRTU	TFF3_HUMAN	Increases Expression	[74]
Regulator of G-protein signaling 1 (RGS1)	OTGXJYMG	RGS1_HUMAN	Decreases Expression	[74]
Neuroblast differentiation-associated protein AHNAK (AHNAK)	OT6KH1WG	AHNK_HUMAN	Decreases Expression	[74]
Coiled-coil domain-containing protein 15 (CCDC15)	OT1NZX84	CCD15_HUMAN	Increases Expression	[74]
Transmembrane protein 62 (TMEM62)	OTJ4SPCM	TMM62_HUMAN	Increases Expression	[74]
Bone marrow stromal antigen 2 (BST2)	OTU4LCJV	BST2_HUMAN	Decreases Expression	[74]
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 (ST3GAL1)	OTFCO8QX	SIA4A_HUMAN	Decreases Expression	[74]
Tyrosine-protein kinase Mer (MERTK)	OTWBRAJ6	MERTK_HUMAN	Decreases Expression	[74]
Transmembrane emp24 domain-containing protein 1 (TMED1)	OTWSH0J8	TMED1_HUMAN	Decreases Expression	[74]
Filamin-C (FLNC)	OT3F8J6Y	FLNC_HUMAN	Decreases Expression	[74]
Transforming growth factor beta activator LRRC32 (LRRC32)	OTG7EDZL	LRC32_HUMAN	Decreases Expression	[74]
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H (PIGH)	OTMCFF0K	PIGH_HUMAN	Decreases Expression	[74]
Desmocollin-3 (DSC3)	OTYG47F8	DSC3_HUMAN	Decreases Expression	[74]
Eukaryotic translation initiation factor 4H (EIF4H)	OTGZI072	IF4H_HUMAN	Decreases Expression	[74]
Periostin (POSTN)	OTWP62UA	POSTN_HUMAN	Decreases Expression	[74]
Phosphoglucomutase-like protein 5 (PGM5)	OTEAS7OC	PGM5_HUMAN	Decreases Expression	[74]
Nicotinate-nucleotide pyrophosphorylase (QPRT)	OT6SKKLL	NADC_HUMAN	Decreases Expression	[74]
Leucine-rich repeat-containing protein 41 (LRRC41)	OT4YSBV5	LRC41_HUMAN	Decreases Expression	[74]
Delta(24)-sterol reductase (DHCR24)	OTP301JW	DHC24_HUMAN	Decreases Expression	[74]
Probable G-protein coupled receptor 19 (GPR19)	OTR7MUS5	GPR19_HUMAN	Increases Expression	[74]
Alpha-internexin (INA)	OT1D33T4	AINX_HUMAN	Increases Expression	[74]
Kynureninase (KYNU)	OTINL2RE	KYNU_HUMAN	Decreases Expression	[74]
Thiosulfate sulfurtransferase (TST)	OTZ4F5LK	THTR_HUMAN	Decreases Expression	[74]
Reticulon-1 (RTN1)	OTCX1SMK	RTN1_HUMAN	Increases Expression	[74]
Discoidin domain-containing receptor 2 (DDR2)	OT9IHOGZ	DDR2_HUMAN	Decreases Expression	[74]
Rho GTPase-activating protein 44 (ARHGAP44)	OTHJUCO1	RHG44_HUMAN	Decreases Expression	[74]
Sodium-coupled monocarboxylate transporter 2 (SLC5A12)	OTKY9NAL	SC5AC_HUMAN	Decreases Expression	[74]
Keratin, type I cytoskeletal 24 (KRT24)	OTR7MT1E	K1C24_HUMAN	Decreases Expression	[74]
Electroneutral sodium bicarbonate exchanger 1 (SLC4A8)	OTKJ0X6Q	S4A8_HUMAN	Decreases Expression	[74]
HLA class II histocompatibility antigen, DR beta 5 chain (HLA-DRB5)	OTUX5TWM	DRB5_HUMAN	Decreases Expression	[74]
Probable ubiquitin carboxyl-terminal hydrolase MINDY-4 (MINDY4)	OTBZ2SZB	MINY4_HUMAN	Decreases Expression	[74]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 (PLCH1)	OT6Z1L2E	PLCH1_HUMAN	Increases Expression	[74]
Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (SVEP1)	OTOBICRD	SVEP1_HUMAN	Decreases Expression	[74]
PDZ and LIM domain protein 3 (PDLIM3)	OTVXQC81	PDLI3_HUMAN	Increases Expression	[74]
Protein LBH (LBH)	OT87AT1X	LBH_HUMAN	Decreases Expression	[74]
Cordon-bleu protein-like 1 (COBLL1)	OTQFN1TC	COBL1_HUMAN	Decreases Expression	[74]
Spindlin-4 (SPIN4)	OT09ZWHM	SPIN4_HUMAN	Decreases Expression	[74]
Trans-2,3-enoyl-CoA reductase-like (TECRL)	OTXLSNCP	TECRL_HUMAN	Decreases Expression	[74]
Placenta-specific protein 9 (PLAC9)	OTZHIJ44	PLAC9_HUMAN	Decreases Expression	[74]
Collectin-12 (COLEC12)	OTIQTK9G	COL12_HUMAN	Decreases Expression	[74]
CUGBP Elav-like family member 3 (CELF3)	OTTP45WK	CELF3_HUMAN	Increases Expression	[74]
KN motif and ankyrin repeat domain-containing protein 4 (KANK4)	OT5WC0Q8	KANK4_HUMAN	Decreases Expression	[74]
Transcription factor HES-5 (HES5)	OTW7JEHV	HES5_HUMAN	Increases Expression	[74]
Collagen alpha-1(XIII) chain (COL13A1)	OTM9IM6J	CODA1_HUMAN	Decreases Expression	[74]
Terminal nucleotidyltransferase 5C (TENT5C)	OTOWVQ4O	TET5C_HUMAN	Decreases Expression	[74]
FYN-binding protein 2 (FYB2)	OTA3NG8M	FYB2_HUMAN	Decreases Expression	[74]
F-actin-uncapping protein LRRC16A (CARMIL1)	OT1A5IX5	CARL1_HUMAN	Decreases Expression	[74]
Pikachurin (EGFLAM)	OTACZZJ0	EGFLA_HUMAN	Decreases Expression	[74]
Carboxypeptidase Z (CPZ)	OT5HUR28	CBPZ_HUMAN	Decreases Expression	[74]
NADH-cytochrome b5 reductase 2 (CYB5R2)	OTTLM7XN	NB5R2_HUMAN	Decreases Expression	[74]
Repulsive guidance molecule B (RGMB)	OT2DROYU	RGMB_HUMAN	Increases Expression	[74]
Caveolae-associated protein 1 (CAVIN1)	OTFO915U	CAVN1_HUMAN	Decreases Expression	[74]
Cdc42 effector protein 5 (CDC42EP5)	OTQQDUCD	BORG3_HUMAN	Decreases Expression	[74]
Cytochrome b5 domain-containing protein 1 (CYB5D1)	OTSZWTPT	CB5D1_HUMAN	Decreases Expression	[74]
Transmembrane protein 88 (TMEM88)	OTA96YEL	TMM88_HUMAN	Decreases Expression	[74]
Protein cornichon homolog 2 (CNIH2)	OTT2ECCW	CNIH2_HUMAN	Increases Expression	[74]
Prostate androgen-regulated mucin-like protein 1 (PARM1)	OTDNK7EX	PARM1_HUMAN	Decreases Expression	[74]
Inactive serine protease PAMR1 (PAMR1)	OT83ZH5U	PAMR1_HUMAN	Decreases Expression	[74]
R-spondin-2 (RSPO2)	OT3HHXU0	RSPO2_HUMAN	Decreases Expression	[74]
Zinc finger protein basonuclin-2 (BNC2)	OTU22H9Z	BNC2_HUMAN	Decreases Expression	[74]
Staphylococcal nuclease domain-containing protein 1 (SND1)	OTT734JN	SND1_HUMAN	Decreases Expression	[74]
Monocarboxylate transporter 9 (SLC16A9)	OTVCLKQQ	MOT9_HUMAN	Increases Expression	[74]
Centriolin (CNTRL)	OTQI3VBA	CNTRL_HUMAN	Increases Expression	[74]
Calcium/calmodulin-dependent protein kinase II inhibitor 1 (CAMK2N1)	OTKCR5XL	CK2N1_HUMAN	Increases Expression	[74]
Schlafen family member 11 (SLFN11)	OTJWFPMY	SLN11_HUMAN	Increases Expression	[74]
Polypeptide N-acetylgalactosaminyltransferase 10 (GALNT10)	OTZ6FDOL	GLT10_HUMAN	Decreases Expression	[74]
Alpha-protein kinase 2 (ALPK2)	OTWZZDQ9	ALPK2_HUMAN	Decreases Expression	[74]
E3 ubiquitin-protein ligase MARCHF3 (MARCHF3)	OT89V4N5	MARH3_HUMAN	Decreases Expression	[74]
Transmembrane protein 200A (TMEM200A)	OTVJZIOR	T200A_HUMAN	Decreases Expression	[74]
Podoplanin (PDPN)	OTBUV19I	PDPN_HUMAN	Decreases Expression	[74]
Rhophilin-2 (RHPN2)	OTTYWMF6	RHPN2_HUMAN	Decreases Expression	[74]
Epidermal growth factor-like protein 6 (EGFL6)	OT331X59	EGFL6_HUMAN	Decreases Expression	[74]
5'-3' exonuclease PLD3 (PLD3)	OTL07SP2	PLD3_HUMAN	Decreases Expression	[74]
Neuron navigator 2 (NAV2)	OTGAOL01	NAV2_HUMAN	Decreases Expression	[74]
Somatomedin-B and thrombospondin type-1 domain-containing protein (SBSPON)	OTBHAW5K	SBSPO_HUMAN	Decreases Expression	[74]
N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase (GCNT2)	OTRUIMC4	GNT2A_HUMAN	Decreases Expression	[74]
Sperm-associated antigen 16 protein (SPAG16)	OTIFUPYD	SPG16_HUMAN	Increases Expression	[74]
Cytochrome P450 4X1 (CYP4X1)	OTMTEUNE	CP4X1_HUMAN	Decreases Expression	[74]
Inactive serine protease 35 (PRSS35)	OT09H6WH	PRS35_HUMAN	Decreases Expression	[74]
Secreted frizzled-related protein 1 (SFRP1)	OT0U9G41	SFRP1_HUMAN	Increases Expression	[74]
Reprimo-like protein (RPRML)	OTPOESFN	RPRML_HUMAN	Increases Expression	[74]
Actin filament-associated protein 1-like 2 (AFAP1L2)	OTJBI0VN	AF1L2_HUMAN	Decreases Expression	[74]
Protocadherin-20 (PCDH20)	OTFSNRXK	PCD20_HUMAN	Decreases Expression	[74]
Fibrous sheath-interacting protein 1 (FSIP1)	OTYLL6GM	FSIP1_HUMAN	Increases Expression	[74]
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 (ST6GALNAC3)	OTLAQ14Q	SIA7C_HUMAN	Decreases Expression	[74]
Trinucleotide repeat-containing gene 6A protein (TNRC6A)	OT493IOM	TNR6A_HUMAN	Increases Expression	[74]
Coiled-coil domain-containing protein 112 (CCDC112)	OT3OEYG6	CC112_HUMAN	Increases Expression	[74]
Class E basic helix-loop-helix protein 22 (BHLHE22)	OTZUQY5L	BHE22_HUMAN	Increases Expression	[74]
Secretory carrier-associated membrane protein 5 (SCAMP5)	OT9MXA2J	SCAM5_HUMAN	Increases Expression	[74]
Protein odd-skipped-related 1 (OSR1)	OTB19LEQ	OSR1_HUMAN	Decreases Expression	[74]
DEP domain-containing mTOR-interacting protein (DEPTOR)	OTCBP1BT	DPTOR_HUMAN	Decreases Expression	[74]
Protein MGARP (MGARP)	OTL90XO8	HUMMR_HUMAN	Decreases Expression	[74]
Mucolipin-3 (MCOLN3)	OTCRPRVS	MCLN3_HUMAN	Decreases Expression	[74]
Breast carcinoma-amplified sequence 4 (BCAS4)	OT596N5E	BCAS4_HUMAN	Decreases Expression	[74]
E3 ubiquitin-protein ligase SH3RF2 (SH3RF2)	OT2IVOK4	SH3R2_HUMAN	Decreases Expression	[74]
Docking protein 4 (DOK4)	OTUEWLG8	DOK4_HUMAN	Decreases Expression	[74]
Probable phospholipid-transporting ATPase IM (ATP8B4)	OT48TSYO	AT8B4_HUMAN	Decreases Expression	[74]
Cell migration-inducing and hyaluronan-binding protein (CEMIP)	OTK80FYN	CEMIP_HUMAN	Decreases Expression	[74]
Leucine-rich repeat neuronal protein 4 (LRRN4)	OTC2T1MP	LRRN4_HUMAN	Decreases Expression	[74]
Selenoprotein M (SELENOM)	OTJ7PORS	SELM_HUMAN	Decreases Expression	[74]
Atlastin-1 (ATL1)	OTR2788Y	ATLA1_HUMAN	Increases Expression	[74]
E3 ubiquitin-protein ligase MYLIP (MYLIP)	OTL0PFGV	MYLIP_HUMAN	Decreases Expression	[74]
Cyclic GMP-AMP phosphodiesterase SMPDL3A (SMPDL3A)	OTQDYH8E	ASM3A_HUMAN	Decreases Expression	[74]
SEC14-like protein 1 (SEC14L1)	OTA75FET	S14L1_HUMAN	Decreases Expression	[74]
Protein NDRG1 (NDRG1)	OTVO66BO	NDRG1_HUMAN	Decreases Expression	[74]
Ankyrin repeat and SAM domain-containing protein 1A (ANKS1A)	OTYZP3MP	ANS1A_HUMAN	Decreases Expression	[74]
Serine protease HTRA1 (HTRA1)	OTR8ACBF	HTRA1_HUMAN	Decreases Expression	[74]
Secreted frizzled-related protein 3 (FRZB)	OTTO3DPY	SFRP3_HUMAN	Decreases Expression	[74]
Hyaluronan synthase 2 (HAS2)	OTTD3PAL	HYAS2_HUMAN	Decreases Expression	[74]
Proprotein convertase subtilisin/kexin type 5 (PCSK5)	OTP0RJ4Y	PCSK5_HUMAN	Decreases Expression	[74]
Kallikrein-6 (KLK6)	OTIEA234	KLK6_HUMAN	Decreases Expression	[74]
Exostosin-2 (EXT2)	OT8IR5QN	EXT2_HUMAN	Decreases Expression	[74]
Ecto-ADP-ribosyltransferase 4 (ART4)	OTTV2J54	NAR4_HUMAN	Decreases Expression	[74]
Caveolae-associated protein 3 (CAVIN3)	OTOLBK79	CAVN3_HUMAN	Decreases Expression	[74]
Myeloid-derived growth factor (MYDGF)	OT9HRPL6	MYDGF_HUMAN	Decreases Expression	[74]
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 (ST6GALNAC6)	OT3C3VWX	SIA7F_HUMAN	Decreases Expression	[74]
Coiled-coil domain-containing protein 102A (CCDC102A)	OTT7XHIP	C102A_HUMAN	Decreases Expression	[74]
Ras-related and estrogen-regulated growth inhibitor (RERG)	OTF6MMLV	RERG_HUMAN	Decreases Expression	[74]
Ras-related protein Rab-37 (RAB37)	OTRL8IUO	RAB37_HUMAN	Decreases Expression	[74]
Store-operated calcium entry-associated regulatory factor (SARAF)	OTH5JIFE	SARAF_HUMAN	Decreases Expression	[74]
BTB/POZ domain-containing protein KCTD12 (KCTD12)	OTPYKT4Z	KCD12_HUMAN	Decreases Expression	[74]
Multivesicular body subunit 12A (MVB12A)	OT3737K0	MB12A_HUMAN	Decreases Expression	[74]
E3 ubiquitin-protein ligase pellino homolog 1 (PELI1)	OTMLBCLC	PELI1_HUMAN	Increases Expression	[74]
Phytanoyl-CoA hydroxylase-interacting protein-like (PHYHIPL)	OT9EIUGH	PHIPL_HUMAN	Increases Expression	[74]
Multidrug and toxin extrusion protein 1 (SLC47A1)	OTZX0U5Q	S47A1_HUMAN	Decreases Expression	[74]
Vacuolar-sorting protein SNF8 (SNF8)	OTRQA2AI	SNF8_HUMAN	Decreases Expression	[74]
Secreted frizzled-related protein 2 (SFRP2)	OT8GZ0CA	SFRP2_HUMAN	Increases Expression	[74]
PC-esterase domain-containing protein 1B (PCED1B)	OT19CDAB	PED1B_HUMAN	Decreases Expression	[74]
Terminal nucleotidyltransferase 5A (TENT5A)	OTSYF511	TET5A_HUMAN	Decreases Expression	[74]
Leucine-rich repeats and immunoglobulin-like domains protein 1 (LRIG1)	OTY5HZN5	LRIG1_HUMAN	Increases Expression	[74]
Lysyl oxidase homolog 4 (LOXL4)	OT6XY2JL	LOXL4_HUMAN	Decreases Expression	[74]
Multiple epidermal growth factor-like domains protein 10 (MEGF10)	OTILSPJ6	MEG10_HUMAN	Increases Expression	[74]
N-terminal kinase-like protein (SCYL1)	OTQ0IN7P	SCYL1_HUMAN	Decreases Expression	[74]
Ecto-ADP-ribosyltransferase 5 (ART5)	OTEZUT8V	NAR5_HUMAN	Decreases Expression	[74]
Protein phosphatase 1M (PPM1M)	OTCPLZQ7	PPM1M_HUMAN	Decreases Expression	[74]
Roundabout homolog 3 (ROBO3)	OTPVG40S	ROBO3_HUMAN	Increases Expression	[74]
Prickle-like protein 1 (PRICKLE1)	OT9HHEM9	PRIC1_HUMAN	Decreases Expression	[74]
Leucine-rich repeat and fibronectin type-III domain-containing protein 5 (LRFN5)	OTK7QZ3B	LRFN5_HUMAN	Decreases Expression	[74]
Guanylate-binding protein 4 (GBP4)	OTSPNGKX	GBP4_HUMAN	Decreases Expression	[74]
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (MAGI1)	OTMV4ASV	MAGI1_HUMAN	Increases Expression	[74]
Myeloid-associated differentiation marker (MYADM)	OTZTZI7P	MYADM_HUMAN	Decreases Expression	[74]
Protein Niban 2 (NIBAN2)	OTVDQSPI	NIBA2_HUMAN	Decreases Expression	[74]
Transcription factor 12 (TCF12)	OTZVONNU	HTF4_HUMAN	Increases Expression	[74]
Protein kinase C-binding protein NELL2 (NELL2)	OTS4MJZ7	NELL2_HUMAN	Increases Expression	[74]
G-protein coupled estrogen receptor 1 (GPER1)	OTUK0TDC	GPER1_HUMAN	Decreases Expression	[74]
Pituitary homeobox 2 (PITX2)	OTWMXAOY	PITX2_HUMAN	Decreases Expression	[74]
Plakophilin-2 (PKP2)	OTJOVF68	PKP2_HUMAN	Decreases Expression	[74]
Cbp/p300-interacting transactivator 2 (CITED2)	OT812TV7	CITE2_HUMAN	Decreases Expression	[74]
Ribosome quality control complex subunit TCF25 (TCF25)	OTTFHHU9	TCF25_HUMAN	Decreases Expression	[74]
Allograft inflammatory factor 1-like (AIF1L)	OTDEOB80	AIF1L_HUMAN	Increases Expression	[74]
SH3-containing GRB2-like protein 3-interacting protein 1 (SGIP1)	OTQW6R3Z	SGIP1_HUMAN	Increases Expression	[74]
Transcription elongation factor A protein-like 7 (TCEAL7)	OTNPDZCN	TCAL7_HUMAN	Increases Expression	[74]
Histone H2A.J (H2AJ)	OTVA4XTW	H2AJ_HUMAN	Decreases Expression	[74]
Ribonuclease P protein subunit p25 (RPP25)	OTEN6QN7	RPP25_HUMAN	Decreases Expression	[74]
EF-hand domain-containing protein D1 (EFHD1)	OTL5INE4	EFHD1_HUMAN	Decreases Expression	[74]
Arginine/serine-rich protein 1 (RSRP1)	OTOAZLCL	RSRP1_HUMAN	Decreases Expression	[74]
Transmembrane emp24 domain-containing protein 9 (TMED9)	OTYGAQS0	TMED9_HUMAN	Decreases Expression	[74]
Max dimerization protein 3 (MXD3)	OT4U88UP	MAD3_HUMAN	Increases Expression	[74]
Transcription factor GATA-5 (GATA5)	OTO81B63	GATA5_HUMAN	Decreases Expression	[74]
Oxysterol-binding protein-related protein 10 (OSBPL10)	OT0TFMBE	OSB10_HUMAN	Decreases Expression	[74]
Uncharacterized protein KIAA1671 (KIAA1671)	OTYGNSCG	K1671_HUMAN	Decreases Expression	[74]
Tripartite motif-containing protein 6 (TRIM6)	OTBSMX0B	TRIM6_HUMAN	Decreases Expression	[74]
Tripartite motif-containing protein 5 (TRIM5)	OTMZH7EJ	TRIM5_HUMAN	Decreases Expression	[74]
RNA exonuclease 4 (REXO4)	OT2NNFKZ	REXO4_HUMAN	Decreases Expression	[74]
Disintegrin and metalloproteinase domain-containing protein 19 (ADAM19)	OTH88TXU	ADA19_HUMAN	Decreases Expression	[74]
Cysteine-rich secretory protein LCCL domain-containing 2 (CRISPLD2)	OTVSFHTL	CRLD2_HUMAN	Decreases Expression	[74]
Gamma-aminobutyric acid receptor-associated protein-like 1 (GABARAPL1)	OT4U7SBG	GBRL1_HUMAN	Decreases Expression	[74]
Small conductance calcium-activated potassium channel protein 2 (KCNN2)	OTQVTMK5	KCNN2_HUMAN	Decreases Expression	[74]
Thiamin pyrophosphokinase 1 (TPK1)	OTCHPUD0	TPK1_HUMAN	Decreases Expression	[74]
SPARC-related modular calcium-binding protein 2 (SMOC2)	OTK1EQ49	SMOC2_HUMAN	Decreases Expression	[74]
Leucine-rich repeat neuronal protein 3 (LRRN3)	OT7X0AA7	LRRN3_HUMAN	Increases Expression	[74]
RWD domain-containing protein 1 (RWDD1)	OTVEZWQG	RWDD1_HUMAN	Increases Expression	[74]
Calcium-binding protein 39-like (CAB39L)	OTQEBL0W	CB39L_HUMAN	Decreases Expression	[74]
Spondin-1 (SPON1)	OTC06MY4	SPON1_HUMAN	Decreases Expression	[74]
Anoctamin-8 (ANO8)	OT07SRRX	ANO8_HUMAN	Increases Expression	[74]
Synaptotagmin-like protein 2 (SYTL2)	OTUIOWKL	SYTL2_HUMAN	Increases Expression	[74]
Solute carrier family 40 member 1 (SLC40A1)	OT8RV2VY	S40A1_HUMAN	Decreases Expression	[74]
Zinc transporter ZIP2 (SLC39A2)	OTE0GI4W	S39A2_HUMAN	Decreases Expression	[74]
NADPH oxidase 4 (NOX4)	OTTYQ097	NOX4_HUMAN	Decreases Expression	[74]
Nuclear receptor-interacting protein 3 (NRIP3)	OTU15GMK	NRIP3_HUMAN	Decreases Expression	[74]
G-protein coupled receptor family C group 5 member C (GPRC5C)	OT45AJT3	GPC5C_HUMAN	Decreases Expression	[74]
PR domain zinc finger protein 8 (PRDM8)	OTRA3265	PRDM8_HUMAN	Increases Expression	[74]
Integral membrane protein 2C (ITM2C)	OTHVMXE3	ITM2C_HUMAN	Decreases Expression	[74]
Rho guanine nucleotide exchange factor 3 (ARHGEF3)	OTHGNC0A	ARHG3_HUMAN	Decreases Expression	[74]
Olfactomedin-like protein 3 (OLFML3)	OTDN45FN	OLFL3_HUMAN	Decreases Expression	[74]
Kinesin-like protein KIF15 (KIF15)	OTJRJEXL	KIF15_HUMAN	Increases Expression	[74]
Serine palmitoyltransferase 3 (SPTLC3)	OTZDX6PT	SPTC3_HUMAN	Decreases Expression	[74]
Transmembrane protein 45A (TMEM45A)	OT54KJG6	TM45A_HUMAN	Decreases Expression	[74]
Host cell factor C1 regulator 1 (HCFC1R1)	OTGDPS5C	HPIP_HUMAN	Decreases Expression	[74]
Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase (BPNT2)	OT65C86U	IMPA3_HUMAN	Decreases Expression	[74]
PH and SEC7 domain-containing protein 3 (PSD3)	OTTN9B9O	PSD3_HUMAN	Increases Expression	[74]
G-protein coupled receptor 83 (GPR83)	OT7A2FE8	GPR83_HUMAN	Decreases Expression	[74]
Podocalyxin-like protein 2 (PODXL2)	OTB3PUR8	PDXL2_HUMAN	Increases Expression	[74]
Ral guanine nucleotide dissociation stimulator-like 1 (RGL1)	OTY6ZHVA	RGL1_HUMAN	Decreases Expression	[74]
Myoferlin (MYOF)	OTRFC3IJ	MYOF_HUMAN	Decreases Expression	[74]
Low-density lipoprotein receptor-related protein 1B (LRP1B)	OT4YZG2N	LRP1B_HUMAN	Decreases Expression	[74]
LIM and cysteine-rich domains protein 1 (LMCD1)	OT3AWE8O	LMCD1_HUMAN	Decreases Expression	[74]
Protein PALS2 (PALS2)	OTV12NKE	PALS2_HUMAN	Decreases Expression	[74]
Spermatogenesis-associated protein 7 (SPATA7)	OT78G2IH	SPAT7_HUMAN	Increases Expression	[74]
Neurotrimin (NTM)	OTHF0UQU	NTRI_HUMAN	Decreases Expression	[74]
C-type lectin domain family 1 member B (CLEC1B)	OTO38TRG	CLC1B_HUMAN	Decreases Expression	[74]
Dynein axonemal heavy chain 2 (DNAH2)	OT7J5LDI	DYH2_HUMAN	Decreases Expression	[74]
Semaphorin-5B (SEMA5B)	OTUVSKK0	SEM5B_HUMAN	Increases Expression	[74]
Signal-induced proliferation-associated 1-like protein 2 (SIPA1L2)	OT8NJE5D	SI1L2_HUMAN	Decreases Expression	[74]
Protein dispatched homolog 3 (DISP3)	OTEW6RYT	DISP3_HUMAN	Increases Expression	[74]
A disintegrin and metalloproteinase with thrombospondin motifs 9 (ADAMTS9)	OTV3Q0DS	ATS9_HUMAN	Decreases Expression	[74]
Vesicular glutamate transporter 2 (SLC17A6)	OTP1MJGP	VGLU2_HUMAN	Increases Expression	[74]
Beta-1,4-galactosyltransferase 7 (B4GALT7)	OTG5WHRW	B4GT7_HUMAN	Decreases Expression	[74]
Tachykinin-3 (TAC3)	OTOJGM38	TKNK_HUMAN	Decreases Expression	[74]
A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS1)	OTTLJH8W	ATS1_HUMAN	Decreases Expression	[74]
Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAIAP2L1)	OTZ71SK9	BI2L1_HUMAN	Decreases Expression	[74]
SERTA domain-containing protein 1 (SERTAD1)	OTBHKZQP	SRTD1_HUMAN	Decreases Expression	[74]
F-box only protein 2 (FBXO2)	OTF3677S	FBX2_HUMAN	Decreases Expression	[74]
Angiopoietin-related protein 2 (ANGPTL2)	OTB6JG41	ANGL2_HUMAN	Decreases Expression	[74]
Microtubule-associated tumor suppressor 1 (MTUS1)	OTBPALMU	MTUS1_HUMAN	Increases Expression	[74]
Y+L amino acid transporter 1 (SLC7A7)	OTYNABBR	YLAT1_HUMAN	Decreases Expression	[74]
Lysosomal thioesterase PPT2 (PPT2)	OTD5VJ9A	PPT2_HUMAN	Decreases Expression	[74]
Protein NDRG2 (NDRG2)	OT5L6KD7	NDRG2_HUMAN	Decreases Expression	[74]
LIM and calponin homology domains-containing protein 1 (LIMCH1)	OTYPC4XA	LIMC1_HUMAN	Increases Expression	[74]
Type 2 lactosamine alpha-2,3-sialyltransferase (ST3GAL6)	OTB17Q43	SIA10_HUMAN	Decreases Expression	[74]
Nuclease EXOG, mitochondrial (EXOG)	OTZAI8L7	EXOG_HUMAN	Decreases Expression	[74]
Netrin-G1 (NTNG1)	OTF48IID	NTNG1_HUMAN	Increases Expression	[74]
Protein SSUH2 homolog (SSUH2)	OTWUBDV0	SSUH2_HUMAN	Increases Expression	[74]
Transmembrane protein 98 (TMEM98)	OTKDUEED	TMM98_HUMAN	Decreases Expression	[74]
Plasmolipin (PLLP)	OTFGCB9U	PLLP_HUMAN	Decreases Expression	[74]
C2 domain-containing protein 2 (C2CD2)	OTL1K0OB	C2CD2_HUMAN	Decreases Expression	[74]
Talin-2 (TLN2)	OT10QQBC	TLN2_HUMAN	Decreases Expression	[74]
Protein mab-21-like 2 (MAB21L2)	OTZM5VMX	MB212_HUMAN	Decreases Expression	[74]
Transient receptor potential cation channel subfamily V member 2 (TRPV2)	OT0A9AVD	TRPV2_HUMAN	Decreases Expression	[74]
Transcription factor SOX-21 (SOX21)	OTNT50CC	SOX21_HUMAN	Increases Expression	[74]
LHFPL tetraspan subfamily member 6 protein (LHFPL6)	OTY6LHJY	LHPL6_HUMAN	Increases Expression	[74]
Stonin-1 (STON1)	OT2HPUAI	STON1_HUMAN	Decreases Expression	[74]
Transcription factor E2F8 (E2F8)	OTQKZGFP	E2F8_HUMAN	Increases Expression	[76]
Thymidine kinase 2, mitochondrial (TK2)	OTS1V4XB	KITM_HUMAN	Decreases Expression	[90]
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)	OTA1CPBV	TR10B_HUMAN	Increases Expression	[91]
Protein regulator of cytokinesis 1 (PRC1)	OTHD0XS0	PRC1_HUMAN	Decreases Expression	[75]
PRA1 family protein 3 (ARL6IP5)	OTYZ6BEQ	PRAF3_HUMAN	Increases Expression	[92]
Prothrombin (F2)	OTNFSM49	THRB_HUMAN	Affects Expression	[93]
Plasminogen (PLG)	OTWWIPPY	PLMN_HUMAN	Affects Localization	[94]
Prolactin (PRL)	OTWFQGX7	PRL_HUMAN	Increases Expression	[95]
Tumor necrosis factor (TNF)	OT4IE164	TNFA_HUMAN	Increases Expression	[96]
Thymidine kinase, cytosolic (TK1)	OTY5JFM1	KITH_HUMAN	Decreases Expression	[90]
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)	OTBPMIMW	G3P_HUMAN	Decreases Activity	[97]
Interleukin-6 (IL6)	OTUOSCCU	IL6_HUMAN	Increases Expression	[96]
Transcription factor Jun (JUN)	OTCYBO6X	JUN_HUMAN	Increases Expression	[98]
High mobility group protein B1 (HMGB1)	OT4B7CPF	HMGB1_HUMAN	Increases Secretion	[99]
Poly polymerase 1 (PARP1)	OT310QSG	PARP1_HUMAN	Increases Degradation	[100]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Decreases Expression	[98]
Histone H2AX (H2AX)	OT18UX57	H2AX_HUMAN	Increases Phosphorylation	[97]
Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A)	OTDRV63V	GA45A_HUMAN	Increases Expression	[76]
Tumor necrosis factor receptor superfamily member 6 (FAS)	OTP9XG86	TNR6_HUMAN	Increases Expression	[76]
Cyclin-dependent kinases regulatory subunit 2 (CKS2)	OTPTMHIV	CKS2_HUMAN	Decreases Expression	[75]
Cyclin-dependent kinase inhibitor 1 (CDKN1A)	OTQWHCZE	CDN1A_HUMAN	Increases Expression	[76]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Increases Activity	[101]
Importin subunit alpha-1 (KPNA2)	OTU7FOE6	IMA1_HUMAN	Decreases Expression	[75]
Sestrin-3 (SESN3)	OTJRY1Y5	SESN3_HUMAN	Decreases Expression	[76]
Beta-2-microglobulin (B2M)	OTDWN6NX	B2MG_HUMAN	Increases Expression	[102]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 (PLCB2)	OTPAHDGO	PLCB2_HUMAN	Affects Localization	[103]
Transcription factor p65 (RELA)	OTUJP9CN	TF65_HUMAN	Decreases Activity	[104]
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Increases Expression	[105]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)	OT2YYI1A	MCL1_HUMAN	Decreases Expression	[106]
Cyclin-dependent kinase 5 activator 1 (CDK5R1)	OTJELWK0	CD5R1_HUMAN	Increases Expression	[76]
Borealin (CDCA8)	OT17D55D	BOREA_HUMAN	Decreases Expression	[75]
Proline/serine-rich coiled-coil protein 1 (PSRC1)	OT7MDJMN	PSRC1_HUMAN	Decreases Expression	[75]
Protein aurora borealis (BORA)	OTV2ZPKP	BORA_HUMAN	Decreases Expression	[75]
Jouberin (AHI1)	OT8K2YWY	AHI1_HUMAN	Increases Expression	[107]
Transient receptor potential cation channel subfamily V member 1 (TRPV1)	OTHHDR03	TRPV1_HUMAN	Affects Localization	[108]
Tumor necrosis factor receptor superfamily member 19 (TNFRSF19)	OTTVT4MB	TNR19_HUMAN	Decreases Expression	[76]
Solute carrier family 12 member 6 (SLC12A6)	OT9CS413	S12A6_HUMAN	Decreases Expression	[76]
Lactosylceramide alpha-2,3-sialyltransferase (ST3GAL5)	OT27CCUF	SIAT9_HUMAN	Decreases Expression	[76]
Hairy/enhancer-of-split related with YRPW motif protein 1 (HEY1)	OTJQL0I3	HEY1_HUMAN	Decreases Expression	[76]
Interleukin-3 (IL3)	OT0CQ35N	IL3_HUMAN	Increases ADR	[109]
Kynurenine 3-monooxygenase (KMO)	OT3MRMM9	KMO_HUMAN	Increases Response To Substance	[110]
Stathmin-4 (STMN4)	OT7ZUKW6	STMN4_HUMAN	Increases Response To Substance	[110]
Histone-lysine N-methyltransferase 2A (KMT2A)	OT9GLJI6	KMT2A_HUMAN	Increases Response To Substance	[111]
Protein lyl-1 (LYL1)	OTCNOV1M	LYL1_HUMAN	Decreases Response To Substance	[112]
Metalloproteinase inhibitor 3 (TIMP3)	OTDGQAD1	TIMP3_HUMAN	Decreases Response To Substance	[113]
Tumor protein p53-inducible protein 11 (TP53I11)	OTFPDYZU	P5I11_HUMAN	Increases Response To Substance	[110]
Hepatocyte growth factor (HGF)	OTGHUA23	HGF_HUMAN	Increases ADR	[109]
Multidrug resistance-associated protein 1 (ABCC1)	OTGUN89S	MRP1_HUMAN	Affects Response To Substance	[114]
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Increases Response To Substance	[115]
14-3-3 protein sigma (SFN)	OTLJCZ1U	1433S_HUMAN	Decreases Response To Substance	[116]
Protein kinase C zeta type (PRKCZ)	OTN2FE42	KPCZ_HUMAN	Decreases Response To Substance	[117]
Calcitonin receptor (CALCR)	OTOVDJ7S	CALCR_HUMAN	Increases Response To Substance	[110]
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN)	OTOWDUNT	PTEN_HUMAN	Increases Response To Substance	[118]
Glutathione S-transferase Mu 1 (GSTM1)	OTSBF2MO	GSTM1_HUMAN	Affects Response To Substance	[78]
Methylenetetrahydrofolate reductase (MTHFR)	OTUBJSR7	MTHR_HUMAN	Affects Response To Substance	[113]
Deoxycytidine kinase (DCK)	OTW8HLZC	DCK_HUMAN	Decreases Response To Substance	[89]

References

• [1] Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
• [2] Sorafenib FDA Label
• [3] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5711).
• [4] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4827).
• [5] Cytarabine FDA Label
• [6] Novel carbocyclic curcumin analog CUR3d modulates genes involved in multiple apoptosis pathways in human hepatocellular carcinoma cells. Chem Biol Interact. 2015 Dec 5;242:107-22.
• [7] Destruxin B inhibits hepatocellular carcinoma cell growth through modulation of the Wnt/-catenin signaling pathway and epithelial-mesenchymal transition. Toxicol In Vitro. 2014 Jun;28(4):552-61. doi: 10.1016/j.tiv.2014.01.002. Epub 2014 Jan 13.
• [8] The kinase inhibitor sorafenib induces cell death through a process involving induction of endoplasmic reticulum stress. Mol Cell Biol. 2007 Aug;27(15):5499-513. doi: 10.1128/MCB.01080-06. Epub 2007 Jun 4.
• [9] Sorafenib induces apoptosis of AML cells via Bim-mediated activation of the intrinsic apoptotic pathway. Leukemia. 2008 Apr;22(4):808-18. doi: 10.1038/sj.leu.2405098. Epub 2008 Jan 17.
• [10] Ovatodiolide suppresses yes-associated protein 1-modulated cancer stem cell phenotypes in highly malignant hepatocellular carcinoma and sensitizes cancer cells to chemotherapy in vitro. Toxicol In Vitro. 2018 Sep;51:74-82. doi: 10.1016/j.tiv.2018.04.010. Epub 2018 Apr 24.
• [11] Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling.Mol Cancer Ther.2008 Oct;7(10):3129-40.
• [12] Nasopharyngeal carcinoma: Current treatment options and future directions. J Nasopharyng Carcinoma, 2014, 1(16): e16.
• [13] Multidrug resistance protein 2 implicates anticancer drug-resistance to sorafenib. Biol Pharm Bull. 2011;34(3):433-5.
• [14] Breast cancer resistance protein and P-glycoprotein limit sorafenib brain accumulation. Mol Cancer Ther. 2010 Feb;9(2):319-26.
• [15] Double-transduced MDCKII cells to study human P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) interplay in drug transport across the blood-brain barrier. Mol Pharm. 2011 Apr 4;8(2):571-82.
• [16] Contribution of OATP1B1 and OATP1B3 to the disposition of sorafenib and sorafenib-glucuronide. Clin Cancer Res. 2013 Mar 15;19(6):1458-66.
• [17] Upregulation of histone acetylation reverses organic anion transporter 2 repression and enhances 5-fluorouracil sensitivity in hepatocellular carcinoma
• [18] Rlip76 transports sunitinib and sorafenib and mediates drug resistance in kidney cancer. Int J Cancer. 2010 Mar 15;126(6):1327-38.
• [19] Interaction of sorafenib and cytochrome P450 isoenzymes in patients with advanced melanoma: a phase I/II pharmacokinetic interaction study. Cancer Chemother Pharmacol. 2011 Nov;68(5):1111-8.
• [20] Ontogeny and sorafenib metabolism. Clin Cancer Res. 2012 Oct 15;18(20):5788-95.
• [21] Drug Interactions Flockhart Table
• [22] Pharmacokinetic interaction involving sorafenib and the calcium-channel blocker felodipine in a patient with hepatocellular carcinoma. Invest New Drugs. 2011 Dec;29(6):1511-4.
• [23] Differential inhibition of human CYP2C8 and molecular docking interactions elicited by sorafenib and its major N-oxide metabolite. Chem Biol Interact. 2021 Apr 1;338:109401. doi: 10.1016/j.cbi.2021.109401. Epub 2021 Feb 5.
• [24] The Enhanced metastatic potential of hepatocellular carcinoma (HCC) cells with sorafenib resistance. PLoS One. 2013 Nov 11;8(11):e78675. doi: 10.1371/journal.pone.0078675. eCollection 2013.
• [25] Sorafenib induces growth suppression in mouse models of gastrointestinal stromal tumor. Mol Cancer Ther. 2009 Jan;8(1):152-9. doi: 10.1158/1535-7163.MCT-08-0553.
• [26] Down-regulation of CYLD as a trigger for NF-B activation and a mechanism of apoptotic resistance in hepatocellular carcinoma cells. Int J Oncol. 2011 Jan;38(1):121-31.
• [27] Sorafenib induces apoptotic cell death in human non-small cell lung cancer cells by down-regulating mammalian target of rapamycin (mTOR)-dependent survivin expression. Biochem Pharmacol. 2011 Aug 1;82(3):216-26. doi: 10.1016/j.bcp.2011.04.011. Epub 2011 May 13.
• [28] Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicol Sci. 2010 Dec; 118(2):485-500.
• [29] Differential effects of arsenic trioxide on chemosensitization in human hepatic tumor and stellate cell lines. BMC Cancer. 2012 Sep 10;12:402.
• [30] The multikinase inhibitor sorafenib potentiates TRAIL lethality in human leukemia cells in association with Mcl-1 and cFLIPL down-regulation. Cancer Res. 2007 Oct 1;67(19):9490-500. doi: 10.1158/0008-5472.CAN-07-0598.
• [31] Apoptosis induced by the kinase inhibitor BAY 43-9006 in human leukemia cells involves down-regulation of Mcl-1 through inhibition of translation. J Biol Chem. 2005 Oct 21;280(42):35217-27. doi: 10.1074/jbc.M506551200. Epub 2005 Aug 18.
• [32] Sorafenib targets the mitochondrial electron transport chain complexes and ATP synthase to activate the PINK1-Parkin pathway and modulate cellular drug response. J Biol Chem. 2017 Sep 8;292(36):15105-15120. doi: 10.1074/jbc.M117.783175. Epub 2017 Jul 3.
• [33] Induction of DNA damage-inducible gene GADD45beta contributes to sorafenib-induced apoptosis in hepatocellular carcinoma cells. Cancer Res. 2010 Nov 15;70(22):9309-18. doi: 10.1158/0008-5472.CAN-10-1033. Epub 2010 Nov 9.
• [34] Growth arrest DNA damage-inducible gene 45 gamma expression as a prognostic and predictive biomarker in hepatocellular carcinoma. Oncotarget. 2015 Sep 29;6(29):27953-65. doi: 10.18632/oncotarget.4446.
• [35] Sorafenib induces apoptosis specifically in cells expressing BCR/ABL by inhibiting its kinase activity to activate the intrinsic mitochondrial pathway. Cancer Res. 2009 May 1;69(9):3927-36. doi: 10.1158/0008-5472.CAN-08-2978. Epub 2009 Apr 14.
• [36] Synergistic antimetastatic effect of cotreatment with licochalcone A and sorafenib on human hepatocellular carcinoma cells through the inactivation of MKK4/JNK and uPA expression. Environ Toxicol. 2018 Dec;33(12):1237-1244. doi: 10.1002/tox.22630. Epub 2018 Sep 6.
• [37] Sorafenib inhibits transforming growth factor 1-mediated epithelial-mesenchymal transition and apoptosis in mouse hepatocytes. Hepatology. 2011 May;53(5):1708-18. doi: 10.1002/hep.24254.
• [38] Activation of inflammasomes by tyrosine kinase inhibitors of vascular endothelial growth factor receptor: Implications for VEGFR TKIs-induced immune related adverse events. Toxicol In Vitro. 2021 Mar;71:105063. doi: 10.1016/j.tiv.2020.105063. Epub 2020 Dec 1.
• [39] Sorafenib is an antagonist of the aryl hydrocarbon receptor. Toxicology. 2022 Mar 30;470:153118. doi: 10.1016/j.tox.2022.153118. Epub 2022 Feb 3.
• [40] Sorafenib induces cell death in chronic lymphocytic leukemia by translational downregulation of Mcl-1. Leukemia. 2011 May;25(5):838-47. doi: 10.1038/leu.2011.2. Epub 2011 Feb 4.
• [41] Cell cycle dependent and schedule-dependent antitumor effects of sorafenib combined with radiation. Cancer Res. 2007 Oct 1;67(19):9443-54. doi: 10.1158/0008-5472.CAN-07-1473.
• [42] Sorafenib functions to potently suppress RET tyrosine kinase activity by direct enzymatic inhibition and promoting RET lysosomal degradation independent of proteasomal targeting. J Biol Chem. 2007 Oct 5;282(40):29230-40. doi: 10.1074/jbc.M703461200. Epub 2007 Jul 30.
• [43] Synergistic activity of letrozole and sorafenib on breast cancer cells. Breast Cancer Res Treat. 2010 Nov;124(1):79-88. doi: 10.1007/s10549-009-0714-5. Epub 2010 Jan 7.
• [44] Coadministration of sorafenib with rottlerin potently inhibits cell proliferation and migration in human malignant glioma cells. J Pharmacol Exp Ther. 2006 Dec;319(3):1070-80. doi: 10.1124/jpet.106.108621. Epub 2006 Sep 7.
• [45] Sorafenib induces apoptosis in HL60 cells by inhibiting Src kinase-mediated STAT3 phosphorylation. Anticancer Drugs. 2011 Jan;22(1):79-88. doi: 10.1097/CAD.0b013e32833f44fd.
• [46] Rap1/B-Raf signaling is activated in neuroendocrine tumors of the digestive tract and Raf kinase inhibition constitutes a putative therapeutic target. Neuroendocrinology. 2007;85(1):45-53. doi: 10.1159/000100508. Epub 2007 Mar 5.
• [47] Potent activity of ponatinib (AP24534) in models of FLT3-driven acute myeloid leukemia and other hematologic malignancies. Mol Cancer Ther. 2011 Jun;10(6):1028-35. doi: 10.1158/1535-7163.MCT-10-1044. Epub 2011 Apr 11.
• [48] Inhibition of autophagy potentiates the antitumor effect of the multikinase inhibitor sorafenib in hepatocellular carcinoma. Int J Cancer. 2012 Aug 1;131(3):548-57. doi: 10.1002/ijc.26374. Epub 2011 Sep 12.
• [49] Cytotoxicity of 34 FDA approved small-molecule kinase inhibitors in primary rat and human hepatocytes. Toxicol Lett. 2018 Jul;291:138-148. doi: 10.1016/j.toxlet.2018.04.010. Epub 2018 Apr 12.
• [50] Sorafenib inhibits signal transducer and activator of transcription 3 signaling associated with growth arrest and apoptosis of medulloblastomas. Mol Cancer Ther. 2008 Nov;7(11):3519-26. doi: 10.1158/1535-7163.MCT-08-0138.
• [51] Therapeutic targeting of hepatocellular carcinoma cells with antrocinol, a novel, dual-specificity, small-molecule inhibitor of the KRAS and ERK oncogenic signaling pathways. Chem Biol Interact. 2023 Jan 25;370:110329. doi: 10.1016/j.cbi.2022.110329. Epub 2022 Dec 22.
• [52] Sorafenib derivatives induce apoptosis through inhibition of STAT3 independent of Raf. Eur J Med Chem. 2011 Jul;46(7):2845-51. doi: 10.1016/j.ejmech.2011.04.007. Epub 2011 Apr 14.
• [53] The multikinase inhibitor sorafenib induces apoptosis in highly imatinib mesylate-resistant bcr/abl+ human leukemia cells in association with signal transducer and activator of transcription 5 inhibition and myeloid cell leukemia-1 down-regulation. Mol Pharmacol. 2007 Sep;72(3):788-95. doi: 10.1124/mol.106.033308. Epub 2007 Jun 26.
• [54] Arsenic trioxide potentiates the anti-cancer activities of sorafenib against hepatocellular carcinoma by inhibiting Akt activation. Tumour Biol. 2015 Apr;36(4):2323-34. doi: 10.1007/s13277-014-2839-3. Epub 2014 Nov 22.
• [55] Proliferation and survival molecules implicated in the inhibition of BRAF pathway in thyroid cancer cells harbouring different genetic mutations. BMC Cancer. 2009 Oct 31;9:387. doi: 10.1186/1471-2407-9-387.
• [56] The multikinase inhibitor Sorafenib induces apoptosis and sensitises endometrial cancer cells to TRAIL by different mechanisms. Eur J Cancer. 2010 Mar;46(4):836-50. doi: 10.1016/j.ejca.2009.12.025. Epub 2010 Jan 12.
• [57] Downregulation of stanniocalcin 1 is responsible for sorafenib-induced cardiotoxicity. Toxicol Sci. 2015 Feb;143(2):374-84. doi: 10.1093/toxsci/kfu235. Epub 2014 Nov 3.
• [58] Sorafenib induces preferential apoptotic killing of a drug- and radio-resistant Hep G2 cells through a mitochondria-dependent oxidative stress mechanism. Cancer Biol Ther. 2009 Oct;8(20):1904-13. doi: 10.4161/cbt.8.20.9436. Epub 2009 Oct 6.
• [59] Protective effect of sestrin2 against iron overload and ferroptosis-induced liver injury. Toxicol Appl Pharmacol. 2019 Sep 15;379:114665. doi: 10.1016/j.taap.2019.114665. Epub 2019 Jul 16.
• [60] Mechanisms of apoptosis induction by simultaneous inhibition of PI3K and FLT3-ITD in AML cells in the hypoxic bone marrow microenvironment. Cancer Lett. 2013 Feb 1;329(1):45-58. doi: 10.1016/j.canlet.2012.09.020. Epub 2012 Oct 2.
• [61] The role of Mcl-1 downregulation in the proapoptotic activity of the multikinase inhibitor BAY 43-9006. Oncogene. 2005 Oct 20;24(46):6861-9. doi: 10.1038/sj.onc.1208841.
• [62] Why are most phospholipidosis inducers also hERG blockers?. Arch Toxicol. 2017 Dec;91(12):3885-3895. doi: 10.1007/s00204-017-1995-9. Epub 2017 May 27.
• [63] The multikinase inhibitor sorafenib induces caspase-dependent apoptosis in PC-3 prostate cancer cells. Asian J Androl. 2010 Jul;12(4):527-34. doi: 10.1038/aja.2010.21. Epub 2010 May 17.
• [64] Synergistic inhibition of human melanoma proliferation by combination treatment with B-Raf inhibitor BAY43-9006 and mTOR inhibitor Rapamycin. J Transl Med. 2005 Oct 28;3:39. doi: 10.1186/1479-5876-3-39.
• [65] GSK-3beta inhibition enhances sorafenib-induced apoptosis in melanoma cell lines. J Biol Chem. 2008 Jan 11;283(2):726-32. doi: 10.1074/jbc.M705343200. Epub 2007 Nov 8.
• [66] Cytotoxic synergy between the multikinase inhibitor sorafenib and the proteasome inhibitor bortezomib in vitro: induction of apoptosis through Akt and c-Jun NH2-terminal kinase pathways. Mol Cancer Ther. 2006 Sep;5(9):2378-87. doi: 10.1158/1535-7163.MCT-06-0235.
• [67] Association of CYP1A1 and CYP1B1 inhibition in in vitro assays with drug-induced liver injury. J Toxicol Sci. 2021;46(4):167-176. doi: 10.2131/jts.46.167.
• [68] Vorinostat and sorafenib increase ER stress, autophagy and apoptosis via ceramide-dependent CD95 and PERK activation. Cancer Biol Ther. 2008 Oct;7(10):1648-62. doi: 10.4161/cbt.7.10.6623. Epub 2008 Oct 12.
• [69] A high-throughput screen for teratogens using human pluripotent stem cells. Toxicol Sci. 2014 Jan;137(1):76-90. doi: 10.1093/toxsci/kft239. Epub 2013 Oct 23.
• [70] TRIM62 silencing represses the proliferation and invasion and increases the chemosensitivity of hepatocellular carcinoma cells by affecting the NF-B pathway. Toxicol Appl Pharmacol. 2022 Jun 15;445:116035. doi: 10.1016/j.taap.2022.116035. Epub 2022 Apr 23.
• [71] Diospyros kaki leaves inhibit HGF/Met signaling-mediated EMT and stemness features in hepatocellular carcinoma. Food Chem Toxicol. 2020 Aug;142:111475. doi: 10.1016/j.fct.2020.111475. Epub 2020 Jun 6.
• [72] Comparative proteomic analysis of SLC13A5 knockdown reveals elevated ketogenesis and enhanced cellular toxic response to chemotherapeutic agents in HepG2 cells. Toxicol Appl Pharmacol. 2020 Sep 1;402:115117. doi: 10.1016/j.taap.2020.115117. Epub 2020 Jul 4.
• [73] The DNA methyltransferase inhibitors azacitidine, decitabine and zebularine exert differential effects on cancer gene expression in acute myeloid leukemia cells. Leukemia. 2009 Jun;23(6):1019-28.
• [74] Cytosine arabinoside induces ectoderm and inhibits mesoderm expression in human embryonic stem cells during multilineage differentiation. Br J Pharmacol. 2011 Apr;162(8):1743-56.
• [75] Characterization of DNA reactive and non-DNA reactive anticancer drugs by gene expression profiling. Mutat Res. 2007 Jun 1;619(1-2):16-29. doi: 10.1016/j.mrfmmm.2006.12.007. Epub 2007 Feb 8.
• [76] Development and validation of the TGx-HDACi transcriptomic biomarker to detect histone deacetylase inhibitors in human TK6 cells. Arch Toxicol. 2021 May;95(5):1631-1645. doi: 10.1007/s00204-021-03014-2. Epub 2021 Mar 26.
• [77] Expression and prognostic significance of IAP-family genes in human cancers and myeloid leukemias. Clin Cancer Res. 2000 May;6(5):1796-803.
• [78] Pharmacogenetics of outcome in children with acute lymphoblastic leukemia. Blood. 2005 Jun 15;105(12):4752-8. doi: 10.1182/blood-2004-11-4544. Epub 2005 Feb 15.
• [79] Vascular endothelial growth factor-C modulates proliferation and chemoresistance in acute myeloid leukemic cells through an endothelin-1-dependent induction of cyclooxygenase-2. Biochim Biophys Acta. 2014 Feb;1843(2):387-97. doi: 10.1016/j.bbamcr.2013.10.015. Epub 2013 Oct 31.
• [80] Chromatin-associated proteins HMGB1/2 and PDIA3 trigger cellular response to chemotherapy-induced DNA damage. Mol Cancer Ther. 2009 Apr;8(4):864-72.
• [81] Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64.
• [82] Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007.
• [83] OCTN1 Is a High-Affinity Carrier of Nucleoside Analogues. Cancer Res. 2017 Apr 15;77(8):2102-2111.
• [84] FLT3 is implicated in cytarabine transport by human equilibrative nucleoside transporter 1 in pediatric acute leukemia. Oncotarget. 2016 Aug 2;7(31):49786-49799.
• [85] Synthesis and characterization of a novel liver-targeted prodrug of cytosine-1-beta-D-arabinofuranoside monophosphate for the treatment of hepatocellular carcinoma. J Med Chem. 2006 Dec 28;49(26):7711-20.
• [86] Genetic factors influencing cytarabine therapy. Pharmacogenomics. 2009 Oct;10(10):1657-74.
• [87] Mycoplasma hyorhinis-encoded cytidine deaminase efficiently inactivates cytosine-based anticancer drugs. FEBS Open Bio. 2015 Aug 3;5:634-9.
• [88] [Relationship between the induction of MDR1, a multidrug resistance gene in tumor cells, and apoptosis]. Ontogenez. 2001 Jul-Aug;32(4):295-301.
• [89] Two distinct molecular mechanisms underlying cytarabine resistance in human leukemic cells. Cancer Res. 2008 Apr 1;68(7):2349-57. doi: 10.1158/0008-5472.CAN-07-5528.
• [90] Arabinosylcytosine downregulates thymidine kinase and induces cross-resistance to zidovudine in T-lymphoid cells. Biochem Biophys Res Commun. 2003 Aug 1;307(3):564-8. doi: 10.1016/s0006-291x(03)01232-4.
• [91] [Combined effect of TNF-related apoptosis induced ligand and Ara-C in inducing apoptosis of HL-60 cells and its mechanism]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2008 Jun;16(3):510-5.
• [92] JWA, a novel signaling molecule, involved in the induction of differentiation of human myeloid leukemia cells. Biochem Biophys Res Commun. 2006 Mar 10;341(2):440-50. doi: 10.1016/j.bbrc.2005.12.197. Epub 2006 Jan 11.
• [93] The effects of chemotherapeutic agents on the regulation of thrombin on cell surfaces. Br J Haematol. 2003 Jan;120(2):315-24. doi: 10.1046/j.1365-2141.2003.03971.x.
• [94] Arsenic trioxide, retinoic acid and Ara-c regulated the expression of annexin II on the surface of APL cells, a novel co-receptor for plasminogen/tissue plasminogen activator. Thromb Res. 2002 Apr 1;106(1):63-70. doi: 10.1016/s0049-3848(02)00075-0.
• [95] Prolactinemia in adolescent males surviving malignancies in childhood: impaired dating activity. J Adolesc Health. 1993 Nov;14(7):543-7. doi: 10.1016/1054-139x(93)90138-f.
• [96] Proinflammatory cytokines mediate the systemic inflammatory response associated with high-dose cytarabine treatment in children. Med Pediatr Oncol. 2001 Nov;37(5):459-64. doi: 10.1002/mpo.1230.
• [97] Glyceraldehyde 3-phosphate dehydrogenase depletion induces cell cycle arrest and resistance to antimetabolites in human carcinoma cell lines. J Pharmacol Exp Ther. 2009 Oct;331(1):77-86. doi: 10.1124/jpet.109.155671. Epub 2009 Jul 23.
• [98] Granulocyte-macrophage colony-stimulating factor/interleukin-3 fusion protein (pIXY 321) enhances high-dose Ara-C-induced programmed cell death or apoptosis in human myeloid leukemia cells. Blood. 1992 Dec 1;80(11):2883-90.
• [99] [Influence of HMGB1/MAPK/m-TOR signaling pathway on cell autophagy and chemotherapy resistance in K562 cells]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2016 Oct 28;41(10):1016-1023. doi: 10.11817/j.issn.1672-7347.2016.10.002.
• [100] Overexpression of Bcl-2 or Bcl-xL inhibits Ara-C-induced CPP32/Yama protease activity and apoptosis of human acute myelogenous leukemia HL-60 cells. Cancer Res. 1996 Oct 15;56(20):4743-8.
• [101] Ara-C induces apoptosis in monkey fibroblast cells. Toxicol In Vitro. 2003 Jun;17(3):367-73. doi: 10.1016/s0887-2333(03)00024-9.
• [102] Cytosine arabinoside induced acute interstitial nephritis in a patient treated for refractory anemia with excess of blasts in transformation. Nephron. 2000 Nov;86(3):356-7. doi: 10.1159/000045798.
• [103] Protein kinase CbetaII activation by 1-beta-D-arabinofuranosylcytosine is antagonistic to stimulation of apoptosis and Bcl-2alpha down-regulation. J Biol Chem. 1997 Sep 19;272(38):23481-4. doi: 10.1074/jbc.272.38.23481.
• [104] Mechanism of cytosine arabinoside-mediated apoptosis: role of Rel A (p65) dephosphorylation. Oncogene. 2003 Jul 10;22(28):4356-69. doi: 10.1038/sj.onc.1206486.
• [105] Differential p53 phosphorylation and activation of apoptosis-promoting genes Bax and Fas/APO-1 by irradiation and ara-C treatment. Cell Death Differ. 1998 Jul;5(7):584-91. doi: 10.1038/sj.cdd.4400382.
• [106] The mechanisms of Ara-C-induced apoptosis of resting B-chronic lymphocytic leukemia cells. Haematologica. 2006 Jul;91(7):912-9.
• [107] [Expression and function of Ahi-1 gene in Jurkat cells]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2009 Apr;17(2):445-9.
• [108] Cytosine arabinoside affects the heat and capsaicin receptor TRPV1 localisation and sensitivity in human sensory neurons. J Neurooncol. 2008 Aug;89(1):1-7. doi: 10.1007/s11060-008-9585-6. Epub 2008 Apr 15.
• [109] ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
• [110] Genome-wide local ancestry approach identifies genes and variants associated with chemotherapeutic susceptibility in African Americans. PLoS One. 2011;6(7):e21920. doi: 10.1371/journal.pone.0021920. Epub 2011 Jul 6.
• [111] In vitro drug-resistance profile in infant acute lymphoblastic leukemia in relation to age, MLL rearrangements and immunophenotype. Leukemia. 2004 Mar;18(3):521-9. doi: 10.1038/sj.leu.2403253.
• [112] Oncogenic potential of the transcription factor LYL1 in acute myeloblastic leukemia. Leukemia. 2005 Nov;19(11):1941-7. doi: 10.1038/sj.leu.2403836.
• [113] DNA methylation and sensitivity to antimetabolites in cancer cell lines. Oncol Rep. 2008 Feb;19(2):407-12.
• [114] Upregulation of multi drug resistance genes in doxorubicin resistant human acute myelogeneous leukemia cells and reversal of the resistance. Hematology. 2007 Dec;12(6):511-7. doi: 10.1080/10245330701562535.
• [115] Chromosome breakage induced by the genotoxic agents mitomycin C and cytosine arabinoside is concentration and p53 dependent. Toxicol Sci. 2014 Jul;140(1):94-102. doi: 10.1093/toxsci/kfu058. Epub 2014 Mar 27.
• [116] Reversible epigenetic regulation of 14-3-3 expression in acquired gemcitabine resistance by uhrf1 and DNA methyltransferase 1. Mol Pharmacol. 2014 Nov;86(5):561-9. doi: 10.1124/mol.114.092544. Epub 2014 Sep 4.
• [117] 4-benzimidazolyl-3-phenylbutanoic acids as novel PIF-pocket-targeting allosteric inhibitors of protein kinase PKC. J Med Chem. 2011 Oct 13;54(19):6714-23. doi: 10.1021/jm2005892. Epub 2011 Sep 14.
• [118] Effect of phosphatase and tensin homology deleted on chromosome 10 (PTEN) gene transfection on reversal of multidrug resistance in K562/ADM cells. Leuk Lymphoma. 2012 Jul;53(7):1383-9. doi: 10.3109/10428194.2011.650695. Epub 2012 Jan 31.