Details of the Drug Combination

General Information of Drug Combination (ID: DCCNBQT)

• Drug Combination Name: Enzastaurin + Warfarin
• Indication: Solid Tumor; Status: Phase 1 [1]
• Component Drugs:
  Enzastaurin (DM5H0R9): Small molecular drug
  Warfarin (DMJYCVW): Small molecular drug

Molecular Interaction Atlas of This Drug Combination

Indication(s) of Enzastaurin

Disease Entry	ICD 11	Status	REF
Diffuse large B-cell lymphoma	2A81	Phase 3	[2]
Non-hodgkin lymphoma	2B33.5	Phase 3	[3]
Glioblastoma multiforme	2A00.0	Phase 2	[3]
Central nervous system disease	8A04-8D87	Phase 1	[3]

Enzastaurin Interacts with 3 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Protein kinase C beta (PRKCB)	TTYPXQF	KPCB_HUMAN	Modulator	[7]
RAC-alpha serine/threonine-protein kinase (AKT1)	TTWTSCV	AKT1_HUMAN	Inhibitor	[2]
PI3-kinase gamma (PIK3CG)	TTHBTOP	PK3CG_HUMAN	Inhibitor	[2]

Enzastaurin Interacts with 1 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Metabolism	[8]

Indication(s) of Warfarin

Disease Entry	ICD 11	Status	REF
Atrial fibrillation	BC81.3	Approved	[4]
Deep vein thrombosis	BD71	Approved	[5]
Pulmonary hypertension	BB01	Approved	[5]
Thrombosis	DB61-GB90	Application submitted	[6]
Intracranial embolism	8B22.1	Investigative	[5]
Venous thromboembolism	BD72	Investigative	[5]

Warfarin Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Vitamin K epoxide reductase complex 1 (VKORC1)	TTEUC8H	VKOR1_HUMAN	Inhibitor	[14]

Warfarin Interacts with 1 DTP Molecule(s)

DTP Name	DTP ID	UniProt ID	Mode of Action	REF
Organic anion transporting polypeptide 1B3 (SLCO1B3)	DT9C1TS	SO1B3_HUMAN	Substrate	[15]

Warfarin Interacts with 8 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Metabolism	[16]
Cytochrome P450 1A2 (CYP1A2)	DEJGDUW	CP1A2_HUMAN	Metabolism	[17]
UDP-glucuronosyltransferase 1A1 (UGT1A1)	DEYGVN4	UD11_HUMAN	Metabolism	[13]
Sulfotransferase 1A1 (SULT1A1)	DEYWLRK	ST1A1_HUMAN	Metabolism	[18]
Cytochrome P450 2C18 (CYP2C18)	DEZMWRE	CP2CI_HUMAN	Metabolism	[19]
Cytochrome P450 2C8 (CYP2C8)	DES5XRU	CP2C8_HUMAN	Metabolism	[20]
Cytochrome P450 2C9 (CYP2C9)	DE5IED8	CP2C9_HUMAN	Metabolism	[21]
Mephenytoin 4-hydroxylase (CYP2C19)	DEGTFWK	CP2CJ_HUMAN	Metabolism	[17]

Warfarin Interacts with 52 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
Cytochrome P450 3A4 (CYP3A4)	OTQGYY83	CP3A4_HUMAN	Decreases Expression	[22]
Cytochrome P450 2C9 (CYP2C9)	OTGLBN29	CP2C9_HUMAN	Increases Response To Substance	[23]
Cytochrome P450 2C19 (CYP2C19)	OTFMJYYE	CP2CJ_HUMAN	Affects Response To Substance	[24]
Cytochrome P450 2C8 (CYP2C8)	OTHCWT42	CP2C8_HUMAN	Affects Response To Substance	[25]
Cytochrome P450 2C18 (CYP2C18)	OTY687L9	CP2CI_HUMAN	Affects Response To Substance	[24]
Solute carrier organic anion transporter family member 1B3 (SLCO1B3)	OTOM3BUH	SO1B3_HUMAN	Affects Response To Substance	[26]
Cytochrome P450 4F2 (CYP4F2)	OTKILAER	CP4F2_HUMAN	Increases Response To Substance	[27]
Cytochrome P450 2D6 (CYP2D6)	OTZJC802	CP2D6_HUMAN	Decreases Activity	[28]
Nuclear receptor subfamily 1 group I member 2 (NR1I2)	OTC5U0N5	NR1I2_HUMAN	Decreases Expression	[22]
Prothrombin (F2)	OTNFSM49	THRB_HUMAN	Decreases Expression	[29]
Antithrombin-III (SERPINC1)	OTDFATG0	ANT3_HUMAN	Increases Expression	[30]
Interleukin-1 beta (IL1B)	OT0DWXXB	IL1B_HUMAN	Decreases Expression	[31]
Albumin (ALB)	OTVMM513	ALBU_HUMAN	Affects Binding	[32]
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Increases Degradation	[33]
Coagulation factor VII (F7)	OTGNJ97M	FA7_HUMAN	Decreases Expression	[29]
Poly polymerase 1 (PARP1)	OT310QSG	PARP1_HUMAN	Increases Expression	[10]
Cadherin-1 (CDH1)	OTFJMXPM	CADH1_HUMAN	Increases Expression	[10]
Arachidonate 5-lipoxygenase-activating protein (ALOX5AP)	OT0DH40W	AL5AP_HUMAN	Increases Expression	[34]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Increases Expression	[10]
Arylsulfatase L (ARSL)	OTF1VTCR	ARSL_HUMAN	Decreases Activity	[35]
Growth arrest-specific protein 6 (GAS6)	OTPOPUUE	GAS6_HUMAN	Decreases Carboxylation	[10]
Endomucin (EMCN)	OTS03CZC	MUCEN_HUMAN	Decreases Expression	[10]
Serine protease 53 (PRSS53)	OT3HUUI3	PRS53_HUMAN	Affects Response To Substance	[36]
Aspartyl/asparaginyl beta-hydroxylase (ASPH)	OT3KGDEE	ASPH_HUMAN	Affects Response To Substance	[37]
Ephrin type-A receptor 7 (EPHA7)	OT3VC211	EPHA7_HUMAN	Affects Response To Substance	[38]
Myosin-6 (MYH6)	OT3YNCH1	MYH6_HUMAN	Affects Response To Substance	[39]
Apolipoprotein A-I (APOA1)	OT5THARI	APOA1_HUMAN	Affects Response To Substance	[40]
Epoxide hydrolase 1 (EPHX1)	OTBKWQER	HYEP_HUMAN	Increases Response To Substance	[41]
Coagulation factor V (F5)	OTDMZ3LT	FA5_HUMAN	Affects Response To Substance	[24]
Solute carrier family 15 member 2 (SLC15A2)	OTDV7YES	S15A2_HUMAN	Affects Response To Substance	[26]
Vitamin K-dependent gamma-carboxylase (GGCX)	OTE0FNAP	VKGC_HUMAN	Decreases Response To Substance	[9]
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Affects Response To Substance	[42]
Apolipoprotein E (APOE)	OTFOWL2H	APOE_HUMAN	Affects Response To Substance	[43]
E3 ubiquitin-protein ligase NEDD4 (NEDD4)	OTFPXLXT	NEDD4_HUMAN	Affects Response To Substance	[37]
Vitamin K-dependent protein C (PROC)	OTGVH484	PROC_HUMAN	Increases Response To Substance	[41]
Apolipoprotein B-100 (APOB)	OTH0UOCZ	APOB_HUMAN	Affects Response To Substance	[44]
Prolow-density lipoprotein receptor-related protein 1 (LRP1)	OTHTEH4G	LRP1_HUMAN	Affects Response To Substance	[40]
Tyrosine-protein kinase receptor UFO (AXL)	OTKA2SUX	UFO_HUMAN	Increases Response To Substance	[10]
Transcription factor GATA-6 (GATA6)	OTO2BC0F	GATA6_HUMAN	Affects Response To Substance	[45]
Transcription factor GATA-4 (GATA4)	OTQHWAZG	GATA4_HUMAN	Affects Response To Substance	[45]
Fibroblast growth factor 5 (FGF5)	OTQXGHBY	FGF5_HUMAN	Affects Response To Substance	[46]
Cytochrome P450 3A5 (CYP3A5)	OTSXFBXB	CP3A5_HUMAN	Affects Response To Substance	[24]
Calumenin (CALU)	OTSYQN71	CALU_HUMAN	Affects Response To Substance	[47]
Coagulation factor IX (F9)	OTT0CX3Q	FA9_HUMAN	Increases Response To Substance	[48]
Heme A synthase COX15 (COX15)	OTUIYHIW	COX15_HUMAN	Affects Response To Substance	[46]
NADPH--cytochrome P450 reductase (POR)	OTVIDOCH	NCPR_HUMAN	Affects Response To Substance	[49]
Folylpolyglutamate synthase, mitochondrial (FPGS)	OTW3F1ZE	FOLC_HUMAN	Affects Response To Substance	[50]
Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2)	OTW8V2V1	ABCG2_HUMAN	Affects Response To Substance	[51]
Phospholipase DDHD1 (DDHD1)	OTWTHOWK	DDHD1_HUMAN	Affects Response To Substance	[37]
Vitamin K-dependent protein S (PROS1)	OTXQWNOI	PROS_HUMAN	Affects Response To Substance	[24]
NAD(P)H dehydrogenase 1 (NQO1)	OTZGGIVK	NQO1_HUMAN	Affects Response To Substance	[52]
Alpha-1-acid glycoprotein 1 (ORM1)	OTZKSBRE	A1AG1_HUMAN	Increases Response To Substance	[41]

References

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