Details of the Drug

General Information of Drug (ID: DM5H0R9)

Drug Name
Enzastaurin
Synonyms
LY317615; LE-0014; LY317615, Enzastaurin; 3-(1-methyl-1H-indol-3-yl)-4-{1-[1-(pyridin-2-ylmethyl)piperidin-4-yl]-1H-indol-3-yl}-1H-pyrrole-2,5-dione; 3-(1-methylindol-3-yl)-4-[1-[1-(pyridin-2-ylmethyl)piperidin-4-yl]indol-3-yl]pyrrole-2,5-dione
Indication
Disease Entry ICD 11 Status REF
Diffuse large B-cell lymphoma 2A81 Phase 3 [1]
Non-hodgkin lymphoma 2B33.5 Phase 3 [2]
Glioblastoma multiforme 2A00.0 Phase 2 [2]
Central nervous system disease 8A04-8D87 Phase 1 [2]
Therapeutic Class
Anticancer Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 1 Molecular Weight (mw) 515.6
Logarithm of the Partition Coefficient (xlogp) 3.7
Rotatable Bond Count (rotbonds) 5
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 4
Chemical Identifiers
Formula
C32H29N5O2
IUPAC Name
3-(1-methylindol-3-yl)-4-[1-[1-(pyridin-2-ylmethyl)piperidin-4-yl]indol-3-yl]pyrrole-2,5-dione
Canonical SMILES
CN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=CN(C5=CC=CC=C54)C6CCN(CC6)CC7=CC=CC=N7
InChI
InChI=1S/C32H29N5O2/c1-35-19-25(23-9-2-4-11-27(23)35)29-30(32(39)34-31(29)38)26-20-37(28-12-5-3-10-24(26)28)22-13-16-36(17-14-22)18-21-8-6-7-15-33-21/h2-12,15,19-20,22H,13-14,16-18H2,1H3,(H,34,38,39)
InChIKey
AXRCEOKUDYDWLF-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
176167
ChEBI ID
CHEBI:91368
CAS Number
170364-57-5
UNII
UC96G28EQF
DrugBank ID
DB06486
TTD ID
D0I6VU
INTEDE ID
DR1898
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
PI3-kinase gamma (PIK3CG) TTHBTOP PK3CG_HUMAN Inhibitor [1]
Protein kinase C beta (PRKCB) TTYPXQF KPCB_HUMAN Modulator [3]
RAC-alpha serine/threonine-protein kinase (AKT1) TTWTSCV AKT1_HUMAN Inhibitor [1]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4)
Main DME 		DE4LYSA CP3A4_HUMAN Substrate [4]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Diffuse large B-cell lymphoma
ICD Disease Classification 2A81
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
PI3-kinase gamma (PIK3CG) DTT PIK3CG 1.98E-01 -0.05 -0.55
Cytochrome P450 3A4 (CYP3A4) DME CYP3A4 2.76E-01 -4.64E-01 -9.16E-01
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC1 5.7018 18.071 -1.4392 28.4994
EW-13 GDSC1 0.3977 2.6171 0.3571 49.0878
ES5 GDSC1 1.5258 5.3126 0.9522 37.8063
ES7 GDSC1 1.5786 10.8182 -1.4227 43.0868
CADO-ES1 GDSC1 2.0804 4.8671 1.7078 30.35
EW-7 GDSC1 2.9942 7.7401 1.4107 27.0657
EW-1 GDSC1 3.7573 5.4793 3.2247 10.9409
EW-18 GDSC1 3.8357 5.8448 3.1252 11.3575
ES1 GDSC1 3.9838 7.1477 2.6182 14.6257
HuO9 GDSC1 4.0082 6.646 2.8891 12.4657
TC-71 GDSC1 4.0513 5.1644 3.6583 6.3038
MHH-ES-1 GDSC1 4.054 5.1378 3.6737 6.1731
NOS-1 [Human HNSCC] GDSC1 4.1271 7.12 2.7574 13.0083
G-292 clone A141B1 GDSC1 4.1876 12.6969 0.022 26.4911
SK-PN-DW GDSC1 4.3383 5.868 3.5625 5.9299
ES6 GDSC1 4.4626 7.2422 2.9773 10.0812
SK-ES-1 GDSC1 4.7721 6.2373 3.7085 3.4299
SJSA-1 GDSC1 5.0729 12.1141 1.0326 20.8175
CHSA0108 GDSC1 5.2875 9.2799 2.5943 10.3385
ES8 GDSC1 5.3286 14.0429 0.2728 23.6
EW-16 GDSC1 5.909 9.9351 2.7021 7.9185
ES4 GDSC1 6.1042 9.3287 3.1016 4.7454
H-EMC-SS GDSC1 6.2241 9.4326 3.1237 4.368
EW-24 GDSC1 6.2246 7.4927 3.9113 0.2621
CAL-72 GDSC1 6.2308 7.8717 3.7759 0.6977
A-673 GDSC1 6.326 7.9539 3.784 0.5995
HOS GDSC1 6.474 9.5143 3.224 3.302
CAL-78 GDSC1 6.5535 8.0379 3.8413 0.2721
CHSA0011 GDSC1 6.5961 13.4396 1.4908 13.8992
CHSA8926 GDSC1 6.6001 15.5216 0.4884 19.0284
MG-63 GDSC1 6.6243 7.9346 3.9023 0.1553
SaOS-2 GDSC1 6.7114 8.383 3.7783 0.4026
U2OS GDSC1 6.7702 9.819 3.2461 2.7329
NY GDSC1 7.1396 9.8798 3.394 1.3806
EW-3 GDSC1 7.3367 9.3466 3.6711 0.4158
EW-11 GDSC1 7.6662 9.775 3.6421 0.3623
HuO-3N1 GDSC1 7.7571 19.0913 -0.4331 20.0663
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 146 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JM1 GDSC1 2.3206 3.678 2.274 25.3127
MV4-11 GDSC1 -1.5913 1.3509 -1.6233 70.9191
697 GDSC1 -1.3388 1.1425 -1.3537 69.177
MOLT-16 GDSC1 -0.7901 0.5513 -0.7903 63.8347
CTV-1 GDSC1 -0.5945 0.9233 -0.5956 61.3632
ALL-PO GDSC1 -0.4729 2.0675 -0.5089 59.2855
HAL-01 GDSC1 -0.3871 1.359 -0.3914 58.7328
SUP-B15 GDSC1 -0.3732 0.4269 -0.3732 58.6888
MOLM-13 GDSC1 -0.2758 6.8462 -1.5557 54.0942
ALL-SIL GDSC1 -0.1568 1.0491 -0.1571 55.9748
ATN-1 GDSC1 0.0267 1.8843 0.0162 53.6246
MY-M12 GDSC1 0.05 0.8875 0.05 53.3992
THP-1 GDSC1 0.071 4.8257 -0.464 52.2817
Loucy GDSC1 0.0938 1.2127 0.0935 52.8496
KE-37 GDSC1 0.2036 0.9276 0.2036 51.4789
Kasumi-1 GDSC1 0.2162 3.443 0.047 51.1586
ST486 GDSC1 0.3558 1.4578 0.3554 49.5769
RPMI-8402 GDSC1 0.4654 1.7305 0.464 48.2102
RL GDSC1 0.5585 2.3684 0.5416 47.0891
WIL2 NS GDSC1 0.5789 3.4847 0.4314 47.0867
PF-382 GDSC1 0.6283 1.886 0.6265 46.1781
Karpas-45 GDSC1 0.6397 1.8492 0.6383 46.0338
NALM-6 GDSC1 0.6634 2.6084 0.6355 45.8255
SU-DHL-6 GDSC1 0.7179 3.1508 0.6355 45.3161
QIMR-WIL GDSC1 0.7639 3.1389 0.6864 44.7482
BE-13 GDSC1 0.7753 2.6735 0.7473 44.4469
Hs 445 GDSC1 0.8298 1.7475 0.8296 43.6533
RS4;11 GDSC1 0.8521 4.5775 0.4624 44.5317
NKM-1 GDSC1 0.8554 4.0926 0.5989 44.1744
VL51 GDSC1 0.8866 3.7208 0.7183 43.5662
DND-41 GDSC1 0.8963 4.1456 0.6301 43.7389
RPMI-6666 GDSC1 0.9006 3.6491 0.748 43.3519
NB4 GDSC1 0.9253 1.8358 0.9251 42.4587
OCI-M1 GDSC1 0.9453 3.1539 0.8777 42.5117
EB2 GDSC1 1.057 4.5478 0.6947 42.2214
MC116 GDSC1 1.1734 1.6912 1.1734 39.357
SU-DHL-5 GDSC1 1.2555 2.3746 1.253 38.3457
MOLT-4 GDSC1 1.3855 4.4771 1.0736 38.288
SUP-T1 GDSC1 1.468 3.3597 1.4076 36.0315
SU-DHL-10 GDSC1 1.5422 2.8262 1.5322 34.8084
KMOE-2 GDSC1 1.6915 4.2392 1.4735 34.1665
MOLP-8 GDSC1 1.7039 3.2287 1.6727 32.9183
CA46 GDSC1 1.7785 3.967 1.6345 32.6737
Reh GDSC1 1.7788 4.5723 1.4743 33.5897
Farage GDSC1 1.7999 3.2295 1.7734 31.6908
P12-Ichikawa GDSC1 1.8749 4.5153 1.5962 32.2839
BV-173 GDSC1 1.9272 6.4062 0.9466 35.2139
MOLT-13 GDSC1 1.9946 3.0458 1.9873 29.1374
SIG-M5 GDSC1 2.0786 3.3036 2.059 28.165
SU-DHL-4 GDSC1 2.1262 4.8044 1.7785 29.6442
MEG-01 GDSC1 2.1467 5.4993 1.5478 30.8838
JVM-3 GDSC1 2.2629 3.8725 2.1797 26.2701
PL-21 GDSC1 2.2839 4.463 2.0577 26.9389
Granta-519 GDSC1 2.2865 5.6499 1.6363 29.5501
SK-MM-2 GDSC1 2.352 5.2812 1.8508 27.8691
GDM-1 GDSC1 2.3905 4.8601 2.0459 26.3979
BALL-1 GDSC1 2.4588 5.0125 2.0656 25.8797
A3/Kawakami GDSC1 2.5957 4.3459 2.4314 22.654
BL-41 GDSC1 2.6937 4.8353 2.3824 22.4356
K-562 GDSC1 2.7076 15.1901 -2.5099 40.0442
HH [Human lymphoma] GDSC1 2.7197 7.6507 1.1874 29.6329
ML-2 GDSC1 2.7213 5.4234 2.1869 23.6238
H9 GDSC1 2.8193 4.9236 2.4858 21.0341
Namalwa GDSC1 2.8199 4.8633 2.5086 20.8724
EoL-1 GDSC1 2.8308 8.0387 1.1108 29.4554
Karpas-620 GDSC1 2.8353 4.1135 2.7513 19.1271
JURL-MK1 GDSC1 2.8511 5.8339 2.1493 23.1944
KY821 GDSC1 2.962 6.4591 1.982 23.7482
KMS-11 GDSC1 3.012 5.5751 2.4273 20.4347
OCI-AML-3 GDSC1 3.0371 6.6509 1.9679 23.4667
OPM-2 GDSC1 3.0493 6.8085 1.9062 23.8086
MLMA GDSC1 3.0533 6.7072 1.9576 23.4546
HEL GDSC1 3.0651 8.4141 1.1529 28.101
DB GDSC1 3.1576 6.8839 1.9765 22.823
CTB-1 GDSC1 3.3376 6.6377 2.2678 19.9814
KOPN-8 GDSC1 3.3514 8.6166 1.3204 25.8856
KCL-22 GDSC1 3.4295 7.9823 1.7036 23.3011
HDLM-2 GDSC1 3.4731 8.9174 1.2834 25.5447
ARH-77 GDSC1 3.4827 5.6073 2.8933 14.7197
LC4-1 GDSC1 3.511 7.2996 2.113 20.2682
HC-1 GDSC1 3.5259 10.2252 0.6832 28.2867
EM-2 GDSC1 3.5353 6.5875 2.4815 17.5425
SUP-M2 GDSC1 3.5521 5.3804 3.0662 13.095
DEL GDSC1 3.5715 8.4103 1.623 23.1638
OCI-Ly19 GDSC1 3.6078 4.7599 3.3909 10.4213
OCI-AML-5 GDSC1 3.6252 6.59 2.5653 16.527
Ku812 GDSC1 3.6297 5.2361 3.2098 11.6487
SU-DHL-1 GDSC1 3.6325 10.2253 0.7777 27.408
P32/ISH GDSC1 3.6731 4.5717 3.5328 9.0619
CESS GDSC1 3.6742 5.4729 3.146 11.92
KMS-12-BM GDSC1 3.6998 6.5707 2.6447 15.6098
Ramos.2G6.4C10 GDSC1 3.7059 4.2873 3.6588 8.0077
LP-1 GDSC1 3.7316 8.6228 1.6617 22.2411
SCC-3 GDSC1 3.7317 4.3457 3.6712 7.7764
VAL GDSC1 3.7335 5.9241 2.9898 12.8439
DG-75 GDSC1 3.7437 7.3725 2.2915 18.0092
YT GDSC1 3.7627 4.4001 3.6886 7.4835
P30/OHK GDSC1 3.768 5.707 3.1269 11.6409
NU-DUL-1 GDSC1 3.7691 4.5042 3.6606 7.6435
A4/Fukuda GDSC1 3.7902 4.3926 3.7209 7.107
SU-DHL-16 GDSC1 3.7915 4.2951 3.7501 6.9007
CCRF-CEM GDSC1 3.7966 4.3698 3.7349 6.9751
MN-60 GDSC1 3.8001 7.936 2.0635 19.3574
SUP-HD1 GDSC1 3.8023 5.4532 3.2809 10.3076
NOMO-1 GDSC1 3.8041 6.9195 2.5698 15.7255
Mono-Mac-6 GDSC1 3.8077 6.2096 2.9215 13.0457
L-363 GDSC1 3.8652 4.3696 3.8097 6.0764
Sc-1 GDSC1 3.8657 4.3807 3.8068 6.0943
Karpas-299 GDSC1 3.8662 7.1529 2.5107 15.9051
JSC-1 GDSC1 3.8744 4.6171 3.7301 6.5914
JJN-3 GDSC1 3.893 4.8233 3.6619 7.0003
RPMI-8226 GDSC1 3.8956 11.056 0.5933 27.1837
SU-DHL-8 GDSC1 3.922 4.5703 3.7993 5.8453
OCI-AML-2 GDSC1 3.9263 4.3576 3.8799 5.2522
TUR GDSC1 3.9299 7.9453 2.174 18.0628
GR-ST GDSC1 3.982 5.7461 3.3099 9.3034
Jiyoye GDSC1 3.9898 6.1802 3.1033 10.8796
KM-H2 GDSC1 4.0073 5.4271 3.4893 7.8021
RPMI-8866 GDSC1 4.0314 5.0532 3.6929 6.1242
KG-1 GDSC1 4.0353 5.1313 3.6591 6.3675
P31/FUJ GDSC1 4.044 4.726 3.8587 4.8023
MHH-PREB-1 GDSC1 4.0535 6.0346 3.2327 9.6122
U-698-M GDSC1 4.0539 5.0749 3.704 5.9393
LAMA-84 GDSC1 4.0657 5.1504 3.6786 6.0845
EJM GDSC1 4.0859 5.1317 3.7068 5.7798
NK-92MI GDSC1 4.1188 7.503 2.5591 14.535
TK [Human B-cell lymphoma] GDSC1 4.1895 17.2881 -2.2718 34.8373
WSU-DLCL2 GDSC1 4.2244 4.9562 3.9202 3.5401
HL-60 GDSC1 4.3041 5.1705 3.8827 3.5295
BC-3 GDSC1 4.3059 6.3978 3.2706 8.3467
SR GDSC1 4.31 11.855 0.5454 25.8274
Karpas-422 GDSC1 4.3566 5.321 3.851 3.5902
L-428 GDSC1 4.4519 6.0614 3.558 5.5704
ROS-50 GDSC1 4.4642 5.8461 3.6749 4.6103
ME1 GDSC1 4.6731 6.1233 3.6945 3.8119
HT GDSC1 4.711 7.1938 3.1959 7.5587
RC-K8 GDSC1 4.8127 6.9055 3.4128 5.5747
AMO1 GDSC1 4.8559 14.1179 -0.1385 26.7557
JVM-2 GDSC1 5.16 7.917 3.1658 6.4792
L-1236 GDSC1 5.4349 9.6965 2.4962 10.6136
Raji GDSC1 5.556 7.2444 3.7158 1.7566
L-540 GDSC1 5.7402 12.5647 1.3145 17.2226
WSU-NHL GDSC1 5.7473 13.7047 0.759 20.1057
Daudi GDSC1 5.8481 8.5697 3.2947 3.9558
BC-1 GDSC1 6.1716 18.589 -1.3349 26.9537
U266B1 GDSC1 6.3467 8.7347 3.4874 1.9588
⏷ Show the Full List of 146 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KYAE-1 GDSC1 -0.5428 8.7544 -2.6192 54.7466
OACM5.1 C GDSC1 -0.0307 4.6986 -0.5362 53.2155
ESO-26 GDSC1 1.7118 10.1749 -0.9879 41.7795
ESO-51 GDSC1 2.1538 4.6652 1.8539 29.0121
SK-GT-4 GDSC1 2.3258 8.0269 0.6243 34.2412
KYSE-50 GDSC1 2.6413 5.516 2.065 24.8733
TE-12 GDSC1 5.3986 11.878 1.3994 17.7721
OACP4 C GDSC1 5.539 8.5888 3.0975 6.0136
HCE-4 GDSC1 5.8007 8.564 3.2698 4.2189
KYSE-220 GDSC1 6.2152 8.3354 3.5875 1.586
FLO-1 GDSC1 6.6544 15.7442 0.4186 19.205
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC1 3.5776 11.6262 0.0323 30.7085
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CHP-212 GDSC1 -0.8426 2.5452 -0.9472 62.3778
NB69 GDSC1 0.7817 4.031 0.5337 44.9831
SK-N-AS GDSC1 1.8392 6.8068 0.6839 36.8067
NH-12 GDSC1 2.1512 9.6699 -0.3228 38.1788
SK-N-MC-IXC GDSC1 2.6618 4.4026 2.4875 21.8977
SJNB-7 GDSC1 2.9163 6.1041 2.0969 23.2137
KP-N-YS GDSC1 3.0806 8.0379 1.3497 26.9843
SJNB-13 GDSC1 3.9741 6.8262 2.7693 13.5212
GI-ME-N GDSC1 4.0124 7.0362 2.6989 13.9029
SJNB-12 GDSC1 4.0986 9.0204 1.7841 19.9823
SiMa GDSC1 4.2088 9.0105 1.8827 18.9207
SK-N-SH GDSC1 4.2684 8.6533 2.1114 17.1672
SJNB-10 GDSC1 4.4466 12.2153 0.4786 25.631
LA-N-6 GDSC1 4.5032 9.8998 1.6826 19.0898
IMR-5 GDSC1 4.6405 9.1198 2.183 15.3227
TGW GDSC1 4.6981 10.256 1.6623 18.5201
CHP-134 GDSC1 4.7069 6.3346 3.6156 4.3217
SK-N-FI GDSC1 4.7749 10.7617 1.4713 19.3971
MHH-NB-11 GDSC1 4.8634 8.8151 2.5091 12.2582
GOTO GDSC1 5.2983 9.3829 2.5518 10.6117
KP-N-YN GDSC1 5.4602 8.4624 3.1061 6.1435
SJNB-6 GDSC1 5.6177 10.3497 2.3077 11.4048
SJNB-14 GDSC1 5.663 8.2285 3.3407 4.0152
NB(TU)1 GDSC1 6.0021 7.758 3.7206 1.1512
SK-N-DZ GDSC1 6.0055 7.7478 3.7262 1.1201
SJNB-5 GDSC1 6.0128 9.7222 2.8671 6.5341
SK-N-BE(2)-M17 GDSC1 6.5143 7.8797 3.8822 0.2247
Kelly GDSC1 6.7725 8.0912 3.9009 0.1254
SJNB-17 GDSC1 7.1837 9.0385 3.7227 0.3498
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC1 2.1366 17.3985 -4.1163 43.6765
Cancer Drug Sensitivity Data Curated from 51 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HCC2218 GDSC1 0.9813 8.2858 -0.845 45.5741
BT-474 GDSC1 1.7621 12.8835 -2.2428 43.274
HCC1954 GDSC1 1.9545 6.5843 0.899 32.0169
HCC1569 GDSC1 2.0395 10.132 -0.6511 39.5102
MDA-MB-330 GDSC1 2.05 7.137 0.7549 35.2705
DU4475 GDSC1 2.1019 4.8599 1.7335 30.0648
EFM-19 GDSC1 2.642 7.6213 1.1251 30.347
AU565 GDSC1 3.0667 7.3988 1.6436 22.9024
HCC1599 GDSC1 3.1099 6.2873 2.2086 21.4827
HCC1500 GDSC1 3.2933 4.1045 2.9284 3.6086
BT-549 GDSC1 3.4911 7.8466 1.827 20.078
MDA-MB-175-VII GDSC1 3.5616 9.7073 0.972 24.5346
HCC1937 GDSC1 3.6362 11.5982 0.0976 28.1025
BT-483 GDSC1 3.642 19.3855 -3.7837 38.8913
MDA-MB-453 GDSC1 3.8662 9.9882 1.1006 22.754
CAL-85-1 GDSC1 4.0739 7.6955 2.4243 14.085
HCC1419 GDSC1 4.121 8.1928 2.2167 15.2955
HCC1187 GDSC1 4.1937 5.536 3.605 6.1363
ZR-75-30 GDSC1 4.4033 8.0743 2.5131 12.3852
MDA-MB-468 GDSC1 4.4515 5.6286 3.7732 3.4628
OCUB-M GDSC1 4.4639 8.4466 2.3766 14.5832
CAMA-1 GDSC1 4.4865 8.6432 2.2969 13.5589
HCC202 GDSC1 4.7277 7.788 2.9144 9.6741
HDQ-P1 GDSC1 4.7767 9.1755 2.263 12.8838
UACC-893 GDSC1 4.8025 10.3039 1.7214 16.1703
YMB-1-E GDSC1 4.9952 8.8891 2.5722 11.3793
HCC1395 GDSC1 5.0011 11.4377 1.313 17.8869
JIMT-1 GDSC1 5.1059 9.326 2.4394 10.7867
HCC70 GDSC1 5.2439 9.4267 2.4912 10.075
BT-20 GDSC1 5.2953 13.0953 0.7177 20.0493
Evsa-T GDSC1 5.3543 7.5505 3.4654 3.8035
HCC2157 GDSC1 5.3946 8.3466 3.118 6.2207
HCC38 GDSC1 5.5482 11.5011 1.6959 14.1803
Hs 578T GDSC1 5.5561 11.3173 1.7919 14.9496
MDA-MB-361 GDSC1 5.782 10.0842 2.5479 9.3085
HCC1428 GDSC1 5.7825 11.5558 1.8381 12.7369
CAL-120 GDSC1 5.8184 8.1262 3.4746 2.525
HCC1806 GDSC1 5.8854 10.9586 2.1988 10.3121
EFM-192A GDSC1 5.9382 10.7423 2.3383 10.3338
CAL-51 GDSC1 5.9616 7.7937 3.6875 1.2183
T-47D GDSC1 5.9815 10.1886 2.6295 7.4103
CAL-148 GDSC1 6.0676 7.3315 3.9095 0.3378
MDA-MB-157 GDSC1 6.0985 8.5472 3.4416 2.2975
UACC-812 GDSC1 6.364 12.3454 1.8579 12.3228
MDA-MB-436 GDSC1 6.5702 13.4 1.4923 12.7846
MDA-MB-231 GDSC1 6.572 8.7514 3.5844 1.089
MDA-MB-415 GDSC1 6.7817 8.4275 3.7888 0.3074
MRK-nu-1 GDSC1 6.8446 8.3846 3.8266 0.2363
MCF-7 GDSC1 6.8761 9.5945 3.3882 1.6472
COLO 824 GDSC1 7.0055 14.906 1.0647 15.1954
MFM-223 GDSC1 8.775 19.0914 0.2362 15.2172
⏷ Show the Full List of 51 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 54 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
D-566MG GDSC1 0.3053 4.3127 -0.059 50.1659
NMC-G1 GDSC1 1.5223 8.4144 -0.3548 41.6187
KS-1 [Human Krukenberg tumour] GDSC1 1.8216 14.4947 -2.9736 43.7794
GaMG GDSC1 2.7897 14.403 -2.0462 39.0272
D-336MG GDSC1 2.9366 15.4214 -2.4207 39.1184
DK-MG GDSC1 3.2548 15.7861 -2.322 37.8821
MOG-G-CCM GDSC1 3.4541 6.1408 2.6166 16.9167
H4 GDSC1 3.6909 10.6083 0.6385 27.8018
MOG-G-UVW GDSC1 3.8329 6.6615 2.7232 14.452
8-MG-BA GDSC1 4.0674 11.4231 0.557 26.6805
M059J GDSC1 4.2913 15.1316 -1.1084 31.7547
U-251MG GDSC1 4.3269 11.0107 0.9817 23.6825
SK-MG-1 GDSC1 4.4241 9.5378 1.7986 16.9073
ONS-76 GDSC1 4.5599 5.8172 3.7622 3.6242
LN-18 GDSC1 4.6012 5.8224 3.7897 3.2876
Daoy GDSC1 4.6768 9.7978 1.8738 17.2626
YH-13 GDSC1 4.7014 7.4901 3.0419 7.8448
D-392MG GDSC1 4.7871 9.9374 1.8918 16.7653
SF295 GDSC1 4.8829 12.7426 0.5695 23.7164
CAS-1 GDSC1 4.9272 6.7071 3.5882 3.9265
U-87MG ATCC GDSC1 4.9681 6.674 3.631 3.505
AM-38 GDSC1 5.1878 8.0056 3.1422 6.5805
SW1783 GDSC1 5.3353 13.914 0.342 23.2798
Onda 11 GDSC1 5.3971 7.4452 3.5393 3.1948
D-423MG GDSC1 5.4021 13.5331 0.5827 20.3766
PFSK-1 GDSC1 5.4232 14.7427 -0.0015 24.4469
DBTRG-05MG GDSC1 5.4267 16.9661 -1.1047 28.2826
Hs 683 GDSC1 5.4648 12.9528 0.918 18.5965
T98G GDSC1 5.5582 9.7453 2.5586 9.8296
D283 Med GDSC1 5.5876 6.9967 3.8343 1.0429
D-263MG GDSC1 5.9084 7.9135 3.6125 1.8468
Becker GDSC1 5.9486 11.0287 2.2082 11.1724
D-542MG GDSC1 6.0147 7.8226 3.7007 1.2368
SF539 GDSC1 6.0169 15.9328 -0.1386 23.271
A-172 GDSC1 6.1681 12.543 1.6297 14.2068
GB-1 GDSC1 6.2767 7.8228 3.8127 0.5304
D-502MG GDSC1 6.2921 10.053 2.8842 5.8169
U-118MG GDSC1 6.3008 7.7722 3.8406 0.4248
GI-1 GDSC1 6.309 10.7007 2.5972 7.6977
SF126 GDSC1 6.4123 7.7245 3.899 0.222
LNZTA3WT4 GDSC1 6.5414 8.1198 3.8078 0.3997
KNS-81-FD GDSC1 6.6059 8.5418 3.6789 0.7947
D-247MG GDSC1 6.7607 8.9621 3.5845 1.052
YKG-1 GDSC1 6.8179 19.4883 -1.295 25.2159
Onda 10 GDSC1 6.8634 15.7139 0.5797 17.9326
SW1088 GDSC1 6.9998 15.3892 0.8296 16.3949
KNS-42 GDSC1 7.3399 15.1754 1.1571 13.9286
KINGS-1 GDSC1 7.4656 15.5461 1.0636 14.1244
SF268 GDSC1 7.551 16.2105 0.8053 15.2162
LN-405 GDSC1 7.7043 17.1331 0.4684 16.4498
42-MG-BA GDSC1 7.9495 17.9173 0.2578 16.8402
KALS-1 GDSC1 8.193 21.8526 -1.4645 22.641
SNB-75 GDSC1 9.1006 27.9601 -3.7902 26.7761
LN-229 GDSC1 9.439 20.4217 0.0316 14.8044
⏷ Show the Full List of 54 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ETK-1 GDSC1 3.3675 13.9246 -1.2962 35.4204
TGBC24TKB GDSC1 5.0764 7.7098 3.2081 6.3892
TGBC1TKB GDSC1 7.7804 16.5016 0.8167 14.65
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KLE GDSC1 0.4676 23.7418 -8.7614 49.6602
AN3-CA GDSC1 5.093 6.8397 3.6329 3.194
MFE-319 GDSC1 5.3938 8.618 2.9882 6.4175
MFE-280 GDSC1 5.6101 8.9565 2.9702 6.756
RL95-2 GDSC1 6.1717 8.3901 3.5444 1.8732
EN GDSC1 6.6241 10.5613 2.8477 4.8452
MFE-296 GDSC1 7.036 8.9256 3.7077 0.4484
ESS-1 GDSC1 7.4227 15.6366 0.9931 14.5794
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 32 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
769-P GDSC1 -0.842 3.0588 -1.0258 56.4481
KTCTL-21 GDSC1 0.147 4.9017 -0.4049 51.5911
VMRC-RCZ GDSC1 0.7063 8.2069 -1.092 44.4475
KTCTL-13 GDSC1 1.1731 11.3508 -2.0686 45.6819
786-O GDSC1 1.2719 7.0694 -0.0165 39.1008
LB1047-RCC GDSC1 1.5659 8.3178 -0.267 38.1969
KTCTL-26A GDSC1 2.4823 6.2991 1.5671 28.8428
Caki-1 GDSC1 2.642 6.3729 1.698 24.4664
KTCTL-195 GDSC1 2.9652 8.9533 0.797 30.2841
KTCTL-1M GDSC1 3.0133 8.5417 1.0422 28.9029
KTCTL-140 GDSC1 3.0649 7.4295 1.6271 25.4712
UO-31 GDSC1 3.2252 10.3203 0.366 28.5788
BB65-RCC GDSC1 3.2517 9.0206 1.0303 25.4575
RXF 393L GDSC1 3.5555 9.1679 1.2339 23.2143
ACHN GDSC1 3.5624 5.8059 2.8803 12.8957
VMRC-RCW GDSC1 3.8475 12.4718 -0.1548 30.3339
TK-10 GDSC1 3.9992 11.5901 0.4156 25.5157
OS-RC-2 GDSC1 5.1447 12.9765 0.6598 20.7594
HA7-RCC GDSC1 5.588 12.5571 1.206 16.7824
BFTC-909 GDSC1 5.7726 7.7221 3.6244 1.9751
SN12C GDSC1 5.9778 7.576 3.7814 0.7926
RCC10RGB GDSC1 6.1448 7.7324 2.8477 0.1884
KMRC-20 GDSC1 6.3145 8.2479 3.6675 0.9699
SW156 GDSC1 6.4498 15.6787 0.3044 18.8676
A-704 GDSC1 6.4936 8.2298 3.7493 0.6131
LB2241-RCC GDSC1 6.5861 8.6977 3.6113 0.9708
A-498 GDSC1 6.5899 15.9831 0.2564 20.0916
SW13 GDSC1 6.8162 8.5335 3.7643 0.3513
CAL-54 GDSC1 6.9831 8.8902 3.7003 0.4942
NCC021 GDSC1 7.0396 8.813 3.7487 0.342
LB996-RCC GDSC1 7.1178 10.1472 3.2784 1.8986
KMRC-1 GDSC1 7.2378 18.296 -0.4094 21.1767
⏷ Show the Full List of 32 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 44 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H747 GDSC1 -0.3923 5.6017 -1.2215 55.5603
CCK-81 GDSC1 -0.3321 3.5364 -0.5663 56.6214
HT-29 GDSC1 1.5444 22.5381 -7.1932 46.8515
SW620 GDSC1 1.5878 5.0104 1.1253 36.6297
SNU-1040 GDSC1 1.6566 12.2139 -2.0179 43.466
LS513 GDSC1 1.7268 8.7535 -0.3063 40.3636
SNU-175 GDSC1 1.8165 6.807 0.6604 37.0329
KM12 GDSC1 2.0636 4.9226 1.6707 30.6733
SNU-61 GDSC1 2.312 14.364 -2.4589 41.3941
COLO205 GDSC1 2.374 7.1861 1.0604 32.0981
LS1034 GDSC1 2.6482 8.5997 0.6669 32.3934
GP5d GDSC1 2.7621 9.5438 0.3194 33.196
NCI-H716 GDSC1 2.9607 6.9015 1.7755 25.0782
RKO GDSC1 2.9881 5.7317 2.3349 21.2081
T84 GDSC1 3.5777 6.4505 2.5879 16.5692
SW626 GDSC1 3.7254 15.0392 -1.5416 34.7371
HCT 116 GDSC1 3.7448 9.1241 1.4244 23.5905
RCM-1 [Human ESC] GDSC1 3.9407 14.4471 -1.0618 32.8011
HCT 15 GDSC1 3.97 9.2293 1.5691 21.8185
HCC2998 GDSC1 3.9721 7.6153 2.3753 16.4634
SNU-C2B GDSC1 3.9948 13.8603 -0.7226 31.6445
LS411N GDSC1 4.0639 7.5342 2.496 15.2166
CW-2 GDSC1 4.1143 7.8415 2.3862 15.8218
COLO 320HSR GDSC1 4.602 7.4443 2.9876 9.5251
LS180 GDSC1 4.6366 10.0571 1.7122 18.4286
SNU-407 GDSC1 5.0057 7.1508 3.4288 4.9168
SW1463 GDSC1 5.1427 24.5573 -5.1202 36.8964
SW1417 GDSC1 5.1746 11.9361 1.2 17.9796
SW48 GDSC1 5.2251 10.3496 2.0237 14.4721
SW948 GDSC1 5.3689 8.5701 2.9943 7.194
SNU-C1 GDSC1 5.4686 9.5026 2.6138 9.6853
COLO 678 GDSC1 5.5255 23.1807 -4.1242 34.6387
SW837 GDSC1 5.618 17.8659 -1.4025 28.6228
LS123 GDSC1 5.9336 15.383 0.0703 22.663
SNU-C5 GDSC1 6.0436 9.9513 2.7799 7.0637
SW1116 GDSC1 6.05 7.6519 3.7833 0.8141
SNU-81 GDSC1 6.1491 12.9012 1.4431 15.3414
HT-55 GDSC1 6.1542 7.6347 3.833 0.5376
CaR-1 GDSC1 6.1656 10.8684 2.4281 9.1619
C2BBe1 GDSC1 6.3984 8.6896 3.5303 1.6674
MDST8 GDSC1 6.5705 15.213 0.6175 18.5047
CL-11 GDSC1 6.9336 8.6967 3.7504 0.3798
LoVo GDSC1 7.2602 9.1636 3.707 0.3583
HT115 GDSC1 8.6724 20.1299 -0.317 17.6706
⏷ Show the Full List of 44 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC1 2.2953 5.5343 1.6919 29.1696
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-475 GDSC1 1.2586 14.7753 -3.635 46.3283
JHH-4 GDSC1 2.0169 4.0519 1.8747 26.5246
SNU-423 GDSC1 2.6489 12.0122 -0.9932 37.52
JHH-7 GDSC1 3.5423 5.4303 3.0338 11.9443
SNU-449 GDSC1 3.5818 8.6211 1.5281 23.6844
JHH-1 GDSC1 4.3985 9.4375 1.8277 16.8151
JHH-6 GDSC1 5.6222 6.2474 4.1232 0.0367
JHH-2 GDSC1 6.0206 7.5442 3.812 0.6405
HuH-1 GDSC1 6.0784 11.1733 2.2263 10.7155
SK-HEP-1 GDSC1 6.103 7.4292 3.888 0.3845
SNU-387 GDSC1 6.1223 24.2814 -4.2 33.4266
Hep-G2/C3A GDSC1 6.3109 7.5726 3.915 0.2212
SNU-398 GDSC1 6.6584 8.5556 3.695 0.6979
Huh-7 GDSC1 6.71 8.3327 3.7956 0.3569
HLE GDSC1 6.9628 8.9944 3.6548 0.5764
Hep 3B2.1-7 GDSC1 6.9935 8.4387 3.8604 0.1404
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 172 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H345 GDSC1 -7.373 673.7094 -340.1668 50.6206
NCI-H1755 GDSC1 -2.0647 18.9813 -8.8312 56.11
NCI-H1944 GDSC1 -0.8333 10.0392 -3.4754 55.5169
NCI-H2804 GDSC1 -0.6141 9.9503 -3.2116 54.592
HCC44 GDSC1 -0.369 4.7276 -0.9138 56.0008
EPLC-272H GDSC1 0.3776 7.2042 -1.0078 49.6048
NCI-H2227 GDSC1 0.9144 15.8711 -4.4908 47.8859
NCI-H211 GDSC1 1.1278 18.5266 -5.591 47.5104
LC-2/ad GDSC1 1.38 12.9099 -2.6165 45.2038
NCI-H1869 GDSC1 1.4023 6.5159 0.3519 40.6882
NCI-H1648 GDSC1 1.7242 7.8713 0.095 39.3807
NCI-H358 GDSC1 1.8518 8.3512 0.0039 38.8985
NCI-H2347 GDSC1 2.0275 17.2257 -4.1293 44.0295
PC-14 GDSC1 2.1757 9.3353 -0.1396 37.5655
CAL-12T GDSC1 2.2581 6.6737 1.1727 32.2103
HOP-62 GDSC1 2.3315 12.0956 -1.327 39.5473
NCI-H2595 GDSC1 2.3624 10.9077 -0.7189 38.1405
NCI-H1573 GDSC1 2.4428 6.5942 1.3966 30.0141
NCI-H727 GDSC1 2.5044 10.1994 -0.2413 36.2453
EMC-BAC-2 GDSC1 2.6228 7.4521 1.1854 30.1465
NCI-H1975 GDSC1 2.7288 9.9094 0.1103 34.0931
NCI-H647 GDSC1 2.8245 8.0743 1.0877 26.9646
HARA [Human squamous cell lung carcinoma] GDSC1 2.8617 15.3469 -2.4502 39.4212
Calu-6 GDSC1 2.954 5.1664 2.5363 19.9609
HCC78 GDSC1 2.9953 12.7723 -1.054 34.1487
NCI-H3122 GDSC1 3.0281 11.6365 -0.4626 34.5678
NCI-H2122 GDSC1 3.0992 5.915 2.3673 20.4225
HCC15 GDSC1 3.1133 8.9645 0.9298 28.9753
NCI-H2869 GDSC1 3.1269 10.9925 -0.055 32.874
NCI-H2085 GDSC1 3.19 7.7972 1.5697 25.2135
NCI-H847 GDSC1 3.2282 7.119 1.9327 22.7735
NCI-H1155 GDSC1 3.2711 6.7206 2.1641 21.0165
NCI-H23 GDSC1 3.3378 11.6161 -0.1746 30.2027
COR-L311 GDSC1 3.3593 8.5184 1.376 25.5421
ChaGo-K-1 GDSC1 3.4051 8.5123 1.421 22.7836
NCI-H1688 GDSC1 3.4332 7.4972 1.944 19.5856
NCI-H522 GDSC1 3.4478 9.9379 0.7559 28.2906
COR-L303 GDSC1 3.545 9.9008 0.8613 27.3829
NCI-H3255 GDSC1 3.5459 9.1006 1.2586 23.1194
DMS 273 GDSC1 3.6002 8.1956 1.755 20.0912
NCI-H196 GDSC1 3.688 10.9353 0.4731 26.3744
NCI-H2023 GDSC1 3.7635 7.6671 2.1639 18.822
NCI-H1563 GDSC1 3.7864 7.9421 2.0483 17.5756
SBC-3 GDSC1 3.8128 4.832 3.5756 8.0339
LCLC-97TM1 GDSC1 3.8627 6.1379 3.0076 12.1489
LB647-SCLC GDSC1 3.9017 8.7698 1.7388 21.0567
NCI-H1437 GDSC1 3.9069 10.934 0.664 26.8211
IST-SL2 GDSC1 3.9084 5.0477 3.5753 7.5794
NCI-H524 GDSC1 3.9611 8.1672 2.0909 18.5088
NCI-H226 GDSC1 3.993 4.5261 3.8921 4.8074
PaCa-3 GDSC1 3.9984 10.8086 0.8052 25.8036
NCI-H520 GDSC1 4.0186 16.3424 -1.9429 34.6753
Lu-135 GDSC1 4.0592 5.3089 3.5954 6.7584
LK-2 GDSC1 4.0786 11.5626 0.4969 26.9028
COR-L321 GDSC1 4.084 8.1988 2.1819 17.3917
NCI-H64 GDSC1 4.1323 4.6406 3.9861 3.426
NCI-H1792 GDSC1 4.141 5.9821 3.3366 7.5412
LXF 289 GDSC1 4.1609 10.7687 0.9634 22.4114
NCI-H322M GDSC1 4.1625 19.0982 -3.1995 36.5952
NCI-H650 GDSC1 4.1627 7.9784 2.3593 15.8286
Lu-65 GDSC1 4.1729 11.084 0.8159 25.0818
NCI-H1915 GDSC1 4.2282 18.6448 -2.9178 35.9383
NCI-H1048 GDSC1 4.2315 8.059 2.3775 15.4346
NCI-H2087 GDSC1 4.2349 13.0023 -0.091 28.6873
RERF-LC-KJ GDSC1 4.3147 11.3883 0.7827 24.7108
Ms-1 GDSC1 4.3156 5.4531 3.7511 4.525
UMC-11 GDSC1 4.3164 6.9077 3.0245 9.1415
IST-SL1 GDSC1 4.3203 7.4058 2.7786 12.1187
EBC-1 GDSC1 4.3271 7.1462 2.9141 9.877
NCI-H2461 GDSC1 4.3282 24.7564 -5.8901 39.5445
NCI-H2110 GDSC1 4.3795 11.1899 0.9358 21.8116
NCI-H810 GDSC1 4.3851 6.8107 3.1298 9.1665
NCI-H1770 GDSC1 4.4033 6.4552 3.3224 7.5914
NCI-H2795 GDSC1 4.414 5.8017 3.6573 4.3882
NCI-H2030 GDSC1 4.4533 15.1706 -0.9933 30.9014
EMC-BAC-1 GDSC1 4.4738 11.6712 0.773 24.178
NCI-H2171 GDSC1 4.4741 5.8801 3.6658 4.6493
NCI-H1435 GDSC1 4.5571 9.7385 1.8071 18.1147
NCI-H1581 GDSC1 4.5601 7.5124 2.9206 10.1821
LCLC-103H GDSC1 4.5638 5.6107 3.8663 2.8067
Lu-139 GDSC1 4.6557 17.247 -1.8646 32.5591
NCI-H2405 GDSC1 4.6839 11.3584 1.1006 21.7782
NCI-H2135 GDSC1 4.7159 8.4395 2.5816 12.2146
NCI-H1703 GDSC1 4.7537 13.6438 0.0158 24.7168
NCI-H446 GDSC1 4.773 6.5728 3.5467 4.6607
NCI-H510A GDSC1 4.7976 7.561 3.0797 8.185
NCI-H2803 GDSC1 4.8349 13.7367 0.0349 26.1549
NCI-H2444 GDSC1 4.8389 6.6833 3.5393 4.0439
NCI-H2081 GDSC1 4.841 7.3263 3.2273 6.9177
IA-LM GDSC1 4.8783 8.6966 2.5792 11.6989
NCI-H2141 GDSC1 4.9293 6.8002 3.5452 4.2438
A-427 GDSC1 4.9829 7.8067 3.095 6.7103
NCI-H2170 GDSC1 4.9891 8.8054 2.6091 11.1293
NCI-H1304 GDSC1 5.0015 7.7399 3.1409 7.1081
NCI-H1436 GDSC1 5.0342 8.8372 2.6269 10.8587
ABC-1 GDSC1 5.0377 9.753 2.1774 14.0339
LC-1/sq GDSC1 5.0689 7.431 3.3373 4.8534
SK-LU-1 GDSC1 5.0721 11.6466 1.2645 19.5732
NCI-H69 GDSC1 5.1667 8.4924 2.8919 8.5071
NCI-H82 GDSC1 5.1697 7.9085 3.1765 6.3726
NCI-H2228 GDSC1 5.2217 9.9356 2.2251 11.8511
COR-L23 GDSC1 5.2382 10.9335 1.7452 16.2127
NCI-H1836 GDSC1 5.2564 7.6792 3.3436 4.9112
SBC-5 GDSC1 5.2705 9.9645 2.2468 12.8323
NCI-H1650 GDSC1 5.3333 15.8366 -0.6158 26.9849
NCI-H1092 GDSC1 5.3687 8.8392 2.8649 8.1434
NCI-H1876 GDSC1 5.3775 7.2765 3.604 2.791
COR-L88 GDSC1 5.4084 13.4246 0.6413 21.6936
NCI-H748 GDSC1 5.4408 12.4087 1.1689 18.923
BEN GDSC1 5.5533 6.9172 3.8504 1
NCI-H1734 GDSC1 5.5776 16.6911 -0.8499 27.0549
NCI-H1781 GDSC1 5.7247 14.1166 0.5388 21.2185
Lu-134-A GDSC1 5.7319 13.5494 0.824 19.8309
SBC-1 GDSC1 5.742 8.1299 3.4307 3.2523
NCI-H187 GDSC1 5.7572 11.6308 1.7836 14.4154
Lu-99A GDSC1 5.807 8.4789 3.3118 3.5021
NCI-H841 GDSC1 5.8275 10.0398 2.5994 8.8345
RERF-LC-Sq1 GDSC1 5.8378 15.433 -0.0264 23.3294
NCI-H526 GDSC1 5.85 12.8425 1.2583 17.2147
CPC-N GDSC1 5.8628 8.0867 3.5155 2.4962
NCI-H2818 GDSC1 5.8817 8.1576 3.495 2.3141
NCI-H2196 GDSC1 5.8928 9.4504 2.9186 6.4496
NCI-H1993 GDSC1 5.9292 18.0959 -1.2757 27.4131
NCI-H1793 GDSC1 5.9302 7.824 3.6603 1.5499
SK-MES-1 GDSC1 5.9327 13.3849 1.0527 18.081
NCI-H2029 GDSC1 6.0066 8.0073 3.6219 1.6618
NCI-H292 GDSC1 6.0085 11.2285 2.153 11.3766
COR-L105 GDSC1 6.024 12.6021 1.5002 15.3574
NCI-H1355 GDSC1 6.0455 13.7155 0.9726 18.1772
DMS 79 GDSC1 6.0508 7.8918 3.6896 1.2522
COLO 668 GDSC1 6.0634 19.8306 -2.0332 29.1477
NCI-H441 GDSC1 6.0755 12.334 1.6665 14.2387
RERF-LC-MS GDSC1 6.077 11.68 1.9828 12.289
NCI-H720 GDSC1 6.1394 7.1709 3.9917 0.1209
NCI-H1568 GDSC1 6.1528 8.3034 3.5709 1.5639
NCI-H2373 GDSC1 6.1741 8.2261 3.6124 1.5049
NCI-H838 GDSC1 6.1991 7.782 3.7965 0.5724
Calu-3 GDSC1 6.2641 7.9402 3.7639 0.7196
NCI-H2591 GDSC1 6.3636 13.1543 1.4697 14.6166
NCI-H1623 GDSC1 6.3659 9.9491 2.9739 5.0775
NCI-H1694 GDSC1 6.3888 8.3612 3.6559 1.0694
DMS 114 GDSC1 6.4411 8.2925 3.7045 0.8188
DMS 53 GDSC1 6.4431 8.3416 3.6867 0.8896
SW1271 GDSC1 6.4671 8.049 3.8048 0.398
NCI-H460 GDSC1 6.496 7.8062 3.9009 0.1713
NCI-H2342 GDSC1 6.5055 12.5898 1.8355 12.1044
COR-L95 GDSC1 6.581 15.1365 0.662 18.2655
NCI-H2291 GDSC1 6.6333 8.2192 3.8071 0.3596
NCI-H2009 GDSC1 6.7111 8.7634 3.639 0.871
EKVX GDSC1 6.7301 14.0124 1.307 14.5862
NCI-H290 GDSC1 6.7884 14.6946 1.0193 15.9642
NCI-H2731 GDSC1 6.7919 8.7987 3.6588 0.7394
NCI-H1651 GDSC1 6.7992 8.4029 3.8038 0.3013
A-549 GDSC1 6.8283 8.8648 3.649 0.6696
HCC827 GDSC1 6.8329 10.5886 2.9509 4.3804
NCI-H1666 GDSC1 6.9639 11.5089 2.6182 6.2083
NCI-H1693 GDSC1 6.9936 9.0047 3.6631 0.6015
LOU-NH91 GDSC1 7.043 8.7263 3.78 0.2707
NCI-H661 GDSC1 7.0666 16.8731 0.1604 19.3026
NCI-H2722 GDSC1 7.1071 8.6304 3.8352 0.1546
HCC33 GDSC1 7.1723 15.3673 0.956 15.3493
NCI-H209 GDSC1 7.2537 9.2167 3.6861 0.4117
HOP-92 GDSC1 7.2684 9.3924 3.6292 0.4999
NCI-H2369 GDSC1 7.2828 15.1073 1.1522 14.0855
NCI-H513 GDSC1 7.3542 18.621 -0.4853 21.1861
NCI-H596 GDSC1 7.4422 20.2563 -1.2183 23.5091
NCI-H1299 GDSC1 7.4464 15.9244 0.8723 15.1267
Lu-165 GDSC1 7.8614 20.0118 -0.805 21.1863
NCI-H1838 GDSC1 8.0868 17.0383 0.7605 14.2611
SHP-77 GDSC1 8.7653 26.6133 -3.3727 26.4922
SW1573 GDSC1 9.0041 20.619 -0.3332 17.0735
NCI-H2172 GDSC1 9.9018 28.0629 -3.2817 24.25
⏷ Show the Full List of 172 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC1 3.9809 6.1112 3.1293 10.714
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KYSE-520 GDSC1 -1.2539 26.8403 -11.8655 53.0525
TE-15 GDSC1 1.2206 17.7948 -5.1463 47.0926
KYSE-450 GDSC1 1.7847 9.9547 -0.8128 41.1025
KYSE-140 GDSC1 3.1786 9.2554 0.8478 29.0592
KYSE-70 GDSC1 3.6659 8.6002 1.6142 22.8091
TE-6 GDSC1 4.1705 8.7104 2.0002 18.2942
KYSE-410 GDSC1 5.0861 12.0404 1.0796 20.5276
TE-4 GDSC1 5.32 10.2871 2.1248 13.5087
TE-1 GDSC1 5.3215 12.9402 0.8149 21.1252
TE-9 GDSC1 5.343 8.9617 2.7881 8.7756
KYSE-510 GDSC1 5.4493 11.2681 1.7378 15.6052
OE19 GDSC1 5.8949 9.6363 2.8333 7.0396
TE-8 GDSC1 6.3704 14.1214 1.0066 17.1114
TE-10 GDSC1 6.3801 12.0533 2.0076 11.3565
T.T GDSC1 6.5049 8.4514 3.671 0.9042
OE33 GDSC1 6.6251 14.7534 0.8786 17.0932
KYSE-150 GDSC1 6.7873 12.5831 2.0207 10.3044
KYSE-270 GDSC1 6.7983 19.6979 -1.4126 25.621
TE-5 GDSC1 6.9461 8.6854 3.759 0.3532
COLO 680N GDSC1 7.1193 32.1599 -7.34 35.6504
EC-GI-10 GDSC1 7.1458 8.9736 3.7315 0.3431
TE-11 GDSC1 8.025 16.1048 1.1561 12.4445
KYSE-180 GDSC1 8.3222 17.7628 0.5709 14.6539
OE21 GDSC1 8.5266 22.4211 -1.5085 22.0878
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-OV-3 GDSC1 -0.9119 9.9804 -3.5302 55.8794
TOV-21G GDSC1 0.327 9.0684 -1.8599 49.9708
IGROV-1 GDSC1 0.8855 5.8134 0.08 44.9957
TOV-112D GDSC1 1.4427 4.1061 1.2359 33.2273
Caov-4 GDSC1 1.579 15.9085 -3.8906 45.3398
JHOS-2 GDSC1 1.6477 4.5958 1.3244 35.2562
A2780 GDSC1 2.0692 7.0287 0.8226 34.8838
Kuramochi GDSC1 2.2763 10.1971 -0.4561 37.9055
OC 314 GDSC1 2.3232 7.5073 0.8625 30.3414
OVTOKO GDSC1 2.347 17.3075 -3.8822 42.82
OVCAR-5 GDSC1 2.5485 19.0676 -4.5764 42.8149
OVCAR-4 GDSC1 2.7629 7.4214 1.3376 28.6249
TYK-nu GDSC1 3.0872 12.6543 -0.9132 35.5479
EFO-21 GDSC1 3.2318 17.9853 -3.4382 39.6239
OAW28 GDSC1 3.7163 27.6122 -7.8317 42.3441
OV56 GDSC1 3.7755 9.3075 1.3603 23.8249
OV-90 GDSC1 4.323 11.8096 0.579 25.6292
OVCAR-8 GDSC1 4.4362 12.4013 0.3771 26.1089
DOV13 GDSC1 4.4827 9.0403 2.0953 16.4848
FU-OV-1 GDSC1 4.9937 12.4753 0.7906 22.3007
RMG-I GDSC1 5.0417 10.4982 1.8112 16.4298
OAW42 GDSC1 5.113 8.8963 2.6558 10.4074
OVISE GDSC1 5.1663 8.1016 3.0811 7.0956
OVKATE GDSC1 5.174 22.5061 -4.0702 35.3743
EFO-27 GDSC1 5.9895 15.3169 0.1447 22.1952
ES-2 GDSC1 6.298 8.6886 3.4827 2.0479
Caov-3 GDSC1 6.6406 15.1749 0.6853 18
OVK18 GDSC1 6.6472 11.5958 2.3918 8.2902
OVCAR-3 GDSC1 7.0652 8.6868 3.8015 0.2215
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 31 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuP-T4 GDSC1 0.9095 5.5287 0.2103 40.6686
BxPC-3 GDSC1 2.4782 6.2997 1.5627 26.0134
KP-1N GDSC1 2.5334 4.6293 1.9495 14.4769
MZ-PC-1 GDSC1 2.7227 5.7335 2.0595 21.9086
Panc 04.03 GDSC1 2.9042 35.9975 -12.7123 44.9664
KP-2 GDSC1 2.9646 6.047 2.1715 20.1096
PSN1 GDSC1 2.9998 5.5921 2.4074 20.6376
Capan-1 GDSC1 3.0762 9.0738 0.8419 29.5585
Panc 08.13 GDSC1 3.2013 10.9258 0.0451 29.9258
KP-4 GDSC1 3.3818 4.8443 3.1177 12.1034
Panc 03.27 GDSC1 3.4287 14.2023 -1.3811 35.3979
Panc 10.05 GDSC1 3.5067 7.0401 2.2354 17.4358
MIA PaCa-2 GDSC1 4.2639 7.9269 2.4709 14.6329
Hs 766T GDSC1 4.4344 10.515 1.3186 19.6348
SUIT-2 GDSC1 4.5598 6.2689 3.5389 4.788
CFPAC-1 GDSC1 4.609 7.6145 2.9083 9.0406
SU.86.86 GDSC1 4.6564 13.3315 0.0927 24.7078
AsPC-1 GDSC1 5.0724 12.6191 0.781 20.3972
HPAF-II GDSC1 5.1783 15.7971 -0.7186 26.1617
PaTu 8902 GDSC1 5.2892 7.787 3.314 4.5068
Capan-2 GDSC1 5.3898 10.8125 1.9179 14.6528
HuP-T3 GDSC1 5.5108 13.5081 0.6781 19.6278
PaTu 8988t GDSC1 5.538 8.3295 3.2182 4.6002
Panc 02.03 GDSC1 5.6779 13.1309 0.9901 17.6501
YAPC GDSC1 5.8531 12.0015 1.6713 13.5237
DAN-G GDSC1 5.9314 9.4596 2.9384 5.5743
QGP-1 GDSC1 5.9534 8.2405 3.4972 2.4637
PL4 GDSC1 6.0033 7.9671 3.6368 1.4139
SW1990 GDSC1 6.289 10.7393 2.5668 7.1518
KP-3 GDSC1 6.4177 16.892 -0.3135 22.8642
HPAC GDSC1 7.56 19.6821 -0.8555 20.8139
⏷ Show the Full List of 31 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MPP 89 GDSC1 5.9007 8.5027 3.3544 3.4595
NCI-H2452 GDSC1 6.6169 9.8417 3.1585 3.4709
MSTO-211H GDSC1 6.7589 8.7047 3.6803 0.6846
NCI-H2052 GDSC1 7.2661 13.2215 2.0206 9.2597
IST-Mes1 GDSC1 7.3929 19.6985 -0.9816 22.8484
NCI-H28 GDSC1 8.0554 18.4045 0.0962 17.2987
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LNCaP clone FGC GDSC1 1.1826 7.915 -0.4754 43.857
VCaP GDSC1 4.1713 5.4215 3.6421 5.9337
PC-3 GDSC1 4.4335 10.3069 1.4219 20.9008
22Rv1 GDSC1 4.7332 9.4572 2.0885 15.6485
DU145 GDSC1 7.3314 14.7595 1.3474 12.9393
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC1 4.7644 7.7338 2.9693 9.1362
Cancer Drug Sensitivity Data Curated from 56 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RVH-421 GDSC1 1.8979 5.9943 1.0869 34.7736
LB2518-MEL GDSC1 2.0349 6.164 1.1608 33.5827
WM278 GDSC1 2.2188 7.0199 0.9787 33.3459
IGR-1 GDSC1 2.2291 4.4345 2.0063 27.5951
HT-144 GDSC1 2.7016 7.8509 1.0751 30.2842
WM1552C GDSC1 2.7527 6.6495 1.6853 26.6933
SK-MEL-2 GDSC1 2.7912 6.0529 1.992 24.557
A101D GDSC1 2.8322 4.4234 2.6673 19.7093
Hs 940.T GDSC1 3.0952 11.666 -0.4166 34.1532
RPMI-7951 GDSC1 3.3499 11.2908 -0.0024 31.7563
A-431 GDSC1 3.5944 9.3283 1.1893 25.5231
WM793 GDSC1 3.6415 21.6769 -4.9289 40.2104
IST-MEL1 GDSC1 3.7264 7.8728 2.0287 19.9031
A-375 GDSC1 3.7871 5.6525 3.1714 11.2151
G-mel GDSC1 4.0582 5.0433 3.7233 5.7718
Mel JuSo GDSC1 4.1193 12.0253 0.3001 27.5835
Mel Ho GDSC1 4.2514 12.2297 0.3091 27.0605
MZ-MEL-7 GDSC1 4.2876 8.3062 2.3011 15.7706
SK-MEL-30 GDSC1 4.3824 6.6466 3.2096 8.5503
HMV-II GDSC1 4.4747 11.5045 0.8571 23.7655
WM35 GDSC1 4.4767 7.0782 3.0706 9.3077
COLO 679 GDSC1 4.6516 11.0513 1.2279 21.2063
G-361 GDSC1 4.6693 7.2868 3.1181 8.2952
SH-4 GDSC1 4.8074 21.449 -3.8404 35.9118
COLO 792 GDSC1 4.8132 7.5046 3.1192 6.9968
SK-MEL-1 GDSC1 4.9409 9.5544 2.2019 14.1788
IPC-298 GDSC1 5.0136 7.839 3.1012 7.3745
MZ-MEL-2 GDSC1 5.0679 14.0857 0.0469 25.3539
CHL-1 GDSC1 5.1173 6.8073 3.663 2.9243
451Lu GDSC1 5.1316 7.2785 3.4517 4.4238
A2058 GDSC1 5.1505 10.6195 1.8342 14.4673
M14 GDSC1 5.2403 9.9853 2.2143 13.1466
GAK GDSC1 5.3889 7.6113 3.4585 3.7758
COLO 783 GDSC1 5.3981 16.0236 -0.658 26.9376
COLO 829 GDSC1 5.4782 19.604 -2.3782 31.4687
CP50-MEL-B GDSC1 5.5511 8.5809 3.1089 5.902
IGR-37 GDSC1 5.5634 7.9826 3.3936 3.8574
A-388 GDSC1 5.5905 7.8763 3.4575 3.3638
CP66-MEL GDSC1 5.6181 9.5957 2.6714 8.871
SK-MEL-28 GDSC1 5.638 6.4646 4.0555 0.1401
WM115 GDSC1 5.7821 11.2434 1.9896 13.0477
COLO 800 GDSC1 5.807 9.5668 2.8098 7.4143
WT2-iPS GDSC1 5.842 8.9726 3.1081 5.2445
SK-MEL-3 GDSC1 5.8538 7.1735 3.8826 0.5034
UACC-62 GDSC1 5.8667 6.9568 3.9672 0.2696
VMRC-MELG GDSC1 6.1045 7.5898 3.8296 0.5842
SK-MEL-24 GDSC1 6.1175 7.9635 3.6914 1.1712
LOX-IMVI GDSC1 6.1603 11.2956 2.2224 10.5331
MMAc-SF GDSC1 6.3714 14.1814 0.9782 17.2551
LB373-MEL-D GDSC1 6.5035 12.0375 2.0954 10.5045
Hs 938.T GDSC1 6.5257 9.2125 3.3775 2.0804
SK-MEL-5 GDSC1 6.6165 14.7037 0.8966 15.7397
UACC-257 GDSC1 6.6592 16.237 0.1821 20.2327
DJM-1 GDSC1 7.0012 8.7193 3.7673 0.3126
MeWo GDSC1 7.0575 8.4836 3.8673 0.119
EquiPSC Line K2 GDSC1 5.6756 9.0667 2.9605 6.6651
⏷ Show the Full List of 56 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC1 3.975 5.5567 3.396 8.6644
Cancer Drug Sensitivity Data Curated from 23 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SW982 GDSC1 -0.165 19.281 -7.1616 51.3522
MES-SA GDSC1 2.9312 6.8627 1.7646 25.2939
SK-LMS-1 GDSC1 3.3123 7.177 1.9852 22.0342
G-402 GDSC1 4.1378 11.9608 0.348 25.3302
Rh41 GDSC1 4.5181 5.6804 3.7985 3.47
EW-8 GDSC1 4.6284 6.3608 3.5453 5.1004
G-401 GDSC1 4.6294 7.6162 2.9234 8.8753
Hs 633.T GDSC1 4.8171 6.4438 3.64 3.8275
A-204 GDSC1 4.8579 17.7437 -1.9477 32.1685
VA-ES-BJ GDSC1 5.0027 7.4259 3.2941 5.942
Rh30 GDSC1 5.5767 8.72 3.06 6.1918
RD GDSC1 5.6047 7.4712 3.6441 2.1194
TE 441.T GDSC1 5.7669 7.0716 3.8848 0.6243
SW872 GDSC1 5.7776 12.9248 1.1652 17.9314
STS-0421 GDSC1 5.8613 11.5717 1.886 13.484
RKN GDSC1 6.0566 7.409 3.8772 0.4462
SW684 GDSC1 6.2183 7.424 3.933 0.2132
MFH-ino GDSC1 6.2378 8.2545 3.6305 1.341
KYM-1 GDSC1 6.3551 7.5897 3.925 0.1859
Rh18 GDSC1 6.3751 7.7589 3.8734 0.2965
HT-1080 GDSC1 6.752 14.1061 1.2768 14.6957
GCT GDSC1 6.9666 8.8435 3.7107 0.4722
SK-UT-1 GDSC1 7.2317 9.3919 3.6153 0.621
⏷ Show the Full List of 23 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 26 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MKN45 GDSC1 -0.2924 11.7124 -3.6815 52.6894
SNU-1 GDSC1 2.0266 9.2792 -0.2576 38.6454
IM95 GDSC1 2.7194 6.7755 1.5942 24.7127
RF-48 GDSC1 3.815 7.3136 2.3852 17.0358
HSC-39 GDSC1 4.1586 12.1305 0.2808 27.5174
MKN1 GDSC1 4.3438 14.0188 -0.5083 29.7637
MKN7 GDSC1 4.4458 9.6565 1.7572 18.8343
SNU-16 GDSC1 4.588 7.5337 2.9321 9.9996
HGC-27 GDSC1 5.1466 9.9658 2.1543 13.8449
TMK-1 GDSC1 5.4261 9.2657 2.6988 9.1931
Hs 746.T GDSC1 5.5151 7.295 3.6725 2.09
Fu97 GDSC1 5.5522 11.1334 1.8792 13.0921
TGBC11TKB GDSC1 5.5798 8.3335 3.2424 4.882
NCI-N87 GDSC1 5.6481 9.3275 2.8193 7.7408
NUGC-4 GDSC1 5.7092 9.4635 2.795 7.7598
ECC10 GDSC1 5.7367 8.1608 3.4139 3.3735
23132/87 GDSC1 6.0559 10.0076 2.7614 7.1624
NUGC-3 GDSC1 6.1574 11.7585 1.9997 11.9712
SCH GDSC1 6.1579 7.3265 3.9449 0.2074
SNU-5 GDSC1 6.1738 7.7156 3.8109 0.605
RERF-GC-1B GDSC1 6.3264 16.6474 -0.2605 22.9031
OCUM-1 GDSC1 6.4016 8.6064 3.5652 1.4864
GCIY GDSC1 6.464 9.3376 3.2941 2.8968
MKN28 GDSC1 6.9705 15.4134 0.7981 16.6215
AGS GDSC1 7.4156 13.105 2.1621 8.1179
SNG-M GDSC1 1.553 5.6928 0.84 38.0647
⏷ Show the Full List of 26 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
B-CPAP GDSC1 3.3203 8.9973 1.1047 27.1661
KMH-2 GDSC1 3.4146 5.5434 2.8537 13.6916
TT2609-C02 GDSC1 3.5357 14.2189 -1.2961 34.8161
HTC-C3 GDSC1 4.511 9.4528 1.9123 17.6025
K5 GDSC1 5.2749 10.8553 1.8115 15.6833
ML-1 [Human leukemia] GDSC1 5.728 14.6285 0.2884 20.7899
FTC-133 GDSC1 5.7718 7.6033 3.674 1.6858
IHH-4 GDSC1 5.9416 7.8146 3.6696 1.3252
CAL-62 GDSC1 6.2529 7.7628 3.8252 0.5023
ASH-3 GDSC1 6.323 8.0396 3.7508 0.648
WRO GDSC1 6.3488 7.8108 3.8451 0.3863
BHT-101 GDSC1 6.4178 8.4002 3.6534 1.0539
TT GDSC1 6.4811 11.525 2.3215 9.1158
8305C GDSC1 6.675 8.1172 3.8579 0.2244
8505C GDSC1 6.7289 14.2588 1.1881 15.2297
CGTH-W-1 GDSC1 7.1906 18.6618 -0.6207 22.0687
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SCC-9 GDSC1 0.8464 14.2732 -3.7812 47.929
NCI-H3118 GDSC1 2.5395 7.1509 1.2423 27.4636
JHU-011 GDSC1 2.5661 8.4495 0.6595 32.8397
PCI-06A GDSC1 2.8629 8.6843 0.831 30.6222
LB771-HNC GDSC1 3.1911 14.7899 -1.8819 37.2978
OSC-20 GDSC1 3.5799 8.3209 1.6748 20.6469
PCI-04B GDSC1 3.7119 13.9636 -1.0162 33.4783
BHY GDSC1 3.8287 9.4504 1.3359 23.7419
PCI-38 GDSC1 4.1127 8.4151 2.0984 17.8549
SCC-25 GDSC1 4.1773 8.6557 2.0334 18.0453
CAL-27 GDSC1 4.2961 10.6811 1.1208 23.076
PCI-15A GDSC1 4.3943 13.305 -0.1094 28.1952
UPCI-SCC-090 GDSC1 4.5416 7.9063 2.7094 11.8551
BB30-HNC GDSC1 4.9796 11.62 1.2054 20.204
HSC-3 GDSC1 5.0768 7.5409 3.2898 5.7729
OSC-19 GDSC1 5.4048 8.8074 2.9049 7.7545
HO-1-N-1 GDSC1 5.5008 10.4317 2.1851 12.5674
Detroit 562 GDSC1 5.5313 13.0733 0.9087 20.0074
SCC-15 GDSC1 5.5689 8.3119 3.2456 4.3619
JHU-022 GDSC1 5.6937 47.0874 -15.9286 42.9453
HSC-2 GDSC1 5.7816 9.0936 3.0151 6.0291
Ca9-22 GDSC1 5.8125 9.6582 2.7703 7.6785
SAS GDSC1 5.8287 14.9602 0.2004 22.4173
BICR 22 GDSC1 5.8631 7.8288 3.6253 1.8374
CAL-33 GDSC1 5.9821 9.3682 3.0114 5.6091
KON GDSC1 6.1216 10.429 2.6062 8.0685
SCC-4 GDSC1 6.1628 10.6387 2.5342 8.4576
BICR 10 GDSC1 6.1763 7.8409 3.7648 0.7853
HSC-4 GDSC1 6.1911 7.5095 3.8928 0.2906
BICR 31 GDSC1 6.2046 7.8174 3.7854 0.68
HO-1-u-1 GDSC1 6.2589 12.0433 1.9318 11.0309
BICR 78 GDSC1 6.426 10.1962 2.8977 5.4587
BB49-HNC GDSC1 6.5495 8.884 3.5222 1.5381
SAT [Human HNSCC] GDSC1 6.6218 9.8723 3.1479 3.5271
SKN-3 GDSC1 6.7726 8.4034 3.7939 0.3355
PCI-30 GDSC1 6.952 14.6904 1.1318 13.8045
DOK GDSC1 7.5168 25.1876 -3.5828 29.3657
FaDu GDSC1 7.7064 18.6194 -0.2407 19.4399
PE/CA-PJ15 GDSC1 8.8263 19.7466 -0.0375 15.2407
⏷ Show the Full List of 39 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
5637 GDSC1 3.4447 14.7601 -1.6451 35.9303
J82 GDSC1 4.2665 23.4494 -5.288 39.0742
RT-4 GDSC1 4.4218 7.2772 2.9267 9.4868
UM-UC-3 GDSC1 4.7485 7.0272 3.3062 6.5882
BFTC-905 GDSC1 4.969 12.4135 0.802 22.3268
KU-19-19 GDSC1 5.0294 7.6365 3.2108 6.4987
639V GDSC1 5.0718 7.2499 3.4258 4.7666
CAL-29 GDSC1 5.1459 21.2634 -3.4723 34.4721
SW780 GDSC1 5.2404 6.8239 3.7281 2.2209
647V GDSC1 5.3274 6.9866 3.7049 2.212
RT-112 GDSC1 5.4122 10.312 2.1798 12.8628
SW1710 GDSC1 5.5661 16.9439 -0.9845 27.5171
HT-1197 GDSC1 5.9331 7.4819 3.7984 0.8533
TCCSUP GDSC1 6.1945 7.8115 3.7835 0.6953
HT-1376 GDSC1 6.8089 8.8072 3.6625 0.6381
T24 GDSC1 7.5789 24.3868 -3.1425 28.3124
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
BPH-1 GDSC1 -1.6932 5.6617 -2.6518 63.1982
ME-180 GDSC1 -0.418 6.4913 -1.5711 55.1831
DSH1 GDSC1 -0.2644 11.2511 -3.442 52.6663
ACC-OV7 GDSC1 0.3607 4.9777 -0.1964 49.641
Ca Ski GDSC1 0.4014 9.7 -2.0671 49.5627
OVMIU GDSC1 2.1582 9.8882 -0.4204 38.3899
SKN GDSC1 2.4264 7.5718 0.9354 29.5128
JHOS-3 GDSC1 2.6572 9.0633 0.4528 33.2022
PA-1 GDSC1 2.6578 6.7575 1.5407 28.0441
OV17R GDSC1 3.2014 8.6734 1.1539 27.4565
JAR GDSC1 3.8868 8.0435 2.0871 18.8371
CAL-39 GDSC1 4.1633 8.0834 2.3074 16.1981
OVCA433 GDSC1 4.3457 10.5499 1.2277 22.3161
NT2-D1 GDSC1 4.4958 10.8413 1.206 21.8828
NCC-IT GDSC1 4.7708 10.9546 1.3718 19.9851
KGN GDSC1 4.89 7.8657 2.9983 8.5227
SW954 GDSC1 4.9071 11.2308 1.3422 19.6874
NEC8 GDSC1 5.188 8.8554 2.7302 9.6405
LB831-BLC GDSC1 5.5032 15.3052 -0.219 25.0549
OMC-1 [Human cervical carcinoma] GDSC1 5.6404 7.6512 3.5852 2.4304
HEY GDSC1 5.6715 8.6142 3.1691 5.194
PEO1 GDSC1 5.7095 13.3798 0.8909 19.5622
C-33 A GDSC1 5.8619 8.0772 3.5192 2.4751
OVCA420 GDSC1 5.9549 15.0794 0.2361 21.9039
SiHa GDSC1 5.9916 7.2335 3.9156 0.359
DoTc2 4510 GDSC1 6.1813 14.0299 0.9168 18.0841
SW756 GDSC1 6.2183 7.641 3.856 0.4215
HT-3 GDSC1 6.2384 13.8827 1.0293 17.3501
JEG-3 GDSC1 6.2493 8.151 3.6765 1.1082
C-4-I GDSC1 6.4239 8.1028 3.7683 0.5914
SiSo GDSC1 6.4692 19.2932 -1.4583 26.5632
SKG-IIIa GDSC1 6.5093 7.885 3.8785 0.2344
HEC-1 GDSC1 6.5368 13.8751 1.2414 15.4326
MS751 GDSC1 6.6757 14.084 1.2358 15.1086
UWB1.289 GDSC1 6.7598 8.9904 3.5733 1.1001
HeLa GDSC1 7.3808 15.7122 0.9299 14.9925
SW962 GDSC1 7.9171 21.4583 -1.4665 23.2338
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug

References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5693).
3 The oral protein-kinase C beta inhibitor enzastaurin (LY317615) suppresses signalling through the AKT pathway, inhibits proliferation and induces apoptosis in multiple myeloma cell lines. Leuk Lymphoma. 2008 Jul;49(7):1374-83.
4 Phase I study of enzastaurin and bevacizumab in patients with advanced cancer: safety, efficacy and pharmacokinetics. Invest New Drugs. 2013 Jun;31(3):653-60.