Details of the Drug Combination

General Information of Drug Combination (ID: DCD5Z3S)

Drug Combination Name
Teduglutide Teduglutide
Indication
Disease Entry Status REF
Crohn's Disease Phase 2 [1]
Component Drugs Teduglutide   DMYOAKS Teduglutide   DMYOAKS
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Teduglutide
Disease Entry ICD 11 Status REF
Short bowel syndrome KB89.1 Approved [2]
Teduglutide Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Glucagon-like peptide 2 receptor (GLP2R) TT1YWO5 GLP2R_HUMAN Modulator [3]
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Teduglutide Interacts with 1 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Insulin-like growth factor I (IGF1) OTIIZR61 IGF1_HUMAN Increases ADR [4]
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Indication(s) of Teduglutide
Disease Entry ICD 11 Status REF
Short bowel syndrome KB89.1 Approved [2]
Teduglutide Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Glucagon-like peptide 2 receptor (GLP2R) TT1YWO5 GLP2R_HUMAN Modulator [3]
------------------------------------------------------------------------------------
Teduglutide Interacts with 1 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Insulin-like growth factor I (IGF1) OTIIZR61 IGF1_HUMAN Increases ADR [4]
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References

1 ClinicalTrials.gov (NCT00072839) Safety and Efficacy of ALX-0600 in Subjects With Active Crohn's Disease
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7049).
3 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
4 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.