Details of the Drug Combination

General Information of Drug Combination (ID: DCHVXBY)

Drug Combination Name
Doxycycline Amoxicillin
Indication
Disease Entry Status REF
Periodontitis Phase 1 [1]
Component Drugs Doxycycline   DM7ICNU Amoxicillin   DMUYNEI
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Doxycycline
Disease Entry ICD 11 Status REF
Acne vulgaris ED80 Approved [2]
Actinomycosis N.A. Approved [2]
Acute gonococcal cervicitis N.A. Approved [2]
Acute gonococcal epididymo-orchitis N.A. Approved [2]
Advanced gum disease DA0D Approved [3]
Anthrax 1B97 Approved [2]
Bartonellosis N.A. Approved [2]
Boutonneuse fever N.A. Approved [2]
Brill-Zinsser disease N.A. Approved [2]
Bronchitis CA20 Approved [2]
Brucellosis N.A. Approved [2]
Chancroid N.A. Approved [2]
Chlamydiaceae infections N.A. Approved [2]
Chronic periodontitis DA0C.Y Approved [3]
Colorectal carcinoma N.A. Approved [2]
Cutaneous anthrax N.A. Approved [2]
Endemic typhus N.A. Approved [2]
Epidemic louse-borne typhus N.A. Approved [2]
Gastrointestinal anthrax N.A. Approved [2]
Inhalational anthrax N.A. Approved [2]
Listeriosis N.A. Approved [2]
Lymphogranuloma venereum N.A. Approved [2]
Mycoplasma pneumoniae pneumonia N.A. Approved [2]
Ornithosis N.A. Approved [2]
Q fever N.A. Approved [2]
Relapsing fever N.A. Approved [2]
Rickettsialpox N.A. Approved [2]
Rickettsiosis N.A. Approved [2]
Rocky mountain spotted fever N.A. Approved [2]
Syphilis N.A. Approved [2]
Trachoma N.A. Approved [2]
Tularemia 1B94 Approved [2]
Typhus N.A. Approved [2]
Yaws N.A. Approved [2]
Diabetic foot ulcer BD54 Phase 2 [4]
Sinusitis CA0A.Z Investigative [2]
Vibrio cholerae infection 1A00 Investigative [2]
Doxycycline Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Bacterial 30S ribosomal RNA (Bact 30S rRNA) TTOVFH2 NOUNIPROTAC Modulator [8]
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Doxycycline Interacts with 1 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [9]
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Doxycycline Interacts with 1 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [10]
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Doxycycline Interacts with 9 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Decreases Expression [11]
Cytochrome P450 1B1 (CYP1B1) OTYXFLSD CP1B1_HUMAN Increases Expression [7]
Aryl hydrocarbon receptor (AHR) OTFE4EYE AHR_HUMAN Increases Expression [7]
HLA class I histocompatibility antigen, B alpha chain (HLA-B) OTNXFWY2 HLAB_HUMAN Affects Expression [12]
72 kDa type IV collagenase (MMP2) OT5NIWA2 MMP2_HUMAN Decreases Activity [13]
Stromelysin-1 (MMP3) OTGBI74Z MMP3_HUMAN Decreases Activity [13]
Neutrophil collagenase (MMP8) OTZXH19L MMP8_HUMAN Decreases Activity [13]
Collagenase 3 (MMP13) OTY8BZIE MMP13_HUMAN Increases Expression [14]
TAR DNA-binding protein 43 (TARDBP) OTVOSFWW TADBP_HUMAN Decreases Expression [15]
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⏷ Show the Full List of 9 DOT(s)
Indication(s) of Amoxicillin
Disease Entry ICD 11 Status REF
Acute otitis media AB00 Approved [5]
Bacterial infection 1A00-1C4Z Approved [6]
Staphylococcus aureus infection N.A. Approved [5]
Streptococcal pneumonia N.A. Approved [5]
Urinary tract infection GC08 Approved [5]
Pneumonia due to Klebsiella pneumoniae CA40.03 Investigative [5]
Sinusitis CA0A.Z Investigative [5]
Amoxicillin Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Bacterial Cell membrane (Bact CM) TTXT4D5 NOUNIPROTAC Modulator [8]
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Amoxicillin Interacts with 4 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [16]
Peptide transporter 1 (SLC15A1) DT9G7XN S15A1_HUMAN Substrate [17]
Peptide transporter 2 (SLC15A2) DT8QKNP S15A2_HUMAN Substrate [17]
Organic anion transporter 1 (SLC22A6) DTQ23VB S22A6_HUMAN Substrate [18]
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Amoxicillin Interacts with 46 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Mephenytoin 4-hydroxylase (CYP2C19) DEGTFWK CP2CJ_HUMAN Metabolism [19]
Beta-lactamase (blaB) DED0TBR A0A414M273_9BACE Metabolism [20]
Beta-lactamase (blaB) DEX8KJO A6NX15_9FIRM Metabolism [21]
Beta-lactamase (blaB) DEAYSTX C0W968_9FIRM Metabolism [22]
Beta-lactamase (blaB) DERGEVU C3WC84_FUSMR Metabolism [23]
Beta-lactamase (blaB) DEV0KWQ Q8KT52_9BACT Metabolism [24]
Beta-lactamase (blaB) DEQMISO F9Z530_ODOSD Metabolism [23]
Beta-lactamase (blaB) DEHFJ4G Q8KT51_9BACT Metabolism [23]
Beta-lactamase (blaB) DEHPJRC Q8KT60_9BACT Metabolism [23]
Beta-lactamase (blaB) DEITMS0 Q9XBM2_ACIFE Metabolism [25]
N-acylhomoserine lactone acylase (lacA) DEIU0XN A0A0A1VBK6_9BURK Metabolism [26]
Beta-lactamase (blaB) DET9I1W BLAC_BACUN Metabolism [27]
Beta-lactamase (blaB) DE7IH52 AMPC_CITFR Metabolism [24]
Beta-lactamase (blaB) DENJ2SQ BLAB_BACFG Metabolism [27]
Beta-lactamase (blaB) DE5HV8P A0A4Q5I6I2_9BACE Metabolism [27]
Beta-lactamase (blaB) DE47ARF B5WXV2_9BACT Metabolism [28]
Beta-lactamase (blaB) DEG2PK9 B5WXV3_BACOV Metabolism [27]
Beta-lactamase (blaB) DEWHJ7A B5WXV7_BACT4 Metabolism [27]
Beta-lactamase (blaB) DEU1RXB BLAC_BACVU Metabolism [27]
Beta-lactamase (blaB) DETDS7E A0A2S0LB67_9FLAO Metabolism [24]
Beta-lactamase (blaB) DE37FJH C6JIU1_FUSVA Metabolism [23]
Beta-lactamase (blaB) DEC7JEF A0A1S1G219_9NEIS Metabolism [24]
Beta-lactamase (blaB) DEP7MN1 Q9X4S7_PREIN Metabolism [29]
Beta-lactamase (blaB) DEAILCM A0A246EJV2_9BACT Metabolism [29]
Beta-lactamase (blaB) DET4XFN Q8KT59_9BACT Metabolism [24]
Metallo-beta-lactamase (blaM) DEPCQ12 Q68K11_ALCXX Metabolism [30]
Beta-lactamase (blaB) DEACNTL Q2F4C6_SHISO Metabolism [31]
Beta-lactamase (blaB) DEE8742 O32372_CAPOC Metabolism [32]
Beta-lactamase (blaB) DEY09SU C9MN73_9BACT Metabolism [24]
Beta-lactamase (blaB) DEQLVCA C9LD75_9BACT Metabolism [29]
Beta-lactamase (blaB) DE2IL34 C2M7J0_CAPGI Metabolism [32]
Beta-lactamase (blaB) DE1NJIW B6VMJ3_PHOAA Metabolism [33]
Beta-lactamase (blaB) DEDIMN9 A0A413GBG0_9BACE Metabolism [27]
Beta-lactamase (blaB) DEJ8X2W A0A412YFL9_9BACE Metabolism [27]
Beta-lactamase (blaB) DEFEVNH A0A381DV31_9FLAO Metabolism [32]
Beta-lactamase (blaB) DEAPGXV A0A347B2J2_9BACT Metabolism [24]
Beta-lactamase (blaB) DE0PDVC A0A2A3N1K0_CAPSP Metabolism [32]
Beta-lactamase (blaB) DEQL32N A0A250F962_9FLAO Metabolism [32]
Beta-lactamase (blaB) DE9HF0I A0A120A1C6_BACSE Metabolism [27]
Beta-lactamase (blaB) DESHI6O A0A108T9G3_9BACE Metabolism [27]
Beta-lactamase (blaB) DEZS3N4 A0A069QS91_PRELO Metabolism [24]
Beta-lactamase (blaB) DE5NSUX A0A095XPV0_9FIRM Metabolism [24]
New delhi metallo-beta-lactamase NDM-1 (blaNDM) DEBGCYQ A0A345N7K5_SALET Metabolism [34]
Beta-lactamase (blaB) DEW193R BLA1_KLEPN Metabolism [30]
Metallo-beta-lactamase (blaM) DEK9VG2 BLAN1_KLEPN Metabolism [30]
Beta-lactamase (blaB) DEQ1CTE A0A2T4TNV5_9BACT Metabolism [35]
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⏷ Show the Full List of 46 DME(s)
Amoxicillin Interacts with 15 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
HLA class II histocompatibility antigen, DQ beta 1 chain (HLA-DQB1) OTVVI3UI DQB1_HUMAN Affects Expression [12]
HLA class I histocompatibility antigen, B alpha chain (HLA-B) OTNXFWY2 HLAB_HUMAN Affects Expression [12]
C-C chemokine receptor type 9 (CCR9) OT5FSOD8 CCR9_HUMAN Increases ADR [36]
C-C chemokine receptor type 4 (CCR4) OT68KZ9B CCR4_HUMAN Increases ADR [36]
HLA class I histocompatibility antigen, A alpha chain (HLA-A) OTAH14LU HLAA_HUMAN Increases ADR [37]
C-X-C chemokine receptor type 3 (CXCR3) OTIGS220 CXCR3_HUMAN Increases ADR [36]
Aromatase (CYP19A1) OTZ6XF74 CP19A_HUMAN Increases Expression [38]
Cytochrome P450 11B2, mitochondrial (CYP11B2) OTIOLWYN C11B2_HUMAN Increases Expression [38]
Cytochrome P450 2C8 (CYP2C8) OTHCWT42 CP2C8_HUMAN Decreases Activity [39]
Aldo-keto reductase family 1 member B10 (AKR1B10) OTOA4HTH AK1BA_HUMAN Increases Expression [40]
NAD(P)H dehydrogenase 1 (NQO1) OTZGGIVK NQO1_HUMAN Increases Expression [40]
Sulfiredoxin-1 (SRXN1) OTYDBO4L SRXN1_HUMAN Increases Expression [40]
C-X-C motif chemokine 10 (CXCL10) OTTLQ6S0 CXL10_HUMAN Decreases Expression [41]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Increases Expression [41]
Organic solute transporter subunit alpha (SLC51A) OTDJRZ0P OSTA_HUMAN Increases Expression [42]
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⏷ Show the Full List of 15 DOT(s)

References

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2 Doxycycline FDA Label
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6464).
4 ClinicalTrials.gov (NCT00764361) Safety Study of Topical Doxycycline Gel for Adult Diabetic Lower Extremity Ulcers. U.S. National Institutes of Health.
5 Amoxicillin FDA Label
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18 The anti-influenza drug oseltamivir exhibits low potential to induce pharmacokinetic drug interactions via renal secretion-correlation of in vivo and in vitro studies. Drug Metab Dispos. 2002 Jan;30(1):13-9.
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23 Beta-lactamase production and susceptibilities to amoxicillin, amoxicillin-clavulanate, ticarcillin, ticarcillin-clavulanate, cefoxitin, imipenem, and metronidazole of 320 non-Bacteroides fragilis Bacteroides isolates and 129 fusobacteria from 28 U.S. centers. Antimicrob Agents Chemother. 1990 Aug;34(8):1546-50.
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26 A novel quorum-quenching N-acylhomoserine lactone acylase from Acidovorax sp. strain MR-S7 mediates antibiotic resistance. Appl Environ Microbiol. 2017 Jun 16;83(13). pii: e00080-17.
27 Prevalence of antimicrobial resistance genes in Bacteroides spp. and Prevotella spp. Dutch clinical isolates. Clin Microbiol Infect. 2019 Sep;25(9):1156.e9-1156.e13.
28 Presence of the cfxA gene in Bacteroides distasonis. Res Microbiol. 2003 Jun;154(5):369-74.
29 Prevotella strains and lactamic resistance gene distribution in different oral environments of children with pulp necrosis. Int Endod J. 2018 Nov;51(11):1196-1204.
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31 IncU plasmid harbouring bla CTX-M-8 in multidrug-resistant Shigella sonnei in Brazil. J Glob Antimicrob Resist. 2018 Sep;14:99-100.
32 High prevalence of beta-lactam and macrolide resistance genes in human oral Capnocytophaga species. J Antimicrob Chemother. 2014 Feb;69(2):381-4.
33 Yersinia enterocolitica and Photorhabdus asymbiotica beta-lactamases BlaA are exported by the twin-arginine translocation pathway. Int J Med Microbiol. 2013 Jan;303(1):16-24.
34 Genomic characterization of an extensively-drug resistance Salmonella enterica serotype Indiana strain harboring bla NDM-1 gene isolated from a chicken carcass in China. Microbiol Res. 2017 Nov;204:48-54.
35 High prevalence of cfxA beta-lactamase in aminopenicillin-resistant Prevotella strains isolated from periodontal pockets. Oral Microbiol Immunol. 2002 Apr;17(2):85-8.
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37 HLA alleles influence the clinical signature of amoxicillin-clavulanate hepatotoxicity. PLoS One. 2013 Jul 9;8(7):e68111. doi: 10.1371/journal.pone.0068111. Print 2013.
38 Modulation of steroidogenic gene expression and hormone production of H295R cells by pharmaceuticals and other environmentally active compounds. Toxicol Appl Pharmacol. 2007 Dec 1;225(2):142-53.
39 Effect of penicillin-based antibiotics, amoxicillin, ampicillin, and piperacillin, on drug-metabolizing activities of human hepatic cytochromes P450. J Toxicol Sci. 2016 Feb;41(1):143-6.
40 Characterization of drug-specific signaling between primary human hepatocytes and immune cells. Toxicol Sci. 2017 Jul 1;158(1):76-89.
41 Systemic drugs inducing non-immediate cutaneous adverse reactions and contact sensitizers evoke similar responses in THP-1 cells. J Appl Toxicol. 2015 Apr;35(4):398-406. doi: 10.1002/jat.3033. Epub 2014 Aug 4.
42 Molecular mechanisms of hepatotoxic cholestasis by clavulanic acid: Role of NRF2 and FXR pathways. Food Chem Toxicol. 2021 Dec;158:112664. doi: 10.1016/j.fct.2021.112664. Epub 2021 Nov 9.