Details of the Drug Combination

General Information of Drug Combination (ID: DCKRQE7)

Drug Combination Name

Terameprocol PMID28870136-Compound-43

Indication

Disease Entry	Status	REF
Adenocarcinoma	Investigative	[1]

Component Drugs

Terameprocol DMC3P45

PMID28870136-Compound-43 DMWGV8N

Small molecular drug

2D MOL

3D MOL

High-throughput Screening Result

Testing Cell Line: DU-145

Zero Interaction Potency (ZIP) Score: 2.69

Bliss Independence Score: 6.21

Loewe Additivity Score: 3.18

LHighest Single Agent (HSA) Score: 1.6

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)

Indication(s) of Terameprocol

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Phase 2	[2]

Terameprocol Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Transcription factor Sp1 (SP1)	TTZEP6S	SP1_HUMAN	Modulator	[2]
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PMID28870136-Compound-43 Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Ecto-5'-nucleotidase (CD73)	TTK0O6Y	5NTD_HUMAN	Inhibitor	[3]
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Test Results of This Drug Combination in Other Disease Systems

Indication	DrugCom ID	Cell Line	Status	REF
Adult acute myeloid leukemia	DCARBDI	HL-60(TB)	Investigative	[4]
Astrocytoma	DC2O9YM	U251	Investigative	[4]
Chronic myelogenous leukemia	DC266YO	KBM-7	Investigative	[4]
Carcinoma	DCZI23M	RXF 393	Investigative	[5]
Invasive ductal carcinoma	DC18G50	T-47D	Investigative	[5]
Adenocarcinoma	DCT1UVP	HT29	Investigative	[1]
Melanoma	DCFY7QN	MALME-3M	Investigative	[1]
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⏷ Show the Full List of 7 DrugCom(s)

References

1	CheMBL Affinity Phenotypic Cellular Interaction Assay ID: CHEMBL1125976
2	Terameprocol, a novel site-specific transcription inhibitor with anticancer activity. IDrugs. 2008 Mar;11(3):204-14.
3	Ectonucleotidase inhibitors: a patent review (2011-2016).Expert Opin Ther Pat. 2017 Dec;27(12):1291-1304.
4	CheMBL Affinity Phenotypic Cellular Interaction Assay ID: CHEMBL1125966
5	CheMBL Affinity Phenotypic Cellular Interaction Assay ID: CHEMBL1126165