Details of the Drug Combination

General Information of Drug Combination (ID: DCZI23M)

Drug Combination Name
Terameprocol PMID28870136-Compound-43
Indication
Disease Entry Status REF
Carcinoma Investigative [1]
Component Drugs Terameprocol   DMC3P45 PMID28870136-Compound-43   DMWGV8N
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL
High-throughput Screening Result Testing Cell Line: RXF 393
Zero Interaction Potency (ZIP) Score: 1.52
Bliss Independence Score: 2.68
Loewe Additivity Score: 1.48
LHighest Single Agent (HSA) Score: 0.57

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Terameprocol
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Phase 2 [2]
Terameprocol Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Transcription factor Sp1 (SP1) TTZEP6S SP1_HUMAN Modulator [2]
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PMID28870136-Compound-43 Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Ecto-5'-nucleotidase (CD73) TTK0O6Y 5NTD_HUMAN Inhibitor [3]
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Test Results of This Drug Combination in Other Disease Systems

Indication DrugCom ID Cell Line Status REF
Adult acute myeloid leukemia DCARBDI HL-60(TB) Investigative [4]
Astrocytoma DC2O9YM U251 Investigative [4]
Chronic myelogenous leukemia DC266YO KBM-7 Investigative [4]
Invasive ductal carcinoma DC18G50 T-47D Investigative [1]
Adenocarcinoma DCKRQE7 DU-145 Investigative [5]
Adenocarcinoma DCT1UVP HT29 Investigative [5]
Melanoma DCFY7QN MALME-3M Investigative [5]
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⏷ Show the Full List of 7 DrugCom(s)

References

1 CheMBL Affinity Phenotypic Cellular Interaction Assay ID: CHEMBL1126165
2 Terameprocol, a novel site-specific transcription inhibitor with anticancer activity. IDrugs. 2008 Mar;11(3):204-14.
3 Ectonucleotidase inhibitors: a patent review (2011-2016).Expert Opin Ther Pat. 2017 Dec;27(12):1291-1304.
4 CheMBL Affinity Phenotypic Cellular Interaction Assay ID: CHEMBL1125966
5 CheMBL Affinity Phenotypic Cellular Interaction Assay ID: CHEMBL1125976