Details of the Drug Combination

General Information of Drug Combination (ID: DCMQI15)

Drug Combination Name
Ketamine Nitroprusside
Indication
Disease Entry Status REF
Depression Phase 2 [1]
Component Drugs Ketamine   DMT5HA4 Nitroprusside   DMLUA2J
Small molecular drug N.A.
2D MOL 2D MOL
3D MOL 3D MOL is unavailable

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Ketamine
Disease Entry ICD 11 Status REF
Anaesthesia 9A78.6 Approved [2]
Anxiety N.A. Approved [3]
Bipolar disorder 6A60 Approved [3]
Depression 6A70-6A7Z Approved [3]
Traumatic brain injury NA07.Z Approved [3]
Coronavirus Disease 2019 (COVID-19) 1D6Y Phase 2 [4]
Chronic pain MG30 Investigative [3]
Ketamine Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
N-methyl-D-aspartate receptor (NMDAR) TT9IK2Z NOUNIPROTAC Antagonist [8]
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Ketamine Interacts with 3 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [9]
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Metabolism [9]
Cytochrome P450 2B6 (CYP2B6) DEPKLMQ CP2B6_HUMAN Metabolism [9]
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Ketamine Interacts with 10 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Zinc finger protein SNAI2 (SNAI2) OT7Y8EJ2 SNAI2_HUMAN Increases Expression [7]
Zinc finger protein SNAI1 (SNAI1) OTDPYAMC SNAI1_HUMAN Increases Expression [7]
Renin (REN) OT52GZR2 RENI_HUMAN Increases Expression [10]
Transforming growth factor beta-1 proprotein (TGFB1) OTV5XHVH TGFB1_HUMAN Increases Expression [7]
Amyloid-beta precursor protein (APP) OTKFD7R4 A4_HUMAN Increases Expression [11]
Cadherin-1 (CDH1) OTFJMXPM CADH1_HUMAN Decreases Expression [7]
Protein S100-A4 (S100A4) OTLRGFSQ S10A4_HUMAN Increases Expression [7]
DNA damage-inducible transcript 3 protein (DDIT3) OTI8YKKE DDIT3_HUMAN Increases Expression [12]
Actin, aortic smooth muscle (ACTA2) OTEDLG8E ACTA_HUMAN Increases Expression [7]
Sodium/hydrogen exchanger 6 (SLC9A6) OT5N47TC SL9A6_HUMAN Decreases Expression [11]
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⏷ Show the Full List of 10 DOT(s)
Indication(s) of Nitroprusside
Disease Entry ICD 11 Status REF
Hypertension BA00-BA04 Approved [5]
Malignant essential hypertension BA00 Approved [6]
Sarcopenia FB32.Y Approved [6]
Nitroprusside Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Inositol 1,4,5-trisphosphate receptor (ITPR) TTC9IZL ITPR1_HUMAN; ITPR2_HUMAN; ITPR3_HUMAN Antagonist [13]
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Nitroprusside Interacts with 1 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
S-(hydroxymethyl)glutathione dehydrogenase (adh) DEAH3PE A0A0A7DS01_VIBCL Metabolism [14]
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References

1 ClinicalTrials.gov (NCT03102736) Ketamine and Nitroprusside for Depression
2 FDA Approved Drug Products from FDA Official Website. 2019. Application Number: (ANDA) 076092.
3 Ketamine FDA Label
4 ClinicalTrials.gov (NCT04365985) Study of Immunomodulation Using Naltrexone and Ketamine for COVID-19. U.S. National Institutes of Health.
5 FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 073465.
6 Nitroprusside FDA Label
7 Ketamine-induced bladder fibrosis involves epithelial-to-mesenchymal transition mediated by transforming growth factor-1. Am J Physiol Renal Physiol. 2017 Oct 1;313(4):F961-F972. doi: 10.1152/ajprenal.00686.2016. Epub 2017 Mar 22.
8 Ketamine modulates theta and gamma oscillations. J Cogn Neurosci. 2010 Jul;22(7):1452-64.
9 Contribution of CYP3A4, CYP2B6, and CYP2C9 isoforms to N-demethylation of ketamine in human liver microsomes. Drug Metab Dispos. 2002 Jul;30(7):853-8.
10 Ketamine hypertension and the renin-angiotensin system. Clin Exp Hypertens A. 1983;5(6):875-83. doi: 10.3109/10641968309081814.
11 Ketamine promotes the amyloidogenic pathway by regulating endosomal pH. Toxicology. 2022 Apr 15;471:153163. doi: 10.1016/j.tox.2022.153163. Epub 2022 Apr 1.
12 Lipoxin A4 methyl ester attenuated ketamine-induced neurotoxicity in SH-SY5Y cells via regulating leptin pathway. Toxicol In Vitro. 2023 Jun;89:105581. doi: 10.1016/j.tiv.2023.105581. Epub 2023 Mar 11.
13 Prostacyclin and sodium nitroprusside inhibit the activity of the platelet inositol 1,4,5-trisphosphate receptor and promote its phosphorylation. J Biol Chem. 1996 Mar 8;271(10):5545-51.
14 Nitrosative stress response in Vibrio cholerae: role of S-nitrosoglutathione reductase. Appl Biochem Biotechnol. 2017 Jul;182(3):871-884.