Details of the Drug Combination

General Information of Drug Combination (ID: DCPVWQW)

Drug Combination Name
Fluconazole Amphotericin B
Indication
Disease Entry Status REF
Cryptococcal Meningitis Phase 1 [1]
Component Drugs Fluconazole   DMOWZ6B Amphotericin B   DMTAJQE
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL is unavailable

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Fluconazole
Disease Entry ICD 11 Status REF
Cryptococcal meningitis N.A. Approved [2]
Fungal infection 1F29-1F2F Approved [3]
Invasive candidiasis 1F23 Approved [2]
Mycoses 1F2Z Approved [2]
Oral candidiasis 1F23.0 Approved [2]
Autoimmune polyendocrine syndrome type 1 N.A. Investigative [2]
Candidemia 1F23.3Y Investigative [2]
Esophageal candidiasis N.A. Investigative [2]
Fluconazole Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Candida Cytochrome P450 51 (Candi ERG11) TTTSOUD CP51_CANAL Modulator [8]
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Fluconazole Interacts with 1 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Metabolism [9]
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Fluconazole Interacts with 8 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Cytochrome P450 2C9 (CYP2C9) OTGLBN29 CP2C9_HUMAN Decreases Activity [10]
Cytochrome P450 3A4 (CYP3A4) OTQGYY83 CP3A4_HUMAN Decreases Activity [11]
Steroid 17-alpha-hydroxylase/17,20 lyase (CYP17A1) OTZKVLVJ CP17A_HUMAN Affects Activity [12]
Aromatase (CYP19A1) OTZ6XF74 CP19A_HUMAN Decreases Activity [12]
Steroidogenic acute regulatory protein, mitochondrial (STAR) OTFEZ5AI STAR_HUMAN Increases Expression [13]
Lanosterol 14-alpha demethylase (CYP51A1) OTAYHG9C CP51A_HUMAN Decreases Response To Substance [14]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Increases ADR [7]
Cytochrome P450 2C19 (CYP2C19) OTFMJYYE CP2CJ_HUMAN Increases Metabolism [15]
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⏷ Show the Full List of 8 DOT(s)
Indication(s) of Amphotericin B
Disease Entry ICD 11 Status REF
Acne vulgaris ED80 Approved [4]
Actinomycosis N.A. Approved [4]
Acute gonococcal cervicitis N.A. Approved [4]
Aspergillosis 1F20 Approved [4]
Blastomycosis 1F22 Approved [4]
Bronchitis CA20 Approved [4]
Brucellosis N.A. Approved [4]
Candidiasis 1F23 Approved [4]
Coccidioidomycosis 1F25 Approved [4]
Cryptococcal meningitis N.A. Approved [4]
Cryptococcosis N.A. Approved [4]
Cutaneous candidiasis 1F23.14 Approved [4]
Disseminated sporotrichosis N.A. Approved [4]
Fungal infection 1F29-1F2F Approved [5]
Histoplasmosis N.A. Approved [4]
Invasive candidiasis 1F23 Approved [4]
Leishmaniasis 1F54 Approved [4]
Lymphogranuloma venereum N.A. Approved [4]
Mycotic endocarditis N.A. Approved [4]
Oral candidiasis 1F23.0 Approved [4]
Ornithosis N.A. Approved [4]
Pneumonia CA40 Approved [4]
Q fever N.A. Approved [4]
Relapsing fever N.A. Approved [4]
Rickettsialpox N.A. Approved [4]
Rocky mountain spotted fever N.A. Approved [4]
Syphilis N.A. Approved [4]
Trachoma N.A. Approved [4]
Typhus N.A. Approved [4]
Urinary tract infection GC08 Approved [4]
Yaws N.A. Approved [4]
Candidemia 1F23.3Y Investigative [4]
Esophageal candidiasis N.A. Investigative [4]
Mycoses 1F2Z Investigative [6]
Pelvic inflammatory disease GA05 Investigative [4]
Sinusitis CA0A.Z Investigative [4]
Amphotericin B Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Fungal Cell membrane ergosterol (Fung CME) TTQKWA4 NOUNIPROTAC Modulator [18]
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Amphotericin B Interacts with 1 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [19]
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Amphotericin B Interacts with 296 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Tumor necrosis factor (TNF) OT4IE164 TNFA_HUMAN Increases Expression [20]
Interferon gamma (IFNG) OTXG9JM7 IFNG_HUMAN Increases Expression [16]
RNA-binding protein 47 (RBM47) OT6W67VM RBM47_HUMAN Decreases Expression [16]
Neural cell adhesion molecule L1-like protein (CHL1) OT6E6E8P NCHL1_HUMAN Decreases Expression [16]
Disks large-associated protein 1 (DLGAP1) OTF2PUUI DLGP1_HUMAN Decreases Expression [16]
Receptor-type tyrosine-protein phosphatase T (PTPRT) OTV5TXNN PTPRT_HUMAN Increases Expression [16]
Proepiregulin (EREG) OTRM4NQY EREG_HUMAN Increases Expression [16]
Transcription factor EC (TFEC) OTUST8MR TFEC_HUMAN Decreases Expression [16]
Calsequestrin-2 (CASQ2) OT09MNQ8 CASQ2_HUMAN Increases Expression [16]
Long-chain fatty acid transport protein 2 (SLC27A2) OT7JEG5F S27A2_HUMAN Decreases Expression [16]
Serine/threonine-protein kinase DCLK1 (DCLK1) OTVSPS98 DCLK1_HUMAN Decreases Expression [16]
Low-density lipoprotein receptor class A domain-containing protein 4 (LDLRAD4) OTQUX50Z LRAD4_HUMAN Increases Expression [16]
Kynurenine 3-monooxygenase (KMO) OT3MRMM9 KMO_HUMAN Decreases Expression [16]
Metabotropic glutamate receptor 6 (GRM6) OTH95T77 GRM6_HUMAN Increases Expression [16]
Transmembrane protease serine 2 (TMPRSS2) OTN44YQ5 TMPS2_HUMAN Increases Expression [21]
Monocarboxylate transporter 7 (SLC16A6) OT7BIIZX MOT7_HUMAN Increases Expression [16]
TOX high mobility group box family member 3 (TOX3) OTC9NR4W TOX3_HUMAN Decreases Expression [16]
Insulin-induced gene 1 protein (INSIG1) OTZF5X1D INSI1_HUMAN Increases Expression [16]
Glutamate receptor ionotropic, delta-2 (GRID2) OTJ3R10R GRID2_HUMAN Increases Expression [16]
Carbonic anhydrase 12 (CA12) OT6WNFU8 CAH12_HUMAN Decreases Expression [16]
Protein sprouty homolog 1 (SPRY1) OT764FXI SPY1_HUMAN Decreases Expression [16]
Germinal-center associated nuclear protein (MCM3AP) OT895FEC GANP_HUMAN Increases Expression [16]
Periplakin (PPL) OTTM4WDO PEPL_HUMAN Decreases Expression [16]
GDNF family receptor alpha-3 (GFRA3) OT07XAZF GFRA3_HUMAN Increases Expression [16]
Galanin receptor type 3 (GALR3) OTXU6PKO GALR3_HUMAN Increases Expression [16]
Receptor activity-modifying protein 3 (RAMP3) OTX6XLLM RAMP3_HUMAN Increases Expression [16]
Nucleolar protein 3 (NOL3) OT1K0L0D NOL3_HUMAN Decreases Expression [16]
Slit homolog 1 protein (SLIT1) OT35RBNT SLIT1_HUMAN Decreases Expression [17]
Transcription factor Maf (MAF) OT1GR3IZ MAF_HUMAN Decreases Expression [16]
Histone deacetylase complex subunit SAP30 (SAP30) OT73OLML SAP30_HUMAN Increases Expression [16]
Carboxypeptidase D (CPD) OT2CS64Y CBPD_HUMAN Decreases Expression [16]
Ribosomal L1 domain-containing protein 1 (RSL1D1) OT3CL4R3 RL1D1_HUMAN Decreases Expression [16]
Annexin A9 (ANXA9) OTKNYMU2 ANXA9_HUMAN Decreases Expression [16]
Cyclin-dependent kinase-like 5 (CDKL5) OTGL5HRV CDKL5_HUMAN Increases Expression [16]
Contactin-5 (CNTN5) OTWU5FLZ CNTN5_HUMAN Increases Expression [16]
Phospholipid-transporting ATPase VB (ATP10B) OTSOUTE1 AT10B_HUMAN Increases Expression [16]
Transmembrane and coiled-coil domains protein 1 (TMCC1) OTRXDL86 TMCC1_HUMAN Decreases Expression [16]
D-glucuronyl C5-epimerase (GLCE) OTPRSHX5 GLCE_HUMAN Decreases Expression [16]
Glutaminase kidney isoform, mitochondrial (GLS) OTGOZG2M GLSK_HUMAN Increases Expression [16]
Protein FAM13A (FAM13A) OTZ6GN0Q FA13A_HUMAN Decreases Expression [16]
Fibrinogen silencer-binding protein (RAD54B) OTMWB2P2 FSBP_HUMAN Decreases Expression [16]
Chondroitin sulfate proteoglycan 5 (CSPG5) OTXFEBWR CSPG5_HUMAN Decreases Expression [16]
RAS guanyl-releasing protein 1 (RASGRP1) OTX9WN2E GRP1_HUMAN Decreases Expression [16]
BAG family molecular chaperone regulator 4 (BAG4) OTUPX3M2 BAG4_HUMAN Decreases Expression [16]
Olfactory receptor 2H2 (OR2H2) OTOSTYE2 OR2H2_HUMAN Increases Expression [16]
G1/S-specific cyclin-E2 (CCNE2) OTBBUKQQ CCNE2_HUMAN Decreases Expression [16]
Alpha-lactalbumin (LALBA) OTA6ZLP4 LALBA_HUMAN Increases Expression [16]
Glycoprotein hormones alpha chain (CGA) OT00U3Y3 GLHA_HUMAN Increases Expression [16]
Interferon alpha-21 (IFNA21) OTUA0R1F IFN21_HUMAN Increases Expression [16]
Interleukin-1 beta (IL1B) OT0DWXXB IL1B_HUMAN Increases Expression [22]
Erythropoietin (EPO) OTZ90CN4 EPO_HUMAN Decreases Expression [23]
Apolipoprotein C-II (APOC2) OTLINYIQ APOC2_HUMAN Increases Expression [16]
Fibrinogen beta chain (FGB) OT6RKLI9 FIBB_HUMAN Decreases Expression [16]
Hemopexin (HPX) OT14T7Q1 HEMO_HUMAN Increases Expression [16]
Granulocyte-macrophage colony-stimulating factor (CSF2) OT1M7D28 CSF2_HUMAN Increases Expression [16]
Trefoil factor 1 (TFF1) OTCYQH4F TFF1_HUMAN Increases Expression [16]
Plasma serine protease inhibitor (SERPINA5) OTTZXPGD IPSP_HUMAN Decreases Expression [16]
Interleukin-6 (IL6) OTUOSCCU IL6_HUMAN Increases Expression [16]
Intercellular adhesion molecule 1 (ICAM1) OTTOIX77 ICAM1_HUMAN Increases Expression [16]
T-cell surface antigen CD2 (CD2) OTLYO0DB CD2_HUMAN Increases Expression [16]
Neurofilament light polypeptide (NEFL) OTQESJV4 NFL_HUMAN Decreases Expression [16]
Neurofilament medium polypeptide (NEFM) OT8VCBNF NFM_HUMAN Decreases Expression [16]
Platelet glycoprotein Ib alpha chain (GP1BA) OT62PSOB GP1BA_HUMAN Increases Expression [16]
T-cell surface glycoprotein CD3 epsilon chain (CD3E) OT13LE5J CD3E_HUMAN Increases Expression [16]
Inhibin beta A chain (INHBA) OTSP64PQ INHBA_HUMAN Increases Expression [16]
Monocyte differentiation antigen CD14 (CD14) OT83GJ47 CD14_HUMAN Decreases Expression [16]
Fibroblast growth factor 4 (FGF4) OTNVV3ZG FGF4_HUMAN Increases Expression [16]
Alpha-2A adrenergic receptor (ADRA2A) OTZFGOTP ADA2A_HUMAN Decreases Expression [16]
Homeobox protein Hox-D4 (HOXD4) OTQR4WCG HXD4_HUMAN Decreases Expression [16]
Growth-regulated alpha protein (CXCL1) OT3WCTZV GROA_HUMAN Increases Expression [16]
Heme oxygenase 1 (HMOX1) OTC1W6UX HMOX1_HUMAN Increases Expression [16]
Tumor-associated calcium signal transducer 2 (TACSTD2) OTLSZR00 TACD2_HUMAN Decreases Expression [16]
Polyunsaturated fatty acid 5-lipoxygenase (ALOX5) OT7FOIK2 LOX5_HUMAN Decreases Expression [16]
Adenosine receptor A3 (ADORA3) OTHO1BLK AA3R_HUMAN Increases Expression [16]
Heat shock 70 kDa protein 1A (HSPA1A) OTKGIE76 HS71A_HUMAN Decreases Expression [16]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Increases Expression [16]
COUP transcription factor 1 (NR2F1) OTGWZWYL COT1_HUMAN Decreases Expression [16]
Clusterin (CLU) OTQGG0JM CLUS_HUMAN Decreases Expression [16]
High affinity immunoglobulin gamma Fc receptor I (FCGR1A) OTOBCS2O FCGR1_HUMAN Increases Expression [16]
Bone morphogenetic protein 2 (BMP2) OT23T37S BMP2_HUMAN Decreases Expression [16]
Cytochrome P450 4B1 (CYP4B1) OTJP46CB CP4B1_HUMAN Decreases Expression [16]
Sodium/glucose cotransporter 1 (SLC5A1) OT0T78JI SC5A1_HUMAN Increases Expression [16]
Phospholipase A2, membrane associated (PLA2G2A) OT1NY7BF PA2GA_HUMAN Increases Expression [16]
Glutamine synthetase (GLUL) OTYGTCGF GLNA_HUMAN Decreases Expression [16]
Interferon gamma receptor 1 (IFNGR1) OTCTQBWW INGR1_HUMAN Increases Expression [24]
Antigen-presenting glycoprotein CD1d (CD1D) OT3ROU4J CD1D_HUMAN Decreases Expression [16]
Platelet endothelial cell adhesion molecule (PECAM1) OTXOM4D9 PECA1_HUMAN Increases Expression [16]
T-cell acute lymphocytic leukemia protein 1 (TAL1) OTX4K6QZ TAL1_HUMAN Increases Expression [16]
Bone morphogenetic protein 7 (BMP7) OTYATP2K BMP7_HUMAN Increases Expression [16]
Erythropoietin receptor (EPOR) OTUIOEU3 EPOR_HUMAN Increases Expression [16]
C-X-C motif chemokine 2 (CXCL2) OTEJCYMY CXCL2_HUMAN Increases Expression [16]
Transcobalamin-1 (TCN1) OTW6A49Y TCO1_HUMAN Decreases Expression [16]
Kallikrein-2 (KLK2) OT9RE37R KLK2_HUMAN Increases Expression [16]
Interferon-induced GTP-binding protein Mx2 (MX2) OT05NF37 MX2_HUMAN Increases Expression [16]
Collagen alpha-1(V) chain (COL5A1) OT24078H CO5A1_HUMAN Increases Expression [16]
Amine oxidase A (MAOA) OT8NIWMQ AOFA_HUMAN Decreases Expression [16]
Tumor necrosis factor alpha-induced protein 3 (TNFAIP3) OTVLI4DD TNAP3_HUMAN Increases Expression [16]
Catechol O-methyltransferase (COMT) OTPWKTQG COMT_HUMAN Increases Expression [16]
Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5) OTZNYEKF GTR5_HUMAN Decreases Expression [16]
Carbonic anhydrase 4 (CA4) OT3K93LZ CAH4_HUMAN Decreases Expression [16]
Fibulin-1 (FBLN1) OT5MHHOP FBLN1_HUMAN Increases Expression [16]
Tumor necrosis factor ligand superfamily member 4 (TNFSF4) OTOCBX7P TNFL4_HUMAN Decreases Expression [16]
Endothelin receptor type B (EDNRB) OTLLZV3P EDNRB_HUMAN Increases Expression [17]
Insulin-like growth factor-binding protein 5 (IGFBP5) OTRE5V0C IBP5_HUMAN Decreases Expression [17]
Acrosomal protein SP-10 (ACRV1) OTUTG7PL ASPX_HUMAN Increases Expression [16]
Interleukin-1 receptor type 2 (IL1R2) OT0G7E35 IL1R2_HUMAN Decreases Expression [16]
Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1) OT5BZ1J9 P85A_HUMAN Decreases Expression [16]
T-cell surface glycoprotein CD1c (CD1C) OT4XINUJ CD1C_HUMAN Increases Expression [16]
HLA class I histocompatibility antigen, alpha chain F (HLA-F) OT76CM19 HLAF_HUMAN Increases Expression [17]
Pyruvate kinase PKLR (PKLR) OTTTM1QI KPYR_HUMAN Increases Expression [16]
Olfactory receptor 10J1 (OR10J1) OTS7B2ZB O10J1_HUMAN Increases Expression [16]
Homeobox protein Hox-D3 (HOXD3) OTBUZ35T HXD3_HUMAN Decreases Expression [16]
Sodium- and chloride-dependent taurine transporter (SLC6A6) OT67U7G3 SC6A6_HUMAN Decreases Expression [16]
Cytochrome P450 2C19 (CYP2C19) OTFMJYYE CP2CJ_HUMAN Increases Expression [16]
Ribonuclease 4 (RNASE4) OTA5SZLC RNAS4_HUMAN Decreases Expression [16]
Cannabinoid receptor 2 (CNR2) OTYP9P43 CNR2_HUMAN Increases Expression [16]
Merlin (NF2) OT6E5ACG MERL_HUMAN Decreases Expression [16]
Nuclear receptor ROR-alpha (RORA) OTGQT12P RORA_HUMAN Decreases Expression [16]
DNA damage-inducible transcript 3 protein (DDIT3) OTI8YKKE DDIT3_HUMAN Increases Expression [16]
Chitinase-3-like protein 1 (CHI3L1) OT2Z7VJH CH3L1_HUMAN Decreases Expression [16]
Amiloride-sensitive sodium channel subunit alpha (SCNN1A) OTE2KVZV SCNNA_HUMAN Decreases Expression [16]
B-cell lymphoma 6 protein (BCL6) OTQAWWO1 BCL6_HUMAN Decreases Expression [16]
Regulator of G-protein signaling 2 (RGS2) OT0FSRW7 RGS2_HUMAN Decreases Expression [16]
C-X-C motif chemokine 5 (CXCL5) OTZOUPCA CXCL5_HUMAN Increases Expression [16]
ATP-binding cassette sub-family G member 1 (ABCG1) OT5BG6MK ABCG1_HUMAN Decreases Expression [16]
5-hydroxytryptamine receptor 3A (HTR3A) OTAIV1AK 5HT3A_HUMAN Increases Expression [16]
DNA-binding protein inhibitor ID-4 (ID4) OTPMJ39I ID4_HUMAN Decreases Expression [16]
Serpin B4 (SERPINB4) OT88LHZ8 SPB4_HUMAN Decreases Expression [16]
Beta-arrestin-1 (ARRB1) OT2NJS37 ARRB1_HUMAN Increases Expression [16]
Retinoic acid receptor responder protein 1 (RARRES1) OTETUPP5 TIG1_HUMAN Decreases Expression [16]
Cytosolic purine 5'-nucleotidase (NT5C2) OTJMF66Z 5NTC_HUMAN Increases Expression [17]
RNA-binding protein FXR1 (FXR1) OTEMQ1SR FXR1_HUMAN Decreases Expression [16]
Stanniocalcin-1 (STC1) OTGVVXYF STC1_HUMAN Decreases Expression [16]
Protein FosB (FOSB) OTW6C05J FOSB_HUMAN Increases Expression [16]
LIM domain kinase 1 (LIMK1) OTFZ8MZ0 LIMK1_HUMAN Increases Expression [16]
Beta-crystallin B1 (CRYBB1) OTDI4W3V CRBB1_HUMAN Increases Expression [16]
DNA polymerase subunit gamma-1 (POLG) OTDUCT04 DPOG1_HUMAN Increases Expression [16]
Heat shock-related 70 kDa protein 2 (HSPA2) OTSDET7B HSP72_HUMAN Decreases Expression [16]
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (PDE1A) OTU7J3F7 PDE1A_HUMAN Decreases Expression [16]
GTP-binding protein RAD (RRAD) OTW2O4GD RAD_HUMAN Decreases Expression [16]
Aquaporin-5 (AQP5) OT77GBY8 AQP5_HUMAN Increases Expression [16]
Galectin-4 (LGALS4) OTKQCG0H LEG4_HUMAN Increases Expression [16]
Potassium voltage-gated channel subfamily KQT member 4 (KCNQ4) OT29B58J KCNQ4_HUMAN Decreases Expression [17]
Serine/threonine-protein kinase SIK1 (SIK1) OT6FCHME SIK1_HUMAN Increases Expression [16]
A disintegrin and metalloproteinase with thrombospondin motifs 12 (ADAMTS12) OTG7HEA2 ATS12_HUMAN Increases Expression [16]
C-X-C chemokine receptor type 4 (CXCR4) OTUFSBX2 CXCR4_HUMAN Decreases Expression [16]
Rho-related GTP-binding protein RhoE (RND3) OTXMXPIH RND3_HUMAN Increases Expression [16]
Small ribosomal subunit protein eS8 (RPS8) OTEBS4HZ RS8_HUMAN Increases Expression [16]
Protein jagged-1 (JAG1) OT3LGT6K JAG1_HUMAN Decreases Expression [16]
Arginase-2, mitochondrial (ARG2) OTCPI0E8 ARGI2_HUMAN Decreases Expression [16]
C-C motif chemokine 20 (CCL20) OTUCJY4N CCL20_HUMAN Increases Expression [16]
Neutrophil gelatinase-associated lipocalin (LCN2) OTSB42BR NGAL_HUMAN Decreases Expression [16]
Zinc finger protein basonuclin-1 (BNC1) OTGJ5WUF BNC1_HUMAN Increases Expression [16]
Blood group Rh(D) polypeptide (RHD) OTUPKABF RHD_HUMAN Increases Expression [16]
DNA-binding protein inhibitor ID-2 (ID2) OT0U1D53 ID2_HUMAN Decreases Expression [16]
Mucin-2 (MUC2) OT3X4QVX MUC2_HUMAN Increases Expression [16]
Cytochrome P450 4A11 (CYP4A11) OTPU5J0S CP4AB_HUMAN Increases Expression [16]
Homeobox protein EMX2 (EMX2) OT0V8OYK EMX2_HUMAN Decreases Expression [16]
Proto-oncogene c-Rel (REL) OTTCKMAC REL_HUMAN Decreases Expression [16]
Neuronal acetylcholine receptor subunit beta-3 (CHRNB3) OTE5XENW ACHB3_HUMAN Increases Expression [16]
Myocyte-specific enhancer factor 2C (MEF2C) OTZGF1Y5 MEF2C_HUMAN Decreases Expression [16]
Adenylate cyclase type 2 (ADCY2) OTYCBR8I ADCY2_HUMAN Increases Expression [16]
3',5'-cyclic-AMP phosphodiesterase 4D (PDE4D) OT1RWFV0 PDE4D_HUMAN Decreases Expression [16]
Killer cell lectin-like receptor subfamily B member 1 (KLRB1) OTQ2959Y KLRB1_HUMAN Increases Expression [16]
Ankyrin-3 (ANK3) OTJ3IRBP ANK3_HUMAN Decreases Expression [16]
Heat shock protein beta-3 (HSPB3) OTE67YM5 HSPB3_HUMAN Increases Expression [16]
AP-3 complex subunit beta-2 (AP3B2) OT7BFBLP AP3B2_HUMAN Increases Expression [16]
Unconventional myosin-VIIa (MYO7A) OTBZSPEL MYO7A_HUMAN Increases Expression [16]
Peptidyl-prolyl cis-trans isomerase FKBP5 (FKBP5) OT404F9K FKBP5_HUMAN Decreases Expression [16]
Mucosal addressin cell adhesion molecule 1 (MADCAM1) OTHIPW4U MADCA_HUMAN Increases Expression [16]
Calcium/calmodulin-dependent protein kinase type II subunit gamma (CAMK2G) OTHD9KJG KCC2G_HUMAN Increases Expression [16]
Interferon regulatory factor 5 (IRF5) OT8SIIAP IRF5_HUMAN Increases Expression [16]
Runt-related transcription factor 3 (RUNX3) OTITK1XD RUNX3_HUMAN Decreases Expression [17]
Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1) OTXEE550 APR_HUMAN Increases Expression [16]
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (ENPP2) OTTUU92F ENPP2_HUMAN Decreases Expression [16]
Plakophilin-1 (PKP1) OT9HSQ8F PKP1_HUMAN Increases Expression [16]
Krueppel-like factor 9 (KLF9) OTBFEJRQ KLF9_HUMAN Decreases Expression [16]
Transcription factor Dp-2 (TFDP2) OTKQFX5H TFDP2_HUMAN Decreases Expression [16]
Calcipressin-2 (RCAN2) OTGGWTWS RCAN2_HUMAN Decreases Expression [16]
Transcription factor E2F2 (E2F2) OTO75RM7 E2F2_HUMAN Increases Expression [16]
Enhancer of filamentation 1 (NEDD9) OTGCFN4M CASL_HUMAN Decreases Expression [16]
Interleukin-13 receptor subunit alpha-2 (IL13RA2) OTPC2G0X I13R2_HUMAN Increases Expression [16]
Potassium voltage-gated channel subfamily B member 1 (KCNB1) OTLCU4FR KCNB1_HUMAN Decreases Expression [16]
FXYD domain-containing ion transport regulator 3 (FXYD3) OT9PPRHE FXYD3_HUMAN Increases Expression [16]
Retinoblastoma-binding protein 5 (RBBP5) OT12W2MK RBBP5_HUMAN Decreases Expression [16]
Corneodesmosin (CDSN) OTQW4HV6 CDSN_HUMAN Increases Expression [16]
Transcription initiation factor TFIID subunit 13 (TAF13) OT1XMYAD TAF13_HUMAN Decreases Expression [16]
BDNF/NT-3 growth factors receptor (NTRK2) OTD557PU NTRK2_HUMAN Decreases Expression [16]
Hypoxia-inducible factor 1-alpha (HIF1A) OTADSC03 HIF1A_HUMAN Decreases Activity [25]
Carbonic anhydrase 9 (CA9) OTNA51XT CAH9_HUMAN Decreases Expression [16]
Reticulon-1 (RTN1) OTCX1SMK RTN1_HUMAN Decreases Expression [16]
Carcinoembryonic antigen-related cell adhesion molecule 21 (CEACAM21) OTHVCMIP CEA21_HUMAN Increases Expression [16]
Transmembrane protein 176B (TMEM176B) OTEGF2BV T176B_HUMAN Decreases Expression [16]
Mitogen-activated protein kinase kinase kinase 19 (MAP3K19) OTBE2OCY M3K19_HUMAN Increases Expression [16]
Transmembrane protein 255A (TMEM255A) OTVIYMEZ T255A_HUMAN Decreases Expression [16]
Protein THEMIS2 (THEMIS2) OTI1OBLN THMS2_HUMAN Decreases Expression [16]
Myomegalin (PDE4DIP) OTS15WNF MYOME_HUMAN Decreases Expression [16]
Kazrin (KAZN) OTPM7BYM KAZRN_HUMAN Increases Expression [16]
Protein aurora borealis (BORA) OTV2ZPKP BORA_HUMAN Decreases Expression [16]
Kelch-like protein 24 (KLHL24) OTWZSX5C KLH24_HUMAN Decreases Expression [16]
BEN domain-containing protein 5 (BEND5) OT6J6LY3 BEND5_HUMAN Decreases Expression [16]
Glucosylceramide transporter ABCA12 (ABCA12) OTKH9YQZ ABCAC_HUMAN Decreases Expression [16]
E3 ubiquitin-protein ligase DZIP3 (DZIP3) OTOFK9KG DZIP3_HUMAN Decreases Expression [16]
Homeodomain-interacting protein kinase 1 (HIPK1) OTSEA8RS HIPK1_HUMAN Decreases Expression [16]
Transmembrane protein 151B (TMEM151B) OTTEDBUJ T151B_HUMAN Increases Expression [16]
Calcium-responsive transcription factor (CARF) OTWE0T6Q CARTF_HUMAN Decreases Expression [16]
Chondroitin sulfate N-acetylgalactosaminyltransferase 2 (CSGALNACT2) OT2SH7HJ CGAT2_HUMAN Increases Expression [16]
RalBP1-associated Eps domain-containing protein 2 (REPS2) OTSE3TRP REPS2_HUMAN Decreases Expression [16]
Centrosomal protein of 76 kDa (CEP76) OTL2SJX0 CEP76_HUMAN Decreases Expression [16]
DEP domain-containing mTOR-interacting protein (DEPTOR) OTCBP1BT DPTOR_HUMAN Decreases Expression [16]
Dynein axonemal heavy chain 3 (DNAH3) OTD2JOKM DYH3_HUMAN Increases Expression [16]
Partitioning defective 3 homolog (PARD3) OTH5BPLO PARD3_HUMAN Decreases Expression [17]
GATOR1 complex protein NPRL2 (NPRL2) OTOB10MO NPRL2_HUMAN Decreases Expression [17]
DnaJ homolog subfamily A member 4 (DNAJA4) OTT7YCD2 DNJA4_HUMAN Increases Expression [16]
Aquaporin-3 (AQP3) OT2J7JPD AQP3_HUMAN Decreases Expression [16]
Zinc transporter SLC39A7 (SLC39A7) OTYMA1VB S39A7_HUMAN Decreases Expression [16]
Carnitine O-palmitoyltransferase 1, muscle isoform (CPT1B) OTDNRW37 CPT1B_HUMAN Decreases Expression [16]
Sortilin-related receptor (SORL1) OTQ8FFNS SORL_HUMAN Decreases Expression [16]
Amyloid beta precursor protein binding family B member 2 (APBB2) OT1VD51B APBB2_HUMAN Increases Expression [16]
Far upstream element-binding protein 1 (FUBP1) OT77SC9N FUBP1_HUMAN Decreases Expression [16]
Serine/threonine-protein kinase Sgk3 (SGK3) OTQ6QO99 SGK3_HUMAN Decreases Expression [16]
Rho guanine nucleotide exchange factor 26 (ARHGEF26) OTX0U8PX ARHGQ_HUMAN Increases Expression [17]
ATP-dependent DNA helicase DDX11 (DDX11) OT1WR3MD DDX11_HUMAN Increases Expression [16]
Unconventional myosin-XVB (MYO15B) OTA3ZP22 MY15B_HUMAN Increases Expression [16]
Testis-specific serine/threonine-protein kinase 2 (TSSK2) OTPZB4XJ TSSK2_HUMAN Increases Expression [16]
M-phase phosphoprotein 8 (MPHOSPH8) OTYI2WNS MPP8_HUMAN Decreases Expression [16]
Calcineurin B homologous protein 1 (CHP1) OTHTXN1A CHP1_HUMAN Decreases Expression [16]
G-protein coupled receptor 20 (GPR20) OTPCR8F7 GPR20_HUMAN Increases Expression [17]
Pituitary homeobox 2 (PITX2) OTWMXAOY PITX2_HUMAN Decreases Expression [16]
Lysosomal-trafficking regulator (LYST) OTIUB1B3 LYST_HUMAN Increases Expression [16]
Sperm-associated antigen 8 (SPAG8) OTZC5XP9 SPAG8_HUMAN Decreases Expression [16]
Growth/differentiation factor 15 (GDF15) OTWQN50N GDF15_HUMAN Increases Expression [16]
Galactosylceramide sulfotransferase (GAL3ST1) OTSFFZRD G3ST1_HUMAN Decreases Expression [16]
Transcription factor Ovo-like 2 (OVOL2) OTFM1GKF OVOL2_HUMAN Increases Expression [16]
Glutathione-specific gamma-glutamylcyclotransferase 1 (CHAC1) OTJGE772 CHAC1_HUMAN Increases Expression [16]
Sorbin and SH3 domain-containing protein 1 (SORBS1) OTWH8762 SRBS1_HUMAN Decreases Expression [16]
Transient receptor potential cation channel subfamily M member 6 (TRPM6) OTW7SPUV TRPM6_HUMAN Increases Expression [16]
Partitioning defective 6 homolog beta (PARD6B) OTLBAVQD PAR6B_HUMAN Increases Expression [16]
Sialoadhesin (SIGLEC1) OTNWSQA9 SN_HUMAN Increases Expression [16]
INO80 complex subunit B (INO80B) OTSHV8JF IN80B_HUMAN Decreases Expression [16]
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 4 (B3GNT4) OTRKV2N8 B3GN4_HUMAN Increases Expression [16]
GDNF family receptor alpha-4 (GFRA4) OTOLGKQM GFRA4_HUMAN Increases Expression [16]
Polyadenylate-binding protein-interacting protein 1 (PAIP1) OTL2F5T5 PAIP1_HUMAN Decreases Expression [17]
Large subunit GTPase 1 homolog (LSG1) OTDAXJ9L LSG1_HUMAN Decreases Expression [17]
Cysteine-rich secretory protein LCCL domain-containing 2 (CRISPLD2) OTVSFHTL CRLD2_HUMAN Increases Expression [16]
Stathmin-4 (STMN4) OT7ZUKW6 STMN4_HUMAN Increases Expression [16]
Matrix metalloproteinase-28 (MMP28) OTHQZXM1 MMP28_HUMAN Decreases Expression [16]
Dendritic cell-specific transmembrane protein (DCSTAMP) OTFKRP2H DCSTP_HUMAN Increases Expression [16]
2-aminomuconic semialdehyde dehydrogenase (ALDH8A1) OTINY3MW AL8A1_HUMAN Decreases Expression [16]
Tumor protein 63 (TP63) OT0WOOKQ P63_HUMAN Increases Expression [16]
Prolyl hydroxylase EGLN3 (EGLN3) OTXV3RYX EGLN3_HUMAN Decreases Expression [16]
E3 ubiquitin-protein transferase RMND5A (RMND5A) OTXJ7HNB RMD5A_HUMAN Decreases Expression [16]
Glyoxalase domain-containing protein 4 (GLOD4) OTBJKFXA GLOD4_HUMAN Decreases Expression [17]
Transient receptor potential cation channel subfamily M member 3 (TRPM3) OTE4CDOQ TRPM3_HUMAN Decreases Expression [16]
X-linked interleukin-1 receptor accessory protein-like 2 (IL1RAPL2) OTP7IOJO IRPL2_HUMAN Increases Expression [16]
DNA-directed DNA/RNA polymerase mu (POLM) OT0SRIP4 DPOLM_HUMAN Increases Expression [17]
Triggering receptor expressed on myeloid cells 1 (TREM1) OTCVFEE6 TREM1_HUMAN Decreases Expression [16]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (PLCB1) OT9HYT7A PLCB1_HUMAN Increases Expression [16]
PDZ and LIM domain protein 7 (PDLIM7) OTAZVODU PDLI7_HUMAN Decreases Expression [16]
Spectrin beta chain, non-erythrocytic 5 (SPTBN5) OT8MUQDU SPTN5_HUMAN Increases Expression [16]
Dual oxidase 2 (DUOX2) OTU14HCN DUOX2_HUMAN Increases Expression [16]
Ubiquitin-like-conjugating enzyme ATG3 (ATG3) OT28VBVK ATG3_HUMAN Decreases Expression [17]
Transmembrane protein 140 (TMEM140) OTQCEGEO TM140_HUMAN Decreases Expression [16]
Transmembrane protein 45A (TMEM45A) OT54KJG6 TM45A_HUMAN Decreases Expression [16]
Leucine-rich repeat transmembrane protein FLRT3 (FLRT3) OT3XMZU3 FLRT3_HUMAN Decreases Expression [16]
Dickkopf-related protein 4 (DKK4) OTWCCVF6 DKK4_HUMAN Increases Expression [16]
Transcription factor 20 (TCF20) OT8LQAOV TCF20_HUMAN Increases Expression [16]
N-acetyltransferase 8 (NAT8) OTU9OWOW NAT8_HUMAN Decreases Expression [16]
Tachykinin-3 (TAC3) OTOJGM38 TKNK_HUMAN Increases Expression [16]
Zinc finger transcription factor Trps1 (TRPS1) OT7XPPEL TRPS1_HUMAN Decreases Expression [16]
Alpha-methylacyl-CoA racemase (AMACR) OTUU22PK AMACR_HUMAN Decreases Expression [16]
Cytohesin-4 (CYTH4) OTOR82ID CYH4_HUMAN Increases Expression [16]
SLAM family member 5 (CD84) OTAY5B0F SLAF5_HUMAN Increases Expression [16]
Protein Hook homolog 1 (HOOK1) OTTTKV7V HOOK1_HUMAN Decreases Expression [16]
Teneurin-1 (TENM1) OTSKSU4V TEN1_HUMAN Decreases Expression [16]
Carbonic anhydrase 14 (CA14) OT1TRKFN CAH14_HUMAN Increases Expression [16]
ALK tyrosine kinase receptor (ALK) OTV3P4V8 ALK_HUMAN Increases Expression [16]
Endoribonuclease Dicer (DICER1) OTTVSEY0 DICER_HUMAN Decreases Expression [16]
Pregnancy-specific beta-1-glycoprotein 11 (PSG11) OTLZJVLL PSG11_HUMAN Increases Expression [16]
Protein phosphatase 1 regulatory subunit 3C (PPP1R3C) OTEU05TX PPR3C_HUMAN Decreases Expression [16]
Solute carrier family 22 member 14 (SLC22A14) OTHRY1XS S22AE_HUMAN Increases Expression [16]
E3 ubiquitin-protein ligase DTX4 (DTX4) OTGX30AO DTX4_HUMAN Decreases Expression [16]
Protein EFR3 homolog B (EFR3B) OTVKWU2L EFR3B_HUMAN Increases Expression [16]
FERM domain-containing protein 4B (FRMD4B) OTVI6YFP FRM4B_HUMAN Decreases Expression [16]
Tyrosine-protein phosphatase non-receptor type 22 (PTPN22) OTDCNTC3 PTN22_HUMAN Decreases Expression [16]
Dehydrogenase/reductase SDR family member 7 (DHRS7) OTV729DT DHRS7_HUMAN Decreases Expression [16]
Nuclear receptor subfamily 2 group E member 1 (NR2E1) OTW47GKM NR2E1_HUMAN Increases Expression [16]
Metal-response element-binding transcription factor 2 (MTF2) OTNL1O2O MTF2_HUMAN Decreases Expression [16]
Krueppel-like factor 12 (KLF12) OTVH4KD4 KLF12_HUMAN Increases Expression [16]
Hypoxia-inducible lipid droplet-associated protein (HILPDA) OTEID3ZM HLPDA_HUMAN Decreases Expression [16]
Phosphoserine aminotransferase (PSAT1) OTVV1YV9 SERC_HUMAN Decreases Expression [16]
Calpain-6 (CAPN6) OT8K5PR5 CAN6_HUMAN Decreases Expression [16]
D-dopachrome decarboxylase (DDT) OTF5HTYL DOPD_HUMAN Increases ADR [7]
Nuclear factor NF-kappa-B p105 subunit (NFKB1) OTNRRD8I NFKB1_HUMAN Increases ADR [7]
Interleukin-1 alpha (IL1A) OTPSGILV IL1A_HUMAN Increases ADR [7]
Macrophage migration inhibitory factor (MIF) OTUCMVCX MIF_HUMAN Increases ADR [7]
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References

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13 Fluconazole inhibits human adrenocortical steroidogenesis in vitro. J Endocrinol. 2012 Dec;215(3):403-12. doi: 10.1530/JOE-12-0310. Epub 2012 Oct 4.
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19 Carotenoids reverse multidrug resistance in cancer cells by interfering with ABC-transporters. Phytomedicine. 2012 Aug 15;19(11):977-87.
20 A cell impedance-based real-time in vitro assay to assess the toxicity of amphotericin B formulations. Toxicol Appl Pharmacol. 2017 Nov 1;334:18-23. doi: 10.1016/j.taap.2017.08.017. Epub 2017 Sep 1.
21 Effect of common medications on the expression of SARS-CoV-2 entry receptors in liver tissue. Arch Toxicol. 2020 Dec;94(12):4037-4041. doi: 10.1007/s00204-020-02869-1. Epub 2020 Aug 17.
22 Profiling the immunotoxicity of chemicals based on in vitro evaluation by a combination of the Multi-ImmunoTox assay and the IL-8 Luc assay. Arch Toxicol. 2018 Jun;92(6):2043-2054. doi: 10.1007/s00204-018-2199-7. Epub 2018 Mar 29.
23 Amphotericin B blunts erythropoietin response to anemia. J Infect Dis. 1990 Feb;161(2):348-51. doi: 10.1093/infdis/161.2.348.
24 Antileishmanial drugs cause up-regulation of interferon-gamma receptor 1, not only in the monocytes of visceral leishmaniasis cases but also in cultured THP1 cells. Ann Trop Med Parasitol. 2003 Apr;97(3):245-57. doi: 10.1179/000349803235001714.
25 Amphotericin B blunts erythropoietin response to hypoxia by reinforcing FIH-mediated repression of HIF-1. Blood. 2006 Feb 1;107(3):916-23. doi: 10.1182/blood-2005-06-2564. Epub 2005 Sep 27.