Details of the Drug Combination

General Information of Drug Combination (ID: DCQ1JJP)

• Drug Combination Name: Methylene blue + Vitamin C
• Indication: Coronavirus Disease 2019 (COVID-19); Status: Phase 1 [1]
• Component Drugs:
  Methylene blue (DMJAPE7): N.A.
  Vitamin C (DMXJ7O8): Small molecular drug

Molecular Interaction Atlas of This Drug Combination

Indication(s) of Methylene blue

Disease Entry	ICD 11	Status	REF
Acquired methemoglobinemia	3A93	Approved	[2]
Coronavirus Disease 2019 (COVID-19)	1D6Y	Phase 2	[1]

Methylene blue Interacts with 2 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Monoamine oxidase (MAO)	TT32XQJ	NOUNIPROTAC	.	[12]
Guanylate cyclase (GC)	TT6HPVC	NOUNIPROTAC	Inhibitor	[13]

Methylene blue Interacts with 1 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
6-phosphogluconate dehydrogenase, decarboxylating (PGD)	OTVG296F	6PGD_HUMAN	Increases Activity	[14]

Indication(s) of Vitamin C

Disease Entry	ICD 11	Status	REF
Adenocarcinoma	2D40	Approved	[3]
Carcinoma	2A00-2F9Z	Approved	[4]
Coagulation defect	3B10.0	Approved	[5]
Desmoplastic small round cell tumor	N.A.	Approved	[6]
Plasma cell myeloma	2A83.1	Approved	[7]
Refractory plasma cell neoplasm	N.A.	Approved	[8]
Shock	MG40	Approved	[9]
Vitamin C deficiency	5B56	Approved	[10]
Vitamin deficiency	5B55-5B71	Approved	[11]
Urinary tract infection	GC08	Phase 2	[10]

Vitamin C Interacts with 3 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Solute carrier family 23 member 2 (SLC23A2)	TTOP832	S23A2_HUMAN	Modulator	[19]
Solute carrier family 23 member 1 (SLC23A1)	TT6XAGK	S23A1_HUMAN	Modulator	[20]
Collagen (CO)	TTK982E	NOUNIPROTAC	Activator	[21]

Vitamin C Interacts with 2 DTP Molecule(s)

DTP Name	DTP ID	UniProt ID	Mode of Action	REF
Sodium-dependent vitamin C transporter 1 (SLC23A1)	DT3KH2X	S23A1_HUMAN	Substrate	[22]
Sodium-dependent vitamin C transporter 2 (SLC23A2)	DTVY9PJ	S23A2_HUMAN	Substrate	[23]

Vitamin C Interacts with 5 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Thiopurine methyltransferase (TPMT)	DEFQ8VO	TPMT_HUMAN	Metabolism	[24]
Prolyl 4-hydroxylase alpha-2 (P4HA2)	DE5EGK0	P4HA2_HUMAN	Metabolism	[25]
Prolyl 4-hydroxylase alpha-1 (P4HA1)	DESO5ZY	P4HA1_HUMAN	Metabolism	[25]
HIF-prolyl hydroxylase 2 (EGLN1)	DEWO724	EGLN1_HUMAN	Metabolism	[26]
Prolyl 4-hydroxylase alpha-3 (P4HA3)	DE2L4RX	P4HA3_HUMAN	Metabolism	[27]

Vitamin C Interacts with 65 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
Prolyl 4-hydroxylase subunit alpha-2 (P4HA2)	OTP45YKX	P4HA2_HUMAN	Decreases Expression	[15]
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 (HSD3B1)	OTNAZVKB	3BHS1_HUMAN	Increases Expression	[28]
Asparagine--tRNA ligase, cytoplasmic (NARS1)	OTFS4J1W	SYNC_HUMAN	Decreases Expression	[15]
Plasminogen activator inhibitor 2 (SERPINB2)	OT72QLZB	PAI2_HUMAN	Decreases Expression	[15]
Bifunctional glutamate/proline--tRNA ligase (EPRS1)	OTXK0FLB	SYEP_HUMAN	Decreases Expression	[15]
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial (MTHFD2)	OT1LQSGX	MTDC_HUMAN	Decreases Expression	[15]
Eukaryotic translation initiation factor 2 subunit 2 (EIF2S2)	OTXF0B09	IF2B_HUMAN	Decreases Expression	[15]
Threonine--tRNA ligase 1, cytoplasmic (TARS1)	OT0PWST5	SYTC_HUMAN	Decreases Expression	[15]
Serine hydroxymethyltransferase, mitochondrial (SHMT2)	OT5NCAZN	GLYM_HUMAN	Decreases Expression	[15]
Stress-70 protein, mitochondrial (HSPA9)	OT4TMVS9	GRP75_HUMAN	Decreases Expression	[15]
Glycine--tRNA ligase (GARS1)	OT5B6R9Y	GARS_HUMAN	Decreases Expression	[15]
Isoleucine--tRNA ligase, cytoplasmic (IARS1)	OT9WXH5N	SYIC_HUMAN	Decreases Expression	[15]
Alanine--tRNA ligase, cytoplasmic (AARS1)	OTW8D813	SYAC_HUMAN	Decreases Expression	[15]
Eukaryotic initiation factor 4A-I (EIF4A1)	OTMTBX6N	IF4A1_HUMAN	Decreases Expression	[15]
Protein disulfide-isomerase A2 (PDIA2)	OTC2WMXS	PDIA2_HUMAN	Decreases Expression	[15]
Eukaryotic translation initiation factor 3 subunit A (EIF3A)	OTFABY9G	EIF3A_HUMAN	Decreases Expression	[15]
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein (HERPUD1)	OT9EROL6	HERP1_HUMAN	Decreases Expression	[15]
Phosphoenolpyruvate carboxykinase , mitochondrial (PCK2)	OTJ8LX4N	PCKGM_HUMAN	Decreases Expression	[15]
Tribbles homolog 3 (TRIB3)	OTG5OS7X	TRIB3_HUMAN	Decreases Expression	[15]
Structural maintenance of chromosomes protein 6 (SMC6)	OT3IBHQD	SMC6_HUMAN	Decreases Expression	[15]
Eukaryotic translation initiation factor 3 subunit C (EIF3C)	OTR8RF9X	EIF3C_HUMAN	Decreases Expression	[15]
Endoplasmic reticulum membrane sensor NFE2L1 (NFE2L1)	OT1QHOS2	NF2L1_HUMAN	Increases Expression	[29]
Nuclear factor erythroid 2-related factor 3 (NFE2L3)	OT1MGXT0	NF2L3_HUMAN	Decreases Expression	[29]
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 (PAPSS1)	OTY3TQYA	PAPS1_HUMAN	Decreases Expression	[16]
Fibulin-1 (FBLN1)	OT5MHHOP	FBLN1_HUMAN	Increases Expression	[16]
Glypican-1 (GPC1)	OTQKRSSV	GPC1_HUMAN	Increases Expression	[16]
Host cell factor 1 (HCFC1)	OT0UCK62	HCFC1_HUMAN	Increases Expression	[16]
Elongator complex protein 6 (ELP6)	OT0T3BLP	ELP6_HUMAN	Decreases Expression	[16]
Putative PRAME family member 13 (PRAMEF13)	OTVJTEXT	PRA13_HUMAN	Increases Expression	[16]
C-Maf-inducing protein (CMIP)	OTZN8Z4A	CMIP_HUMAN	Increases Expression	[16]
Prolyl 3-hydroxylase OGFOD1 (OGFOD1)	OTTUQ5O3	OGFD1_HUMAN	Decreases Expression	[16]
Autism susceptibility gene 2 protein (AUTS2)	OTAEXHSC	AUTS2_HUMAN	Increases Expression	[16]
Ester hydrolase C11orf54 (C11ORF54)	OT5B6EU8	CK054_HUMAN	Decreases Expression	[16]
Ketosamine-3-kinase (FN3KRP)	OT9HR05S	KT3K_HUMAN	Increases Expression	[16]
GPN-loop GTPase 1 (GPN1)	OTM03SFL	GPN1_HUMAN	Decreases Expression	[16]
Mitochondrial import receptor subunit TOM7 homolog (TOMM7)	OTJJOI2B	TOM7_HUMAN	Decreases Expression	[16]
Aldo-keto reductase family 1 member B10 (AKR1B10)	OTOA4HTH	AK1BA_HUMAN	Increases Expression	[30]
Aldo-keto reductase family 1 member C2 (AKR1C2)	OTQ2XMO3	AK1C2_HUMAN	Increases Expression	[30]
Glycerol-3-phosphate acyltransferase 3 (GPAT3)	OTJUGPK0	GPAT3_HUMAN	Increases Expression	[30]
Integrin-binding sialoprotein (IBSP)	OT29944Y	SIAL_HUMAN	Increases Expression	[31]
Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B)	OTQ4W7MT	TR11B_HUMAN	Decreases Expression	[32]
Baculoviral IAP repeat-containing protein 5 (BIRC5)	OTILXZYL	BIRC5_HUMAN	Decreases Expression	[33]
Adenylate cyclase type 6 (ADCY6)	OTFOY4WW	ADCY6_HUMAN	Decreases Expression	[34]
Forkhead box protein O3 (FOXO3)	OTHXQG4P	FOXO3_HUMAN	Increases Expression	[35]
Metalloproteinase inhibitor 1 (TIMP1)	OTOXC51H	TIMP1_HUMAN	Increases Expression	[36]
Collagen alpha-1(I) chain (COL1A1)	OTI31178	CO1A1_HUMAN	Increases Expression	[36]
Superoxide dismutase , mitochondrial (SOD2)	OTIWXGZ9	SODM_HUMAN	Increases Expression	[37]
Hepatocyte growth factor receptor (MET)	OT7K55MU	MET_HUMAN	Decreases Expression	[33]
Interleukin-8 (CXCL8)	OTS7T5VH	IL8_HUMAN	Affects Expression	[37]
C-C motif chemokine 2 (CCL2)	OTAD2HEL	CCL2_HUMAN	Affects Expression	[37]
Aldo-keto reductase family 1 member B1 (AKR1B1)	OTRX72TH	ALDR_HUMAN	Increases Reduction	[38]
Tumor necrosis factor ligand superfamily member 10 (TNFSF10)	OT4PXBTA	TNF10_HUMAN	Decreases Response To Substance	[39]
Biotin--protein ligase (HLCS)	OTPDUX30	BPL1_HUMAN	Decreases Activity	[40]
C-X-C motif chemokine 6 (CXCL6)	OTFTCQ4O	CXCL6_HUMAN	Increases Expression	[37]
Peripheral myelin protein 22 (PMP22)	OTXWYWCZ	PMP22_HUMAN	Decreases Expression	[41]
POU domain, class 5, transcription factor 1 (POU5F1)	OTDHHN7O	PO5F1_HUMAN	Increases Expression	[42]
Transcription factor Sp4 (SP4)	OTWB30IZ	SP4_HUMAN	Decreases Expression	[33]
Transcription factor Sp3 (SP3)	OTYDQZ1T	SP3_HUMAN	Decreases Expression	[33]
Sterol regulatory element-binding protein 2 (SREBF2)	OTBXUNPL	SRBP2_HUMAN	Decreases Metabolism	[35]
DNA-binding protein Ikaros (IKZF1)	OTCW1FKL	IKZF1_HUMAN	Decreases Activity	[32]
Kelch-like ECH-associated protein 1 (KEAP1)	OTFHOD0C	KEAP1_HUMAN	Decreases Expression	[43]
Plasma membrane ascorbate-dependent reductase CYBRD1 (CYBRD1)	OTUTVBES	CYBR1_HUMAN	Decreases Expression	[44]
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A)	OTHCDQ22	PRGC1_HUMAN	Increases Expression	[45]
Amyloid-beta precursor protein (APP)	OTKFD7R4	A4_HUMAN	Increases Oxidation	[46]
Solute carrier family 22 member 7 (SLC22A7)	OTKTNH1W	S22A7_HUMAN	Increases Transport	[47]

References

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