Details of the Drug Combination

General Information of Drug Combination (ID: DCRFN2Y)

Drug Combination Name
ABIRATERONE Niclosamide
Indication
Disease Entry Status REF
Metastatic Prostate Carcinoma Phase 2 [1]
Component Drugs ABIRATERONE   DM8V75C Niclosamide   DMJAGXQ
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of ABIRATERONE
Disease Entry ICD 11 Status REF
Prostate cancer 2C82.0 Approved [2]
ABIRATERONE Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Steroid 17-alpha-monooxygenase (S17AH) TTRA5BZ CP17A_HUMAN Modulator [5]
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ABIRATERONE Interacts with 4 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Steroid 17-alpha-hydroxylase/17,20 lyase (CYP17A1) OTZKVLVJ CP17A_HUMAN Decreases Activity [6]
Tissue factor (F3) OT3MSU3B TF_HUMAN Increases Expression [7]
Membrane cofactor protein (CD46) OTQ8NWJD MCP_HUMAN Increases Expression [8]
Androgen receptor (AR) OTUBKAZZ ANDR_HUMAN Decreases Response To Substance [9]
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Indication(s) of Niclosamide
Disease Entry ICD 11 Status REF
Cestodes infection 1F70-1F76 Approved [3]
Haemophilus influenza 1G40 Approved [4]
Taeniasis N.A. Approved [4]
Niclosamide Interacts with 2 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Metabolism [19]
Nitroreductase (NTR) DE0K82S A0A5K1UB29_SALTM Metabolism [20]
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Niclosamide Interacts with 766 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Cytochrome P450 2C9 (CYP2C9) OTGLBN29 CP2C9_HUMAN Increases Activity [21]
Cytochrome P450 3A4 (CYP3A4) OTQGYY83 CP3A4_HUMAN Decreases Activity [21]
Cytochrome P450 2D6 (CYP2D6) OTZJC802 CP2D6_HUMAN Decreases Activity [21]
Cytochrome P450 1A1 (CYP1A1) OTE4EFH8 CP1A1_HUMAN Increases Activity [22]
Frizzled-9 (FZD9) OTTZ9MKK FZD9_HUMAN Decreases Expression [10]
NADH dehydrogenase iron-sulfur protein 8, mitochondrial (NDUFS8) OTMEAWKO NDUS8_HUMAN Decreases Expression [10]
Segment polarity protein dishevelled homolog DVL-1 (DVL1) OTD67RF1 DVL1_HUMAN Increases Expression [10]
NADH dehydrogenase 1 subunit C1, mitochondrial (NDUFC1) OTJ5TNHB NDUC1_HUMAN Increases Expression [10]
NADH dehydrogenase iron-sulfur protein 7, mitochondrial (NDUFS7) OTIRMB2O NDUS7_HUMAN Decreases Expression [10]
NADH dehydrogenase iron-sulfur protein 2, mitochondrial (NDUFS2) OTBT8KW9 NDUS2_HUMAN Decreases Expression [10]
NADH dehydrogenase iron-sulfur protein 3, mitochondrial (NDUFS3) OTX61TQQ NDUS3_HUMAN Decreases Expression [10]
ATP synthase subunit g, mitochondrial (ATP5MG) OTD569IJ ATP5L_HUMAN Decreases Expression [10]
NADH dehydrogenase 1 beta subcomplex subunit 6 (NDUFB6) OTIXNT91 NDUB6_HUMAN Decreases Expression [10]
NADH dehydrogenase 1 alpha subcomplex subunit 7 (NDUFA7) OT8CV3H5 NDUA7_HUMAN Decreases Expression [10]
NADH dehydrogenase 1 alpha subcomplex subunit 10, mitochondrial (NDUFA10) OTBURQ3A NDUAA_HUMAN Decreases Expression [10]
Apoptosis-inducing factor 1, mitochondrial (AIFM1) OTKPWB7Q AIFM1_HUMAN Increases Cleavage [10]
NADH dehydrogenase 1 beta subcomplex subunit 10 (NDUFB10) OTFLILEO NDUBA_HUMAN Decreases Expression [10]
Aspartate aminotransferase, mitochondrial (GOT2) OT6XBWN0 AATM_HUMAN Increases Expression [10]
Fructose-bisphosphate aldolase B (ALDOB) OT7FR69A ALDOB_HUMAN Increases Expression [10]
ATP-dependent 6-phosphofructokinase, muscle type (PFKM) OT1QY9JM PFKAM_HUMAN Decreases Expression [10]
Gamma-enolase (ENO2) OTRODL0T ENOG_HUMAN Increases Expression [10]
Fructose-bisphosphate aldolase C (ALDOC) OTEC13I5 ALDOC_HUMAN Decreases Expression [10]
Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1) OTA675TJ GTR1_HUMAN Decreases Expression [10]
Solute carrier family 2, facilitated glucose transporter member 3 (SLC2A3) OT2HZK5M GTR3_HUMAN Decreases Expression [10]
Pyruvate carboxylase, mitochondrial (PC) OT6O0V51 PYC_HUMAN Increases Expression [10]
Beta-enolase (ENO3) OT3HYKYI ENOB_HUMAN Decreases Expression [10]
Pyruvate kinase PKM (PKM) OTLHHMC2 KPYM_HUMAN Increases Expression [10]
Fos-related antigen 1 (FOSL1) OT9YTYMB FOSL1_HUMAN Increases Expression [10]
ATP synthase F(0) complex subunit B1, mitochondrial (ATP5PB) OTPOAAUW AT5F1_HUMAN Decreases Expression [10]
ATP synthase subunit alpha, mitochondrial (ATP5F1A) OT3FZDLX ATPA_HUMAN Increases Expression [10]
ATP synthase subunit delta, mitochondrial (ATP5F1D) OTXTAG2V ATPD_HUMAN Increases Expression [10]
Enoyl-CoA hydratase, mitochondrial (ECHS1) OTS0593S ECHM_HUMAN Decreases Expression [10]
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PPP2R1A) OTYA3GB4 2AAA_HUMAN Increases Expression [10]
G1/S-specific cyclin-D3 (CCND3) OTNKPQ22 CCND3_HUMAN Decreases Expression [10]
Long-chain-fatty-acid--CoA ligase 1 (ACSL1) OTB06ESI ACSL1_HUMAN Decreases Expression [10]
Catenin beta-1 (CTNNB1) OTZ932A3 CTNB1_HUMAN Increases Expression [10]
ATP synthase F(0) complex subunit C3, mitochondrial (ATP5MC3) OTX674BU AT5G3_HUMAN Decreases Expression [10]
Casein kinase I isoform epsilon (CSNK1E) OTF0UXX6 KC1E_HUMAN Increases Expression [10]
Glycogen synthase kinase-3 beta (GSK3B) OTL3L14B GSK3B_HUMAN Decreases Expression [10]
NADH dehydrogenase 1 alpha subcomplex subunit 8 (NDUFA8) OTBO0YKI NDUA8_HUMAN Decreases Expression [10]
ATP synthase subunit f, mitochondrial (ATP5MF) OTE4TBG9 ATPK_HUMAN Decreases Expression [10]
NADH dehydrogenase flavoprotein 3, mitochondrial (NDUFV3) OTSCYB9P NDUV3_HUMAN Increases Expression [10]
Triosephosphate isomerase (TPI1) OT14KP4B TPIS_HUMAN Increases Expression [10]
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (PPP2CB) OT24GMCM PP2AB_HUMAN Decreases Expression [10]
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform (PPP2R2B) OTSFVC82 2ABB_HUMAN Decreases Expression [10]
Peroxisome proliferator-activated receptor delta (PPARD) OTI4WTOP PPARD_HUMAN Increases Expression [10]
Protein kinase C theta type (PRKCQ) OTH2VABH KPCT_HUMAN Increases Expression [10]
Histone acetyltransferase p300 (EP300) OTL8QJDX EP300_HUMAN Increases Expression [10]
Acetyl-CoA carboxylase 1 (ACACA) OT5CQPZY ACACA_HUMAN Decreases Expression [10]
C-terminal-binding protein 1 (CTBP1) OTVYH2DH CTBP1_HUMAN Increases Expression [10]
Frizzled-5 (FZD5) OTXFFY56 FZD5_HUMAN Increases Expression [10]
Frizzled-2 (FZD2) OT952ML1 FZD2_HUMAN Decreases Expression [10]
V-type proton ATPase subunit S1 (ATP6AP1) OTX1K0SJ VAS1_HUMAN Decreases Expression [10]
2,4-dienoyl-CoA reductase , mitochondrial (DECR1) OTCDIR6X DECR_HUMAN Decreases Expression [10]
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial (HADH) OTJDOL20 HCDH_HUMAN Decreases Expression [10]
CREB-binding protein (CREBBP) OTPA4QGM CBP_HUMAN Increases Expression [10]
Segment polarity protein dishevelled homolog DVL-3 (DVL3) OTPRROHJ DVL3_HUMAN Increases Expression [10]
Protein naked cuticle homolog 1 (NKD1) OTY3MO97 NKD1_HUMAN Increases Expression [10]
ATP synthase subunit s, mitochondrial (DMAC2L) OT2OQ1UD ATP5S_HUMAN Decreases Expression [10]
NADH dehydrogenase 1 alpha subcomplex subunit 4-like 2 (NDUFA4L2) OTK0PG7R NUA4L_HUMAN Increases Expression [10]
Ethylmalonyl-CoA decarboxylase (ECHDC1) OTMS00PY ECHD1_HUMAN Decreases Expression [10]
Axin-2 (AXIN2) OTRMGQNU AXIN2_HUMAN Decreases Expression [10]
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform (PPP2R2C) OTXK0SDM 2ABG_HUMAN Decreases Expression [10]
Aldehyde dehydrogenase 1A1 (ALDH1A1) OTCUWZKB AL1A1_HUMAN Decreases Expression [23]
Transcription factor E2F8 (E2F8) OTQKZGFP E2F8_HUMAN Decreases Expression [11]
Hyaluronan mediated motility receptor (HMMR) OT4M0JTZ HMMR_HUMAN Decreases Expression [11]
Low-density lipoprotein receptor-related protein 6 (LRP6) OTM7PSUR LRP6_HUMAN Decreases Expression [11]
Kinesin-like protein KIF20A (KIF20A) OTXOQHE0 KI20A_HUMAN Decreases Expression [11]
Metallothionein-2 (MT2A) OTHOACHD MT2_HUMAN Increases Expression [11]
RAF proto-oncogene serine/threonine-protein kinase (RAF1) OT51LSFO RAF1_HUMAN Decreases Expression [11]
Phosphatidylcholine-sterol acyltransferase (LCAT) OTRLMLK0 LCAT_HUMAN Increases Expression [11]
Thymidine kinase, cytosolic (TK1) OTY5JFM1 KITH_HUMAN Decreases Expression [11]
Metallothionein-1E (MT1E) OTXJKU4Y MT1E_HUMAN Increases Expression [11]
Metallothionein-1F (MT1F) OTZVUYG1 MT1F_HUMAN Increases Expression [11]
Cytochrome P450 1A2 (CYP1A2) OTLLBX48 CP1A2_HUMAN Increases Expression [11]
All-trans-retinol dehydrogenase ADH4 (ADH4) OTKDKKNG ADH4_HUMAN Decreases Expression [11]
Serine/threonine-protein kinase A-Raf (ARAF) OTZJ0FNO ARAF_HUMAN Decreases Expression [11]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Decreases Expression [11]
G2/mitotic-specific cyclin-B1 (CCNB1) OT19S7E5 CCNB1_HUMAN Decreases Expression [11]
Serine/threonine-protein kinase B-raf (BRAF) OT7S81XQ BRAF_HUMAN Decreases Expression [11]
Properdin (CFP) OTHZBLQK PROP_HUMAN Increases Expression [11]
Ribonucleoside-diphosphate reductase subunit M2 (RRM2) OTOB6J6R RIR2_HUMAN Decreases Expression [11]
Signal transducer and activator of transcription 3 (STAT3) OTAAGKYZ STAT3_HUMAN Decreases Expression [11]
Proliferation marker protein Ki-67 (MKI67) OTA8N1QI KI67_HUMAN Decreases Expression [11]
Histone H3-like centromeric protein A (CENPA) OT0NEJ4X CENPA_HUMAN Decreases Expression [11]
DNA replication licensing factor MCM2 (MCM2) OTGGORIQ MCM2_HUMAN Decreases Expression [11]
Kinesin-like protein KIF11 (KIF11) OTHRGLCQ KIF11_HUMAN Decreases Expression [11]
Protein FosB (FOSB) OTW6C05J FOSB_HUMAN Increases Expression [11]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Decreases Expression [11]
Mitotic spindle assembly checkpoint protein MAD2A (MAD2L1) OTXNGZCG MD2L1_HUMAN Decreases Expression [11]
Origin recognition complex subunit 1 (ORC1) OTHWU8IJ ORC1_HUMAN Decreases Expression [11]
Eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1) OTHBQVD5 4EBP1_HUMAN Decreases Expression [11]
Apolipoprotein F (APOF) OT12S5QS APOF_HUMAN Decreases Expression [11]
Pachytene checkpoint protein 2 homolog (TRIP13) OTFM3TI9 PCH2_HUMAN Decreases Expression [11]
Cyclin-dependent kinase inhibitor 3 (CDKN3) OTBE3H07 CDKN3_HUMAN Decreases Expression [11]
Borealin (CDCA8) OT17D55D BOREA_HUMAN Decreases Expression [11]
Cell division cycle-associated protein 2 (CDCA2) OTX8UF9J CDCA2_HUMAN Decreases Expression [11]
Serine protease FAM111B (FAM111B) OT9IQ9NV F111B_HUMAN Decreases Expression [11]
Epidermal growth factor receptor kinase substrate 8-like protein 3 (EPS8L3) OT7XYA2T ES8L3_HUMAN Increases Expression [11]
Pleckstrin homology-like domain family A member 1 (PHLDA1) OTFTWMIQ PHLA1_HUMAN Increases Expression [11]
DNA repair and recombination protein RAD54-like (RAD54L) OTEGMAKG RAD54_HUMAN Increases Expression [11]
Sororin (CDCA5) OTZLCQ5U CDCA5_HUMAN Decreases Expression [11]
Aurora kinase B (AURKB) OTIY4VHU AURKB_HUMAN Decreases Expression [11]
Cysteine/serine-rich nuclear protein 1 (CSRNP1) OTDK1FPH CSRN1_HUMAN Increases Expression [11]
Cell division control protein 6 homolog (CDC6) OTX93FE7 CDC6_HUMAN Decreases Expression [11]
Kinesin-like protein KIFC1 (KIFC1) OTNQDS00 KIFC1_HUMAN Decreases Expression [11]
Protein FAM83D (FAM83D) OTQWZ1UO FA83D_HUMAN Decreases Expression [11]
Transcriptional and immune response regulator (TCIM) OTARUXQF TCIM_HUMAN Increases Expression [11]
Histone chaperone ASF1B (ASF1B) OTKXX12I ASF1B_HUMAN Decreases Expression [11]
24-hydroxycholesterol 7-alpha-hydroxylase (CYP39A1) OTBAJT4I CP39A_HUMAN Increases Expression [11]
Cadherin EGF LAG seven-pass G-type receptor 3 (CELSR3) OT8P6QNJ CELR3_HUMAN Increases Expression [11]
G2 and S phase-expressed protein 1 (GTSE1) OTPP742Z GTSE1_HUMAN Decreases Expression [11]
Targeting protein for Xklp2 (TPX2) OTWLJYH0 TPX2_HUMAN Decreases Expression [11]
Transforming acidic coiled-coil-containing protein 3 (TACC3) OTRNEZTA TACC3_HUMAN Decreases Expression [11]
Collectin-10 (COLEC10) OTMBADGZ COL10_HUMAN Increases Expression [11]
Cathepsin D (CTSD) OTQZ36F3 CATD_HUMAN Decreases Expression [24]
Neprilysin (MME) OT5Q39P8 NEP_HUMAN Decreases Expression [24]
Dipeptidyl peptidase 1 (CTSC) OT79WJZZ CATC_HUMAN Decreases Expression [24]
Arachidonate 12-lipoxygenase, 12R-type (ALOX12B) OTQ0BYK6 LX12B_HUMAN Increases Expression [25]
Polyunsaturated fatty acid 5-lipoxygenase (ALOX5) OT7FOIK2 LOX5_HUMAN Increases Expression [25]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Increases Expression [25]
Bcl-2-binding component 3, isoforms 3/4 (BBC3) OTUAXDAY BBC3B_HUMAN Increases Expression [25]
Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B) OTUYHB84 MLP3B_HUMAN Increases Expression [25]
SPEG neighbor protein (SPEGNB) OTAC32TJ SPEGN_HUMAN Increases Expression [12]
Glucoside xylosyltransferase 2 (GXYLT2) OTMLQQKP GXLT2_HUMAN Increases Expression [12]
Homeobox protein HMX2 (HMX2) OTBRXY6D HMX2_HUMAN Increases Expression [12]
Protein FAM221A (FAM221A) OT13M8XE F221A_HUMAN Increases Expression [12]
Transmembrane protein 8B (TMEM8B) OTJZWPS6 TMM8B_HUMAN Increases Expression [12]
Nuclear protein 2 (NUPR2) OTNS6IEC NUPR2_HUMAN Increases Expression [12]
Arginine-fifty homeobox (ARGFX) OTV7LGJV ARGFX_HUMAN Decreases Expression [12]
Ras association domain-containing protein 10 (RASSF10) OTGB7EBG RASFA_HUMAN Decreases Expression [12]
Choriogonadotropin subunit beta variant 1 (CGB1) OT7NFGXF CGB1_HUMAN Increases Expression [12]
LYR motif-containing protein 9 (LYRM9) OT1MILTK LYRM9_HUMAN Increases Expression [12]
Putative transmembrane protein INAFM1 (INAFM1) OTXC8QBG INAM1_HUMAN Increases Expression [12]
Fibronectin type III domain-containing protein 10 (FNDC10) OT06NW7W FND10_HUMAN Increases Expression [12]
Galectin-8 (LGALS8) OT71LJ8T LEG8_HUMAN Decreases Expression [12]
E3 SUMO-protein ligase CBX4 (CBX4) OT4XVRRF CBX4_HUMAN Increases Expression [12]
Synaptotagmin-5 (SYT5) OT718PRY SYT5_HUMAN Increases Expression [12]
Butyrophilin subfamily 3 member A1 (BTN3A1) OTGZADIX BT3A1_HUMAN Increases Expression [12]
SH2B adapter protein 2 (SH2B2) OTEDHHDH SH2B2_HUMAN Increases Expression [12]
Class E basic helix-loop-helix protein 40 (BHLHE40) OTITX14U BHE40_HUMAN Increases Expression [12]
Suppressor of cytokine signaling 2 (SOCS2) OTBPNKJQ SOCS2_HUMAN Increases Expression [12]
Receptor-type tyrosine-protein phosphatase T (PTPRT) OTV5TXNN PTPRT_HUMAN Decreases Expression [12]
F-BAR domain only protein 1 (FCHO1) OTDNDGI9 FCHO1_HUMAN Increases Expression [12]
Suppressor of cytokine signaling 3 (SOCS3) OTY183WJ SOCS3_HUMAN Increases Expression [12]
Segment polarity protein dishevelled homolog DVL-2 (DVL2) OTMNYNCM DVL2_HUMAN Decreases Expression [26]
Golgi SNAP receptor complex member 2 (GOSR2) OTYHIYN2 GOSR2_HUMAN Decreases Expression [12]
Prostaglandin E synthase (PTGES) OTB7YQFU PTGES_HUMAN Increases Expression [12]
Serine/threonine-protein phosphatase with EF-hands 2 (PPEF2) OT0KW3GX PPE2_HUMAN Decreases Expression [12]
Inhibitor of nuclear factor kappa-B kinase subunit beta (IKBKB) OT9RDS3H IKKB_HUMAN Affects Localization [27]
Regulator of G-protein signaling 13 (RGS13) OTPAMQ18 RGS13_HUMAN Decreases Expression [12]
Protein KHNYN (KHNYN) OT5ZFS95 KHNYN_HUMAN Increases Expression [12]
Lysine-specific demethylase 6B (KDM6B) OTMZVHSG KDM6B_HUMAN Increases Expression [12]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Decreases Expression [12]
Glutamate receptor ionotropic, NMDA 2D (GRIN2D) OTTEKYKQ NMDE4_HUMAN Increases Expression [12]
Interleukin-1 receptor-associated kinase-like 2 (IRAK2) OT6Y1QZN IRAK2_HUMAN Increases Expression [12]
Transforming growth factor beta-1-induced transcript 1 protein (TGFB1I1) OTIK337D TGFI1_HUMAN Increases Expression [12]
Ras GTPase-activating protein 4 (RASA4) OTW0178L RASL2_HUMAN Increases Expression [12]
Regulator of G-protein signaling 14 (RGS14) OTYN79AG RGS14_HUMAN Increases Expression [12]
Lysine-specific demethylase hairless (HR) OTHEZWPW HAIR_HUMAN Increases Expression [12]
Zinc finger protein SNAI2 (SNAI2) OT7Y8EJ2 SNAI2_HUMAN Decreases Expression [13]
Regulator of G-protein signaling 10 (RGS10) OTQ8N1QH RGS10_HUMAN Increases Expression [12]
Peptidase inhibitor 15 (PI15) OTPJL6ML PI15_HUMAN Decreases Expression [12]
ER lumen protein-retaining receptor 3 (KDELR3) OTW8C1V0 ERD23_HUMAN Increases Expression [12]
Protein phosphatase 1 regulatory subunit 12B (PPP1R12B) OTONIS87 MYPT2_HUMAN Increases Expression [12]
Heparan-sulfate 6-O-sulfotransferase 1 (HS6ST1) OTABV7D2 H6ST1_HUMAN Decreases Expression [12]
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 (GNG7) OTHS1L0E GBG7_HUMAN Increases Expression [12]
tRNA wybutosine-synthesizing protein 4 (LCMT2) OT4RUVCM TYW4_HUMAN Decreases Expression [12]
HMG box-containing protein 1 (HBP1) OTDPGGDV HBP1_HUMAN Increases Expression [12]
ATP-binding cassette sub-family C member 9 (ABCC9) OTGAXLQN ABCC9_HUMAN Decreases Expression [12]
Liprin-alpha-3 (PPFIA3) OTNPZ6HT LIPA3_HUMAN Increases Expression [12]
Growth arrest and DNA damage-inducible protein GADD45 beta (GADD45B) OTL9I7LO GA45B_HUMAN Increases Expression [12]
Large neutral amino acids transporter small subunit 3 (SLC43A1) OTQJQY3S LAT3_HUMAN Increases Expression [12]
Cytokine receptor-like factor 1 (CRLF1) OT55PXIN CRLF1_HUMAN Decreases Expression [12]
GSK-3-binding protein FRAT2 (FRAT2) OT481GQ4 FRAT2_HUMAN Increases Expression [12]
Transcription initiation protein SPT3 homolog (SUPT3H) OT7B6FRO SUPT3_HUMAN Increases Expression [12]
Ribosomal protein S6 kinase alpha-5 (RPS6KA5) OTAVZJ3J KS6A5_HUMAN Increases Expression [12]
Paralemmin-1 (PALM) OTTZONUX PALM_HUMAN Increases Expression [12]
Protein phosphatase 1 regulatory subunit 15A (PPP1R15A) OTYG179K PR15A_HUMAN Increases Expression [12]
Short-chain dehydrogenase/reductase 3 (DHRS3) OTSK1DTP DHRS3_HUMAN Increases Expression [12]
Stanniocalcin-2 (STC2) OT86YP8G STC2_HUMAN Increases Expression [12]
Olfactory receptor 7C1 (OR7C1) OTQKD84O OR7C1_HUMAN Increases Expression [12]
Tubulin polymerization-promoting protein (TPPP) OTCFMSUF TPPP_HUMAN Increases Expression [12]
Kelch repeat and BTB domain-containing protein 11 (KBTBD11) OTBOY3WH KBTBB_HUMAN Increases Expression [12]
Rho-related BTB domain-containing protein 1 (RHOBTB1) OTGE8K45 RHBT1_HUMAN Increases Expression [12]
Dickkopf-related protein 1 (DKK1) OTRDLUSP DKK1_HUMAN Decreases Expression [12]
Neurexophilin-2 (NXPH2) OTHD8HPU NXPH2_HUMAN Decreases Expression [12]
Neurexophilin-4 (NXPH4) OTV057AG NXPH4_HUMAN Increases Expression [12]
Voltage-dependent T-type calcium channel subunit alpha-1H (CACNA1H) OTM705TH CAC1H_HUMAN Increases Expression [12]
Uncharacterized protein C1orf105 (C1ORF105) OTALIGHW CA105_HUMAN Decreases Expression [12]
Persulfide dioxygenase ETHE1, mitochondrial (ETHE1) OTP9A2BQ ETHE1_HUMAN Increases Expression [12]
Follistatin-related protein 3 (FSTL3) OT75489W FSTL3_HUMAN Increases Expression [12]
Fibroblast growth factor 19 (FGF19) OT2DVJWY FGF19_HUMAN Increases Expression [12]
Probable G-protein coupled receptor 75 (GPR75) OT8SPUGC GPR75_HUMAN Decreases Expression [12]
Echinoderm microtubule-associated protein-like 2 (EML2) OTRX2NTA EMAL2_HUMAN Increases Expression [12]
Zinc finger protein SNAI1 (SNAI1) OTDPYAMC SNAI1_HUMAN Decreases Expression [16]
Putative hydrolase DDAH2 (DDAH2) OT8Q40G2 DDAH2_HUMAN Increases Expression [12]
Uncharacterized protein C6orf47 (C6ORF47) OTMKBNDD CF047_HUMAN Affects Expression [12]
Polyglutamylase complex subunit TTLL1 (TTLL1) OTCE097J TTLL1_HUMAN Increases Expression [12]
T-box transcription factor TBX6 (TBX6) OTW1Q8RM TBX6_HUMAN Increases Expression [12]
G1/S-specific cyclin-E2 (CCNE2) OTBBUKQQ CCNE2_HUMAN Decreases Expression [12]
L-lactate dehydrogenase A chain (LDHA) OTN7K4XB LDHA_HUMAN Decreases Expression [12]
Dihydrofolate reductase (DHFR) OT3DVIGM DYR_HUMAN Decreases Expression [12]
Epidermal growth factor receptor (EGFR) OTAPLO1S EGFR_HUMAN Decreases Expression [28]
Coagulation factor X (F10) OT2BLK17 FA10_HUMAN Increases Expression [12]
Coagulation factor XII (F12) OTBFD2FU FA12_HUMAN Increases Expression [12]
2'-5'-oligoadenylate synthase 1 (OAS1) OT8ZLOCY OAS1_HUMAN Decreases Expression [12]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Decreases Expression [29]
Pro-epidermal growth factor (EGF) OTANRJ0L EGF_HUMAN Decreases Expression [28]
Tumor necrosis factor (TNF) OT4IE164 TNFA_HUMAN Decreases Activity [18]
Collagen alpha-1(I) chain (COL1A1) OTI31178 CO1A1_HUMAN Decreases Expression [15]
N-myc proto-oncogene protein (MYCN) OTWD33K1 MYCN_HUMAN Decreases Expression [12]
Alpha-1B-glycoprotein (A1BG) OTFVUGNQ A1BG_HUMAN Increases Expression [12]
Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1) OTM0GDTP IF2A_HUMAN Increases Phosphorylation [30]
Fibroblast growth factor 1 (FGF1) OT8I64X8 FGF1_HUMAN Decreases Expression [13]
Transcription factor Jun (JUN) OTCYBO6X JUN_HUMAN Increases Phosphorylation [31]
Progesterone receptor (PGR) OT0FZ3QE PRGR_HUMAN Decreases Expression [12]
Prostate-specific antigen (KLK3) OTFGSBFJ KLK3_HUMAN Decreases Expression [14]
Complement decay-accelerating factor (CD55) OTZ3HWTO DAF_HUMAN Increases Expression [12]
72 kDa type IV collagenase (MMP2) OT5NIWA2 MMP2_HUMAN Decreases Expression [17]
Alpha-2A adrenergic receptor (ADRA2A) OTZFGOTP ADA2A_HUMAN Decreases Expression [12]
Annexin A4 (ANXA4) OTUCRYXL ANXA4_HUMAN Increases Expression [12]
Platelet-derived growth factor receptor beta (PDGFRB) OTYSNK9Q PGFRB_HUMAN Increases Expression [12]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Decreases Expression [30]
Protein ELFN1 (ELFN1) OTM7M52U ELFN1_HUMAN Increases Expression [12]
Proline-rich protein 29 (PRR29) OT8GLHGQ PRR29_HUMAN Decreases Expression [12]
Glutathione S-transferase theta-2 (GSTT2) OTANW3TJ GST2_HUMAN Decreases Expression [12]
Small integral membrane protein 10-like protein 2A (SMIM10L2B) OT04IG2N SIL2A_HUMAN Increases Expression [12]
Androgen receptor (AR) OTUBKAZZ ANDR_HUMAN Decreases Expression [14]
Microtubule-associated protein tau (MAPT) OTMTP2Z7 TAU_HUMAN Increases Expression [12]
Acetylcholine receptor subunit beta (CHRNB1) OTTJXD24 ACHB_HUMAN Increases Expression [12]
Serine/threonine-protein kinase pim-1 (PIM1) OTWEKXTU PIM1_HUMAN Increases Expression [12]
DNA topoisomerase 2-alpha (TOP2A) OT6LPS08 TOP2A_HUMAN Affects Binding [32]
Cyclin-dependent kinase 4 (CDK4) OT7EP05T CDK4_HUMAN Decreases Expression [33]
Proliferating cell nuclear antigen (PCNA) OTHZ1RIA PCNA_HUMAN Decreases Expression [12]
Collagen alpha-2(VI) chain (COL6A2) OTQC6PPO CO6A2_HUMAN Increases Expression [12]
Protein L-Myc (MYCL) OT1MFQ5U MYCL_HUMAN Increases Expression [12]
Cadherin-1 (CDH1) OTFJMXPM CADH1_HUMAN Increases Expression [16]
Platelet glycoprotein Ib beta chain (GP1BB) OTD7XNLL GP1BB_HUMAN Increases Expression [12]
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 (HSD3B1) OTNAZVKB 3BHS1_HUMAN Increases Expression [12]
Insulin receptor-related protein (INSRR) OT3F75WA INSRR_HUMAN Decreases Expression [12]
Matrix metalloproteinase-9 (MMP9) OTB2QDAV MMP9_HUMAN Decreases Expression [16]
Ras-related C3 botulinum toxin substrate 2 (RAC2) OTAOHFNH RAC2_HUMAN Increases Expression [12]
Metalloproteinase inhibitor 2 (TIMP2) OT8S1RRP TIMP2_HUMAN Increases Expression [16]
Atrial natriuretic peptide receptor 1 (NPR1) OTRWART5 ANPRA_HUMAN Increases Expression [12]
Heat shock 70 kDa protein 6 (HSPA6) OTH4S7WB HSP76_HUMAN Increases Expression [12]
CCAAT/enhancer-binding protein beta (CEBPB) OTM9MQIA CEBPB_HUMAN Increases Expression [12]
Endoglin (ENG) OTL2LSMI EGLN_HUMAN Increases Expression [12]
Galectin-3 (LGALS3) OTYQT0ZI LEG3_HUMAN Increases Expression [12]
Early growth response protein 1 (EGR1) OTCP6XGZ EGR1_HUMAN Decreases Expression [12]
Arylamine N-acetyltransferase 1 (NAT1) OTCCNQ3H ARY1_HUMAN Decreases Expression [12]
Gamma-aminobutyric acid receptor subunit beta-1 (GABRB1) OT4L2SSB GBRB1_HUMAN Increases Expression [12]
Cyclic AMP-dependent transcription factor ATF-3 (ATF3) OTC1UOHP ATF3_HUMAN Increases Expression [30]
Cyclic AMP-dependent transcription factor ATF-4 (ATF4) OTRFV19J ATF4_HUMAN Increases Expression [30]
Nuclear factor NF-kappa-B p105 subunit (NFKB1) OTNRRD8I NFKB1_HUMAN Affects Localization [27]
Ras-related protein Rab-3A (RAB3A) OT2GIUO5 RAB3A_HUMAN Increases Expression [12]
Nuclear receptor subfamily 1 group D member 1 (NR1D1) OTJ38PTB NR1D1_HUMAN Increases Expression [12]
B-cell lymphoma 3 protein (BCL3) OT1M5B95 BCL3_HUMAN Increases Expression [12]
Ephrin-A1 (EFNA1) OTU2NUA2 EFNA1_HUMAN Increases Expression [12]
Biglycan (BGN) OT3AV6IF PGS1_HUMAN Increases Expression [12]
D(4) dopamine receptor (DRD4) OTAJTO7N DRD4_HUMAN Increases Expression [12]
Cartilage matrix protein (MATN1) OTBRTCTQ MATN1_HUMAN Increases Expression [12]
Fibroblast growth factor receptor 4 (FGFR4) OTRQERG2 FGFR4_HUMAN Increases Expression [12]
Insulin-like growth factor-binding protein 4 (IGFBP4) OT2HZRBD IBP4_HUMAN Increases Expression [12]
Nuclear receptor subfamily 4immunitygroup A member 1 (NR4A1) OTGP6GA4 NR4A1_HUMAN Increases Expression [12]
Ribosomal protein S6 kinase beta-1 (RPS6KB1) OTAELNGX KS6B1_HUMAN Decreases Phosphorylation [34]
Receptor-type tyrosine-protein phosphatase gamma (PTPRG) OT9N2WOF PTPRG_HUMAN Decreases Expression [12]
Tumor necrosis factor ligand superfamily member 4 (TNFSF4) OTOCBX7P TNFL4_HUMAN Increases Expression [12]
Stromelysin-3 (MMP11) OTRTXDBM MMP11_HUMAN Increases Expression [12]
G1/S-specific cyclin-D1 (CCND1) OT8HPTKJ CCND1_HUMAN Decreases Expression [29]
G1/S-specific cyclin-E1 (CCNE1) OTLD7UID CCNE1_HUMAN Decreases Expression [12]
Cyclin-dependent kinase 2 (CDK2) OTB5DYYZ CDK2_HUMAN Decreases Expression [33]
NF-kappa-B inhibitor alpha (NFKBIA) OTFT924M IKBA_HUMAN Decreases Phosphorylation [27]
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 (HSD3B2) OT02MSKN 3BHS2_HUMAN Increases Expression [12]
Protein S100-A4 (S100A4) OTLRGFSQ S10A4_HUMAN Decreases Expression [35]
CD27 antigen (CD27) OTH7NA58 CD27_HUMAN Increases Expression [12]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Decreases Phosphorylation [27]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Decreases Phosphorylation [27]
5-hydroxytryptamine receptor 1E (HTR1E) OTOK64JC 5HT1E_HUMAN Decreases Expression [12]
Ephrin type-A receptor 8 (EPHA8) OTHOESG6 EPHA8_HUMAN Increases Expression [12]
G1/S-specific cyclin-D2 (CCND2) OTDULQF9 CCND2_HUMAN Decreases Expression [12]
S-adenosylmethionine synthase isoform type-2 (MAT2A) OTFJMIQR METK2_HUMAN Decreases Expression [12]
Transcription factor HIVEP2 (HIVEP2) OTVOMCW4 ZEP2_HUMAN Increases Expression [12]
DnaJ homolog subfamily A member 1 (DNAJA1) OT38BZQQ DNJA1_HUMAN Decreases Expression [12]
RAC-alpha serine/threonine-protein kinase (AKT1) OT8H2YY7 AKT1_HUMAN Increases Expression [36]
ETS-related transcription factor Elf-1 (ELF1) OTV5LKIA ELF1_HUMAN Increases Expression [12]
Lymphocyte-specific protein 1 (LSP1) OTSPSIFO LSP1_HUMAN Decreases Expression [12]
DNA replication licensing factor MCM5 (MCM5) OTAHLB62 MCM5_HUMAN Decreases Expression [12]
DNA replication licensing factor MCM7 (MCM7) OT6FXC6K MCM7_HUMAN Decreases Expression [33]
Macrosialin (CD68) OTOYEY3J CD68_HUMAN Increases Expression [12]
Histamine H1 receptor (HRH1) OT8F9FV6 HRH1_HUMAN Increases Expression [12]
Prostaglandin E2 receptor EP4 subtype (PTGER4) OT2GBV06 PE2R4_HUMAN Decreases Expression [12]
Apelin receptor (APLNR) OT8585HU APJ_HUMAN Decreases Expression [12]
Thrombospondin-4 (THBS4) OTA1T9KK TSP4_HUMAN Increases Expression [12]
DNA damage-inducible transcript 3 protein (DDIT3) OTI8YKKE DDIT3_HUMAN Increases Expression [30]
Hydroxymethylglutaryl-CoA lyase, mitochondrial (HMGCL) OTRO9RII HMGCL_HUMAN Increases Expression [12]
Monocarboxylate transporter 8 (SLC16A2) OTLRA7C0 MOT8_HUMAN Increases Expression [12]
Transcription factor 7 (TCF7) OT1ID822 TCF7_HUMAN Decreases Expression [12]
Peroxisome proliferator-activated receptor gamma (PPARG) OTHMARHO PPARG_HUMAN Increases Expression [12]
Alpha-synuclein (SNCA) OTPWC1MR SYUA_HUMAN Increases Expression [12]
Flap endonuclease 1 (FEN1) OT6QGG7O FEN1_HUMAN Decreases Expression [12]
Pre-B-cell leukemia transcription factor 1 (PBX1) OTORABGO PBX1_HUMAN Increases Expression [12]
Pre-B-cell leukemia transcription factor 2 (PBX2) OTEBYCAW PBX2_HUMAN Increases Expression [12]
DNA-binding protein inhibitor ID-1 (ID1) OTKGNZN5 ID1_HUMAN Increases Expression [12]
B-cell lymphoma 6 protein (BCL6) OTQAWWO1 BCL6_HUMAN Increases Expression [12]
Signal transducer and activator of transcription 5A (STAT5A) OTBSJGN3 STA5A_HUMAN Increases Expression [12]
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA) OTTOMI8J PK3CA_HUMAN Increases Expression [36]
Serine/threonine-protein kinase mTOR (MTOR) OTHH8KU7 MTOR_HUMAN Increases Expression [36]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Decreases Expression [18]
Phosphorylase b kinase regulatory subunit alpha, liver isoform (PHKA2) OTJE1KXL KPB2_HUMAN Decreases Expression [12]
C-C chemokine receptor type 10 (CCR10) OT7ZWSSD CCR10_HUMAN Increases Expression [12]
Neurogenic locus notch homolog protein 1 (NOTCH1) OTI1WADQ NOTC1_HUMAN Decreases Activity [29]
Stromal cell-derived factor 1 (CXCL12) OT2QX5LL SDF1_HUMAN Decreases Expression [12]
Gamma-aminobutyric acid receptor subunit alpha-4 (GABRA4) OT5I7OI2 GBRA4_HUMAN Increases Expression [12]
Glutamate--cysteine ligase regulatory subunit (GCLM) OT6CP234 GSH0_HUMAN Decreases Expression [12]
Mannan-binding lectin serine protease 1 (MASP1) OTWWCNZP MASP1_HUMAN Increases Expression [12]
Anion exchange protein 3 (SLC4A3) OTXIRX39 B3A3_HUMAN Increases Expression [12]
Transmembrane ascorbate-dependent reductase CYB561 (CYB561) OT61GMNV CY561_HUMAN Decreases Expression [12]
Presenilin-2 (PSEN2) OTOW778B PSN2_HUMAN Decreases Expression [12]
PDZ and LIM domain protein 4 (PDLIM4) OT23LZYY PDLI4_HUMAN Increases Expression [12]
Max-interacting protein 1 (MXI1) OTUQ9E0D MXI1_HUMAN Increases Expression [12]
Amiloride-sensitive sodium channel subunit delta (SCNN1D) OTTX2G9M SCNND_HUMAN Increases Expression [12]
Matrix metalloproteinase-15 (MMP15) OT1XF517 MMP15_HUMAN Increases Expression [12]
Calponin-1 (CNN1) OTVPG39Z CNN1_HUMAN Increases Expression [12]
Tyrosine-protein kinase JAK3 (JAK3) OTQ8QW2L JAK3_HUMAN Increases Expression [12]
Rho GDP-dissociation inhibitor 2 (ARHGDIB) OT9PD6CS GDIR2_HUMAN Increases Expression [12]
Hexokinase-3 (HK3) OTZKONGB HXK3_HUMAN Decreases Expression [12]
Ephrin-A3 (EFNA3) OTJGOUMZ EFNA3_HUMAN Increases Expression [12]
Beta-crystallin B1 (CRYBB1) OTDI4W3V CRBB1_HUMAN Increases Expression [12]
Caspase-7 (CASP7) OTAPJ040 CASP7_HUMAN Increases Expression [27]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Increases Expression [12]
Cadherin-4 (CDH4) OT8LH3HN CADH4_HUMAN Increases Expression [12]
Cadherin-6 (CDH6) OT81Y80S CADH6_HUMAN Decreases Expression [12]
Cadherin-11 (CDH11) OTIZKPTF CAD11_HUMAN Decreases Expression [12]
Transmembrane protein 50B (TMEM50B) OTWJK2XZ TM50B_HUMAN Decreases Expression [12]
Transcription factor SOX-8 (SOX8) OTEJXYZM SOX8_HUMAN Increases Expression [12]
Regulator of G-protein signaling 8 (RGS8) OTX60JDJ RGS8_HUMAN Decreases Expression [12]
Inhibin beta E chain (INHBE) OTOI2NYG INHBE_HUMAN Increases Expression [12]
Lysyl oxidase homolog 3 (LOXL3) OTLLY1QI LOXL3_HUMAN Increases Expression [12]
Neurexin-2-beta (NRXN2) OTB04QSU NRX2B_HUMAN Increases Expression [12]
Neurexophilin-1 (NXPH1) OTGKX860 NXPH1_HUMAN Decreases Expression [12]
Major intrinsically disordered NOTCH2-binding receptor 1-like (MINAR2) OTDGVXJ6 MNARL_HUMAN Decreases Expression [12]
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN) OTOWDUNT PTEN_HUMAN Increases Expression [36]
Cell division control protein 42 homolog (CDC42) OT5QBC5M CDC42_HUMAN Decreases Expression [17]
Actin, aortic smooth muscle (ACTA2) OTEDLG8E ACTA_HUMAN Decreases Expression [15]
Small ribosomal subunit protein eS6 (RPS6) OTT4D1LN RS6_HUMAN Affects Phosphorylation [34]
Disks large homolog 4 (DLG4) OTD9E2LU DLG4_HUMAN Increases Expression [12]
Butyrophilin subfamily 3 member A2 (BTN3A2) OT3DIBU3 BT3A2_HUMAN Increases Expression [12]
Protein BTG2 (BTG2) OTZF6K1H BTG2_HUMAN Increases Expression [12]
Hepcidin (HAMP) OT607RBL HEPC_HUMAN Decreases Expression [37]
FYVE, RhoGEF and PH domain-containing protein 1 (FGD1) OTV3T64P FGD1_HUMAN Increases Expression [12]
Forkhead box protein O4 (FOXO4) OT90X9LN FOXO4_HUMAN Increases Expression [12]
Cytochrome c (CYCS) OTBFALJD CYC_HUMAN Increases Expression [38]
Cdc42 effector protein 1 (CDC42EP1) OTT525WA BORG5_HUMAN Increases Expression [12]
Nuclear factor NF-kappa-B p100 subunit (NFKB2) OTS231V7 NFKB2_HUMAN Increases Expression [12]
Transcription factor E2F1 (E2F1) OTLKYBBC E2F1_HUMAN Decreases Expression [36]
Sodium channel protein type 7 subunit alpha (SCN7A) OTK05PXY SCN7A_HUMAN Decreases Expression [12]
Serine/arginine-rich splicing factor 2 (SRSF2) OTVDHO6U SRSF2_HUMAN Decreases Expression [12]
Transcription factor RelB (RELB) OTU3QYEF RELB_HUMAN Increases Expression [12]
DNA-binding protein SATB1 (SATB1) OTT7SUVW SATB1_HUMAN Increases Expression [12]
POU domain, class 5, transcription factor 1 (POU5F1) OTDHHN7O PO5F1_HUMAN Decreases Phosphorylation [39]
Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase , mitochondrial (ALDH6A1) OT8LCZCT MMSA_HUMAN Increases Expression [12]
Sterol 26-hydroxylase, mitochondrial (CYP27A1) OT649C01 CP27A_HUMAN Increases Expression [12]
POU domain, class 3, transcription factor 1 (POU3F1) OTYARA94 PO3F1_HUMAN Increases Expression [12]
Transforming growth factor beta receptor type 3 (TGFBR3) OTQOOUC4 TGBR3_HUMAN Decreases Expression [12]
Transcription factor p65 (RELA) OTUJP9CN TF65_HUMAN Decreases Expression [40]
P protein (OCA2) OTDWIGBF P_HUMAN Increases Expression [12]
Transducin-like enhancer protein 4 (TLE4) OT4QEH6T TLE4_HUMAN Decreases Expression [12]
Protein kinase C delta type (PRKCD) OTSEH90E KPCD_HUMAN Increases Expression [12]
Voltage-dependent calcium channel gamma-1 subunit (CACNG1) OT6OCR3H CCG1_HUMAN Increases Expression [12]
3',5'-cyclic-AMP phosphodiesterase 4B (PDE4B) OTOA8WU2 PDE4B_HUMAN Increases Expression [12]
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Decreases Expression [14]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) OT2YYI1A MCL1_HUMAN Decreases Expression [18]
Prolow-density lipoprotein receptor-related protein 1 (LRP1) OTHTEH4G LRP1_HUMAN Increases Expression [12]
Forkhead box protein M1 (FOXM1) OT5887KR FOXM1_HUMAN Decreases Expression [40]
Epithelial discoidin domain-containing receptor 1 (DDR1) OTYW1SH8 DDR1_HUMAN Increases Expression [12]
Golgin subfamily A member 2 (GOLGA2) OT5S9KYM GOGA2_HUMAN Increases Expression [12]
Kelch-like protein 30 (KLHL30) OTKVRLU3 KLH30_HUMAN Increases Expression [12]
Protein INCA1 (INCA1) OTTTN3EW INCA1_HUMAN Increases Expression [12]
D site-binding protein (DBP) OTE0W7LN DBP_HUMAN Increases Expression [12]
Proline-rich nuclear receptor coactivator 1 (PNRC1) OTQMLEE1 PNRC1_HUMAN Increases Expression [12]
Forkhead box protein L1 (FOXL1) OT89XFPN FOXL1_HUMAN Increases Expression [12]
Ankyrin-3 (ANK3) OTJ3IRBP ANK3_HUMAN Increases Expression [12]
Chromatin assembly factor 1 subunit A (CHAF1A) OTXSSY4H CAF1A_HUMAN Decreases Expression [12]
Dual specificity protein phosphatase 4 (DUSP4) OT6WAO12 DUS4_HUMAN Increases Expression [12]
Dual specificity protein phosphatase 8 (DUSP8) OTPLMPG9 DUS8_HUMAN Increases Expression [12]
Serine/arginine-rich splicing factor 6 (SRSF6) OTGLOSYE SRSF6_HUMAN Decreases Expression [12]
Semaphorin-3F (SEMA3F) OTQFMS8S SEM3F_HUMAN Increases Expression [12]
Syntaxin-3 (STX3) OT4CIWLJ STX3_HUMAN Increases Expression [12]
Peptidyl-prolyl cis-trans isomerase FKBP5 (FKBP5) OT404F9K FKBP5_HUMAN Decreases Expression [14]
Rho-associated protein kinase 1 (ROCK1) OTSXYVW1 ROCK1_HUMAN Decreases Expression [17]
Ras and Rab interactor 1 (RIN1) OTPBROUD RIN1_HUMAN Increases Expression [12]
Krueppel-like factor 9 (KLF9) OTBFEJRQ KLF9_HUMAN Increases Expression [12]
Calcyphosin (CAPS) OTC9GZ2M CAYP1_HUMAN Increases Expression [12]
Transcription factor E2F2 (E2F2) OTO75RM7 E2F2_HUMAN Decreases Expression [12]
Eukaryotic initiation factor 4A-II (EIF4A2) OT08H03R IF4A2_HUMAN Increases Expression [12]
Protein-tyrosine kinase 2-beta (PTK2B) OTGAS0I8 FAK2_HUMAN Increases Expression [12]
Transcription factor HES-1 (HES1) OT8P19W2 HES1_HUMAN Decreases Expression [29]
DNA replication licensing factor MCM6 (MCM6) OTKLIAWT MCM6_HUMAN Decreases Expression [12]
Next to BRCA1 gene 1 protein (NBR1) OTVRL7J9 NBR1_HUMAN Increases Expression [12]
Transmembrane protein 187 (TMEM187) OTOE4G8T TM187_HUMAN Increases Expression [12]
DNA replication complex GINS protein PSF1 (GINS1) OTVQZMMQ PSF1_HUMAN Decreases Expression [12]
Major vault protein (MVP) OTJGHJRB MVP_HUMAN Increases Expression [12]
Caspase-8 (CASP8) OTA8TVI8 CASP8_HUMAN Increases Cleavage [15]
Myocyte-specific enhancer factor 2D (MEF2D) OT7CEIG0 MEF2D_HUMAN Increases Expression [12]
Nuclear factor 1 X-type (NFIX) OT1DPZAE NFIX_HUMAN Increases Expression [12]
Opioid-binding protein/cell adhesion molecule (OPCML) OT93PQ6Y OPCM_HUMAN Increases Expression [12]
Nuclear receptor subfamily 1 group D member 2 (NR1D2) OT9CVF41 NR1D2_HUMAN Increases Expression [12]
FAST kinase domain-containing protein 3, mitochondrial (FASTKD3) OT1TI8K0 FAKD3_HUMAN Decreases Expression [12]
P2Y purinoceptor 6 (P2RY6) OT7VNPQ0 P2RY6_HUMAN Decreases Expression [12]
kinase isozyme 3, mitochondrial (PDK3) OTCPSTID PDK3_HUMAN Decreases Expression [12]
Plectin (PLEC) OTU4XDEG PLEC_HUMAN Increases Expression [12]
Cdc42-interacting protein 4 (TRIP10) OTGOUILO CIP4_HUMAN Increases Expression [12]
Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (INPP5J) OT8M7KWA PI5PA_HUMAN Increases Expression [12]
Ephrin-B3 (EFNB3) OT12WTXQ EFNB3_HUMAN Increases Expression [12]
Voltage-dependent R-type calcium channel subunit alpha-1E (CACNA1E) OTHATMLU CAC1E_HUMAN Increases Expression [12]
Glutamate receptor ionotropic, kainate 5 (GRIK5) OTBW671W GRIK5_HUMAN Increases Expression [12]
Neuronatin (NNAT) OTNRLO7G NNAT_HUMAN Decreases Expression [12]
Cyclin-G2 (CCNG2) OTII38K2 CCNG2_HUMAN Increases Expression [12]
Survival motor neuron protein (SMN2) OT54RLO1 SMN_HUMAN Decreases Expression [12]
Hypoxia-inducible factor 1-alpha (HIF1A) OTADSC03 HIF1A_HUMAN Decreases Expression [28]
Anti-Muellerian hormone type-2 receptor (AMHR2) OT95APPM AMHR2_HUMAN Increases Expression [12]
Histone H2B type 2-E (H2BC21) OT0FDCUC H2B2E_HUMAN Increases Expression [12]
NADP-dependent malic enzyme, mitochondrial (ME3) OT3XMLYG MAON_HUMAN Decreases Expression [12]
LON peptidase N-terminal domain and RING finger protein 1 (LONRF1) OT0S9MFX LONF1_HUMAN Increases Expression [12]
Centrosomal protein kizuna (KIZ) OT5VCKSM KIZ_HUMAN Increases Expression [12]
Leucine-rich repeat-containing protein 75B (LRRC75B) OTAHOBSS LR75B_HUMAN Increases Expression [12]
DDB1- and CUL4-associated factor 4-like protein 1 (DCAF4L1) OT50KJQ6 DC4L1_HUMAN Decreases Expression [12]
Annexin-2 receptor (ANXA2R) OT82TU39 AX2R_HUMAN Increases Expression [12]
Protein FAM135B (FAM135B) OTCSYBI7 F135B_HUMAN Increases Expression [12]
Angiomotin (AMOT) OTWHDG9B AMOT_HUMAN Increases Expression [12]
Programmed cell death protein 4 (PDCD4) OTZ6NXUX PDCD4_HUMAN Increases Expression [12]
Protein LBH (LBH) OT87AT1X LBH_HUMAN Increases Expression [12]
Puratrophin-1 (PLEKHG4) OT3RBPFL PKHG4_HUMAN Increases Expression [12]
RILP-like protein 1 (RILPL1) OTW4LHU8 RIPL1_HUMAN Increases Expression [12]
UMP-CMP kinase 2, mitochondrial (CMPK2) OTOG90R0 CMPK2_HUMAN Decreases Expression [12]
F-box only protein 48 (FBXO48) OTVMFNOK FBX48_HUMAN Increases Expression [12]
BCL-6 corepressor-like protein 1 (BCORL1) OTPTFQN5 BCORL_HUMAN Increases Expression [12]
Protein crumbs homolog 2 (CRB2) OTG0L2CE CRUM2_HUMAN Increases Expression [12]
Germinal center-associated signaling and motility-like protein (GCSAML) OTYWDOA6 GSAML_HUMAN Decreases Expression [12]
Leucine-rich repeat-containing protein 73 (LRRC73) OTNFHROL LRC73_HUMAN Increases Expression [12]
Solute carrier family 35 member D3 (SLC35D3) OTHKRBGM S35D3_HUMAN Decreases Expression [12]
Cilia- and flagella-associated protein 70 (CFAP70) OTIRTNXU CFA70_HUMAN Increases Expression [12]
Arginine vasopressin-induced protein 1 (AVPI1) OTXSBR60 AVPI1_HUMAN Increases Expression [12]
Immediate early response gene 5-like protein (IER5L) OT6IG629 IER5L_HUMAN Increases Expression [12]
NEDD4-binding protein 2-like 1 (N4BP2L1) OTEGV3GO N42L1_HUMAN Increases Expression [12]
Radial spoke head protein 4 homolog A (RSPH4A) OTNDPGEE RSH4A_HUMAN Decreases Expression [12]
Myomesin-3 (MYOM3) OT8GGH11 MYOM3_HUMAN Increases Expression [12]
Succinate dehydrogenase assembly factor 4, mitochondrial (SDHAF4) OTDXI4H8 SDHF4_HUMAN Increases Expression [12]
OTU domain-containing protein 1 (OTUD1) OTE6O5XB OTUD1_HUMAN Increases Expression [12]
Uncharacterized protein KIAA1614 (KIAA1614) OTCG3B86 K1614_HUMAN Decreases Expression [12]
Janus kinase and microtubule-interacting protein 3 (JAKMIP3) OT4EDANR JKIP3_HUMAN Increases Expression [12]
Meteorin-like protein (METRNL) OTB0DDL0 METRL_HUMAN Increases Expression [12]
Formin-1 (FMN1) OT9CID5R FMN1_HUMAN Increases Expression [12]
BTB/POZ domain-containing protein KCTD11 (KCTD11) OT64DFBU KCD11_HUMAN Increases Expression [12]
Sodium-dependent neutral amino acid transporter B(0)AT1 (SLC6A19) OT04I3OW S6A19_HUMAN Decreases Expression [12]
Transmembrane protein 42 (TMEM42) OTCG6EZ0 TMM42_HUMAN Increases Expression [12]
Ankyrin repeat domain-containing protein 34A (ANKRD34A) OTI00ROL AN34A_HUMAN Increases Expression [12]
Tigger transposable element-derived protein 3 (TIGD3) OT61NEUF TIGD3_HUMAN Decreases Expression [12]
Fc receptor-like B (FCRLB) OTL0PMQX FCRLB_HUMAN Increases Expression [12]
Rab15 effector protein (REP15) OTGOX4E7 REP15_HUMAN Decreases Expression [12]
Pleckstrin homology-like domain family B member 3 (PHLDB3) OTPFKXFA PHLB3_HUMAN Increases Expression [12]
Probable G-protein coupled receptor 153 (GPR153) OT81CA1Z GP153_HUMAN Increases Expression [12]
Golgi-associated RAB2 interactor protein 1A (GARIN1A) OTSJROUO GAR1A_HUMAN Increases Expression [12]
Transmembrane protein 53 (TMEM53) OTSXTGQK TMM53_HUMAN Increases Expression [12]
Pre-mRNA-processing-splicing factor 8 (PRPF8) OTU39JZI PRP8_HUMAN Decreases Expression [12]
PiggyBac transposable element-derived protein 2 (PGBD2) OT82WVBH PGBD2_HUMAN Decreases Expression [12]
ATP synthase subunit C lysine N-methyltransferase (ATPSCKMT) OTMPVCHS ACKMT_HUMAN Decreases Expression [12]
Palmitoleoyl-protein carboxylesterase NOTUM (NOTUM) OT03MYQ2 NOTUM_HUMAN Increases Expression [12]
Potassium voltage-gated channel subfamily V member 1 (KCNV1) OTU2MLSU KCNV1_HUMAN Decreases Expression [12]
Fidgetin-like protein 1 (FIGNL1) OTKII63K FIGL1_HUMAN Decreases Expression [12]
Kelch-like protein 24 (KLHL24) OTWZSX5C KLH24_HUMAN Increases Expression [12]
Ankyrin repeat domain-containing protein 12 (ANKRD12) OTK16BL9 ANR12_HUMAN Increases Expression [12]
Kin of IRRE-like protein 2 (KIRREL2) OTSLTR4Y KIRR2_HUMAN Increases Expression [12]
Protein SNORC (SNORC) OTY3IJK5 SNORC_HUMAN Increases Expression [12]
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 (B3GNT9) OTO385AU B3GN9_HUMAN Increases Expression [12]
Transcription factor LBX2 (LBX2) OTGWRSI2 LBX2_HUMAN Increases Expression [12]
SH3 and cysteine-rich domain-containing protein 2 (STAC2) OTRJ9PG0 STAC2_HUMAN Increases Expression [12]
Lysine-specific demethylase 7A (KDM7A) OT1VGYCX KDM7A_HUMAN Increases Expression [12]
GDP-D-glucose phosphorylase 1 (GDPGP1) OT40ETFK GDPP1_HUMAN Decreases Expression [12]
Leucine-rich repeat-containing protein 55 (LRRC55) OT8LQI1W LRC55_HUMAN Decreases Expression [12]
Protein FAM43B (FAM43B) OTLND7C6 FA43B_HUMAN Increases Expression [12]
Tripartite motif-containing protein 67 (TRIM67) OTXRZN27 TRI67_HUMAN Increases Expression [12]
Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1 (NYAP1) OT8FPF5F NYAP1_HUMAN Increases Expression [12]
8-oxo-dGDP phosphatase NUDT18 (NUDT18) OT03IQA5 NUD18_HUMAN Increases Expression [12]
Uncharacterized protein C16orf86 (C16ORF86) OTUT18HF CP086_HUMAN Increases Expression [12]
Centromere protein U (CENPU) OTQ4TZRS CENPU_HUMAN Decreases Expression [12]
Protein MCM10 homolog (MCM10) OTV0O3JN MCM10_HUMAN Decreases Expression [12]
Atos homolog protein B (ATOSB) OTU2TXCA ATOSB_HUMAN Increases Expression [12]
Equilibrative nucleoside transporter 4 (SLC29A4) OTWTZXMX S29A4_HUMAN Increases Expression [12]
Stereocilin (STRC) OT3JQYVJ STRC_HUMAN Increases Expression [12]
Monocarboxylate transporter 14 (SLC16A14) OTUGDEUV MOT14_HUMAN Increases Expression [12]
Monocarboxylate transporter 9 (SLC16A9) OTVCLKQQ MOT9_HUMAN Increases Expression [12]
Transmembrane channel-like protein 6 (TMC6) OTKH50J4 TMC6_HUMAN Increases Expression [12]
Low-density lipoprotein receptor-related protein 10 (LRP10) OT8490HT LRP10_HUMAN Increases Expression [12]
Protein ADM2 (ADM2) OTJVN41C ADM2_HUMAN Increases Expression [12]
Cytochrome c oxidase subunit 8C, mitochondrial (COX8C) OT6G8E4Q COX8C_HUMAN Increases Expression [12]
Microtubule organization protein AKNA (AKNA) OTQ6E2C8 AKNA_HUMAN Increases Expression [12]
Interferon regulatory factor 2-binding protein 2 (IRF2BP2) OTSSRRCA I2BP2_HUMAN Increases Expression [12]
Protein TAMALIN (TAMALIN) OTK75X47 GRASP_HUMAN Increases Expression [12]
Phosphatidylinositol-glycan biosynthesis class W protein (PIGW) OTT9SMTF PIGW_HUMAN Decreases Expression [12]
Synaptotagmin-9 (SYT9) OT7S8WU0 SYT9_HUMAN Decreases Expression [12]
Store-operated calcium entry regulator STIMATE (STIMATE) OTEDLKEW STIMA_HUMAN Decreases Expression [12]
Glucosylceramide transporter ABCA12 (ABCA12) OTKH9YQZ ABCAC_HUMAN Decreases Expression [12]
Reticulon-4 receptor-like 1 (RTN4RL1) OTDKKOE7 R4RL1_HUMAN Increases Expression [12]
SEC14 domain and spectrin repeat-containing protein 1 (SESTD1) OTHH06X8 SESD1_HUMAN Decreases Expression [12]
Caytaxin (ATCAY) OTSIAM08 ATCAY_HUMAN Increases Expression [12]
4-hydroxy-2-oxoglutarate aldolase, mitochondrial (HOGA1) OT7XETW4 HOGA1_HUMAN Increases Expression [12]
Protein phosphatase 1 regulatory subunit 3B (PPP1R3B) OTVCRXEZ PPR3B_HUMAN Decreases Expression [12]
Enoyl-CoA hydratase domain-containing protein 2, mitochondrial (ECHDC2) OTL0DWCO ECHD2_HUMAN Decreases Expression [12]
Testis development-related protein (TDRP) OTEFLMGF TDRP_HUMAN Increases Expression [12]
Homer protein homolog 1 (HOMER1) OTWFD3SI HOME1_HUMAN Decreases Expression [12]
Complement C1q-like protein 4 (C1QL4) OT9L6DLK C1QL4_HUMAN Increases Expression [12]
Unconventional myosin-XVIIIb (MYO18B) OTGYY4NK MY18B_HUMAN Increases Expression [12]
RNA-binding protein 45 (RBM45) OTWTHD77 RBM45_HUMAN Decreases Expression [12]
Neuronal PAS domain-containing protein 4 (NPAS4) OTA3HH6W NPAS4_HUMAN Increases Expression [12]
CREB3 regulatory factor (CREBRF) OT2GK1HI CRERF_HUMAN Increases Expression [12]
Protein HID1 (HID1) OTVJIFSU HID1_HUMAN Increases Expression [12]
Ankyrin repeat and MYND domain-containing protein 2 (ANKMY2) OTMOGNCV ANKY2_HUMAN Increases Expression [12]
Nostrin (NOSTRIN) OT0LDSGS NOSTN_HUMAN Decreases Expression [12]
Glucose-induced degradation protein 4 homolog (GID4) OT0TOD0M GID4_HUMAN Increases Expression [12]
Cyclin-dependent kinase-like 3 (CDKL3) OTJ0TQ9T CDKL3_HUMAN Increases Expression [12]
Transmembrane protein 151B (TMEM151B) OTTEDBUJ T151B_HUMAN Increases Expression [12]
Sphingosine-1-phosphate phosphatase 2 (SGPP2) OTIDIJCR SGPP2_HUMAN Decreases Expression [12]
DNA damage-induced apoptosis suppressor protein (DDIAS) OTTGG2PM DDIAS_HUMAN Decreases Expression [12]
Kelch domain-containing protein 8B (KLHDC8B) OTKP6LCR KLD8B_HUMAN Increases Expression [12]
Probable inactive peptidyl-prolyl cis-trans isomerase-like 6 (PPIL6) OTOZQMQE PPIL6_HUMAN Increases Expression [12]
Kelch domain-containing protein 8A (KLHDC8A) OTIZA3AM KLD8A_HUMAN Increases Expression [12]
REST corepressor 2 (RCOR2) OTXRQS9E RCOR2_HUMAN Increases Expression [12]
B-cell CLL/lymphoma 6 member B protein (BCL6B) OT1T5KM6 BCL6B_HUMAN Increases Expression [12]
Glypican-2 (GPC2) OT3WSQE1 GPC2_HUMAN Increases Expression [12]
Homeobox protein SIX5 (SIX5) OTT1I9WY SIX5_HUMAN Increases Expression [12]
Kelch-like protein 34 (KLHL34) OTHU2OSE KLH34_HUMAN Decreases Expression [12]
Protein FAM43A (FAM43A) OT5RPQRE FA43A_HUMAN Increases Expression [12]
Latent-transforming growth factor beta-binding protein 4 (LTBP4) OTC8WL2V LTBP4_HUMAN Increases Expression [12]
Transmembrane protein 256 (TMEM256) OTLNGZLX TM256_HUMAN Increases Expression [12]
Ligand-dependent nuclear receptor corepressor-like protein (LCORL) OTJNQRC5 LCORL_HUMAN Increases Expression [12]
Protein limb expression 1 homolog (LIX1) OT1CPNCC LIX1_HUMAN Decreases Expression [12]
T-complex protein 11-like protein 2 (TCP11L2) OTTIZO7B T11L2_HUMAN Increases Expression [12]
DnaJ homolog subfamily C member 22 (DNAJC22) OTGGDK70 DJC22_HUMAN Increases Expression [12]
Tetratricopeptide repeat protein 9B (TTC9B) OTHBKTIU TTC9B_HUMAN Increases Expression [12]
Protein NATD1 (NATD1) OTQF3C4I NATD1_HUMAN Increases Expression [12]
Protocadherin-20 (PCDH20) OTFSNRXK PCD20_HUMAN Decreases Expression [12]
Probable N-acetyltransferase 16 (NAT16) OTGRHAJQ NAT16_HUMAN Increases Expression [12]
Stabilizer of axonemal microtubules 5 (SAXO5) OTS9VCFR SAXO5_HUMAN Increases Expression [12]
Fanconi anemia group B protein (FANCB) OTMZTXB5 FANCB_HUMAN Decreases Expression [12]
Zinc finger protein GLIS1 (GLIS1) OTBDNB26 GLIS1_HUMAN Increases Expression [12]
NFATC2-interacting protein (NFATC2IP) OTOQ4AZ9 NF2IP_HUMAN Decreases Expression [12]
Beta-galactosidase-1-like protein 3 (GLB1L3) OTWAWGX4 GLBL3_HUMAN Decreases Expression [12]
Structural maintenance of chromosomes protein 1B (SMC1B) OTQVMF74 SMC1B_HUMAN Decreases Expression [12]
Lymphocyte antigen 6 complex locus protein G5b (LY6G5B) OTW89R8K LY65B_HUMAN Decreases Expression [12]
Transmembrane protein 52 (TMEM52) OTDLQSAX TMM52_HUMAN Increases Expression [12]
Cytosolic carboxypeptidase 3 (AGBL3) OTVH64PO CBPC3_HUMAN Decreases Expression [12]
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7 (B3GNT7) OT8UTTXF B3GN7_HUMAN Increases Expression [12]
Interleukin-17 receptor E (IL17RE) OTMFTNLS I17RE_HUMAN Increases Expression [12]
Olfactory receptor 2L3 (OR2L3) OTL6ZMOC OR2L3_HUMAN Decreases Expression [12]
Olfactory receptor 4F17 (OR4F17) OTJZ7HYD O4F17_HUMAN Decreases Expression [12]
Protocadherin-19 (PCDH19) OTSOW3MV PCD19_HUMAN Decreases Expression [12]
Arrestin domain-containing protein 2 (ARRDC2) OTVEOXAG ARRD2_HUMAN Increases Expression [12]
Guanine nucleotide exchange factor for Rab-3A (RAB3IL1) OT18H5HD R3GEF_HUMAN Increases Expression [12]
Large ribosomal subunit protein uL30m (MRPL30) OT26OPYV RM30_HUMAN Decreases Expression [12]
Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12) OT0EDNV9 GTR12_HUMAN Increases Expression [12]
Transient receptor potential cation channel subfamily M member 4 (TRPM4) OT354X8E TRPM4_HUMAN Increases Expression [12]
A disintegrin and metalloproteinase with thrombospondin motifs 17 (ADAMTS17) OTCFITM9 ATS17_HUMAN Decreases Expression [12]
ATP-dependent RNA helicase DQX1 (DQX1) OTE7BT00 DQX1_HUMAN Increases Expression [12]
Partitioning defective 3 homolog B (PARD3B) OTGZ43YI PAR3L_HUMAN Increases Expression [12]
SH3 domain and tetratricopeptide repeat-containing protein 2 (SH3TC2) OTJ6XY2A S3TC2_HUMAN Decreases Expression [12]
Glycerophosphodiester phosphodiesterase domain-containing protein 5 (GDPD5) OTUM65JL GDPD5_HUMAN Increases Expression [12]
Glutathione-specific gamma-glutamylcyclotransferase 2 (CHAC2) OTOGC15N CHAC2_HUMAN Decreases Expression [12]
DnaJ homolog subfamily A member 4 (DNAJA4) OTT7YCD2 DNJA4_HUMAN Decreases Expression [12]
G2/mitotic-specific cyclin-B3 (CCNB3) OT5V72D3 CCNB3_HUMAN Decreases Expression [12]
Junctophilin-3 (JPH3) OTHTJO2I JPH3_HUMAN Increases Expression [12]
DnaJ homolog subfamily C member 9 (DNAJC9) OTDBQBNZ DNJC9_HUMAN Decreases Expression [12]
Jun dimerization protein 2 (JDP2) OTW35WKX JDP2_HUMAN Increases Expression [12]
Microprocessor complex subunit DGCR8 (DGCR8) OT62LXE4 DGCR8_HUMAN Decreases Expression [12]
CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase (ST8SIA4) OTENME7S SIA8D_HUMAN Increases Expression [12]
Phytanoyl-CoA hydroxylase-interacting protein (PHYHIP) OTPC9JBM PHYIP_HUMAN Increases Expression [12]
Protein NDRG1 (NDRG1) OTVO66BO NDRG1_HUMAN Increases Expression [12]
General transcription factor IIH subunit 4 (GTF2H4) OTPD1DIU TF2H4_HUMAN Decreases Expression [12]
Secreted frizzled-related protein 3 (FRZB) OTTO3DPY SFRP3_HUMAN Increases Expression [12]
Bcl-2-like protein 2 (BCL2L2) OTMKVO0J B2CL2_HUMAN Decreases Expression [41]
N-alpha-acetyltransferase 80 (NAA80) OTLWR71Z NAA80_HUMAN Increases Expression [12]
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 (ATP2A3) OTFYDEES AT2A3_HUMAN Increases Expression [12]
Glycine N-acyltransferase-like protein 1 (GLYATL1) OTS8JSRY GLYL1_HUMAN Decreases Expression [12]
Terminal nucleotidyltransferase 5B (TENT5B) OTO2P28B TET5B_HUMAN Increases Expression [12]
Ras-related protein Rab-7b (RAB7B) OT60A0E9 RAB7B_HUMAN Increases Expression [12]
Pre-B-cell leukemia transcription factor-interacting protein 1 (PBXIP1) OTEAAUBY PBIP1_HUMAN Increases Expression [12]
Protein FAM131C (FAM131C) OTQPI1OZ F131C_HUMAN Increases Expression [12]
Transcription factor E2F7 (E2F7) OTWW358N E2F7_HUMAN Decreases Expression [12]
Dapper homolog 3 (DACT3) OTSNQ55G DACT3_HUMAN Increases Expression [12]
Repulsive guidance molecule A (RGMA) OTZAMDO2 RGMA_HUMAN Decreases Expression [12]
Transmembrane and immunoglobulin domain-containing protein 2 (TMIGD2) OTWWAHTV TMIG2_HUMAN Increases Expression [12]
Solute carrier family 22 member 18 (SLC22A18) OT9C3KR4 S22AI_HUMAN Increases Expression [12]
ELL-associated factor 2 (EAF2) OTSOET5L EAF2_HUMAN Decreases Expression [12]
Netrin-G2 (NTNG2) OTTY88DL NTNG2_HUMAN Increases Expression [12]
Reticulocalbin-3 (RCN3) OTHWE0NF RCN3_HUMAN Increases Expression [12]
Voltage-gated hydrogen channel 1 (HVCN1) OT4ALYU4 HVCN1_HUMAN Increases Expression [12]
Protein shisa-4 (SHISA4) OTJ8H832 SHSA4_HUMAN Increases Expression [12]
CAP-Gly domain-containing linker protein 3 (CLIP3) OTGJEGIB CLIP3_HUMAN Increases Expression [12]
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 (LINGO1) OTDCBTBS LIGO1_HUMAN Increases Expression [12]
Phosphoinositide-3-kinase-interacting protein 1 (PIK3IP1) OTWE5G4T P3IP1_HUMAN Increases Expression [12]
BLOC-1-related complex subunit 6 (BORCS6) OTTO4SWD BORC6_HUMAN Increases Expression [12]
Receptor expression-enhancing protein 6 (REEP6) OTY4FPO8 REEP6_HUMAN Increases Expression [12]
Terminal nucleotidyltransferase 5A (TENT5A) OTSYF511 TET5A_HUMAN Decreases Expression [12]
Putative protein-lysine deacylase ABHD14B (ABHD14B) OTFIYC6Y ABHEB_HUMAN Increases Expression [12]
CUGBP Elav-like family member 6 (CELF6) OT111JZ3 CELF6_HUMAN Increases Expression [12]
Junctophilin-4 (JPH4) OTRLNPJK JPH4_HUMAN Increases Expression [12]
HHIP-like protein 1 (HHIPL1) OT3GMU2X HIPL1_HUMAN Increases Expression [12]
Cadherin-related family member 1 (CDHR1) OT1ORXCM CDHR1_HUMAN Increases Expression [12]
Bcl-2-modifying factor (BMF) OT90NSLI BMF_HUMAN Increases Expression [12]
Uncharacterized protein C8orf48 (C8ORF48) OT4KE69P CH048_HUMAN Decreases Expression [12]
Cyclic nucleotide-binding domain-containing protein 2 (CNBD2) OTF42F52 CNBD2_HUMAN Increases Expression [12]
Lysophospholipid acyltransferase 7 (MBOAT7) OTHRCBLK MBOA7_HUMAN Increases Expression [12]
Sideroflexin-2 (SFXN2) OTRFKK0G SFXN2_HUMAN Decreases Expression [12]
Sterile alpha motif domain-containing protein 11 (SAMD11) OT6WRQOX SAM11_HUMAN Increases Expression [12]
AP-1 complex subunit sigma-3 (AP1S3) OTPCMV24 AP1S3_HUMAN Decreases Expression [12]
Trafficking protein particle complex subunit 9 (TRAPPC9) OTF0CVMC TPPC9_HUMAN Increases Expression [12]
Cyclin-dependent kinase 15 (CDK15) OT8S67QS CDK15_HUMAN Decreases Expression [12]
Small integral membrane protein 14 (SMIM14) OT47IF19 SIM14_HUMAN Increases Expression [12]
Tribbles homolog 3 (TRIB3) OTG5OS7X TRIB3_HUMAN Increases Expression [12]
Protein ABHD1 (ABHD1) OTY56U02 ABHD1_HUMAN Increases Expression [12]
Histone-lysine N-methyltransferase SETDB2 (SETDB2) OTBVVP9Q SETB2_HUMAN Increases Expression [12]
Calponin-2 (CNN2) OTH3CSXA CNN2_HUMAN Increases Expression [12]
TSC22 domain family protein 3 (TSC22D3) OT03UM03 T22D3_HUMAN Increases Expression [12]
Transcriptional enhancer factor TEF-5 (TEAD3) OTJ1ER44 TEAD3_HUMAN Increases Expression [12]
Monoglyceride lipase (MGLL) OT5ES4IE MGLL_HUMAN Increases Expression [12]
Homeobox protein Meis3 (MEIS3) OTQXB3XL MEIS3_HUMAN Increases Expression [12]
Septin-5 (SEPTIN5) OT6JTJBO SEPT5_HUMAN Increases Expression [12]
Chemerin-like receptor 1 (CMKLR1) OTHA8ESR CML1_HUMAN Decreases Expression [12]
Homeobox protein Nkx-3.1 (NKX3-1) OT0DO6ZU NKX31_HUMAN Decreases Expression [14]
Dual specificity protein phosphatase 9 (DUSP9) OTZZWEQL DUS9_HUMAN Increases Expression [12]
Growth/differentiation factor 15 (GDF15) OTWQN50N GDF15_HUMAN Increases Expression [12]
17-beta-hydroxysteroid dehydrogenase 14 (HSD17B14) OT0ETO72 DHB14_HUMAN Increases Expression [12]
Synaptotagmin-3 (SYT3) OT8XTGQ8 SYT3_HUMAN Increases Expression [12]
Phosphatidate phosphatase LPIN3 (LPIN3) OTK1C2KL LPIN3_HUMAN Increases Expression [12]
Calsyntenin-3 (CLSTN3) OTPUFK4C CSTN3_HUMAN Increases Expression [12]
Transcription factor COE4 (EBF4) OTGK0V7W COE4_HUMAN Increases Expression [12]
Mesoderm posterior protein 1 (MESP1) OTY5QDBN MESP1_HUMAN Increases Expression [12]
Protein orai-3 (ORAI3) OTUP3OH3 ORAI3_HUMAN Increases Expression [12]
La-related protein 6 (LARP6) OTUQ9QS9 LARP6_HUMAN Increases Expression [12]
DNA replication complex GINS protein SLD5 (GINS4) OTCVOO3S SLD5_HUMAN Decreases Expression [12]
DNA replication complex GINS protein PSF3 (GINS3) OT8NVXTD PSF3_HUMAN Decreases Expression [12]
Polycomb group RING finger protein 1 (PCGF1) OTHOU68T PCGF1_HUMAN Increases Expression [12]
Synaptotagmin-17 (SYT17) OTTW4MI3 SYT17_HUMAN Increases Expression [12]
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial (ALKBH7) OTJVS8CF ALKB7_HUMAN Increases Expression [12]
CDK5 and ABL1 enzyme substrate 2 (CABLES2) OTGD9A2A CABL2_HUMAN Decreases Expression [12]
Centromere protein O (CENPO) OTXAH83Y CENPO_HUMAN Decreases Expression [12]
Glutathione-specific gamma-glutamylcyclotransferase 1 (CHAC1) OTJGE772 CHAC1_HUMAN Increases Expression [12]
Transcriptional repressor scratch 1 (SCRT1) OTWTE24S SCRT1_HUMAN Increases Expression [12]
Transcription factor GATA-5 (GATA5) OTO81B63 GATA5_HUMAN Increases Expression [12]
Bardet-Biedl syndrome 2 protein (BBS2) OTPF9JIB BBS2_HUMAN Increases Expression [12]
TBC1 domain family member 10A (TBC1D10A) OTR2CI46 TB10A_HUMAN Increases Expression [12]
S phase cyclin A-associated protein in the endoplasmic reticulum (SCAPER) OT7S3B3P SCAPE_HUMAN Increases Expression [12]
Cadherin-related family member 2 (CDHR2) OTTHEUPO CDHR2_HUMAN Decreases Expression [12]
3'-5' exoribonuclease HELZ2 (HELZ2) OTM6HVO6 HELZ2_HUMAN Increases Expression [12]
Leucine-rich repeat-containing protein 2 (LRRC2) OTX6P291 LRRC2_HUMAN Increases Expression [12]
Zinc finger protein GLIS2 (GLIS2) OTOUUV1X GLIS2_HUMAN Increases Expression [12]
Reticulon-4 receptor (RTN4R) OT8J693X RTN4R_HUMAN Increases Expression [12]
Glutamate receptor-interacting protein 2 (GRIP2) OT8DGYZ5 GRIP2_HUMAN Increases Expression [12]
DNA-directed RNA polymerase II subunit RPB11-b1 (POLR2J3) OTXTSHH8 RPB1B_HUMAN Decreases Expression [12]
Phospholysine phosphohistidine inorganic pyrophosphate phosphatase (LHPP) OT9AGAIJ LHPP_HUMAN Increases Expression [12]
Coiled-coil domain-containing protein 113 (CFAP263) OTE206QS CC113_HUMAN Increases Expression [12]
Gamma-aminobutyric acid receptor-associated protein-like 1 (GABARAPL1) OT4U7SBG GBRL1_HUMAN Increases Expression [12]
Stathmin-4 (STMN4) OT7ZUKW6 STMN4_HUMAN Increases Expression [12]
ATP-binding cassette sub-family G member 4 (ABCG4) OT2XJIOG ABCG4_HUMAN Increases Expression [12]
Opsin-3 (OPN3) OTON6BFU OPN3_HUMAN Increases Expression [12]
Spectrin beta chain, non-erythrocytic 4 (SPTBN4) OTAJAVP9 SPTN4_HUMAN Increases Expression [12]
Carbohydrate sulfotransferase 8 (CHST8) OTQT4TKR CHST8_HUMAN Increases Expression [12]
Coiled-coil domain-containing protein 68 (CCDC68) OT4KF6TL CCD68_HUMAN Decreases Expression [12]
Solute carrier organic anion transporter family member 5A1 (SLCO5A1) OTNXXTH0 SO5A1_HUMAN Increases Expression [12]
Potassium voltage-gated channel subfamily F member 1 (KCNF1) OTEROKP4 KCNF1_HUMAN Increases Expression [12]
Semaphorin-4A (SEMA4A) OT8901H3 SEM4A_HUMAN Increases Expression [12]
Semaphorin-6B (SEMA6B) OT3VVVUO SEM6B_HUMAN Increases Expression [12]
Actin-like protein 8 (ACTL8) OTUDD0QT ACTL8_HUMAN Decreases Expression [12]
PDZ domain-containing protein 7 (PDZD7) OTX3VAOB PDZD7_HUMAN Increases Expression [12]
Fibronectin type III domain-containing protein 4 (FNDC4) OTOQK0WK FNDC4_HUMAN Increases Expression [12]
Proline-rich protein 36 (PRR36) OTUJII07 PRR36_HUMAN Increases Expression [12]
Transmembrane protein 231 (TMEM231) OTF4UYIE TM231_HUMAN Increases Expression [12]
PDZ domain-containing protein MAGIX (MAGIX) OT8EU651 MAGIX_HUMAN Increases Expression [12]
Gremlin-2 (GREM2) OTE91EWT GREM2_HUMAN Decreases Expression [12]
Exonuclease V (EXO5) OTIN7L7I EXO5_HUMAN Decreases Expression [12]
Dedicator of cytokinesis protein 5 (DOCK5) OT63I0CL DOCK5_HUMAN Decreases Expression [12]
RING finger protein 122 (RNF122) OT8RE3IM RN122_HUMAN Increases Expression [12]
TBC1 domain family member 17 (TBC1D17) OT75ZWLB TBC17_HUMAN Increases Expression [12]
Claspin (CLSPN) OTZZXNDK CLSPN_HUMAN Decreases Expression [12]
Potassium channel subfamily K member 13 (KCNK13) OTMOT2KX KCNKD_HUMAN Decreases Expression [12]
Pleckstrin homology domain-containing family A member 2 (PLEKHA2) OTY2AP6T PKHA2_HUMAN Increases Expression [12]
MAP kinase-interacting serine/threonine-protein kinase 2 (MKNK2) OTNA9G8V MKNK2_HUMAN Increases Expression [12]
Nuclear receptor coactivator 5 (NCOA5) OTOGWTWB NCOA5_HUMAN Decreases Expression [12]
DNA polymerase delta subunit 4 (POLD4) OTG578YH DPOD4_HUMAN Increases Expression [12]
Receptor-type tyrosine-protein phosphatase H (PTPRH) OTDUHQGF PTPRH_HUMAN Increases Expression [12]
5'(3')-deoxyribonucleotidase, mitochondrial (NT5M) OTJF73BA NT5M_HUMAN Increases Expression [12]
Transcriptional repressor scratch 2 (SCRT2) OTXN2VYF SCRT2_HUMAN Increases Expression [12]
G-protein coupled receptor family C group 5 member C (GPRC5C) OT45AJT3 GPC5C_HUMAN Increases Expression [12]
Fructose-2,6-bisphosphatase TIGAR (TIGAR) OTR7NMRJ TIGAR_HUMAN Decreases Expression [12]
E3 ubiquitin-protein ligase Jade-2 (JADE2) OTVG2MYF JADE2_HUMAN Increases Expression [12]
Nectin-3 (NECTIN3) OTS8N7MK NECT3_HUMAN Decreases Expression [12]
Beta-catenin-interacting protein 1 (CTNNBIP1) OTX9SBJG CNBP1_HUMAN Increases Expression [12]
Homer protein homolog 3 (HOMER3) OTQ6D9X1 HOME3_HUMAN Increases Expression [12]
Cytokine-inducible SH2-containing protein (CISH) OT8T5NYL CISH_HUMAN Increases Expression [12]
Kinesin light chain 4 (KLC4) OTACUFB2 KLC4_HUMAN Increases Expression [12]
SERTA domain-containing protein 4 (SERTAD4) OTZ1GUD9 SRTD4_HUMAN Decreases Expression [12]
Shiftless antiviral inhibitor of ribosomal frameshifting protein (SHFL) OTZ4771K SHFL_HUMAN Increases Expression [12]
Inactive ubiquitin thioesterase OTULINL (OTULINL) OTNOC9L1 OTULL_HUMAN Decreases Expression [12]
Protein eva-1 homolog B (EVA1B) OTDNAKQD EVA1B_HUMAN Increases Expression [12]
Transmembrane protein 45A (TMEM45A) OT54KJG6 TM45A_HUMAN Increases Expression [12]
Spermine oxidase (SMOX) OT11E62Y SMOX_HUMAN Increases Expression [12]
Nicotinamide riboside kinase 1 (NMRK1) OT0STQLV NRK1_HUMAN Increases Expression [12]
DNA damage-inducible transcript 4 protein (DDIT4) OTHY8SY4 DDIT4_HUMAN Increases Expression [12]
Protein FAM13B (FAM13B) OTNQTYSM FA13B_HUMAN Decreases Expression [12]
BET1-like protein (BET1L) OT5QVYBZ BET1L_HUMAN Increases Expression [12]
Denticleless protein homolog (DTL) OTC29RYE DTL_HUMAN Decreases Expression [12]
Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3) OT0DZGY4 E2AK3_HUMAN Increases Expression [30]
Programmed cell death 1 ligand 1 (CD274) OTJ0VFDL PD1L1_HUMAN Decreases Expression [15]
Leucine-rich repeat transmembrane protein FLRT3 (FLRT3) OT3XMZU3 FLRT3_HUMAN Decreases Expression [12]
Calcium permeable stress-gated cation channel 1 (TMEM63C) OTKDX01I CSC1_HUMAN Increases Expression [12]
Calmodulin-regulated spectrin-associated protein 3 (CAMSAP3) OTQGT916 CAMP3_HUMAN Increases Expression [12]
BTB/POZ domain-containing protein 7 (BTBD7) OTNUV6MQ BTBD7_HUMAN Decreases Expression [12]
Armadillo repeat-containing X-linked protein 1 (ARMCX1) OTOGL58Z ARMX1_HUMAN Increases Expression [12]
Vesicular glutamate transporter 1 (SLC17A7) OTTYXG3C VGLU1_HUMAN Increases Expression [12]
Homologous-pairing protein 2 homolog (PSMC3IP) OT9UB5UO HOP2_HUMAN Decreases Expression [12]
NF-kappa-B inhibitor-like protein 1 (NFKBIL1) OTYFTPS0 IKBL1_HUMAN Increases Expression [12]
C-type mannose receptor 2 (MRC2) OTLWQAX1 MRC2_HUMAN Increases Expression [12]
Hairy/enhancer-of-split related with YRPW motif protein 2 (HEY2) OTU4J3ZI HEY2_HUMAN Increases Expression [29]
Heat shock protein beta-7 (HSPB7) OTLATAOV HSPB7_HUMAN Increases Expression [12]
CAP-Gly domain-containing linker protein 2 (CLIP2) OTSCIQIY CLIP2_HUMAN Increases Expression [12]
Small conductance calcium-activated potassium channel protein 3 (KCNN3) OT11KYA8 KCNN3_HUMAN Increases Expression [12]
Lysine-specific demethylase 5B (KDM5B) OT5DL94T KDM5B_HUMAN Increases Expression [12]
NADPH-dependent diflavin oxidoreductase 1 (NDOR1) OTKEA582 NDOR1_HUMAN Decreases Expression [12]
rRNA methyltransferase 2, mitochondrial (MRM2) OTRYA1HU MRM2_HUMAN Decreases Expression [12]
Krueppel-like factor 15 (KLF15) OTGMQMVR KLF15_HUMAN Increases Expression [12]
F-box only protein 2 (FBXO2) OTF3677S FBX2_HUMAN Increases Expression [12]
Peroxisomal carnitine O-octanoyltransferase (CROT) OTWK68MM OCTC_HUMAN Decreases Expression [12]
Zinc finger protein Helios (IKZF2) OTZIMARJ IKZF2_HUMAN Increases Expression [12]
Polyadenylate-binding protein-interacting protein 2B (PAIP2B) OT7MUY3B PAI2B_HUMAN Increases Expression [12]
Ras-related protein Rab-26 (RAB26) OTHMPRJK RAB26_HUMAN Increases Expression [12]
Intercellular adhesion molecule 5 (ICAM5) OTDGGAFH ICAM5_HUMAN Increases Expression [12]
Ornithine decarboxylase antizyme 3 (OAZ3) OT8Q5PVB OAZ3_HUMAN Increases Expression [12]
RNA-binding protein Nova-2 (NOVA2) OTQ2X3Q4 NOVA2_HUMAN Increases Expression [12]
Frizzled-1 (FZD1) OTZATHVS FZD1_HUMAN Affects Localization [26]
Cytosolic phospholipase A2 gamma (PLA2G4C) OTIK5GT5 PA24C_HUMAN Increases Expression [12]
LIM/homeobox protein Lhx6 (LHX6) OT47UQZ5 LHX6_HUMAN Increases Expression [12]
IQ motif and SEC7 domain-containing protein 3 (IQSEC3) OTBHQK29 IQEC3_HUMAN Increases Expression [12]
PHD finger protein 24 (PHF24) OTTIYK64 PHF24_HUMAN Increases Expression [12]
GRB2-associated-binding protein 2 (GAB2) OTBFN705 GAB2_HUMAN Increases Expression [12]
Histone deacetylase 5 (HDAC5) OTWG387P HDAC5_HUMAN Increases Expression [12]
Calcium/calmodulin-dependent protein kinase type II subunit alpha (CAMK2A) OTJGX19T KCC2A_HUMAN Increases Expression [12]
C-type lectin domain family 11 member A (CLEC11A) OT9KBH7C CLC11_HUMAN Increases Expression [12]
DNA replication complex GINS protein PSF2 (GINS2) OT974IYI PSF2_HUMAN Decreases Expression [12]
Nuclease EXOG, mitochondrial (EXOG) OTZAI8L7 EXOG_HUMAN Decreases Expression [12]
Myelin regulatory factor (MYRF) OTKF6AEB MYRF_HUMAN Increases Expression [12]
Microtubule-associated serine/threonine-protein kinase 1 (MAST1) OTEYFN5O MAST1_HUMAN Increases Expression [12]
R3H domain-containing protein 2 (R3HDM2) OTMJ3S6J R3HD2_HUMAN Increases Expression [12]
Lambda-crystallin homolog (CRYL1) OT0SJSJM CRYL1_HUMAN Increases Expression [12]
Mediator of RNA polymerase II transcription subunit 31 (MED31) OTFVKXJE MED31_HUMAN Decreases Expression [12]
RWD domain-containing protein 3 (RWDD3) OTE76DY5 RWDD3_HUMAN Decreases Expression [12]
Dual specificity tyrosine-phosphorylation-regulated kinase 1B (DYRK1B) OTO7O3CU DYR1B_HUMAN Increases Expression [12]
Tesmin (TESMIN) OTZ5UILU MTL5_HUMAN Increases Expression [12]
Tubulin monoglycylase TTLL3 (TTLL3) OT7JWXHA TTLL3_HUMAN Increases Expression [12]
NADPH oxidase 1 (NOX1) OTZPJQCC NOX1_HUMAN Decreases Expression [12]
Endothelial lipase (LIPG) OTHEE942 LIPG_HUMAN Decreases Expression [12]
NF-kappa-B essential modulator (IKBKG) OTNWJWSD NEMO_HUMAN Affects Localization [27]
Diacylglycerol kinase beta (DGKB) OTTT9SZJ DGKB_HUMAN Increases Expression [12]
RING finger protein 215 (RNF215) OT44XNT7 RN215_HUMAN Increases Expression [12]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Increases Response To Substance [25]
Insulin-like growth factor 1 receptor (IGF1R) OTXJIF13 IGF1R_HUMAN Affects Response To Substance [42]
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⏷ Show the Full List of 766 DOT(s)

References

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3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8494).
4 Niclosamide FDA Label
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8 Targeting CD46 for both adenocarcinoma and neuroendocrine prostate cancer. JCI Insight. 2018 Sep 6;3(17):e121497. doi: 10.1172/jci.insight.121497. eCollection 2018 Sep 6.
9 Targeting chromatin binding regulation of constitutively active AR variants to overcome prostate cancer resistance to endocrine-based therapies. Nucleic Acids Res. 2015 Jul 13;43(12):5880-97. doi: 10.1093/nar/gkv262. Epub 2015 Apr 23.
10 Growth inhibition of ovarian tumor-initiating cells by niclosamide. Mol Cancer Ther. 2012 Aug;11(8):1703-12.
11 Computational discovery of niclosamide ethanolamine, a repurposed drug candidate that reduces growth of hepatocellular carcinoma cells initro and in mice by inhibiting cell division cycle 37 signaling. Gastroenterology. 2017 Jun;152(8):2022-2036.
12 Mitochondrial Uncoupling Induces Epigenome Remodeling and Promotes Differentiation in Neuroblastoma. Cancer Res. 2023 Jan 18;83(2):181-194. doi: 10.1158/0008-5472.CAN-22-1029.
13 WNT7A/-catenin signaling induces FGF1 and influences sensitivity to niclosamide in ovarian cancer. Oncogene. 2015 Jun;34(26):3452-62. doi: 10.1038/onc.2014.277. Epub 2014 Sep 1.
14 Niclosamide and Bicalutamide Combination Treatment Overcomes Enzalutamide- and Bicalutamide-Resistant Prostate Cancer. Mol Cancer Ther. 2017 Aug;16(8):1521-1530. doi: 10.1158/1535-7163.MCT-16-0912. Epub 2017 May 12.
15 The anthelmintic drug niclosamide induces GSK--mediated -catenin degradation to potentiate gemcitabine activity, reduce immune evasion ability and suppress pancreatic cancer progression. Cell Death Dis. 2022 Feb 3;13(2):112. doi: 10.1038/s41419-022-04573-7.
16 The Antihelminthic Niclosamide Inhibits Cancer Stemness, Extracellular Matrix Remodeling, and Metastasis through Dysregulation of the Nuclear -catenin/c-Myc axis in OSCC. Sci Rep. 2018 Aug 24;8(1):12776. doi: 10.1038/s41598-018-30692-3.
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18 Antineoplastic mechanisms of niclosamide in acute myelogenous leukemia stem cells: inactivation of the NF-kappaB pathway and generation of reactive oxygen species. Cancer Res. 2010 Mar 15;70(6):2516-27. doi: 10.1158/0008-5472.CAN-09-3950. Epub 2010 Mar 9.
19 Generation and evaluation of a CYP2C9 heteroactivation pharmacophore. J Pharmacol Exp Ther. 2003 Dec;307(3):878-87.
20 CYP1A1 and Cnr nitroreductase bioactivated niclosamide in vitro. Mutagenesis. 2013 Nov;28(6):645-51.
21 Application of higher throughput screening (HTS) inhibition assays to evaluate the interaction of antiparasitic drugs with cytochrome P450s. Drug Metab Dispos. 2001 Jan;29(1):30-5.
22 Cytochrome P450 1A1/2 induction by antiparasitic drugs: dose-dependent increase in ethoxyresorufin O-deethylase activity and mRNA caused by quinine, primaquine and albendazole in HepG2 cells. Eur J Clin Pharmacol. 2002 Nov;58(8):537-42.
23 Inhibition of Wnt/beta-catenin pathway by niclosamide: a therapeutic target for ovarian cancer. Gynecol Oncol. 2014 Jul;134(1):112-20.
24 Niclosamide, an oral antihelmintic drug, exhibits antimetastatic activity in hepatocellular carcinoma cells through downregulating twist-mediated CD10 expression. Environ Toxicol. 2018 Jun;33(6):659-669.
25 Mitochondrial uncoupling reveals a novel therapeutic opportunity for p53-defective cancers. Nat Commun. 2018 Sep 26;9(1):3931.
26 The anti-helminthic niclosamide inhibits Wnt/Frizzled1 signaling. Biochemistry. 2009 Nov 3;48(43):10267-74. doi: 10.1021/bi9009677.
27 Niclosamide, an anti-helminthic molecule, downregulates the retroviral oncoprotein Tax and pro-survival Bcl-2 proteins in HTLV-1-transformed T lymphocytes. Biochem Biophys Res Commun. 2015 Aug 14;464(1):221-228. doi: 10.1016/j.bbrc.2015.06.120. Epub 2015 Jun 23.
28 EGF promotes HIF-1 expression in colorectal cancer cells and tumor metastasis by regulating phosphorylation of STAT3. Eur Rev Med Pharmacol Sci. 2019 Feb;23(3):1055-1062. doi: 10.26355/eurrev_201902_16993.
29 The autonomous notch signal pathway is activated by baicalin and baicalein but is suppressed by niclosamide in K562 cells. J Cell Biochem. 2009 Mar 1;106(4):682-92. doi: 10.1002/jcb.22065.
30 Niclosamide induced cell apoptosis via upregulation of ATF3 and activation of PERK in Hepatocellular carcinoma cells. BMC Gastroenterol. 2016 Feb 25;16:25. doi: 10.1186/s12876-016-0442-3.
31 Niclosamide enhances ROS-mediated cell death through c-Jun activation. Biomed Pharmacother. 2014 Jun;68(5):619-24. doi: 10.1016/j.biopha.2014.03.018. Epub 2014 Mar 28.
32 Niclosamide inhibits epithelial-mesenchymal transition with apoptosis induction in BRAF/ NRAS mutated metastatic melanoma cells. Toxicol In Vitro. 2023 Jun;89:105579. doi: 10.1016/j.tiv.2023.105579. Epub 2023 Mar 3.
33 Targeting of cell cycle and let-7a/STAT3 pathway by niclosamide inhibits proliferation, migration and invasion in oral squamous cell carcinoma cells. Biomed Pharmacother. 2017 Dec;96:434-442. doi: 10.1016/j.biopha.2017.09.149. Epub 2017 Oct 12.
34 Computational drugs repositioning identifies inhibitors of oncogenic PI3K/AKT/P70S6K-dependent pathways among FDA-approved compounds. Oncotarget. 2016 Sep 13;7(37):58743-58758. doi: 10.18632/oncotarget.11318.
35 Novel effect of antihelminthic Niclosamide on S100A4-mediated metastatic progression in colon cancer. J Natl Cancer Inst. 2011 Jul 6;103(13):1018-36. doi: 10.1093/jnci/djr190. Epub 2011 Jun 17.
36 Niclosamide Exhibits Potent Anticancer Activity and Synergizes with Sorafenib in Human Renal Cell Cancer Cells. Cell Physiol Biochem. 2018;47(3):957-971. doi: 10.1159/000490140. Epub 2018 May 24.
37 A HAMP promoter bioassay system for identifying chemical compounds that modulate hepcidin expression. Exp Hematol. 2015 May;43(5):404-413.e5. doi: 10.1016/j.exphem.2015.01.005. Epub 2015 Jan 26.
38 Niclosamide induces apoptosis in human rheumatoid arthritis fibroblast-like synoviocytes. Int Immunopharmacol. 2016 Feb;31:45-9. doi: 10.1016/j.intimp.2015.11.002. Epub 2015 Dec 17.
39 Role of the IL-6-JAK1-STAT3-Oct-4 pathway in the conversion of non-stem cancer cells into cancer stem-like cells. Cell Signal. 2013 Apr;25(4):961-9. doi: 10.1016/j.cellsig.2013.01.007. Epub 2013 Jan 16.
40 Anthelmintic Niclosamide Disrupts the Interplay of p65 and FOXM1/-catenin and Eradicates Leukemia Stem Cells in Chronic Myelogenous Leukemia. Clin Cancer Res. 2017 Feb 1;23(3):789-803. doi: 10.1158/1078-0432.CCR-16-0226. Epub 2016 Aug 4.
41 Niclosamide overcomes acquired resistance to erlotinib through suppression of STAT3 in non-small cell lung cancer. Mol Cancer Ther. 2013 Oct;12(10):2200-12. doi: 10.1158/1535-7163.MCT-13-0095. Epub 2013 Jul 26.
42 A Blockade of IGF Signaling Sensitizes Human Ovarian Cancer Cells to the Anthelmintic Niclosamide-Induced Anti-Proliferative and Anticancer Activities. Cell Physiol Biochem. 2016;39(3):871-88. doi: 10.1159/000447797. Epub 2016 Aug 9.