Details of the Drug Combination

General Information of Drug Combination (ID: DCRVBBM)

Drug Combination Name
Tropicamide Tropicamide
Indication
Disease Entry Status REF
Sialorrhea Secondary to Parkinson's Disease Phase 2 [1]
Component Drugs Tropicamide   DM1D90W Tropicamide   DM1D90W
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Tropicamide
Disease Entry ICD 11 Status REF
Mydriasis LA11.62 Approved [2]
Tropicamide Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Muscarinic acetylcholine receptor M4 (CHRM4) TTQ3JTF ACM4_HUMAN Antagonist [3]
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Tropicamide Interacts with 1 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Apolipoprotein E (APOE) OTFOWL2H APOE_HUMAN Increases Response To Substance [4]
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Indication(s) of Tropicamide
Disease Entry ICD 11 Status REF
Mydriasis LA11.62 Approved [2]
Tropicamide Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Muscarinic acetylcholine receptor M4 (CHRM4) TTQ3JTF ACM4_HUMAN Antagonist [3]
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Tropicamide Interacts with 1 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Apolipoprotein E (APOE) OTFOWL2H APOE_HUMAN Increases Response To Substance [4]
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References

1 ClinicalTrials.gov (NCT00761137) Safety and Efficacy Study of NH004 Films for Relief of Sialorrhea Symptoms in Parkinson's Disease Patients
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7319).
3 The muscarinic receptor antagonist tropicamide suppresses tremulous jaw movements in a rodent model of parkinsonian tremor: possible role of M4 rec... Psychopharmacology (Berl). 2007 Oct;194(3):347-59.
4 Pupil dilatation assay by tropicamide is modulated by apolipoprotein E epsilon 4 allele dosage in Alzheimer's disease. Neuroreport. 1996 Mar 22;7(4):918-20. doi: 10.1097/00001756-199603220-00017.