Details of the Drug Combination

General Information of Drug Combination (ID: DCUGMZJ)

Drug Combination Name
Pindolol METHYLENEDIOXYMETHAMPHETAMINE
Indication
Disease Entry Status REF
Mood Disorder Phase 1 [1]
Component Drugs Pindolol   DMD2NV7 METHYLENEDIOXYMETHAMPHETAMINE   DMYVU47
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Pindolol
Disease Entry ICD 11 Status REF
Hypertension BA00-BA04 Approved [2]
Pindolol Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Adrenergic receptor beta-1 (ADRB1) TTR6W5O ADRB1_HUMAN Antagonist [4]
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Pindolol Interacts with 2 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Renin (REN) OT52GZR2 RENI_HUMAN Decreases Activity [5]
Beta-2 adrenergic receptor (ADRB2) OTSDOX4Q ADRB2_HUMAN Decreases Expression [6]
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Indication(s) of METHYLENEDIOXYMETHAMPHETAMINE
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [3]
METHYLENEDIOXYMETHAMPHETAMINE Interacts with 7 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Norepinephrine transporter (NET) TTAWNKZ SC6A2_HUMAN Inhibitor [7]
Serotonin transporter (SERT) TT3ROYC SC6A4_HUMAN Inhibitor [7]
5-HT 2B receptor (HTR2B) TT0K1SC 5HT2B_HUMAN Agonist [7]
5-HT 2A receptor (HTR2A) TTJQOD7 5HT2A_HUMAN Agonist [7]
Synaptic vesicle amine transporter (SLC18A2) TTNZRI3 VMAT2_HUMAN Antagonist [7]
Dopamine transporter (DAT) TTVBI8W SC6A3_HUMAN Inhibitor [7]
5-HT 2C receptor (HTR2C) TTWJBZ5 5HT2C_HUMAN Agonist [7]
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⏷ Show the Full List of 7 DTT(s)
METHYLENEDIOXYMETHAMPHETAMINE Interacts with 3 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 2D6 (CYP2D6) DECB0K3 CP2D6_HUMAN Metabolism [8]
Catechol O-methyltransferase (COMT) DEV3T4A COMT_HUMAN Metabolism [8]
Cytochrome P450 102A1 (cyp102) DE4OGUF CPXB_BACMB Metabolism [9]
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METHYLENEDIOXYMETHAMPHETAMINE Interacts with 9 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Bcl-2-like protein 11 (BCL2L11) OTNQQWFJ B2L11_HUMAN Increases Expression [10]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Decreases Activity [11]
Sodium-dependent serotonin transporter (SLC6A4) OT6FGDLW SC6A4_HUMAN Decreases Activity [12]
BH3-interacting domain death agonist (BID) OTOSHSHU BID_HUMAN Increases Expression [10]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Decreases Expression [10]
Bcl-2 homologous antagonist/killer (BAK1) OTDP6ILW BAK_HUMAN Increases Expression [10]
Bcl2-associated agonist of cell death (BAD) OT63ERYM BAD_HUMAN Increases Expression [10]
Bcl-2-binding component 3, isoforms 3/4 (BBC3) OTUAXDAY BBC3B_HUMAN Increases Expression [10]
Arylamine N-acetyltransferase 2 (NAT2) OTBPDQOY ARY2_HUMAN Increases Acetylation [13]
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⏷ Show the Full List of 9 DOT(s)

References

1 ClinicalTrials.gov (NCT00895804) Pharmacological Interaction Between Pindolol and MDMA (3,4-Methylenedioxymethamphetamine)
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 91).
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4574).
4 Are we misunderstanding beta-blockers. Int J Cardiol. 2007 Aug 9;120(1):10-27.
5 Beta-adrenergic receptor blocking drugs, hypertension and plasma renin. Br J Clin Pharmacol. 1975 Apr;2(2):159-64. doi: 10.1111/j.1365-2125.1975.tb01571.x.
6 Effects of chronic pindolol treatment on human myocardial beta 1- and beta 2-adrenoceptor function. Naunyn Schmiedebergs Arch Pharmacol. 1990 Oct;342(4):429-35. doi: 10.1007/BF00169460.
7 The origin of MDMA (ecstasy) revisited: the true story reconstructed from the original documents. Addiction. 2006 Sep;101(9):1241-5.
8 Human pharmacology of MDMA: pharmacokinetics, metabolism, and disposition. Ther Drug Monit. 2004 Apr;26(2):137-44.
9 The bacterial P450 BM3: a prototype for a biocatalyst with human P450 activities. Trends Biotechnol. 2007 Jul;25(7):289-98.
10 An insight into the hepatocellular death induced by amphetamines, individually and in combination: the involvement of necrosis and apoptosis. Arch Toxicol. 2013 Dec;87(12):2165-85. doi: 10.1007/s00204-013-1082-9. Epub 2013 Jul 3.
11 P-glycoprotein modulation by the designer drugs methylenedioxymethamphetamine, methylenedioxyethylamphetamine and paramethoxyamphetamine. Addict Biol. 2003 Dec;8(4):413-8. doi: 10.1080/13556210310001646475.
12 Pharmacological characterization of the aminorex analogs 4-MAR, 4,4'-DMAR, and 3,4-DMAR. Neurotoxicology. 2019 May;72:95-100. doi: 10.1016/j.neuro.2019.02.011. Epub 2019 Feb 15.
13 N-acetyltransferase 2 genetic polymorphism modifies genotoxic and oxidative damage from new psychoactive substances. Arch Toxicol. 2023 Jan;97(1):189-199. doi: 10.1007/s00204-022-03383-2. Epub 2022 Sep 23.