Details of the Drug Combination

General Information of Drug Combination (ID: DCV5KDL)

Drug Combination Name
Lomustine DTI-015
Indication
Disease Entry Status REF
Glioblastoma Multiforme Phase 1 [1]
Component Drugs Lomustine   DMMWSUL DTI-015   DMXZRW0
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Lomustine
Disease Entry ICD 11 Status REF
Brain cancer 2A00 Approved [2]
Central nervous system neoplasm N.A. Approved [3]
Primitive neuroectodermal tumor N.A. Approved [3]
Classic Hodgkin lymphoma N.A. Investigative [3]
Lomustine Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Human Deoxyribonucleic acid (hDNA) TTUTN1I NOUNIPROTAC Inhibitor [9]
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Lomustine Interacts with 5 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Increases Expression [10]
DNA damage-inducible transcript 3 protein (DDIT3) OTI8YKKE DDIT3_HUMAN Increases Expression [11]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Increases Expression [12]
DNA polymerase eta (POLH) OTN07WXU POLH_HUMAN Increases Expression [13]
Methylated-DNA--protein-cysteine methyltransferase (MGMT) OT40A9WH MGMT_HUMAN Decreases Response To Substance [14]
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Indication(s) of DTI-015
Disease Entry ICD 11 Status REF
Brain cancer 2A00 Approved [4]
Glioblastoma of brain 2A00.00 Approved [5]
Liver cancer 2C12 Approved [6]
Malignant glioma 2A00.0 Approved [7]
Plasma cell myeloma 2A83.1 Approved [8]
Classic Hodgkin lymphoma N.A. Investigative [8]
DTI-015 Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Human Deoxyribonucleic acid (hDNA) TTUTN1I NOUNIPROTAC Binder [6]
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DTI-015 Interacts with 2 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 1A2 (CYP1A2) DEJGDUW CP1A2_HUMAN Metabolism [18]
Glutathione S-transferase alpha-1 (GSTA1) DE4ZHS1 GSTA1_HUMAN Metabolism [19]
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DTI-015 Interacts with 293 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Methylated-DNA--protein-cysteine methyltransferase (MGMT) OT40A9WH MGMT_HUMAN Decreases Response To Substance [16]
Probable G-protein coupled receptor 25 (GPR25) OTXTNEW3 GPR25_HUMAN Decreases Expression [15]
Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B) OTQ4W7MT TR11B_HUMAN Decreases Expression [15]
Ladinin-1 (LAD1) OT6YGTVX LAD1_HUMAN Decreases Expression [15]
Immunoglobulin superfamily containing leucine-rich repeat protein (ISLR) OTOLYLGI ISLR_HUMAN Decreases Expression [15]
Homeobox protein CDX-4 (CDX4) OTD1SQKM CDX4_HUMAN Decreases Expression [15]
Segment polarity protein dishevelled homolog DVL-1 (DVL1) OTD67RF1 DVL1_HUMAN Decreases Expression [15]
Tetraspanin-4 (TSPAN4) OTKFK57F TSN4_HUMAN Decreases Expression [15]
Actin-related protein 2/3 complex subunit 2 (ARPC2) OTSOKOMY ARPC2_HUMAN Decreases Expression [15]
Short stature homeobox protein (SHOX) OTE0YZJO SHOX_HUMAN Decreases Expression [15]
Polyunsaturated fatty acid lipoxygenase ALOX15B (ALOX15B) OTWQQ08W LX15B_HUMAN Decreases Expression [15]
Prosaposin receptor GPR37 (GPR37) OTIMDDI3 GPR37_HUMAN Decreases Expression [15]
Protein phosphatase 1G (PPM1G) OTLZL9CG PPM1G_HUMAN Decreases Expression [15]
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (INPPL1) OTCDAVBQ SHIP2_HUMAN Decreases Expression [15]
Insulin-induced gene 1 protein (INSIG1) OTZF5X1D INSI1_HUMAN Decreases Expression [15]
Beta-1,4-galactosyltransferase 5 (B4GALT5) OTHMZY12 B4GT5_HUMAN Decreases Expression [15]
NADH dehydrogenase 1 subunit C1, mitochondrial (NDUFC1) OTJ5TNHB NDUC1_HUMAN Decreases Expression [15]
Transcription factor 21 (TCF21) OT393IMA TCF21_HUMAN Decreases Expression [15]
Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 (DHX16) OTW8KZAU DHX16_HUMAN Decreases Expression [15]
LIM homeobox transcription factor 1-beta (LMX1B) OTM8145D LMX1B_HUMAN Decreases Expression [15]
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 (PFKFB2) OTG7NW98 F262_HUMAN Decreases Expression [15]
A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS4) OT4CA13K ATS4_HUMAN Decreases Expression [15]
Probable G-protein coupled receptor 32 (GPR32) OTTWHSP9 GPR32_HUMAN Decreases Expression [15]
Leucine-rich repeat and calponin homology domain-containing protein 4 (LRCH4) OTJFA4AV LRCH4_HUMAN Decreases Expression [15]
Extracellular matrix protein 2 (ECM2) OTNGYVMR ECM2_HUMAN Increases Expression [15]
Aquaporin-8 (AQP8) OT99JKME AQP8_HUMAN Decreases Expression [15]
BAI1-associated protein 3 (BAIAP3) OTS1H0J0 BAIP3_HUMAN Decreases Expression [15]
Sorbin and SH3 domain-containing protein 2 (SORBS2) OTJSX44Y SRBS2_HUMAN Decreases Expression [15]
Homeobox protein Nkx-2.2 (NKX2-2) OTDCOYNG NKX22_HUMAN Decreases Expression [15]
Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein (ASMTL) OTPUGCZO ASML_HUMAN Decreases Expression [15]
Adenomatous polyposis coli protein 2 (APC2) OTRH91CX APCL_HUMAN Decreases Expression [15]
B-cell lymphoma/leukemia 10 (BCL10) OT47MCLI BCL10_HUMAN Increases Expression [15]
Ferritin light chain (FTL) OTYQA8A6 FRIL_HUMAN Decreases Expression [15]
Ferritin heavy chain (FTH1) OT6IFS0O FRIH_HUMAN Decreases Expression [15]
Muellerian-inhibiting factor (AMH) OT5FH4BD MIS_HUMAN Decreases Expression [15]
Protamine-2 (PRM2) OTSAXTSQ PRM2_HUMAN Decreases Expression [15]
Non-histone chromosomal protein HMG-17 (HMGN2) OTN20MEF HMGN2_HUMAN Decreases Expression [15]
Tyrosine-protein kinase Fyn (FYN) OTLSLVZS FYN_HUMAN Decreases Expression [15]
Creatine kinase M-type (CKM) OTME0KO7 KCRM_HUMAN Decreases Expression [15]
Acetylcholine receptor subunit gamma (CHRNG) OTXC2UR7 ACHG_HUMAN Decreases Expression [15]
Profilin-1 (PFN1) OTHTGA1H PROF1_HUMAN Decreases Expression [15]
ATP-dependent 6-phosphofructokinase, muscle type (PFKM) OT1QY9JM PFKAM_HUMAN Decreases Expression [15]
U2 small nuclear ribonucleoprotein B'' (SNRPB2) OT6XISJD RU2B_HUMAN Increases Expression [15]
Glycodelin (PAEP) OTQA0NV4 PAEP_HUMAN Decreases Expression [15]
B-cell antigen receptor complex-associated protein alpha chain (CD79A) OTOJC8DV CD79A_HUMAN Decreases Expression [15]
Alpha-actinin-1 (ACTN1) OTUCLNXH ACTN1_HUMAN Decreases Expression [15]
Platelet glycoprotein Ib beta chain (GP1BB) OTD7XNLL GP1BB_HUMAN Decreases Expression [15]
C-C motif chemokine 2 (CCL2) OTAD2HEL CCL2_HUMAN Increases Expression [15]
Sodium/potassium-transporting ATPase subunit alpha-3 (ATP1A3) OTM8EG6H AT1A3_HUMAN Decreases Expression [15]
Glial fibrillary acidic protein (GFAP) OTQ01ZAS GFAP_HUMAN Decreases Expression [15]
Myoblast determination protein 1 (MYOD1) OTV2S79X MYOD1_HUMAN Decreases Expression [15]
Myogenin (MYOG) OTPLJKFA MYOG_HUMAN Decreases Expression [15]
Beta-galactoside alpha-2,6-sialyltransferase 1 (ST6GAL1) OT7US3NO SIAT1_HUMAN Increases Expression [15]
Histone H2AX (H2AX) OT18UX57 H2AX_HUMAN Decreases Expression [15]
Pituitary adenylate cyclase-activating polypeptide (ADCYAP1) OT0LQH93 PACA_HUMAN Decreases Expression [15]
DNA-directed RNA polymerases I, II, and III subunit RPABC1 (POLR2E) OTH5IL2A RPAB1_HUMAN Decreases Expression [15]
Inter-alpha-trypsin inhibitor heavy chain H1 (ITIH1) OTSXJGQF ITIH1_HUMAN Decreases Expression [15]
Protachykinin-1 (TAC1) OTM842YW TKN1_HUMAN Decreases Expression [15]
Collagen alpha-1(IX) chain (COL9A1) OTWBR27Y CO9A1_HUMAN Decreases Expression [15]
Midkine (MDK) OTF24HKC MK_HUMAN Decreases Expression [15]
Macrophage scavenger receptor types I and II (MSR1) OTHANJ7A MSRE_HUMAN Decreases Expression [15]
Calretinin (CALB2) OTSNMCG9 CALB2_HUMAN Decreases Expression [15]
Splicing factor, proline- and glutamine-rich (SFPQ) OTLCIAPJ SFPQ_HUMAN Decreases Expression [15]
Carbonic anhydrase 6 (CA6) OTIX56CJ CAH6_HUMAN Decreases Expression [15]
Integrin alpha-3 (ITGA3) OTBCH21D ITA3_HUMAN Decreases Expression [15]
Tyrosine-protein phosphatase non-receptor type 3 (PTPN3) OTSLZBVY PTN3_HUMAN Decreases Expression [15]
Elongation factor 1-gamma (EEF1G) OTW7DH2F EF1G_HUMAN Increases Expression [15]
V-type proton ATPase 16 kDa proteolipid subunit c (ATP6V0C) OTKPL09B VATL_HUMAN Decreases Expression [15]
Cystatin-D (CST5) OTHJXNJG CYTD_HUMAN Decreases Expression [15]
Cellular retinoic acid-binding protein 1 (CRABP1) OTISDG5X RABP1_HUMAN Decreases Expression [15]
ATP synthase subunit delta, mitochondrial (ATP5F1D) OTXTAG2V ATPD_HUMAN Decreases Expression [15]
Rab GDP dissociation inhibitor alpha (GDI1) OTYM3928 GDIA_HUMAN Increases Expression [15]
T-lymphocyte activation antigen CD80 (CD80) OTJBLUQE CD80_HUMAN Increases Expression [15]
Ribonuclease 4 (RNASE4) OTA5SZLC RNAS4_HUMAN Increases Expression [15]
Macrosialin (CD68) OTOYEY3J CD68_HUMAN Decreases Expression [15]
Serine hydroxymethyltransferase, mitochondrial (SHMT2) OT5NCAZN GLYM_HUMAN Decreases Expression [15]
General transcription factor IIF subunit 1 (GTF2F1) OTVXS75P T2FA_HUMAN Decreases Expression [15]
Small proline-rich protein 2B (SPRR2B) OTQ9WPKY SPR2B_HUMAN Decreases Expression [15]
Alpha-1B adrenergic receptor (ADRA1B) OTSAYAFD ADA1B_HUMAN Decreases Expression [15]
Fibrillin-1 (FBN1) OTYCJT63 FBN1_HUMAN Decreases Expression [15]
Monocarboxylate transporter 8 (SLC16A2) OTLRA7C0 MOT8_HUMAN Increases Expression [15]
Signal recognition particle 14 kDa protein (SRP14) OTAVZ94Y SRP14_HUMAN Decreases Expression [15]
Carcinoembryonic antigen-related cell adhesion molecule 3 (CEACAM3) OTZG1W8W CEAM3_HUMAN Decreases Expression [15]
Pre-B-cell leukemia transcription factor 2 (PBX2) OTEBYCAW PBX2_HUMAN Decreases Expression [15]
Radiation-inducible immediate-early gene IEX-1 (IER3) OTZJI5FZ IEX1_HUMAN Decreases Expression [15]
Solute carrier organic anion transporter family member 1A2 (SLCO1A2) OTO70C5O SO1A2_HUMAN Decreases Expression [15]
RPE-retinal G protein-coupled receptor (RGR) OTKCF5AZ RGR_HUMAN Decreases Expression [15]
Gamma-aminobutyric acid receptor subunit alpha-2 (GABRA2) OT9TZ2E0 GBRA2_HUMAN Decreases Expression [15]
Olfactory marker protein (OMP) OT7JH0DY OMP_HUMAN Decreases Expression [15]
Neuropeptides B/W receptor type 2 (NPBWR2) OTABA9JW NPBW2_HUMAN Decreases Expression [15]
CD151 antigen (CD151) OTF3UZS7 CD151_HUMAN Decreases Expression [15]
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (FNTA) OTCV2Q89 FNTA_HUMAN Decreases Expression [15]
Choline-phosphate cytidylyltransferase A (PCYT1A) OTMH0YLN PCY1A_HUMAN Decreases Expression [15]
Rab GDP dissociation inhibitor beta (GDI2) OTGLY3I7 GDIB_HUMAN Increases Expression [15]
Potassium-transporting ATPase subunit beta (ATP4B) OTIP2EYJ ATP4B_HUMAN Decreases Expression [15]
Tyrosine-protein kinase Blk (BLK) OT1EB8MT BLK_HUMAN Decreases Expression [15]
Insulin-like 3 (INSL3) OT7KUNTE INSL3_HUMAN Decreases Expression [15]
Host cell factor 1 (HCFC1) OT0UCK62 HCFC1_HUMAN Decreases Expression [15]
Clathrin heavy chain 2 (CLTCL1) OT6W5BNR CLH2_HUMAN Increases Expression [15]
Mitogen-activated protein kinase 10 (MAPK10) OTC46VX1 MK10_HUMAN Decreases Expression [15]
UV excision repair protein RAD23 homolog A (RAD23A) OTBPAWHX RD23A_HUMAN Decreases Expression [15]
Eukaryotic translation initiation factor 6 (EIF6) OTEXMUED IF6_HUMAN Decreases Expression [15]
Syntaxin-1B (STX1B) OTSW59X0 STX1B_HUMAN Decreases Expression [15]
Pterin-4-alpha-carbinolamine dehydratase (PCBD1) OTDSRUD5 PHS_HUMAN Decreases Expression [15]
Peptidyl-prolyl cis-trans isomerase FKBP1A (FKBP1A) OT6285L4 FKB1A_HUMAN Decreases Expression [15]
Actin, gamma-enteric smooth muscle (ACTG2) OTRDWUO0 ACTH_HUMAN Decreases Expression [15]
Actin, alpha cardiac muscle 1 (ACTC1) OTJU04B1 ACTC_HUMAN Decreases Expression [15]
Contactin-associated protein 1 (CNTNAP1) OT5Y03EU CNTP1_HUMAN Increases Expression [15]
Homeobox protein Hox-A4 (HOXA4) OTNVTQDT HXA4_HUMAN Decreases Expression [15]
S-adenosylmethionine synthase isoform type-1 (MAT1A) OTK72E4F METK1_HUMAN Decreases Expression [15]
Cytochrome c oxidase subunit 6A2, mitochondrial (COX6A2) OTQR5SXD CX6A2_HUMAN Decreases Expression [15]
Mucin-2 (MUC2) OT3X4QVX MUC2_HUMAN Decreases Expression [15]
Transducin-like enhancer protein 3 (TLE3) OTR9PH95 TLE3_HUMAN Decreases Expression [15]
Sex-determining region Y protein (SRY) OT516T6D SRY_HUMAN Decreases Expression [15]
Neuronal acetylcholine receptor subunit beta-3 (CHRNB3) OTE5XENW ACHB3_HUMAN Decreases Expression [15]
Paired box protein Pax-8 (PAX8) OTRPD9MI PAX8_HUMAN Decreases Expression [15]
Golgin subfamily A member 2 (GOLGA2) OT5S9KYM GOGA2_HUMAN Decreases Expression [15]
Lysyl oxidase homolog 1 (LOXL1) OTA0NEJU LOXL1_HUMAN Decreases Expression [15]
Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase (MGAT3) OTXI5X4T MGAT3_HUMAN Decreases Expression [15]
Kinesin heavy chain isoform 5A (KIF5A) OT3ETTI6 KIF5A_HUMAN Decreases Expression [15]
Mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2) OTM7V78U M4K2_HUMAN Decreases Expression [15]
Inositol 1,4,5-triphosphate receptor associated 2 (IRAG2) OTLUTKJQ IRAG2_HUMAN Decreases Expression [15]
TNF receptor-associated factor 1 (TRAF1) OTTLM5RU TRAF1_HUMAN Decreases Expression [15]
Myosin-binding protein H (MYBPH) OTQJBPUR MYBPH_HUMAN Decreases Expression [15]
Golgin subfamily A member 4 (GOLGA4) OTCMEHNJ GOGA4_HUMAN Increases Expression [15]
Disintegrin and metalloproteinase domain-containing protein 15 (ADAM15) OTZ7VLTP ADA15_HUMAN Decreases Expression [15]
Laminin subunit beta-3 (LAMB3) OTFPU6W8 LAMB3_HUMAN Decreases Expression [15]
Translation initiation factor eIF2B subunit alpha (EIF2B1) OT4NCVY1 EI2BA_HUMAN Increases Expression [15]
Guanidinoacetate N-methyltransferase (GAMT) OTVC87ES GAMT_HUMAN Decreases Expression [15]
Growth factor receptor-bound protein 7 (GRB7) OTF8Y9XY GRB7_HUMAN Decreases Expression [15]
Procollagen C-endopeptidase enhancer 1 (PCOLCE) OTJXOAN4 PCOC1_HUMAN Decreases Expression [15]
Reticulocalbin-1 (RCN1) OT3JBGAG RCN1_HUMAN Decreases Expression [15]
Keratin, type I cuticular Ha1 (KRT31) OTB6RCAH K1H1_HUMAN Decreases Expression [15]
Cytohesin-1 (CYTH1) OTYH9NRJ CYH1_HUMAN Increases Expression [15]
Mediator of RNA polymerase II transcription subunit 1 (MED1) OTOO24C4 MED1_HUMAN Decreases Expression [15]
Striated muscle preferentially expressed protein kinase (SPEG) OTQXWJR4 SPEG_HUMAN Decreases Expression [15]
Syntaxin-binding protein 2 (STXBP2) OTX8GUC4 STXB2_HUMAN Decreases Expression [15]
Gamma-aminobutyric acid receptor subunit alpha-6 (GABRA6) OTX4UC3O GBRA6_HUMAN Decreases Expression [15]
snRNA-activating protein complex subunit 1 (SNAPC1) OTAPN1NI SNPC1_HUMAN Increases Expression [15]
Alpha-sarcoglycan (SGCA) OTCLJVZV SGCA_HUMAN Decreases Expression [15]
Hydroxyacylglutathione hydrolase, mitochondrial (HAGH) OTYMDAYV GLO2_HUMAN Decreases Expression [15]
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial (HADH) OTJDOL20 HCDH_HUMAN Decreases Expression [15]
Artemin (ARTN) OTWIWGL6 ARTN_HUMAN Decreases Expression [15]
Leukocyte-associated immunoglobulin-like receptor 1 (LAIR1) OTXIGC6I LAIR1_HUMAN Increases Expression [15]
Psychosine receptor (GPR65) OTCF5O4G PSYR_HUMAN Increases Expression [15]
Ataxin-2-like protein (ATXN2L) OTP5M3R9 ATX2L_HUMAN Decreases Expression [15]
Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase (ST8SIA1) OTGND2YZ SIA8A_HUMAN Increases Expression [15]
Phosphatidylinositol 3-kinase regulatory subunit gamma (PIK3R3) OTXGJ8N1 P55G_HUMAN Increases Expression [15]
Signal transducing adapter molecule 1 (STAM) OT6X5RR1 STAM1_HUMAN Decreases Expression [15]
Deoxyribonuclease-1-like 2 (DNASE1L2) OT56VFRL DNSL2_HUMAN Decreases Expression [15]
Forkhead box protein J1 (FOXJ1) OT7LLBZ7 FOXJ1_HUMAN Decreases Expression [15]
snRNA-activating protein complex subunit 3 (SNAPC3) OTSGZZCJ SNPC3_HUMAN Increases Expression [15]
Transcription factor IIIB 90 kDa subunit (BRF1) OTQC6DMG TF3B_HUMAN Decreases Expression [15]
Protein bicaudal D homolog 1 (BICD1) OT78IYPF BICD1_HUMAN Decreases Expression [15]
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 (SMARCD1) OTHFFT6G SMRD1_HUMAN Increases Expression [15]
GTP-binding protein Rit2 (RIT2) OTSNYG0D RIT2_HUMAN Decreases Expression [15]
Cell cycle checkpoint control protein RAD9A (RAD9A) OTJ3AJQU RAD9A_HUMAN Decreases Expression [15]
Septin-5 (SEPTIN5) OT6JTJBO SEPT5_HUMAN Decreases Expression [15]
Probable proton-coupled zinc antiporter SLC30A3 (SLC30A3) OTEY876E ZNT3_HUMAN Decreases Expression [15]
Neuronal PAS domain-containing protein 1 (NPAS1) OTZKO6ZN NPAS1_HUMAN Decreases Expression [15]
Neurturin (NRTN) OT4PAKUY NRTN_HUMAN Decreases Expression [15]
Chorion-specific transcription factor GCMa (GCM1) OT5CPAUT GCM1_HUMAN Increases Expression [15]
Alpha-catulin (CTNNAL1) OTESJ6JD CTNL1_HUMAN Increases Expression [15]
Intercellular adhesion molecule 5 (ICAM5) OTDGGAFH ICAM5_HUMAN Decreases Expression [15]
Protocadherin gamma-C3 (PCDHGC3) OTDXTUMI PCDGK_HUMAN Decreases Expression [15]
Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) OT1KKMYZ BAIP2_HUMAN Decreases Expression [15]
Mitotic spindle assembly checkpoint protein MAD1 (MAD1L1) OTJCX8K9 MD1L1_HUMAN Decreases Expression [15]
NF-kappa-B essential modulator (IKBKG) OTNWJWSD NEMO_HUMAN Decreases Expression [15]
Superoxide dismutase , mitochondrial (SOD2) OTIWXGZ9 SODM_HUMAN Decreases Activity [20]
Protein regulator of cytokinesis 1 (PRC1) OTHD0XS0 PRC1_HUMAN Decreases Expression [21]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Increases Expression [10]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Increases Cleavage [22]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Increases Expression [23]
Transcription factor E2F1 (E2F1) OTLKYBBC E2F1_HUMAN Increases Expression [24]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Decreases Expression [25]
Fanconi anemia group D2 protein (FANCD2) OTVEB5LF FACD2_HUMAN Increases Ubiquitination [26]
Three-prime repair exonuclease 1 (TREX1) OTQG7K12 TREX1_HUMAN Increases Expression [27]
Eukaryotic initiation factor 4A-II (EIF4A2) OT08H03R IF4A2_HUMAN Affects Response To Substance [16]
Sodium channel protein type 8 subunit alpha (SCN8A) OT0JGIZN SCN8A_HUMAN Affects Response To Substance [16]
Transmembrane protein 158 (TMEM158) OT0KUBBI TM158_HUMAN Affects Response To Substance [16]
Four and a half LIM domains protein 2 (FHL2) OT0OAYWT FHL2_HUMAN Affects Response To Substance [16]
Glutaminyl-peptide cyclotransferase (QPCT) OT0TSHP4 QPCT_HUMAN Affects Response To Substance [16]
Rho-related BTB domain-containing protein 3 (RHOBTB3) OT1BFKPH RHBT3_HUMAN Affects Response To Substance [16]
Retinaldehyde dehydrogenase 3 (ALDH1A3) OT1C9NKQ AL1A3_HUMAN Affects Response To Substance [16]
Nuclear factor 1 X-type (NFIX) OT1DPZAE NFIX_HUMAN Affects Response To Substance [16]
ATP-binding cassette sub-family G member 5 (ABCG5) OT1OMY93 ABCG5_HUMAN Affects Response To Substance [16]
Protein Lines homolog 1 (LINS1) OT1USO08 LINES_HUMAN Affects Response To Substance [16]
Protein ERGIC-53-like (LMAN1L) OT2CSBR3 LMA1L_HUMAN Affects Response To Substance [16]
Spermatogenesis-associated protein 12 (SPATA12) OT2EPI7P SPT12_HUMAN Affects Response To Substance [16]
Importin-4 (IPO4) OT2N5020 IPO4_HUMAN Affects Response To Substance [16]
Msx2-interacting protein (SPEN) OT37A2MD MINT_HUMAN Affects Response To Substance [16]
Probable RNA-binding protein 19 (RBM19) OT3Q6UIM RBM19_HUMAN Affects Response To Substance [16]
Growth-regulated alpha protein (CXCL1) OT3WCTZV GROA_HUMAN Affects Response To Substance [16]
DNA replication ATP-dependent helicase/nuclease DNA2 (DNA2) OT4DJFFU DNA2_HUMAN Affects Response To Substance [16]
Tumor necrosis factor ligand superfamily member 10 (TNFSF10) OT4PXBTA TNF10_HUMAN Affects Response To Substance [16]
Diamine acetyltransferase 1 (SAT1) OT52AU22 SAT1_HUMAN Affects Response To Substance [16]
DNA repair nuclease/redox regulator APEX1 (APEX1) OT53OI14 APEX1_HUMAN Increases Response To Substance [28]
Leukocyte elastase inhibitor (SERPINB1) OT5RDUFO ILEU_HUMAN Affects Response To Substance [16]
Cytoplasmic phosphatidylinositol transfer protein 1 (PITPNC1) OT64TTGC PITC1_HUMAN Affects Response To Substance [16]
CCN family member 4 (CCN4) OT69BER9 CCN4_HUMAN Affects Response To Substance [16]
ETS translocation variant 1 (ETV1) OT6PMJIK ETV1_HUMAN Affects Response To Substance [16]
Transcription factor Dp-1 (TFDP1) OT6RZ7VT TFDP1_HUMAN Affects Response To Substance [16]
Melanophilin (MLPH) OT7ADCXL MELPH_HUMAN Affects Response To Substance [16]
Golgin subfamily A member 8B (GOLGA8B) OT807QHZ GOG8B_HUMAN Affects Response To Substance [16]
Paired mesoderm homeobox protein 2 (PRRX2) OT8UR4AU PRRX2_HUMAN Affects Response To Substance [16]
Serine/threonine-protein kinase LMTK2 (LMTK2) OT93MVIC LMTK2_HUMAN Affects Response To Substance [16]
Doublesex- and mab-3-related transcription factor C2 (DMRTC2) OT959L3E DMRTD_HUMAN Affects Response To Substance [16]
Metallothionein-1X (MT1X) OT9AKFVS MT1X_HUMAN Affects Response To Substance [16]
Secretory carrier-associated membrane protein 5 (SCAMP5) OT9MXA2J SCAM5_HUMAN Affects Response To Substance [16]
CD44 antigen (CD44) OT9TTJ41 CD44_HUMAN Affects Response To Substance [16]
N-acetylneuraminate lyase (NPL) OTA7P0TO NPL_HUMAN Affects Response To Substance [16]
DNA-3-methyladenine glycosylase (MPG) OTAHW80B 3MG_HUMAN Decreases Response To Substance [29]
Transcriptional and immune response regulator (TCIM) OTARUXQF TCIM_HUMAN Increases Response To Substance [16]
Cyclin-dependent kinase inhibitor 1C (CDKN1C) OTASTJ3Q CDN1C_HUMAN Affects Response To Substance [16]
Chondroitin sulfate N-acetylgalactosaminyltransferase 1 (CSGALNACT1) OTBML9D9 CGAT1_HUMAN Affects Response To Substance [16]
Bone morphogenetic protein 5 (BMP5) OTC0Y6E0 BMP5_HUMAN Affects Response To Substance [16]
Organic cation/carnitine transporter 2 (SLC22A5) OTC36TYB S22A5_HUMAN Affects Response To Substance [16]
Synaptopodin-2 (SYNPO2) OTC3U0YH SYNP2_HUMAN Affects Response To Substance [16]
3-mercaptopyruvate sulfurtransferase (MPST) OTCDPH5D THTM_HUMAN Affects Response To Substance [16]
Protein naked cuticle homolog 2 (NKD2) OTCYT3I6 NKD2_HUMAN Affects Response To Substance [16]
Cadherin-13 (CDH13) OTD2CYM5 CAD13_HUMAN Affects Response To Substance [16]
Notch homolog 2 N-terminal-like protein A (NOTCH2NLA) OTD5QPCI NT2NA_HUMAN Affects Response To Substance [16]
DNA polymerase subunit gamma-2 (POLG2) OTDBMZJB DPOG2_HUMAN Affects Response To Substance [16]
Maturin (MTURN) OTEBJNVG MTURN_HUMAN Affects Response To Substance [16]
Cysteine and glycine-rich protein 3 (CSRP3) OTECBJMV CSRP3_HUMAN Affects Response To Substance [16]
Testis development-related protein (TDRP) OTEFLMGF TDRP_HUMAN Affects Response To Substance [16]
Glycine receptor subunit beta (GLRB) OTF37UG4 GLRB_HUMAN Affects Response To Substance [16]
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 (ST3GAL1) OTFCO8QX SIA4A_HUMAN Affects Response To Substance [16]
Pleckstrin homology-like domain family A member 1 (PHLDA1) OTFTWMIQ PHLA1_HUMAN Affects Response To Substance [16]
Glutathione S-transferase Mu 2 (GSTM2) OTG4WT05 GSTM2_HUMAN Decreases Nitrosation [30]
Polyhomeotic-like protein 2 (PHC2) OTG7ZO80 PHC2_HUMAN Affects Response To Substance [16]
COUP transcription factor 1 (NR2F1) OTGWZWYL COT1_HUMAN Affects Response To Substance [16]
Voltage-gated potassium channel subunit beta-2 (KCNAB2) OTH115IE KCAB2_HUMAN Affects Response To Substance [16]
Ankyrin repeat domain-containing protein 1 (ANKRD1) OTHJ7JV9 ANKR1_HUMAN Affects Response To Substance [16]
Collagen alpha-1(I) chain (COL1A1) OTI31178 CO1A1_HUMAN Affects Response To Substance [16]
Phosphopentomutase (PGM2) OTIR1VDW PGM2_HUMAN Affects Response To Substance [16]
Differentially expressed in FDCP 6 homolog (DEF6) OTIRBYVK DEFI6_HUMAN Affects Response To Substance [16]
Protocadherin beta-2 (PCDHB2) OTJ9UCIH PCDB2_HUMAN Affects Response To Substance [16]
Alpha-(1,6)-fucosyltransferase (FUT8) OTJJCVG1 FUT8_HUMAN Affects Response To Substance [16]
Nuclear factor of activated T-cells 5 (NFAT5) OTKIE59S NFAT5_HUMAN Affects Response To Substance [16]
Adenomatous polyposis coli protein (APC) OTKV0TIK APC_HUMAN Affects Response To Substance [16]
Transmembrane protein 19 (TMEM19) OTKWMDYH TMM19_HUMAN Affects Response To Substance [16]
Pleckstrin homology domain-containing family G member 5 (PLEKHG5) OTL0S21W PKHG5_HUMAN Affects Response To Substance [16]
Glutathione S-transferase Mu 3 (GSTM3) OTLA2WJT GSTM3_HUMAN Decreases Nitrosation [30]
Splicing factor 1 (SF1) OTLEDM2S SF01_HUMAN Affects Response To Substance [16]
Phosphatidylinositol 3-kinase catalytic subunit type 3 (PIK3C3) OTLUM9L7 PK3C3_HUMAN Affects Response To Substance [16]
Probable ATP-dependent RNA helicase DHX37 (DHX37) OTM1A5KP DHX37_HUMAN Affects Response To Substance [16]
T-box transcription factor TBX3 (TBX3) OTM64N7K TBX3_HUMAN Affects Response To Substance [16]
Neuronal PAS domain-containing protein 2 (NPAS2) OTMRT2TS NPAS2_HUMAN Affects Response To Substance [16]
Exostosin-like 1 (EXTL1) OTMSNY9N EXTL1_HUMAN Affects Response To Substance [16]
Cyclin-dependent kinase inhibitor 2A (CDKN2A) OTN0ZWAE CDN2A_HUMAN Increases Response To Substance [31]
Popeye domain-containing protein 3 (POPDC3) OTN4FJ5J POPD3_HUMAN Affects Response To Substance [16]
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (PIK3CD) OTOMP6TH PK3CD_HUMAN Affects Response To Substance [16]
Anterior gradient protein 3 (AGR3) OTONJPDP AGR3_HUMAN Affects Response To Substance [16]
Histone-lysine N-methyltransferase MECOM (MECOM) OTP983W8 MECOM_HUMAN Affects Response To Substance [16]
Ras-related protein Rab-27B (RAB27B) OTPF9D0K RB27B_HUMAN Affects Response To Substance [16]
Plakophilin-3 (PKP3) OTPL1HRB PKP3_HUMAN Affects Response To Substance [16]
SPARC (SPARC) OTPN90H0 SPRC_HUMAN Affects Response To Substance [16]
Aldo-keto reductase family 1 member C1 (AKR1C1) OTQKR4CM AK1C1_HUMAN Affects Response To Substance [16]
Prolyl 3-hydroxylase 3 (P3H3) OTRC8QCM P3H3_HUMAN Affects Response To Substance [16]
Chromodomain-helicase-DNA-binding protein 2 (CHD2) OTRKL6YC CHD2_HUMAN Affects Response To Substance [16]
Cell adhesion molecule 1 (CADM1) OTRWG9QS CADM1_HUMAN Affects Response To Substance [16]
Aldo-keto reductase family 1 member B1 (AKR1B1) OTRX72TH ALDR_HUMAN Affects Response To Substance [16]
Tumor protein D53 (TPD52L1) OTSA6U0I TPD53_HUMAN Affects Response To Substance [16]
Neuroblastoma suppressor of tumorigenicity 1 (NBL1) OTT37U4O NBL1_HUMAN Affects Response To Substance [16]
Fanconi anemia group C protein (FANCC) OTTIDM3P FANCC_HUMAN Affects Response To Substance [16]
Keratin, type II cytoskeletal 8 (KRT8) OTTM4X11 K2C8_HUMAN Affects Response To Substance [16]
Tumor necrosis factor receptor superfamily member 19 (TNFRSF19) OTTVT4MB TNR19_HUMAN Affects Response To Substance [16]
RAB6A-GEF complex partner protein 2 (RGP1) OTTZ63A6 RGP1_HUMAN Affects Response To Substance [16]
Protein Mdm4 (MDM4) OTU10BSF MDM4_HUMAN Decreases Response To Substance [32]
5'-AMP-activated protein kinase catalytic subunit alpha-2 (PRKAA2) OTU1KZPV AAPK2_HUMAN Affects Response To Substance [16]
Transcription factor AP-2 gamma (TFAP2C) OTUDIW05 AP2C_HUMAN Affects Response To Substance [16]
F-box only protein 32 (FBXO32) OTUE978R FBX32_HUMAN Affects Response To Substance [16]
Syntaxin-binding protein 6 (STXBP6) OTUEKTIP STXB6_HUMAN Affects Response To Substance [16]
Antileukoproteinase (SLPI) OTUNFUU8 SLPI_HUMAN Affects Response To Substance [16]
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (PREX1) OTUTPVA9 PREX1_HUMAN Affects Response To Substance [16]
Forkhead box protein F2 (FOXF2) OTV20NGX FOXF2_HUMAN Affects Response To Substance [16]
Transcription factor SOX-9 (SOX9) OTVDJFGN SOX9_HUMAN Affects Response To Substance [16]
Arrestin domain-containing protein 2 (ARRDC2) OTVEOXAG ARRD2_HUMAN Affects Response To Substance [16]
Ninein (NIN) OTVH3M4Z NIN_HUMAN Affects Response To Substance [16]
Polypeptide N-acetylgalactosaminyltransferase 15 (GALNT15) OTVK9EHD GLT15_HUMAN Affects Response To Substance [16]
Tumor necrosis factor alpha-induced protein 3 (TNFAIP3) OTVLI4DD TNAP3_HUMAN Increases Response To Substance [16]
Ankyrin-2 (ANK2) OTWB4R1Y ANK2_HUMAN Affects Response To Substance [16]
Mannan-binding lectin serine protease 1 (MASP1) OTWWCNZP MASP1_HUMAN Affects Response To Substance [16]
Nuclear factor 1 B-type (NFIB) OTX94PD0 NFIB_HUMAN Affects Response To Substance [16]
E3 ubiquitin-protein ligase TRIM50 (TRIM50) OTXA2IXF TRI50_HUMAN Affects Response To Substance [16]
Interferon-induced protein with tetratricopeptide repeats 1 (IFIT1) OTXOQDSG IFIT1_HUMAN Affects Response To Substance [16]
Engulfment and cell motility protein 1 (ELMO1) OTY2ORXK ELMO1_HUMAN Affects Response To Substance [16]
Regulator of cell cycle RGCC (RGCC) OTYJMLWM RGCC_HUMAN Affects Response To Substance [16]
GTPase-activating Rap/Ran-GAP domain-like protein 3 (GARNL3) OTYK950M GARL3_HUMAN Affects Response To Substance [16]
Tissue factor pathway inhibitor 2 (TFPI2) OTZCRWOR TFPI2_HUMAN Affects Response To Substance [16]
AP-1 complex subunit sigma-2 (AP1S2) OTZHJFYI AP1S2_HUMAN Affects Response To Substance [16]
Metallothionein-1F (MT1F) OTZVUYG1 MT1F_HUMAN Affects Response To Substance [16]
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⏷ Show the Full List of 293 DOT(s)

Test Results of This Drug Combination in Other Disease Systems

Indication DrugCom ID Cell Line Status REF
Brain and Central Nervous System Tumors DCA70XC N. A. Phase 1 [33]
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References

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3 Lomustine FDA Label
4 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6800).
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33 ClinicalTrials.gov (NCT00004259) Radiation Therapy Combined With Chemotherapy in Treating Patients With Anaplastic Astrocytoma or Mixed Gliomas