Details of the Drug Combination

General Information of Drug Combination (ID: DCVP2BS)

• Drug Combination Name: Mebendazole + Mifepristone
• Indication: Diffuse intrinsic pontine glioma; Status: Investigative [1]
• Component Drugs:
  Mebendazole (DMO14SG): Small molecular drug
  Mifepristone (DMGZQEF): Small molecular drug
• High-throughput Screening Result:
  Testing Cell Line: SU-DIPG-XIII
  Zero Interaction Potency (ZIP) Score: 12.164
  Bliss Independence Score: 15.509
  Loewe Additivity Score: 1.278
  LHighest Single Agent (HSA) Score: 0.072

Molecular Interaction Atlas of This Drug Combination

Indication(s) of Mebendazole

Disease Entry	ICD 11	Status	REF
Ascariasis	1F62	Approved	[2]
Enterobiasis	1F65	Approved	[2]
Helminth infection	1F90.0	Approved	[2]
Trichuris trichiura infection	1F6G	Approved	[2]
Worm infection	1F90.Z	Approved	[3]

Mebendazole Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Tubulin beta (TUBB)	TTYFKSZ	NOUNIPROTAC	Binder	[6]

Mebendazole Interacts with 1 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Metabolism	[7]

Mebendazole Interacts with 23 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
Proepiregulin (EREG)	OTRM4NQY	EREG_HUMAN	Increases Expression	[8]
Protein c-Fos (FOS)	OTJBUVWS	FOS_HUMAN	Increases Expression	[9]
Myc proto-oncogene protein (MYC)	OTPV5LUK	MYC_HUMAN	Decreases Expression	[10]
Antileukoproteinase (SLPI)	OTUNFUU8	SLPI_HUMAN	Increases Expression	[8]
Protein S100-A8 (S100A8)	OTVMOB3F	S10A8_HUMAN	Increases Expression	[11]
Protein S100-A9 (S100A9)	OTOARHCS	S10A9_HUMAN	Increases Expression	[11]
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Decreases Expression	[12]
Hepatocyte growth factor receptor (MET)	OT7K55MU	MET_HUMAN	Increases Expression	[8]
Interleukin-6 receptor subunit alpha (IL6R)	OTCQL07Z	IL6RA_HUMAN	Increases Expression	[5]
Interleukin-8 (CXCL8)	OTS7T5VH	IL8_HUMAN	Increases Expression	[13]
Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1)	OTA675TJ	GTR1_HUMAN	Decreases Expression	[14]
C-C motif chemokine 2 (CCL2)	OTAD2HEL	CCL2_HUMAN	Increases Expression	[5]
Hexokinase-1 (HK1)	OTMPHE8O	HXK1_HUMAN	Decreases Expression	[14]
Mitogen-activated protein kinase 3 (MAPK3)	OTCYKGKO	MK03_HUMAN	Increases Phosphorylation	[13]
Mitogen-activated protein kinase 1 (MAPK1)	OTH85PI5	MK01_HUMAN	Increases Phosphorylation	[13]
Mitogen-activated protein kinase 8 (MAPK8)	OTEREYS5	MK08_HUMAN	Increases Phosphorylation	[13]
Mitogen-activated protein kinase 9 (MAPK9)	OTCEVJ9E	MK09_HUMAN	Increases Phosphorylation	[13]
Neurogenic locus notch homolog protein 1 (NOTCH1)	OTI1WADQ	NOTC1_HUMAN	Decreases Expression	[15]
Transcription factor HES-1 (HES1)	OT8P19W2	HES1_HUMAN	Decreases Expression	[15]
PTB-containing, cubilin and LRP1-interacting protein (PID1)	OT5YJ7FI	PCLI1_HUMAN	Increases Expression	[8]
Rho guanine nucleotide exchange factor 2 (ARHGEF2)	OTBQTFRT	ARHG2_HUMAN	Decreases Expression	[16]
Multidrug and toxin extrusion protein 1 (SLC47A1)	OTZX0U5Q	S47A1_HUMAN	Decreases Expression	[12]
NACHT, LRR and PYD domains-containing protein 3 (NLRP3)	OTZM6MHU	NLRP3_HUMAN	Increases Expression	[11]

Indication(s) of Mifepristone

Disease Entry	ICD 11	Status	REF
Cushing disease	5A70	Approved	[4]

Mifepristone Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Glucocorticoid receptor (NR3C1)	TTYRL6O	GCR_HUMAN	Modulator	[19]

Mifepristone Interacts with 2 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Metabolism	[20]
Cytochrome P450 3A5 (CYP3A5)	DEIBDNY	CP3A5_HUMAN	Metabolism	[21]

Mifepristone Interacts with 171 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
Pro-neuropeptide Y (NPY)	OT4ICV3P	NPY_HUMAN	Increases ADR	[22]
Nuclear receptor subfamily 1 group I member 3 (NR1I3)	OTS3SGH7	NR1I3_HUMAN	Increases Expression	[23]
Frizzled-9 (FZD9)	OTTZ9MKK	FZD9_HUMAN	Increases Expression	[17]
Forkhead box protein N3 (FOXN3)	OTOJYJZP	FOXN3_HUMAN	Increases Expression	[17]
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 (PLOD2)	OTKOZRZP	PLOD2_HUMAN	Increases Expression	[17]
Actin-binding LIM protein 1 (ABLIM1)	OTHXEK3E	ABLM1_HUMAN	Increases Expression	[17]
Ectoderm-neural cortex protein 1 (ENC1)	OTJEUB6U	ENC1_HUMAN	Increases Expression	[17]
Histone-lysine N-methyltransferase 2D (KMT2D)	OTTVHCLY	KMT2D_HUMAN	Decreases Expression	[17]
17-beta-hydroxysteroid dehydrogenase type 6 (HSD17B6)	OTSB55D2	H17B6_HUMAN	Decreases Expression	[17]
Branched-chain-amino-acid aminotransferase, mitochondrial (BCAT2)	OT8L6EGI	BCAT2_HUMAN	Decreases Expression	[17]
Calpain-5 (CAPN5)	OTQ8QM7K	CAN5_HUMAN	Decreases Expression	[17]
Leucine-rich repeat transmembrane protein FLRT2 (FLRT2)	OTGD8TID	FLRT2_HUMAN	Decreases Expression	[17]
Septin-4 (SEPTIN4)	OTD16B30	SEPT4_HUMAN	Decreases Expression	[17]
Cationic amino acid transporter 4 (SLC7A4)	OTAVC6QS	CTR4_HUMAN	Decreases Expression	[17]
Proline dehydrogenase 1, mitochondrial (PRODH)	OT7SQ1C7	PROD_HUMAN	Decreases Expression	[17]
Synaptogyrin-1 (SYNGR1)	OT0MBUK5	SNG1_HUMAN	Decreases Expression	[17]
Frizzled-6 (FZD6)	OTBCPII8	FZD6_HUMAN	Increases Expression	[17]
Sushi repeat-containing protein SRPX2 (SRPX2)	OT6A63TX	SRPX2_HUMAN	Increases Expression	[17]
Sorting nexin-2 (SNX2)	OT889MQA	SNX2_HUMAN	Increases Expression	[17]
P antigen family member 4 (PAGE4)	OT2VLWT0	PAGE4_HUMAN	Decreases Expression	[17]
Slit homolog 3 protein (SLIT3)	OTU8MKEU	SLIT3_HUMAN	Decreases Expression	[17]
Large neutral amino acids transporter small subunit 3 (SLC43A1)	OTQJQY3S	LAT3_HUMAN	Decreases Expression	[17]
Solute carrier family 22 member 3 (SLC22A3)	OTQYGVXX	S22A3_HUMAN	Decreases Expression	[17]
E3 ubiquitin-protein ligase NEURL1 (NEURL1)	OT2C4P70	NEUL1_HUMAN	Increases Expression	[17]
Cystatin-F (CST7)	OTQWZUVQ	CYTF_HUMAN	Decreases Expression	[17]
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 (B3GAT3)	OTDSN5XF	B3GA3_HUMAN	Decreases Expression	[17]
Myelin protein zero-like protein 1 (MPZL1)	OTJSUUHR	MPZL1_HUMAN	Decreases Expression	[17]
Supervillin (SVIL)	OTWQQ1WK	SVIL_HUMAN	Increases Expression	[17]
Protein LDOC1 (LDOC1)	OTWZH4O9	LDOC1_HUMAN	Decreases Expression	[17]
Myc proto-oncogene protein (MYC)	OTPV5LUK	MYC_HUMAN	Decreases Expression	[17]
Collagen alpha-1(II) chain (COL2A1)	OT5E59C8	CO2A1_HUMAN	Decreases Expression	[17]
Apolipoprotein C-I (APOC1)	OTA58CED	APOC1_HUMAN	Decreases Expression	[17]
Annexin A1 (ANXA1)	OT5OFDJC	ANXA1_HUMAN	Increases Expression	[17]
Plasminogen activator inhibitor 1 (SERPINE1)	OTT0MPQ3	PAI1_HUMAN	Decreases Expression	[17]
Protein S100-A6 (S100A6)	OTHHPZQ8	S10A6_HUMAN	Decreases Expression	[17]
Stromelysin-1 (MMP3)	OTGBI74Z	MMP3_HUMAN	Increases Expression	[17]
Matrilysin (MMP7)	OTVT3SEJ	MMP7_HUMAN	Increases Expression	[17]
Stromelysin-2 (MMP10)	OTJDWW8Q	MMP10_HUMAN	Increases Expression	[17]
Growth-regulated alpha protein (CXCL1)	OT3WCTZV	GROA_HUMAN	Decreases Expression	[17]
Fructose-bisphosphate aldolase C (ALDOC)	OTEC13I5	ALDOC_HUMAN	Decreases Expression	[17]
Glutathione S-transferase theta-2 (GSTT2)	OTANW3TJ	GST2_HUMAN	Decreases Expression	[17]
C-C motif chemokine 3 (CCL3)	OTW2H3ND	CCL3_HUMAN	Decreases Expression	[17]
Pyruvate carboxylase, mitochondrial (PC)	OT6O0V51	PYC_HUMAN	Decreases Expression	[17]
Creatine kinase B-type (CKB)	OTUCKOTT	KCRB_HUMAN	Decreases Expression	[17]
Cadherin-1 (CDH1)	OTFJMXPM	CADH1_HUMAN	Increases Expression	[17]
HLA class II histocompatibility antigen, DO beta chain (HLA-DOB)	OTKADDUB	DOB_HUMAN	Decreases Expression	[17]
15-hydroxyprostaglandin dehydrogenase (HPGD)	OTYZI6JB	PGDH_HUMAN	Decreases Expression	[17]
Fumarylacetoacetase (FAH)	OTGZA1YR	FAAA_HUMAN	Decreases Expression	[17]
Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A)	OT2D9DOV	TNR1A_HUMAN	Increases Expression	[17]
Fibulin-1 (FBLN1)	OT5MHHOP	FBLN1_HUMAN	Decreases Expression	[17]
Laminin subunit alpha-2 (LAMA2)	OTFROQWE	LAMA2_HUMAN	Decreases Expression	[17]
Endothelin receptor type B (EDNRB)	OTLLZV3P	EDNRB_HUMAN	Increases Expression	[17]
Insulin-like growth factor-binding protein 5 (IGFBP5)	OTRE5V0C	IBP5_HUMAN	Decreases Expression	[17]
Atypical chemokine receptor 3 (ACKR3)	OTA6GA4F	ACKR3_HUMAN	Decreases Expression	[17]
Collagen alpha-5(IV) chain (COL4A5)	OTHG60RE	CO4A5_HUMAN	Decreases Expression	[17]
ER lumen protein-retaining receptor 2 (KDELR2)	OT9QW7Q0	ERD22_HUMAN	Increases Expression	[17]
Catenin beta-1 (CTNNB1)	OTZ932A3	CTNB1_HUMAN	Increases Expression	[17]
Prostaglandin-H2 D-isomerase (PTGDS)	OT71NN7C	PTGDS_HUMAN	Decreases Expression	[17]
5-hydroxytryptamine receptor 2B (HTR2B)	OTM1AD9J	5HT2B_HUMAN	Increases Expression	[17]
C-X-C motif chemokine 5 (CXCL5)	OTZOUPCA	CXCL5_HUMAN	Increases Expression	[17]
Small ribosomal subunit protein eS10 (RPS10)	OTE3VSAH	RS10_HUMAN	Increases Expression	[17]
Microtubule-associated protein 1B (MAP1B)	OTVXW089	MAP1B_HUMAN	Increases Expression	[17]
Transcription factor SOX-9 (SOX9)	OTVDJFGN	SOX9_HUMAN	Increases Expression	[17]
Heat shock 70 kDa protein 13 (HSPA13)	OTYXMC4G	HSP13_HUMAN	Increases Expression	[17]
DNA polymerase delta subunit 2 (POLD2)	OTBNASP6	DPOD2_HUMAN	Decreases Expression	[17]
MARCKS-related protein (MARCKSL1)	OT13J2FM	MRP_HUMAN	Increases Expression	[17]
Steroidogenic acute regulatory protein, mitochondrial (STAR)	OTFEZ5AI	STAR_HUMAN	Decreases Expression	[17]
ADP-ribosylation factor-like protein 4D (ARL4D)	OTG5I3KU	ARL4D_HUMAN	Decreases Expression	[17]
RNA-binding protein Nova-1 (NOVA1)	OT6A9KHY	NOVA1_HUMAN	Increases Expression	[17]
Lumican (LUM)	OTSRC874	LUM_HUMAN	Increases Expression	[17]
Cadherin-11 (CDH11)	OTIZKPTF	CAD11_HUMAN	Increases Expression	[17]
BH3-interacting domain death agonist (BID)	OTOSHSHU	BID_HUMAN	Increases Expression	[17]
Sestrin-3 (SESN3)	OTJRY1Y5	SESN3_HUMAN	Increases Expression	[17]
Actin, cytoplasmic 1 (ACTB)	OT1MCP2F	ACTB_HUMAN	Decreases Expression	[17]
Ras-related protein Rap-1b (RAP1B)	OTHEIIMM	RAP1B_HUMAN	Increases Expression	[17]
26S proteasome regulatory subunit 10B (PSMC6)	OTG8997V	PRS10_HUMAN	Increases Expression	[17]
Large ribosomal subunit protein eL39 (RPL39)	OTL8TZHQ	RL39_HUMAN	Increases Expression	[17]
Contactin-associated protein 1 (CNTNAP1)	OT5Y03EU	CNTP1_HUMAN	Decreases Expression	[17]
Sushi repeat-containing protein SRPX (SRPX)	OT5B9LXS	SRPX_HUMAN	Decreases Expression	[17]
C-C motif chemokine 8 (CCL8)	OTCTWYN8	CCL8_HUMAN	Decreases Expression	[17]
Rho-related GTP-binding protein RhoG (RHOG)	OTJ7J1WA	RHOG_HUMAN	Decreases Expression	[17]
Small EDRK-rich factor 2 (SERF2)	OTZQDYCZ	SERF2_HUMAN	Increases Expression	[17]
Norrin (NDP)	OTGDJ4US	NDP_HUMAN	Decreases Expression	[17]
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha (PPP2R3A)	OTSK5GFC	P2R3A_HUMAN	Increases Expression	[17]
Tight junction protein ZO-1 (TJP1)	OTBDCUPK	ZO1_HUMAN	Increases Expression	[17]
Sperm-associated antigen 1 (SPAG1)	OT29JZKW	SPAG1_HUMAN	Increases Expression	[17]
ATP-binding cassette sub-family C member 8 (ABCC8)	OTCWQ54I	ABCC8_HUMAN	Decreases Expression	[17]
Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 (AIMP1)	OTTA5C3U	AIMP1_HUMAN	Increases Expression	[17]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 (BNIP2)	OTVZD4H6	BNIP2_HUMAN	Increases Expression	[17]
Metastasis-associated protein MTA1 (MTA1)	OTBHW3S9	MTA1_HUMAN	Decreases Expression	[17]
Laminin subunit gamma-2 (LAMC2)	OTJMTM72	LAMC2_HUMAN	Increases Expression	[17]
Collagen alpha-6(IV) chain (COL4A6)	OTUREU5Z	CO4A6_HUMAN	Decreases Expression	[17]
Interleukin-13 receptor subunit alpha-2 (IL13RA2)	OTPC2G0X	I13R2_HUMAN	Increases Expression	[17]
ADP-ribosylation factor-like protein 6-interacting protein 1 (ARL6IP1)	OT536XAV	AR6P1_HUMAN	Increases Expression	[17]
Receptor-type tyrosine-protein phosphatase kappa (PTPRK)	OTAP5AT3	PTPRK_HUMAN	Increases Expression	[17]
Monocyte to macrophage differentiation factor (MMD)	OTB5I4OC	PAQRB_HUMAN	Increases Expression	[17]
TSC22 domain family protein 1 (TSC22D1)	OTN4GFWD	T22D1_HUMAN	Increases Expression	[17]
Adipogenesis regulatory factor (ADIRF)	OTTJP8D4	ADIRF_HUMAN	Decreases Expression	[17]
Mitogen-activated protein kinase 6 (MAPK6)	OTDDNF3Q	MK06_HUMAN	Increases Expression	[17]
Laminin subunit alpha-3 (LAMA3)	OTFME7HT	LAMA3_HUMAN	Decreases Expression	[17]
Centrosomal protein kizuna (KIZ)	OT5VCKSM	KIZ_HUMAN	Increases Expression	[17]
Carboxypeptidase Z (CPZ)	OT5HUR28	CBPZ_HUMAN	Increases Expression	[17]
F-box only protein 46 (FBXO46)	OT773EPG	FBX46_HUMAN	Decreases Expression	[17]
Plexin domain-containing protein 2 (PLXDC2)	OTS1FUV6	PXDC2_HUMAN	Increases Expression	[17]
Acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase (B3GNT6)	OTAX8BNJ	B3GN6_HUMAN	Decreases Expression	[17]
Kinesin-like protein KIF27 (KIF27)	OTV70I2Q	KIF27_HUMAN	Increases Expression	[17]
Osteopetrosis-associated transmembrane protein 1 (OSTM1)	OTKNJDH7	OSTM1_HUMAN	Increases Expression	[17]
Membrane progestin receptor alpha (PAQR7)	OTIWX5AM	PAQR7_HUMAN	Decreases Expression	[17]
Secreted frizzled-related protein 1 (SFRP1)	OT0U9G41	SFRP1_HUMAN	Increases Expression	[17]
RB1-inducible coiled-coil protein 1 (RB1CC1)	OTZK8PFX	RBCC1_HUMAN	Increases Expression	[17]
Protein phosphatase 1 regulatory subunit 1C (PPP1R1C)	OTVH6BND	PPR1C_HUMAN	Increases Expression	[17]
Kelch-like protein 6 (KLHL6)	OTLDECOX	KLHL6_HUMAN	Increases Expression	[17]
C-type lectin domain family 2 member B (CLEC2B)	OT0W0M0L	CLC2B_HUMAN	Increases Expression	[17]
(3R)-3-hydroxyacyl-CoA dehydrogenase (HSD17B8)	OTX1DWEF	DHB8_HUMAN	Decreases Expression	[17]
Tribbles homolog 2 (TRIB2)	OTHSX3MX	TRIB2_HUMAN	Increases Expression	[17]
Type II iodothyronine deiodinase (DIO2)	OTGPNSLH	IOD2_HUMAN	Increases Expression	[17]
Stathmin-2 (STMN2)	OT0FUHLH	STMN2_HUMAN	Increases Expression	[17]
Seipin (BSCL2)	OT73V6Y4	BSCL2_HUMAN	Decreases Expression	[17]
Receptor expression-enhancing protein 6 (REEP6)	OTY4FPO8	REEP6_HUMAN	Decreases Expression	[17]
Mannose-1-phosphate guanyltransferase alpha (GMPPA)	OTADC03N	GMPPA_HUMAN	Decreases Expression	[17]
Mastermind-like protein 3 (MAML3)	OTZFV53Z	MAML3_HUMAN	Increases Expression	[17]
Translocation protein SEC62 (SEC62)	OTCWEL5F	SEC62_HUMAN	Increases Expression	[17]
Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A)	OTVFRL8G	TI17A_HUMAN	Increases Expression	[17]
C-C motif chemokine 13 (CCL13)	OTNX0JD0	CCL13_HUMAN	Decreases Expression	[17]
SH3-containing GRB2-like protein 3-interacting protein 1 (SGIP1)	OTQW6R3Z	SGIP1_HUMAN	Increases Expression	[17]
Receptor expression-enhancing protein 2 (REEP2)	OTPCRA5O	REEP2_HUMAN	Decreases Expression	[17]
Latexin (LXN)	OTZQ2M6Y	LXN_HUMAN	Increases Expression	[17]
Complement C1q tumor necrosis factor-related protein 6 (C1QTNF6)	OT57EPQC	C1QT6_HUMAN	Increases Expression	[17]
Cysteine-rich secretory protein LCCL domain-containing 2 (CRISPLD2)	OTVSFHTL	CRLD2_HUMAN	Decreases Expression	[17]
E3 ubiquitin-protein ligase SMURF2 (SMURF2)	OT3TRVL7	SMUF2_HUMAN	Increases Expression	[17]
Netrin-4 (NTN4)	OTDRRMP3	NET4_HUMAN	Increases Expression	[17]
Endothelial cell-specific molecule 1 (ESM1)	OT331Y8V	ESM1_HUMAN	Increases Expression	[17]
Exosome complex component RRP46 (EXOSC5)	OTADUQ7H	EXOS5_HUMAN	Decreases Expression	[17]
Protein reprimo (RPRM)	OTNNBAS1	RPRM_HUMAN	Decreases Expression	[17]
E3 ubiquitin-protein ligase RNF146 (RNF146)	OTE4CO7E	RN146_HUMAN	Increases Expression	[17]
DNA damage-inducible transcript 4 protein (DDIT4)	OTHY8SY4	DDIT4_HUMAN	Decreases Expression	[17]
CKLF-like MARVEL transmembrane domain-containing protein 6 (CMTM6)	OT70T27A	CKLF6_HUMAN	Increases Expression	[17]
Ankyrin repeat domain-containing protein 10 (ANKRD10)	OTIZ2VK8	ANR10_HUMAN	Increases Expression	[17]
LIM and cysteine-rich domains protein 1 (LMCD1)	OT3AWE8O	LMCD1_HUMAN	Decreases Expression	[17]
DnaJ homolog subfamily B member 9 (DNAJB9)	OT38EQT6	DNJB9_HUMAN	Increases Expression	[17]
Alpha-catulin (CTNNAL1)	OTESJ6JD	CTNL1_HUMAN	Increases Expression	[17]
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 (ST6GALNAC2)	OT9PBQVT	SIA7B_HUMAN	Increases Expression	[17]
Polypyrimidine tract-binding protein 2 (PTBP2)	OTF4S7NE	PTBP2_HUMAN	Increases Expression	[17]
Frizzled-4 (FZD4)	OTGLZIE0	FZD4_HUMAN	Increases Expression	[17]
Lysosomal thioesterase PPT2 (PPT2)	OTD5VJ9A	PPT2_HUMAN	Increases Expression	[17]
Sorting nexin-12 (SNX12)	OTARRSWB	SNX12_HUMAN	Decreases Expression	[17]
HIG1 domain family member 1A, mitochondrial (HIGD1A)	OTS351DV	HIG1A_HUMAN	Increases Expression	[17]
Band 4.1-like protein 3 (EPB41L3)	OTS6CHG2	E41L3_HUMAN	Increases Expression	[17]
Long-chain fatty acid transport protein 5 (SLC27A5)	OT4OK511	S27A5_HUMAN	Decreases Expression	[17]
Axin-2 (AXIN2)	OTRMGQNU	AXIN2_HUMAN	Increases Expression	[17]
Cytosolic Fe-S cluster assembly factor NUBP2 (NUBP2)	OTYOTM2B	NUBP2_HUMAN	Increases Expression	[17]
Adhesion G-protein coupled receptor G1 (ADGRG1)	OTQBB8NT	AGRG1_HUMAN	Decreases Expression	[17]
Calcineurin-binding protein cabin-1 (CABIN1)	OT4G5CIK	CABIN_HUMAN	Increases Expression	[17]
SEC23-interacting protein (SEC23IP)	OTTZ0FXP	S23IP_HUMAN	Increases Expression	[17]
Bile salt export pump (ABCB11)	OTRU7THO	ABCBB_HUMAN	Decreases Activity	[24]
ATP-binding cassette sub-family C member 3 (ABCC3)	OTC3IJV4	MRP3_HUMAN	Increases Expression	[25]
Interleukin-1 receptor-associated kinase-like 2 (IRAK2)	OT6Y1QZN	IRAK2_HUMAN	Decreases Expression	[26]
Nuclear receptor subfamily 1 group I member 2 (NR1I2)	OTC5U0N5	NR1I2_HUMAN	Increases Activity	[27]
Retinoblastoma-associated protein (RB1)	OTQJUJMZ	RB_HUMAN	Increases Activity	[28]
Poly polymerase 1 (PARP1)	OT310QSG	PARP1_HUMAN	Increases Cleavage	[29]
Cyclin-dependent kinase inhibitor 1B (CDKN1B)	OTNY5LLZ	CDN1B_HUMAN	Increases Expression	[30]
Tumor necrosis factor ligand superfamily member 6 (FASLG)	OTZARCHH	TNFL6_HUMAN	Increases Expression	[31]
Forkhead box protein L2 (FOXL2)	OTFRQUYL	FOXL2_HUMAN	Increases Expression	[30]
Neutrophil defensin 1 (DEFA1)	OT5N1B9B	DEF1_HUMAN	Decreases Expression	[26]
Neutrophil defensin 3 (DEFA3)	OTO3N8E1	DEF3_HUMAN	Decreases Expression	[26]
Transcription factor E2F1 (E2F1)	OTLKYBBC	E2F1_HUMAN	Decreases Expression	[32]
Protein GREB1 (GREB1)	OTU6ZA26	GREB1_HUMAN	Increases Expression	[33]
Progesterone-induced-blocking factor 1 (PIBF1)	OTCBT1A1	PIBF1_HUMAN	Decreases Expression	[26]
Interleukin-1 receptor-associated kinase 4 (IRAK4)	OT9JTJWC	IRAK4_HUMAN	Decreases Expression	[26]
Semaphorin-3B (SEMA3B)	OTCZCPMS	SEM3B_HUMAN	Increases Response To Substance	[34]
Semaphorin-3F (SEMA3F)	OTQFMS8S	SEM3F_HUMAN	Increases Response To Substance	[34]

References

• [1] CheMBL Affinity Phenotypic Cellular Interaction Assay ID: CHEMBL1125966
• [2] Mebendazole FDA Label
• [3] Emerging drugs for irritable bowel syndrome. Expert Opin Emerg Drugs. 2006 May;11(2):293-313.
• [4] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2805).
• [5] Cell-based and cytokine-directed chemical screen to identify potential anti-multiple myeloma agents. Leuk Res. 2010 Jul;34(7):917-24. doi: 10.1016/j.leukres.2009.12.002. Epub 2010 Feb 8.
• [6] Flubendazole interferes with a wide spectrum of cell homeostatic mechanisms in Echinococcus granulosus protoscoleces. Parasitol Int. 2009 Sep;58(3):270-7.
• [7] Alveolar echinococcosis of the liver in an adult with human immunodeficiency virus type-1 infection. Infection. 2004 Oct;32(5):299-302.
• [8] An in vitro coculture system of human peripheral blood mononuclear cells with hepatocellular carcinoma-derived cells for predicting drug-induced liver injury. Arch Toxicol. 2021 Jan;95(1):149-168. doi: 10.1007/s00204-020-02882-4. Epub 2020 Aug 20.
• [9] Selection of drugs to test the specificity of the Tg.AC assay by screening for induction of the gadd153 promoter in vitro. Toxicol Sci. 2003 Aug;74(2):260-70. doi: 10.1093/toxsci/kfg113. Epub 2003 May 2.
• [10] Mebendazole induces apoptosis via C-MYC inactivation in malignant ascites cell line (AGP01). Toxicol In Vitro. 2019 Oct;60:305-312. doi: 10.1016/j.tiv.2019.06.010. Epub 2019 Jun 14.
• [11] Development of a cell-based assay system considering drug metabolism and immune- and inflammatory-related factors for the risk assessment of drug-induced liver injury. Toxicol Lett. 2014 Jul 3;228(1):13-24. doi: 10.1016/j.toxlet.2014.04.005. Epub 2014 Apr 15.
• [12] Mebendazole, an antiparasitic drug, inhibits drug transporters expression in preclinical model of gastric peritoneal carcinomatosis. Toxicol In Vitro. 2017 Sep;43:87-91. doi: 10.1016/j.tiv.2017.06.007. Epub 2017 Jun 9.
• [13] Stimulation of pro-inflammatory responses by mebendazole in human monocytic THP-1 cells through an ERK signaling pathway. Arch Toxicol. 2011 Mar;85(3):199-207. doi: 10.1007/s00204-010-0584-y. Epub 2010 Sep 17.
• [14] Mebendazole targets essential proteins in glucose metabolism leading gastric cancer cells to death. Toxicol Appl Pharmacol. 2023 Sep 15;475:116630. doi: 10.1016/j.taap.2023.116630. Epub 2023 Jul 18.
• [15] Mebendazole is a potent inhibitor to chemoresistant T cell acute lymphoblastic leukemia cells. Toxicol Appl Pharmacol. 2020 Jun 1;396:115001. doi: 10.1016/j.taap.2020.115001. Epub 2020 Apr 8.
• [16] Flubendazole and mebendazole impair migration and epithelial to mesenchymal transition in oral cell lines. Chem Biol Interact. 2018 Sep 25;293:124-132. doi: 10.1016/j.cbi.2018.07.026. Epub 2018 Jul 31.
• [17] Mifepristone induced progesterone withdrawal reveals novel regulatory pathways in human endometrium. Mol Hum Reprod. 2007 Sep;13(9):641-54.
• [18] [Induction of apoptosis by mifepristone in androgen-independent prostate cancer cell lines in vitro]. Zhonghua Wai Ke Za Zhi. 2006 Mar 15;44(6):382-5.
• [19] The glucocorticoid agonist activities of mifepristone (RU486) and progesterone are dependent on glucocorticoid receptor levels but not on EC50 values. Steroids. 2007 Jun;72(6-7):600-8.
• [20] Evaluation of strategies for the assessment of drug-drug interactions involving cytochrome P450 enzymes. Eur J Drug Metab Pharmacokinet. 2018 Dec;43(6):737-750.
• [21] Comparative analysis of substrate and inhibitor interactions with CYP3A4 and CYP3A5. Xenobiotica. 2006 Apr;36(4):287-99.
• [22] ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
• [23] Ketoconazole and miconazole are antagonists of the human glucocorticoid receptor: consequences on the expression and function of the constitutive androstane receptor and the pregnane X receptor. Mol Pharmacol. 2006 Jul;70(1):329-39.
• [24] A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicol Sci. 2013 Nov;136(1):216-41.
• [25] Induction of ABCC3 (MRP3) by pregnane X receptor activators. Drug Metab Dispos. 2003 Nov;31(11):1296-9. doi: 10.1124/dmd.31.11.1296.
• [26] Expression and modulation of progesterone induced blocking factor (PIBF) and innate immune factors in human leukemia cell lines by progesterone and mifepristone. Leuk Lymphoma. 2007 Aug;48(8):1610-7. doi: 10.1080/10428190701471999.
• [27] Improved assays for xenosensor activation based on reverse transfection. Toxicol In Vitro. 2015 Oct;29(7):1759-65. doi: 10.1016/j.tiv.2015.07.011. Epub 2015 Jul 14.
• [28] Mifepristone induces growth arrest, caspase activation, and apoptosis of estrogen receptor-expressing, antiestrogen-resistant breast cancer cells. Clin Cancer Res. 2004 Aug 1;10(15):5215-25. doi: 10.1158/1078-0432.CCR-03-0637.
• [29] Effects of progesterone and anti-progestin (mifepristone) treatment on proliferation and apoptosis of the human ovarian cancer cell line, OVCAR-3. Oncol Rep. 2006 Apr;15(4):743-8.
• [30] MiR-17-5p/FOXL2/CDKN1B signal programming in oocytes mediates transgenerational inheritance of diminished ovarian reserve in female offspring rats induced by prenatal dexamethasone exposure. Cell Biol Toxicol. 2023 Jun;39(3):867-883. doi: 10.1007/s10565-021-09645-6. Epub 2021 Sep 19.
• [31] Effect of mifepristone on proliferation and apoptosis of Ishikawa endometrial adenocarcinoma cells. Fertil Steril. 2005 Jul;84(1):202-11. doi: 10.1016/j.fertnstert.2005.01.126.
• [32] Mifepristone inhibits ovarian cancer cell growth in vitro and in vivo. Clin Cancer Res. 2007 Jun 1;13(11):3370-9. doi: 10.1158/1078-0432.CCR-07-0164.
• [33] A Gene Expression Biomarker Identifies Chemical Modulators of Estrogen Receptor in an MCF-7 Microarray Compendium. Chem Res Toxicol. 2021 Feb 15;34(2):313-329. doi: 10.1021/acs.chemrestox.0c00243. Epub 2021 Jan 6.
• [34] Progesterone and 1,25-dihydroxyvitamin D? inhibit endometrial cancer cell growth by upregulating semaphorin 3B and semaphorin 3F. Mol Cancer Res. 2011 Nov;9(11):1479-92. doi: 10.1158/1541-7786.MCR-11-0213. Epub 2011 Sep 20.