Details of the Drug Combination

General Information of Drug Combination (ID: DCZ4CBC)

Drug Combination Name
Flucytosine Rotenone
Indication
Disease Entry Status REF
Embryonal rhabdomyosarcoma Investigative [1]
Component Drugs Flucytosine   DM13VTW Rotenone   DMV04ES
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL
High-throughput Screening Result Testing Cell Line: CTR
Zero Interaction Potency (ZIP) Score: 34.055
Bliss Independence Score: 33.669
Loewe Additivity Score: 18.669
LHighest Single Agent (HSA) Score: 19.183

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Flucytosine
Disease Entry ICD 11 Status REF
Cryptococcal meningitis N.A. Approved [2]
Endocarditis BB40-BA42 Approved [3]
Flucytosine Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Candida Thymidylate synthase (Candi TMP1) TTU6BFZ TYSY_CANAL Inhibitor [3]
------------------------------------------------------------------------------------
Indication(s) of Rotenone
Disease Entry ICD 11 Status REF
Piscicide N.A. Approved [4]

Test Results of This Drug Combination in Other Disease Systems

Indication DrugCom ID Cell Line Status REF
Embryonal rhabdomyosarcoma DC1AJYO Rh36 Investigative [1]
Embryonal rhabdomyosarcoma DCR1QK4 RD Investigative [1]
------------------------------------------------------------------------------------

References

1 CheMBL Affinity Phenotypic Cellular Interaction Assay ID: CHEMBL1125966
2 Flucytosine FDA Label
3 Antifungal agents: mode of action in yeast cells. Rev Esp Quimioter. 2006 Jun;19(2):130-9.
4 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015