Details of the Drug Combinations

General Information of This Drug (ID: DM0659E)

Drug Name

Cannabidiol DM0659E

Synonyms

cannabidiol; 13956-29-1; (-)-Cannabidiol; (-)-trans-Cannabidiol; Epidiolex; UNII-19GBJ60SN5; (-)-trans-2-p-Mentha-1,8-dien-3-yl-5-pentylresorcinol; delta1(2)-trans-Cannabidiol; (-)-CBD; GWP42003-P; CBD; 19GBJ60SN5; QHMBSVQNZZTUGM-ZWKOTPCHSA-N

Indication

Disease Entry	ICD 11	Status	REF
Dravet syndrome	8A61.11	Approved	[1]
LennoxGastaut syndrome	8A62.1	Approved	[1]
Infantile spasm	8A62.0	Phase 3	[2]
Epilepsy	8A60-8A68	Phase 2	[2]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

9 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Cannabidiol + Remifentanil	DCEFAFV	Remifentanil	Acute Nociceptive Pain	[3]
Cannabidiol + Marinol	DCLSBDT	Marinol	Dyslipidemias	[4]
Cannabidiol + Marinol	DCU4EJU	Marinol	Cannabis Use Disorder	[5]
Cannabidiol + Marinol	DCYHVK0	Marinol	Behavioral Pharmacology of Cannabinoids	[6]
Cannabidiol + Citalopram	DC8XFJS	Citalopram	Cannabidiol	[7]
Cannabidiol + Morphine	DCFZBNB	Morphine	Cannabidiol	[7]
Cannabidiol + Methotrexate	DCZAKYG	Methotrexate	Graft vs Host Disease	[8]
Cannabidiol + Clobazam	DCKJM36	Clobazam	Epilepsy	[9]
Cannabidiol + Norethindrone	DCKJE7K	Norethindrone	Endometriosis	[10]
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⏷ Show the Full List of 9 DrugCom(s)

References

1	2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89.
2	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3	ClinicalTrials.gov (NCT04059978) Pain Response to Cannabidiol in Opioid-induced Hyperalgesia, Acute Nociceptive Pain and Allodynia By Using a Model Mimicking Acute Pain in Healthy Adults
4	ClinicalTrials.gov (NCT01217112) GWMD1092 - GWP42003 : GWP42004 Together Plus Alone in Type II Diabetes
5	ClinicalTrials.gov (NCT03398083) Evaluation of the Effects of Cannabidiol (CBD) Compared to Delta-9-Tetrahydrocannabinol (THC) and Alprazolam
6	ClinicalTrials.gov (NCT05478863) The Pharmacodynamics of Cannabinoid-Caffeine Combinations
7	ClinicalTrials.gov (NCT06192589) Clinical Study to Evaluate Cannabidiol Liver Enzyme Elevations and Drug Interactions
8	ClinicalTrials.gov (NCT02478424) Extended Use of Cannabidiol for the Prevention of Graft-versus-host-disease
9	ClinicalTrials.gov (NCT02564952) An Open-label Extension Study to Investigate Possible Drug-drug Interactions Between Clobazam and Cannabidiol
10	ClinicalTrials.gov (NCT04527003) Cannabidiol and Management of Endometriosis Pain