Details of the Drug Combination

General Information of Drug Combination (ID: DCKJM36)

Drug Combination Name
Cannabidiol Clobazam - Lundbeck
Indication
Disease Entry Status REF
Epilepsy Phase 2 [1]
Component Drugs Cannabidiol   DM0659E Clobazam - Lundbeck   DMW1OQ0
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Cannabidiol
Disease Entry ICD 11 Status REF
Dravet syndrome 8A61.11 Approved [2]
LennoxGastaut syndrome 8A62.1 Approved [2]
Infantile spasm 8A62.0 Phase 3 [3]
Epilepsy 8A60-8A68 Phase 2 [3]
Cannabidiol Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Cannabinoid receptor (CB) TT94IAG NOUNIPROTAC Binder [17]
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Cannabidiol Interacts with 1 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [18]
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Cannabidiol Interacts with 5 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [19]
Cytochrome P450 2D6 (CYP2D6) DECB0K3 CP2D6_HUMAN Metabolism [20]
Cytochrome P450 3A5 (CYP3A5) DEIBDNY CP3A5_HUMAN Metabolism [20]
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Metabolism [19]
Mephenytoin 4-hydroxylase (CYP2C19) DEGTFWK CP2CJ_HUMAN Metabolism [19]
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Cannabidiol Interacts with 739 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) OTQGYY83 CP3A4_HUMAN Decreases Activity [21]
Cytochrome P450 2C9 (CYP2C9) OTGLBN29 CP2C9_HUMAN Decreases Activity [21]
Cytochrome P450 2D6 (CYP2D6) OTZJC802 CP2D6_HUMAN Decreases Activity [22]
Cytochrome P450 2C19 (CYP2C19) OTFMJYYE CP2CJ_HUMAN Decreases Activity [21]
Cytochrome P450 3A5 (CYP3A5) OTSXFBXB CP3A5_HUMAN Decreases Activity [21]
Transient receptor potential cation channel subfamily V member 2 (TRPV2) OT0A9AVD TRPV2_HUMAN Increases Activity [23]
Multidrug resistance-associated protein 1 (ABCC1) OTGUN89S MRP1_HUMAN Decreases Activity [24]
Prostaglandin G/H synthase 2 (PTGS2) OT75U9M4 PGH2_HUMAN Increases Expression [25]
Peroxisome proliferator-activated receptor gamma (PPARG) OTHMARHO PPARG_HUMAN Increases Expression [25]
Cytochrome P450 1A2 (CYP1A2) OTLLBX48 CP1A2_HUMAN Decreases Activity [21]
Cytochrome P450 2B6 (CYP2B6) OTOYO4S7 CP2B6_HUMAN Decreases Activity [21]
AP-3 complex subunit beta-1 (AP3B1) OTYTIH5Q AP3B1_HUMAN Increases Expression [9]
Huntingtin-interacting protein 1 (HIP1) OT7AKCFQ HIP1_HUMAN Increases Expression [9]
Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B) OTQ4W7MT TR11B_HUMAN Decreases Expression [16]
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (PIK3CD) OTOMP6TH PK3CD_HUMAN Decreases Expression [5]
RNA polymerase II elongation factor ELL2 (ELL2) OTZJRTFM ELL2_HUMAN Increases Expression [8]
Serine/threonine-protein kinase 25 (STK25) OT4YPNTF STK25_HUMAN Increases Expression [14]
B-cell CLL/lymphoma 9 protein (BCL9) OTRBIPR4 BCL9_HUMAN Increases Expression [6]
Fatty-acid amide hydrolase 1 (FAAH) OT9DX3N1 FAAH1_HUMAN Decreases Expression [26]
Importin subunit alpha-3 (KPNA4) OTP0EX18 IMA3_HUMAN Increases Expression [9]
Claudin-4 (CLDN4) OT9C4PZ4 CLD4_HUMAN Increases Expression [27]
Apoptotic protease-activating factor 1 (APAF1) OTJWIVY0 APAF_HUMAN Decreases Expression [16]
Serine/threonine-protein kinase Chk1 (CHEK1) OTTTI622 CHK1_HUMAN Decreases Expression [7]
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) OTA1CPBV TR10B_HUMAN Decreases Expression [16]
Apolipoprotein L1 (APOL1) OT8QBVTY APOL1_HUMAN Decreases Expression [8]
Transcription regulator protein BACH1 (BACH1) OTY8004K BACH1_HUMAN Decreases Expression [11]
Proepiregulin (EREG) OTRM4NQY EREG_HUMAN Increases Expression [7]
Inhibitor of nuclear factor kappa-B kinase subunit alpha (CHUK) OTLF4ZB1 IKKA_HUMAN Decreases Expression [5]
Fanconi anemia group G protein (FANCG) OT7MC8TZ FANCG_HUMAN Decreases Expression [7]
Apoptosis regulatory protein Siva (SIVA1) OTDT0XZK SIVA_HUMAN Decreases Expression [16]
Fanconi anemia group A protein (FANCA) OTPEFJD4 FANCA_HUMAN Decreases Expression [7]
ATP-binding cassette sub-family C member 3 (ABCC3) OTC3IJV4 MRP3_HUMAN Increases Expression [11]
Transcription factor MafG (MAFG) OTBQFUZH MAFG_HUMAN Increases Expression [11]
Mitogen-activated protein kinase kinase kinase 7 (MAP3K7) OTUXEASC M3K7_HUMAN Decreases Expression [5]
Histone-lysine N-methyltransferase SUV39H1 (SUV39H1) OTDTF5BU SUV91_HUMAN Decreases Expression [8]
Serine protease HTRA2, mitochondrial (HTRA2) OTC7616F HTRA2_HUMAN Decreases Expression [14]
Krueppel-like factor 4 (KLF4) OT4O9RQW KLF4_HUMAN Increases Expression [28]
Mitotic checkpoint serine/threonine-protein kinase BUB1 (BUB1) OT80DZMT BUB1_HUMAN Decreases Expression [7]
Origin recognition complex subunit 5 (ORC5) OTFPW8DE ORC5_HUMAN Increases Expression [6]
Kinesin heavy chain isoform 5C (KIF5C) OT35570Y KIF5C_HUMAN Decreases Expression [9]
Trafficking kinesin-binding protein 2 (TRAK2) OTXVA7FN TRAK2_HUMAN Decreases Expression [14]
Dynamin-like 120 kDa protein, mitochondrial (OPA1) OTJGNWPW OPA1_HUMAN Increases Expression [14]
Nuclear protein 1 (NUPR1) OT4FU8C0 NUPR1_HUMAN Increases Expression [8]
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (BUB1B) OT8KME51 BUB1B_HUMAN Decreases Expression [7]
Growth arrest-specific protein 7 (GAS7) OT0M5TNY GAS7_HUMAN Increases Expression [29]
Microphthalmia-associated transcription factor (MITF) OT6XJCZH MITF_HUMAN Increases Expression [12]
Growth arrest and DNA damage-inducible protein GADD45 beta (GADD45B) OTL9I7LO GA45B_HUMAN Increases Expression [8]
Liprin-alpha-2 (PPFIA2) OT34BLXJ LIPA2_HUMAN Increases Expression [30]
Nuclear receptor corepressor 1 (NCOR1) OT04XNOU NCOR1_HUMAN Increases Expression [5]
Cell division control protein 45 homolog (CDC45) OT6NNLOD CDC45_HUMAN Decreases Expression [7]
Serine/threonine-protein kinase/endoribonuclease IRE1 (ERN1) OTY9R6FZ ERN1_HUMAN Increases Phosphorylation [15]
Ribosomal protein S6 kinase alpha-5 (RPS6KA5) OTAVZJ3J KS6A5_HUMAN Increases Expression [6]
Transient receptor potential cation channel subfamily A member 1 (TRPA1) OTRDIR5M TRPA1_HUMAN Increases Expression [6]
Ribonuclease H2 subunit A (RNASEH2A) OT8G3G7K RNH2A_HUMAN Decreases Expression [7]
Protein phosphatase 1 regulatory subunit 15A (PPP1R15A) OTYG179K PR15A_HUMAN Increases Expression [28]
Calcium-binding tyrosine phosphorylation-regulated protein (CABYR) OTKYMT99 CABYR_HUMAN Increases Expression [6]
Stanniocalcin-2 (STC2) OT86YP8G STC2_HUMAN Increases Expression [8]
monooxygenase MICAL2 (MICAL2) OT04OQQJ MICA2_HUMAN Decreases Expression [14]
Endonuclease domain-containing 1 protein (ENDOD1) OTME0ZW5 ENDD1_HUMAN Decreases Expression [9]
G2/mitotic-specific cyclin-B2 (CCNB2) OTIEXTDK CCNB2_HUMAN Decreases Expression [7]
Fibrinogen silencer-binding protein (RAD54B) OTMWB2P2 FSBP_HUMAN Decreases Expression [7]
Growth arrest and DNA damage-inducible protein GADD45 gamma (GADD45G) OT8V1J4M GA45G_HUMAN Increases Expression [7]
Cyclin-D1-binding protein 1 (CCNDBP1) OTBWG1M0 CCDB1_HUMAN Decreases Expression [6]
NADH dehydrogenase 1 subunit C2 (NDUFC2) OT9M119L NDUC2_HUMAN Increases Expression [14]
Solute carrier family 2, facilitated glucose transporter member 10 (SLC2A10) OTL32QH7 GTR10_HUMAN Increases Expression [11]
Claudin-1 (CLDN1) OT27KV99 CLD1_HUMAN Increases Expression [27]
Securin (PTTG1) OTIMYS4W PTTG1_HUMAN Decreases Expression [7]
Serine/threonine-protein kinase Chk2 (CHEK2) OT8ZPCNS CHK2_HUMAN Decreases Expression [7]
G1/S-specific cyclin-E2 (CCNE2) OTBBUKQQ CCNE2_HUMAN Decreases Expression [7]
NADH-cytochrome b5 reductase 3 (CYB5R3) OTUGT3G8 NB5R3_HUMAN Decreases Expression [9]
Glutathione reductase, mitochondrial (GSR) OTM2TUYM GSHR_HUMAN Decreases Activity [31]
Alpha-1-antitrypsin (SERPINA1) OTACYW9J A1AT_HUMAN Increases Expression [11]
Metalloproteinase inhibitor 1 (TIMP1) OTOXC51H TIMP1_HUMAN Increases Expression [32]
Protein c-Fos (FOS) OTJBUVWS FOS_HUMAN Increases Expression [6]
Platelet-derived growth factor subunit B (PDGFB) OTMFMFC3 PDGFB_HUMAN Increases Expression [11]
Transforming growth factor beta-1 proprotein (TGFB1) OTV5XHVH TGFB1_HUMAN Increases Expression [5]
Beta-nerve growth factor (NGF) OTOLABJT NGF_HUMAN Increases Expression [7]
Tumor necrosis factor (TNF) OT4IE164 TNFA_HUMAN Decreases Secretion [33]
Interleukin-1 alpha (IL1A) OTPSGILV IL1A_HUMAN Increases Expression [8]
Interleukin-1 beta (IL1B) OT0DWXXB IL1B_HUMAN Decreases Expression [16]
Collagen alpha-1(I) chain (COL1A1) OTI31178 CO1A1_HUMAN Increases Expression [34]
Collagen alpha-1(III) chain (COL3A1) OTT1EMLM CO3A1_HUMAN Increases Expression [34]
Ferritin light chain (FTL) OTYQA8A6 FRIL_HUMAN Increases Expression [11]
Ferritin heavy chain (FTH1) OT6IFS0O FRIH_HUMAN Increases Expression [11]
Metallothionein-2 (MT2A) OTHOACHD MT2_HUMAN Increases Expression [8]
Osteocalcin (BGLAP) OTK1YLWQ OSTCN_HUMAN Increases Expression [27]
Interstitial collagenase (MMP1) OTI4I2V1 MMP1_HUMAN Increases Expression [7]
Catalase (CAT) OTHEBX9R CATA_HUMAN Decreases Activity [31]
RAF proto-oncogene serine/threonine-protein kinase (RAF1) OT51LSFO RAF1_HUMAN Decreases Expression [35]
N-myc proto-oncogene protein (MYCN) OTWD33K1 MYCN_HUMAN Decreases Expression [29]
Thy-1 membrane glycoprotein (THY1) OTVONVTB THY1_HUMAN Decreases Expression [16]
Receptor tyrosine-protein kinase erbB-2 (ERBB2) OTOAUNCK ERBB2_HUMAN Decreases Expression [35]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Decreases Expression [29]
Metallothionein-1E (MT1E) OTXJKU4Y MT1E_HUMAN Increases Expression [28]
Metallothionein-1F (MT1F) OTZVUYG1 MT1F_HUMAN Increases Expression [8]
Heat shock protein beta-1 (HSPB1) OTHFZ8ED HSPB1_HUMAN Increases Expression [14]
Cytochrome P450 1A1 (CYP1A1) OTE4EFH8 CP1A1_HUMAN Increases Expression [36]
Histone H2A type 1-B/E (H2AC4) OTMFQ662 H2A1B_HUMAN Decreases Expression [8]
Plasminogen activator inhibitor 2 (SERPINB2) OT72QLZB PAI2_HUMAN Increases Expression [8]
Plasminogen activator inhibitor 1 (SERPINE1) OTT0MPQ3 PAI1_HUMAN Decreases Expression [37]
Alkaline phosphatase, tissue-nonspecific isozyme (ALPL) OTG7J4BP PPBT_HUMAN Increases Expression [34]
Fibroblast growth factor 1 (FGF1) OT8I64X8 FGF1_HUMAN Decreases Expression [8]
Interleukin-6 (IL6) OTUOSCCU IL6_HUMAN Increases Expression [8]
Intercellular adhesion molecule 1 (ICAM1) OTTOIX77 ICAM1_HUMAN Increases Expression [32]
Transcription factor Jun (JUN) OTCYBO6X JUN_HUMAN Increases Phosphorylation [38]
Integrin beta-1 (ITGB1) OT6G1IAR ITB1_HUMAN Increases Expression [16]
Cyclin-dependent kinase 1 (CDK1) OTW1SC2N CDK1_HUMAN Decreases Expression [7]
Neurofilament medium polypeptide (NEFM) OT8VCBNF NFM_HUMAN Increases Expression [6]
Calpain-1 catalytic subunit (CAPN1) OTK6OQZR CAN1_HUMAN Decreases Expression [10]
Cathepsin B (CTSB) OTP9G5QB CATB_HUMAN Decreases Expression [14]
Heat shock protein HSP 90-alpha (HSP90AA1) OTLG1WPK HS90A_HUMAN Increases Expression [16]
Tumor necrosis factor receptor superfamily member 16 (NGFR) OTPKSM49 TNR16_HUMAN Decreases Expression [8]
Muscarinic acetylcholine receptor M2 (CHRM2) OTUMZ2WR ACM2_HUMAN Increases Expression [6]
Complement decay-accelerating factor (CD55) OTZ3HWTO DAF_HUMAN Increases Expression [16]
Heat shock protein HSP 90-beta (HSP90AB1) OTR69EG7 HS90B_HUMAN Increases Expression [10]
Asparagine synthetase (ASNS) OT8R922G ASNS_HUMAN Increases Expression [28]
Stromelysin-1 (MMP3) OTGBI74Z MMP3_HUMAN Decreases Expression [16]
Keratin, type II cytoskeletal 7 (KRT7) OTLT3JFN K2C7_HUMAN Increases Expression [6]
Fibroblast growth factor 2 (FGF2) OT7YUJ9F FGF2_HUMAN Increases Expression [6]
Glutathione S-transferase P (GSTP1) OTLP0A0Y GSTP1_HUMAN Increases Expression [11]
Stromelysin-2 (MMP10) OTJDWW8Q MMP10_HUMAN Increases Expression [8]
Growth-regulated alpha protein (CXCL1) OT3WCTZV GROA_HUMAN Increases Expression [8]
Heme oxygenase 1 (HMOX1) OTC1W6UX HMOX1_HUMAN Increases Expression [28]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Decreases Expression [8]
DNA polymerase alpha catalytic subunit (POLA1) OT1WXFVY DPOLA_HUMAN Decreases Expression [7]
Interferon alpha-inducible protein 6 (IFI6) OTWOOAM4 IFI6_HUMAN Decreases Expression [16]
Granulocyte colony-stimulating factor (CSF3) OT9GC6TP CSF3_HUMAN Increases Expression [8]
Furin (FURIN) OTM2665Z FURIN_HUMAN Increases Expression [5]
Fructose-bisphosphate aldolase C (ALDOC) OTEC13I5 ALDOC_HUMAN Decreases Expression [9]
Histone H2A type 1 (H2AC11) OTN9P0BO H2A1_HUMAN Decreases Expression [8]
Keratin-associated protein 2-3 (KRTAP2-3) OTE97BCI KRA23_HUMAN Increases Expression [8]
Heat shock 70 kDa protein 1A (HSPA1A) OTKGIE76 HS71A_HUMAN Increases Expression [28]
Chimeric ERCC6-PGBD3 protein (ERCC6) OT2QZKSF ERPG3_HUMAN Decreases Expression [7]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Increases Expression [39]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Decreases Expression [8]
Osteopontin (SPP1) OTJGC23Y OSTP_HUMAN Increases Expression [34]
Microtubule-associated protein tau (MAPT) OTMTP2Z7 TAU_HUMAN Decreases Expression [10]
Mast/stem cell growth factor receptor Kit (KIT) OTHUY3VZ KIT_HUMAN Increases Expression [6]
Endoplasmic reticulum chaperone BiP (HSPA5) OTFUIRAO BIP_HUMAN Increases Expression [10]
Myosin-3 (MYH3) OTOCCGEB MYH3_HUMAN Increases Expression [9]
Heat shock cognate 71 kDa protein (HSPA8) OTJI2RCI HSP7C_HUMAN Increases Expression [10]
Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1) OTA675TJ GTR1_HUMAN Decreases Expression [9]
Solute carrier family 2, facilitated glucose transporter member 3 (SLC2A3) OT2HZK5M GTR3_HUMAN Increases Expression [11]
Spectrin beta chain, erythrocytic (SPTB) OT1Q9ABM SPTB1_HUMAN Decreases Expression [9]
Lysosome-associated membrane glycoprotein 1 (LAMP1) OTYE92QY LAMP1_HUMAN Increases Expression [9]
DNA topoisomerase 2-alpha (TOP2A) OT6LPS08 TOP2A_HUMAN Decreases Activity [40]
Glucose-6-phosphate 1-dehydrogenase (G6PD) OT300SMK G6PD_HUMAN Decreases Expression [9]
Aromatase (CYP19A1) OTZ6XF74 CP19A_HUMAN Decreases Activity [41]
Cyclin-dependent kinase 4 (CDK4) OT7EP05T CDK4_HUMAN Decreases Expression [13]
Ornithine decarboxylase (ODC1) OTNDAGRR DCOR_HUMAN Increases Expression [8]
Proliferating cell nuclear antigen (PCNA) OTHZ1RIA PCNA_HUMAN Decreases Expression [8]
Neurofilament heavy polypeptide (NEFH) OTMSCW5I NFH_HUMAN Increases Expression [6]
Bone morphogenetic protein 4 (BMP4) OTPZMDFH BMP4_HUMAN Decreases Expression [8]
Metallothionein-1G (MT1G) OTAV1OCR MT1G_HUMAN Increases Expression [28]
Tissue factor (F3) OT3MSU3B TF_HUMAN Increases Expression [42]
Troponin T, slow skeletal muscle (TNNT1) OT8PBOAR TNNT1_HUMAN Increases Expression [43]
Sodium/glucose cotransporter 1 (SLC5A1) OT0T78JI SC5A1_HUMAN Increases Expression [11]
CD59 glycoprotein (CD59) OTSUMQDH CD59_HUMAN Decreases Expression [16]
CD99 antigen (CD99) OTPUZ5DE CD99_HUMAN Decreases Expression [16]
Endoplasmin (HSP90B1) OT02XLBR ENPL_HUMAN Increases Expression [10]
G2/mitotic-specific cyclin-B1 (CCNB1) OT19S7E5 CCNB1_HUMAN Decreases Expression [7]
Insulin-degrading enzyme (IDE) OT5GQTJ5 IDE_HUMAN Increases Expression [10]
Interleukin-1 receptor type 1 (IL1R1) OTTU8959 IL1R1_HUMAN Decreases Expression [16]
Matrix metalloproteinase-9 (MMP9) OTB2QDAV MMP9_HUMAN Decreases Expression [44]
Leukemia inhibitory factor (LIF) OTO46S5S LIF_HUMAN Increases Expression [8]
Aminopeptidase N (ANPEP) OTP3WYFD AMPN_HUMAN Increases Expression [16]
Myogenin (MYOG) OTPLJKFA MYOG_HUMAN Increases Expression [43]
Interferon gamma receptor 1 (IFNGR1) OTCTQBWW INGR1_HUMAN Decreases Expression [16]
Ezrin (EZR) OTHBPF1Z EZRI_HUMAN Decreases Expression [9]
Amphiregulin (AREG) OTJFOR67 AREG_HUMAN Increases Expression [8]
Membrane cofactor protein (CD46) OTQ8NWJD MCP_HUMAN Decreases Expression [16]
NAD(P)H dehydrogenase 1 (NQO1) OTZGGIVK NQO1_HUMAN Increases Expression [11]
Replication protein A 32 kDa subunit (RPA2) OTZ54WAF RFA2_HUMAN Decreases Expression [7]
CD44 antigen (CD44) OT9TTJ41 CD44_HUMAN Decreases Expression [16]
Histone H2AX (H2AX) OT18UX57 H2AX_HUMAN Increases Expression [45]
Cyclic AMP-responsive element-binding protein 1 (CREB1) OT1MDLA1 CREB1_HUMAN Increases Phosphorylation [12]
Beta-galactosidase (GLB1) OTB0TKAG BGAL_HUMAN Increases Activity [7]
Histone H1.5 (H1-5) OTAN7RD9 H15_HUMAN Decreases Expression [8]
Heat shock 70 kDa protein 6 (HSPA6) OTH4S7WB HSP76_HUMAN Increases Expression [28]
Calpain-2 catalytic subunit (CAPN2) OTIAPE5J CAN2_HUMAN Decreases Expression [10]
CCAAT/enhancer-binding protein beta (CEBPB) OTM9MQIA CEBPB_HUMAN Increases Expression [8]
Vascular endothelial growth factor receptor 1 (FLT1) OTT0OGYS VGFR1_HUMAN Increases Expression [34]
Early growth response protein 1 (EGR1) OTCP6XGZ EGR1_HUMAN Increases Expression [28]
Glutathione peroxidase 2 (GPX2) OTXI2NTI GPX2_HUMAN Increases Expression [11]
Cyclic AMP-dependent transcription factor ATF-3 (ATF3) OTC1UOHP ATF3_HUMAN Increases Expression [28]
DNA ligase 1 (LIG1) OTEEQS43 DNLI1_HUMAN Decreases Expression [7]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1) OTSBQR6D PLCG1_HUMAN Decreases Expression [9]
Nucleolin (NCL) OTBXPKMP NUCL_HUMAN Increases Expression [6]
ETS domain-containing protein Elk-1 (ELK1) OTH9MXD6 ELK1_HUMAN Decreases Expression [35]
Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A) OT2D9DOV TNR1A_HUMAN Increases Expression [5]
C-X-C motif chemokine 2 (CXCL2) OTEJCYMY CXCL2_HUMAN Increases Expression [8]
C-X-C motif chemokine 3 (CXCL3) OTSL94KH CXCL3_HUMAN Increases Expression [8]
Cyclin-A2 (CCNA2) OTPHHYZJ CCNA2_HUMAN Decreases Expression [35]
Nuclear receptor subfamily 1 group D member 1 (NR1D1) OTJ38PTB NR1D1_HUMAN Increases Expression [8]
Calpain-3 (CAPN3) OTCHG3YK CAN3_HUMAN Decreases Expression [16]
Pleiotrophin (PTN) OTYC7M2A PTN_HUMAN Decreases Expression [16]
Cannabinoid receptor 1 (CNR1) OTEALO6G CNR1_HUMAN Increases Expression [16]
Tumor necrosis factor alpha-induced protein 3 (TNFAIP3) OTVLI4DD TNAP3_HUMAN Increases Expression [8]
Kit ligand (KITLG) OTB9AVQ4 SCF_HUMAN Increases Expression [7]
5'-nucleotidase (NT5E) OT7J5LT6 5NTD_HUMAN Increases Expression [16]
Fibroblast growth factor 7 (FGF7) OTGK6ANL FGF7_HUMAN Increases Expression [6]
Glutathione peroxidase 3 (GPX3) OT6PK94R GPX3_HUMAN Increases Expression [11]
Cornifin-B (SPRR1B) OTXNW3P6 SPR1B_HUMAN Increases Expression [8]
Small proline-rich protein 2D (SPRR2D) OT47THNK SPR2D_HUMAN Increases Expression [8]
Liver carboxylesterase 1 (CES1) OT9L0LR8 EST1_HUMAN Increases Expression [6]
Sarcoplasmic reticulum histidine-rich calcium-binding protein (HRC) OTDLEJ4T SRCH_HUMAN Decreases Expression [9]
Small ribosomal subunit protein uS3 (RPS3) OT0K3TMH RS3_HUMAN Decreases Expression [9]
G1/S-specific cyclin-D1 (CCND1) OT8HPTKJ CCND1_HUMAN Decreases Expression [46]
Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A) OTDRV63V GA45A_HUMAN Increases Expression [28]
G1/S-specific cyclin-E1 (CCNE1) OTLD7UID CCNE1_HUMAN Decreases Expression [8]
Cyclin-dependent kinase 2 (CDK2) OTB5DYYZ CDK2_HUMAN Decreases Expression [7]
DNA replication licensing factor MCM3 (MCM3) OTOOHQPM MCM3_HUMAN Decreases Expression [7]
Laminin subunit alpha-1 (LAMA1) OTQZMP86 LAMA1_HUMAN Increases Expression [7]
Small ribosomal subunit protein eS12 (RPS12) OTBRQ8MS RS12_HUMAN Increases Expression [9]
DnaJ homolog subfamily B member 1 (DNAJB1) OTCOSEVH DNJB1_HUMAN Increases Expression [28]
ATP synthase subunit alpha, mitochondrial (ATP5F1A) OT3FZDLX ATPA_HUMAN Decreases Expression [9]
Protein S100-P (S100P) OTJCXNJG S100P_HUMAN Increases Expression [8]
Tumor necrosis factor receptor superfamily member 5 (CD40) OT5YU2XB TNR5_HUMAN Decreases Expression [16]
NF-kappa-B inhibitor alpha (NFKBIA) OTFT924M IKBA_HUMAN Increases Expression [16]
High mobility group protein B2 (HMGB2) OTGEGAOK HMGB2_HUMAN Increases Expression [6]
Threonine--tRNA ligase 1, cytoplasmic (TARS1) OT0PWST5 SYTC_HUMAN Increases Expression [9]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Increases Phosphorylation [12]
Replication protein A 70 kDa DNA-binding subunit (RPA1) OT76POLP RFA1_HUMAN Decreases Expression [7]
CD82 antigen (CD82) OTH8MC64 CD82_HUMAN Decreases Expression [16]
5-hydroxytryptamine receptor 1D (HTR1D) OTLS74AF 5HT1D_HUMAN Decreases Expression [8]
DNA polymerase delta catalytic subunit (POLD1) OTWO4UCJ DPOD1_HUMAN Decreases Expression [7]
Homeobox protein MSX-1 (MSX1) OT5U41ZP MSX1_HUMAN Decreases Expression [6]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Decreases Expression [16]
Dual specificity protein phosphatase 1 (DUSP1) OTN6BR75 DUS1_HUMAN Increases Expression [8]
Retinoblastoma-like protein 1 (RBL1) OTDEBFYC RBL1_HUMAN Decreases Expression [7]
CCN family member 2 (CCN2) OTC39NSU CCN2_HUMAN Increases Expression [8]
Caspase-1 (CASP1) OTZ3YQFU CASP1_HUMAN Decreases Expression [16]
Aquaporin-1 (AQP1) OTX5MYX9 AQP1_HUMAN Decreases Expression [16]
Flavin reductase (BLVRB) OTHCFN2C BLVRB_HUMAN Increases Expression [11]
D-dopachrome decarboxylase (DDT) OTF5HTYL DOPD_HUMAN Decreases Expression [16]
G1/S-specific cyclin-D3 (CCND3) OTNKPQ22 CCND3_HUMAN Decreases Expression [7]
M-phase inducer phosphatase 1 (CDC25A) OTSLKKCO MPIP1_HUMAN Decreases Expression [7]
M-phase inducer phosphatase 2 (CDC25B) OT12MSRY MPIP2_HUMAN Decreases Expression [7]
M-phase inducer phosphatase 3 (CDC25C) OTPQI71S MPIP3_HUMAN Decreases Expression [7]
S-adenosylmethionine synthase isoform type-2 (MAT2A) OTFJMIQR METK2_HUMAN Decreases Expression [9]
Ribonucleoside-diphosphate reductase subunit M2 (RRM2) OTOB6J6R RIR2_HUMAN Decreases Expression [7]
Sodium/glucose cotransporter 2 (SLC5A2) OT93UUDI SC5A2_HUMAN Increases Expression [11]
RAC-alpha serine/threonine-protein kinase (AKT1) OT8H2YY7 AKT1_HUMAN Decreases Expression [29]
14-3-3 protein sigma (SFN) OTLJCZ1U 1433S_HUMAN Increases Expression [7]
Stress-induced-phosphoprotein 1 (STIP1) OT7TXLOX STIP1_HUMAN Increases Expression [14]
Cystathionine gamma-lyase (CTH) OTC90LA0 CGL_HUMAN Increases Expression [28]
Dual specificity protein kinase TTK (TTK) OTBY1Z5H TTK_HUMAN Decreases Expression [7]
DNA replication licensing factor MCM4 (MCM4) OT19PNNG MCM4_HUMAN Decreases Expression [7]
DNA replication licensing factor MCM5 (MCM5) OTAHLB62 MCM5_HUMAN Decreases Expression [7]
DNA replication licensing factor MCM7 (MCM7) OT6FXC6K MCM7_HUMAN Decreases Expression [7]
Macrosialin (CD68) OTOYEY3J CD68_HUMAN Decreases Expression [16]
Heat shock 70 kDa protein 4 (HSPA4) OT5HR0AR HSP74_HUMAN Increases Expression [10]
Cannabinoid receptor 2 (CNR2) OTYP9P43 CNR2_HUMAN Affects Expression [47]
Catenin beta-1 (CTNNB1) OTZ932A3 CTNB1_HUMAN Decreases Phosphorylation [38]
Polycomb group RING finger protein 2 (PCGF2) OTIY1J5L PCGF2_HUMAN Decreases Expression [6]
Prohibitin 1 (PHB1) OTZNXYS2 PHB1_HUMAN Increases Expression [9]
Replication protein A 14 kDa subunit (RPA3) OT8JAQGL RFA3_HUMAN Decreases Expression [7]
Replication factor C subunit 4 (RFC4) OTWALD2R RFC4_HUMAN Decreases Expression [7]
Replication factor C subunit 2 (RFC2) OTJ9N6BD RFC2_HUMAN Decreases Expression [7]
Pro-adrenomedullin (ADM) OT7T0TA4 ADML_HUMAN Increases Expression [6]
Histamine H1 receptor (HRH1) OT8F9FV6 HRH1_HUMAN Increases Expression [6]
Sodium channel protein type 1 subunit alpha (SCN1A) OTJ9ZTYI SCN1A_HUMAN Decreases Activity [48]
Sodium channel protein type 4 subunit alpha (SCN4A) OT0MYDHC SCN4A_HUMAN Decreases Activity [48]
Basigin (BSG) OTD0CVEC BASI_HUMAN Decreases Expression [45]
DNA damage-inducible transcript 3 protein (DDIT3) OTI8YKKE DDIT3_HUMAN Increases Expression [28]
Dual specificity mitogen-activated protein kinase kinase 2 (MAP2K2) OTUE7Z91 MP2K2_HUMAN Increases Expression [35]
Neuronal acetylcholine receptor subunit alpha-7 (CHRNA7) OTBUSUTE ACHA7_HUMAN Decreases Activity [49]
TGF-beta receptor type-1 (TGFBR1) OT40S1SJ TGFR1_HUMAN Increases Expression [5]
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial (DLST) OTBDF9HJ ODO2_HUMAN Decreases Expression [9]
Transgelin-2 (TAGLN2) OTUXZGDQ TAGL2_HUMAN Decreases Expression [9]
Breast cancer type 1 susceptibility protein (BRCA1) OT5BN6VH BRCA1_HUMAN Decreases Expression [8]
Interferon gamma receptor 2 (IFNGR2) OTVOPCHW INGR2_HUMAN Decreases Expression [16]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Decreases Expression [6]
Flap endonuclease 1 (FEN1) OT6QGG7O FEN1_HUMAN Decreases Expression [8]
L-dopachrome tautomerase (DCT) OTYVNTBG TYRP2_HUMAN Increases Expression [12]
Interleukin-6 receptor subunit beta (IL6ST) OT1N9C70 IL6RB_HUMAN Decreases Expression [16]
T-complex protein 1 subunit zeta (CCT6A) OTCYWL5F TCPZ_HUMAN Increases Expression [9]
All-trans-retinol dehydrogenase ADH7 (ADH7) OTO2ZATJ ADH7_HUMAN Increases Expression [11]
Large ribosomal subunit protein uL13 (RPL13A) OTME3VXN RL13A_HUMAN Increases Expression [9]
ADP-ribosylation factor-like protein 1 (ARL1) OTB6N6BR ARL1_HUMAN Increases Expression [6]
Signal transducer and activator of transcription 3 (STAT3) OTAAGKYZ STAT3_HUMAN Decreases Expression [16]
Interleukin-15 (IL15) OTQSYWQS IL15_HUMAN Increases Expression [7]
Replication factor C subunit 5 (RFC5) OTAD79RT RFC5_HUMAN Decreases Expression [7]
Replication factor C subunit 3 (RFC3) OT1MS7AO RFC3_HUMAN Decreases Expression [7]
Cyclin-F (CCNF) OTJFVU43 CCNF_HUMAN Decreases Expression [8]
DNA-binding protein inhibitor ID-1 (ID1) OTKGNZN5 ID1_HUMAN Decreases Expression [50]
Peripherin (PRPH) OT6VUH78 PERI_HUMAN Increases Expression [8]
Eukaryotic translation initiation factor 1 (EIF1) OTB4GZ0V EIF1_HUMAN Increases Expression [6]
Signal transducer and activator of transcription 6 (STAT6) OTCKMP49 STAT6_HUMAN Decreases Expression [16]
Glutamate receptor 3 (GRIA3) OT34CNBR GRIA3_HUMAN Decreases Expression [14]
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA) OTTOMI8J PK3CA_HUMAN Increases Expression [16]
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (PIK3CB) OTO8JQJA PK3CB_HUMAN Increases Expression [6]
Serine/threonine-protein kinase mTOR (MTOR) OTHH8KU7 MTOR_HUMAN Increases Expression [5]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Increases Expression [29]
Cyclin-dependent kinase inhibitor 2A (CDKN2A) OTN0ZWAE CDN2A_HUMAN Increases Expression [7]
Cyclin-dependent kinase 4 inhibitor B (CDKN2B) OTAG24N1 CDN2B_HUMAN Increases Expression [7]
Cyclin-dependent kinase 4 inhibitor C (CDKN2C) OTCLOV90 CDN2C_HUMAN Decreases Expression [8]
C-X-C motif chemokine 5 (CXCL5) OTZOUPCA CXCL5_HUMAN Increases Expression [7]
Endothelin-converting enzyme 1 (ECE1) OTPFHC6F ECE1_HUMAN Increases Expression [10]
DNA mismatch repair protein Msh2 (MSH2) OT10H1AB MSH2_HUMAN Decreases Expression [7]
Biotinidase (BTD) OTJYTQ69 BTD_HUMAN Increases Expression [6]
26S proteasome regulatory subunit 6B (PSMC4) OTS3XN41 PRS6B_HUMAN Increases Expression [14]
Elongation factor Ts, mitochondrial (TSFM) OTP6OKPJ EFTS_HUMAN Increases Expression [14]
Mitogen-activated protein kinase 8 (MAPK8) OTEREYS5 MK08_HUMAN Increases Phosphorylation [38]
Mitogen-activated protein kinase 9 (MAPK9) OTCEVJ9E MK09_HUMAN Increases Phosphorylation [38]
Chemerin-like receptor 2 (CMKLR2) OTDNO0SL CML2_HUMAN Increases Expression [6]
Radiation-inducible immediate-early gene IEX-1 (IER3) OTZJI5FZ IEX1_HUMAN Increases Expression [8]
Lys-63-specific deubiquitinase BRCC36 (BRCC3) OTK0ZN7Y BRCC3_HUMAN Decreases Expression [16]
Large ribosomal subunit protein eL21 (RPL21) OT74GE74 RL21_HUMAN Decreases Expression [9]
Microtubule-associated protein 1B (MAP1B) OTVXW089 MAP1B_HUMAN Increases Expression [14]
Large ribosomal subunit protein eL29 (RPL29) OTUFIBJL RL29_HUMAN Increases Expression [9]
Sodium- and chloride-dependent glycine transporter 1 (SLC6A9) OTHRUON2 SC6A9_HUMAN Increases Expression [11]
NADP-dependent malic enzyme (ME1) OTSVEUQE MAOX_HUMAN Increases Expression [11]
Transcription factor SOX-9 (SOX9) OTVDJFGN SOX9_HUMAN Increases Expression [6]
Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform (PPP3CC) OT0AQD93 PP2BC_HUMAN Decreases Expression [14]
Glutamate--cysteine ligase catalytic subunit (GCLC) OTESDI4D GSH1_HUMAN Increases Expression [11]
Glutamate--cysteine ligase regulatory subunit (GCLM) OT6CP234 GSH0_HUMAN Increases Expression [11]
CD151 antigen (CD151) OTF3UZS7 CD151_HUMAN Decreases Expression [16]
Serpin B4 (SERPINB4) OT88LHZ8 SPB4_HUMAN Increases Expression [9]
Nestin (NES) OTZ9PZ14 NEST_HUMAN Increases Expression [6]
Heat shock 70 kDa protein 13 (HSPA13) OTYXMC4G HSP13_HUMAN Decreases Expression [14]
Troponin I, fast skeletal muscle (TNNI2) OTGGZFSC TNNI2_HUMAN Decreases Expression [8]
4-trimethylaminobutyraldehyde dehydrogenase (ALDH9A1) OTNWHUJ1 AL9A1_HUMAN Decreases Expression [9]
DNA primase small subunit (PRIM1) OTWWP8Y6 PRI1_HUMAN Decreases Expression [7]
DNA primase large subunit (PRIM2) OTGT0KTF PRI2_HUMAN Decreases Expression [7]
Caspase-4 (CASP4) OTVQTV1L CASP4_HUMAN Decreases Expression [16]
DNA replication licensing factor MCM2 (MCM2) OTGGORIQ MCM2_HUMAN Decreases Expression [8]
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial (ACADVL) OT50L4XB ACADV_HUMAN Decreases Expression [9]
Transmembrane emp24 domain-containing protein 10 (TMED10) OTUXSHH7 TMEDA_HUMAN Increases Expression [10]
Presenilin-1 (PSEN1) OTKL39RT PSN1_HUMAN Decreases Expression [10]
Fms-related tyrosine kinase 3 ligand (FLT3LG) OTU0YGC4 FLT3L_HUMAN Decreases Expression [16]
Presenilin-2 (PSEN2) OTOW778B PSN2_HUMAN Decreases Expression [10]
Glycogen synthase kinase-3 beta (GSK3B) OTL3L14B GSK3B_HUMAN Decreases Expression [10]
Double-strand break repair protein MRE11 (MRE11) OTGU8TZM MRE11_HUMAN Decreases Expression [7]
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 (GNG10) OTLMZGBE GBG10_HUMAN Decreases Expression [16]
Isocitrate dehydrogenase subunit alpha, mitochondrial (IDH3A) OT5QQB5L IDH3A_HUMAN Increases Expression [14]
DNA replication ATP-dependent helicase/nuclease DNA2 (DNA2) OT4DJFFU DNA2_HUMAN Decreases Expression [7]
Breast cancer type 2 susceptibility protein (BRCA2) OTF1XSV1 BRCA2_HUMAN Decreases Expression [35]
Sulfite oxidase, mitochondrial (SUOX) OTEJQ9FC SUOX_HUMAN Decreases Expression [8]
DNA mismatch repair protein Msh6 (MSH6) OT46FP09 MSH6_HUMAN Decreases Expression [7]
High mobility group protein HMGI-C (HMGA2) OTBMBHHL HMGA2_HUMAN Decreases Expression [6]
Tricarboxylate transport protein, mitochondrial (SLC25A1) OTIDXQ9F TXTP_HUMAN Increases Expression [9]
Serine/threonine-protein phosphatase 5 (PPP5C) OTC3HT6Y PPP5_HUMAN Increases Expression [9]
Serine/threonine-protein kinase PLK1 (PLK1) OTRZX45T PLK1_HUMAN Decreases Expression [7]
Protein FosB (FOSB) OTW6C05J FOSB_HUMAN Increases Expression [28]
Mitogen-activated protein kinase 12 (MAPK12) OTTCKE27 MK12_HUMAN Decreases Expression [14]
RecQ-like DNA helicase BLM (BLM) OTEJOAJX BLM_HUMAN Decreases Expression [7]
Heat shock-related 70 kDa protein 2 (HSPA2) OTSDET7B HSP72_HUMAN Decreases Expression [8]
Galactocerebrosidase (GALC) OT1F6BZK GALC_HUMAN Decreases Expression [6]
Growth arrest-specific protein 1 (GAS1) OTKJXG52 GAS1_HUMAN Decreases Expression [16]
Aquaporin-4 (AQP4) OTA9MYD5 AQP4_HUMAN Affects Expression [51]
Caspase-7 (CASP7) OTAPJ040 CASP7_HUMAN Increases Expression [44]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Increases Expression [8]
Caspase-6 (CASP6) OTXLD3EC CASP6_HUMAN Decreases Expression [16]
BH3-interacting domain death agonist (BID) OTOSHSHU BID_HUMAN Decreases Expression [16]
Homeobox protein DLX-5 (DLX5) OTEEFBEU DLX5_HUMAN Increases Expression [27]
NADH dehydrogenase flavoprotein 3, mitochondrial (NDUFV3) OTSCYB9P NDUV3_HUMAN Increases Expression [14]
DNA polymerase epsilon subunit 2 (POLE2) OTAC9V6L DPOE2_HUMAN Decreases Expression [7]
Period circadian protein homolog 3 (PER3) OTVKYVJA PER3_HUMAN Decreases Expression [8]
Beta-secretase 1 (BACE1) OTCA7B6A BACE1_HUMAN Decreases Expression [10]
Junctional adhesion molecule B (JAM2) OTHVJJRJ JAM2_HUMAN Decreases Expression [6]
Gasdermin-D (GSDMD) OTH39BKI GSDMD_HUMAN Decreases Expression [33]
Sestrin-2 (SESN2) OT889IXY SESN2_HUMAN Increases Expression [28]
Uncharacterized protein C21orf58 (C21ORF58) OTJR84YR CU058_HUMAN Decreases Expression [8]
CD81 antigen (CD81) OTQFXNAZ CD81_HUMAN Decreases Expression [16]
Protein transport protein Sec61 subunit beta (SEC61B) OTY1X6A2 SC61B_HUMAN Increases Expression [9]
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN) OTOWDUNT PTEN_HUMAN Increases Expression [29]
Actin-related protein 3 (ACTR3) OT05LJSH ARP3_HUMAN Decreases Expression [9]
Large ribosomal subunit protein eL15 (RPL15) OT7Y42LL RL15_HUMAN Increases Expression [9]
Transforming protein RhoA (RHOA) OT6YOJ9N RHOA_HUMAN Decreases Expression [35]
Rho-related GTP-binding protein RhoE (RND3) OTXMXPIH RND3_HUMAN Increases Expression [28]
Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PPP1CB) OTYFTYFR PP1B_HUMAN Increases Expression [5]
Small ribosomal subunit protein eS6 (RPS6) OTT4D1LN RS6_HUMAN Decreases Phosphorylation [52]
Histone H4 (H4C1) OTB71W46 H4_HUMAN Decreases Expression [8]
Large ribosomal subunit protein eL30 (RPL30) OTLQVY1Z RL30_HUMAN Increases Expression [9]
Ubiquitin-ribosomal protein eS31 fusion protein (RPS27A) OTIIGGZ2 RS27A_HUMAN Decreases Expression [5]
Small ribosomal subunit protein RACK1 (RACK1) OTZBCQ1U RACK1_HUMAN Decreases Expression [5]
Histone H3.1 (H3C1) OTGBGOZW H31_HUMAN Decreases Expression [8]
Melanoma antigen preferentially expressed in tumors (PRAME) OTOG1JKJ PRAME_HUMAN Decreases Expression [8]
Arginase-2, mitochondrial (ARG2) OTCPI0E8 ARGI2_HUMAN Increases Expression [8]
ETS-related transcription factor Elf-3 (ELF3) OTUTLEQO ELF3_HUMAN Increases Expression [8]
Interleukin-13 receptor subunit alpha-1 (IL13RA1) OT59OYXP I13R1_HUMAN Decreases Expression [16]
C-C motif chemokine 20 (CCL20) OTUCJY4N CCL20_HUMAN Increases Expression [8]
Neutrophil gelatinase-associated lipocalin (LCN2) OTSB42BR NGAL_HUMAN Increases Expression [8]
Metallothionein-1H (MT1H) OT0MVBM6 MT1H_HUMAN Increases Expression [28]
Metallothionein-1X (MT1X) OT9AKFVS MT1X_HUMAN Increases Expression [28]
Small ribosomal subunit protein uS10m (MRPS10) OTXF7D9J RT10_HUMAN Increases Expression [14]
Serine beta-lactamase-like protein LACTB, mitochondrial (LACTB) OTRWGNBF LACTB_HUMAN Increases Expression [14]
Enhancer of rudimentary homolog (ERH) OTJDWX99 ERH_HUMAN Increases Expression [9]
Cytochrome c (CYCS) OTBFALJD CYC_HUMAN Decreases Expression [16]
Cyclin-dependent kinase 6 (CDK6) OTR95N0X CDK6_HUMAN Decreases Expression [13]
Cyclin-dependent kinase 5 (CDK5) OT1YAK9F CDK5_HUMAN Decreases Expression [6]
Fanconi anemia group C protein (FANCC) OTTIDM3P FANCC_HUMAN Decreases Expression [7]
Nuclear factor NF-kappa-B p100 subunit (NFKB2) OTS231V7 NFKB2_HUMAN Decreases Expression [16]
E3 ubiquitin-protein ligase Mdm2 (MDM2) OTOVXARF MDM2_HUMAN Increases Expression [16]
Transcription factor E2F1 (E2F1) OTLKYBBC E2F1_HUMAN Decreases Expression [8]
Transcription factor RelB (RELB) OTU3QYEF RELB_HUMAN Increases Expression [35]
Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMGCS1) OTCO26FV HMCS1_HUMAN Decreases Expression [9]
Pro-neuregulin-1, membrane-bound isoform (NRG1) OTZO6F1X NRG1_HUMAN Increases Expression [7]
Dual specificity mitogen-activated protein kinase kinase 1 (MAP2K1) OT4Y9NQI MP2K1_HUMAN Decreases Expression [35]
Peptidyl-prolyl cis-trans isomerase FKBP4 (FKBP4) OTPV1D60 FKBP4_HUMAN Increases Expression [14]
DNA topoisomerase 2-beta (TOP2B) OTDHKQZ8 TOP2B_HUMAN Decreases Activity [40]
Peroxisome proliferator-activated receptor delta (PPARD) OTI4WTOP PPARD_HUMAN Increases Expression [11]
Transcription factor p65 (RELA) OTUJP9CN TF65_HUMAN Decreases Expression [16]
DNA repair protein RAD51 homolog 1 (RAD51) OTNVWGC1 RAD51_HUMAN Decreases Expression [7]
Large ribosomal subunit protein eL18 (RPL18) OTJCH62J RL18_HUMAN Increases Expression [9]
Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP) OTPYQX3K C1QBP_HUMAN Increases Expression [14]
Tight junction protein ZO-1 (TJP1) OTBDCUPK ZO1_HUMAN Increases Expression [27]
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Increases Expression [8]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Decreases Expression [29]
DNA polymerase epsilon catalytic subunit A (POLE) OTFM3MMU DPOE1_HUMAN Decreases Expression [7]
Quinone oxidoreductase (CRYZ) OTD2F4C8 QOR_HUMAN Increases Expression [9]
Leukocyte surface antigen CD47 (CD47) OTLDZ0KZ CD47_HUMAN Increases Expression [16]
Histone-binding protein RBBP4 (RBBP4) OTG3BT3M RBBP4_HUMAN Decreases Expression [9]
Aspartyl/asparaginyl beta-hydroxylase (ASPH) OT3KGDEE ASPH_HUMAN Increases Expression [9]
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (SMARCB1) OT2LP7LJ SNF5_HUMAN Decreases Expression [9]
Cell division cycle protein 20 homolog (CDC20) OTCOEZRV CDC20_HUMAN Decreases Expression [7]
Heat shock protein 75 kDa, mitochondrial (TRAP1) OTNG0L8J TRAP1_HUMAN Increases Expression [14]
Glutamate receptor ionotropic, kainate 2 (GRIK2) OTQ41U3D GRIK2_HUMAN Increases Expression [6]
Interleukin-24 (IL24) OT4VUWH1 IL24_HUMAN Increases Expression [8]
Dual specificity protein phosphatase 4 (DUSP4) OT6WAO12 DUS4_HUMAN Increases Expression [8]
FAS-associated death domain protein (FADD) OTV7GFHH FADD_HUMAN Decreases Expression [8]
Mitotic spindle assembly checkpoint protein MAD2A (MAD2L1) OTXNGZCG MD2L1_HUMAN Decreases Expression [7]
Transcription intermediary factor 1-beta (TRIM28) OTE38OBF TIF1B_HUMAN Decreases Expression [9]
Semaphorin-3F (SEMA3F) OTQFMS8S SEM3F_HUMAN Increases Expression [6]
S-phase kinase-associated protein 2 (SKP2) OTD5B41X SKP2_HUMAN Decreases Expression [8]
Serine-protein kinase ATM (ATM) OTQVOHLT ATM_HUMAN Increases Expression [53]
Dentin matrix acidic phosphoprotein 1 (DMP1) OTBWBWW7 DMP1_HUMAN Increases Expression [34]
Origin recognition complex subunit 1 (ORC1) OTHWU8IJ ORC1_HUMAN Decreases Expression [8]
Treacle protein (TCOF1) OT4BOYTM TCOF_HUMAN Increases Expression [9]
Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9) OT70Z4II ADAM9_HUMAN Increases Expression [10]
Sequestosome-1 (SQSTM1) OTGY5D5J SQSTM_HUMAN Decreases Expression [5]
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) OTC41R1E RIPK1_HUMAN Increases Expression [5]
Calcium/calmodulin-dependent protein kinase type II subunit beta (CAMK2B) OTS9YK3E KCC2B_HUMAN Decreases Expression [10]
Transformer-2 protein homolog alpha (TRA2A) OT5NHOO3 TRA2A_HUMAN Increases Expression [9]
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) OTPLXCDN DYR1A_HUMAN Decreases Expression [10]
CD166 antigen (ALCAM) OTCO4LP7 CD166_HUMAN Decreases Expression [16]
Laminin subunit gamma-2 (LAMC2) OTJMTM72 LAMC2_HUMAN Increases Expression [7]
Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1) OTXEE550 APR_HUMAN Increases Expression [28]
Runt-related transcription factor 2 (RUNX2) OT97RQQM RUNX2_HUMAN Increases Expression [34]
Core-binding factor subunit beta (CBFB) OTIAC6W4 PEBB_HUMAN Decreases Expression [6]
Interleukin-18 (IL18) OTBB2A8O IL18_HUMAN Decreases Expression [16]
DNA polymerase alpha subunit B (POLA2) OTTWQ73N DPOA2_HUMAN Decreases Expression [7]
Transcription factor Dp-1 (TFDP1) OT6RZ7VT TFDP1_HUMAN Decreases Expression [7]
Transcription factor E2F2 (E2F2) OTO75RM7 E2F2_HUMAN Decreases Expression [8]
Lymphocyte antigen 6D (LY6D) OTXCR0SB LY6D_HUMAN Decreases Expression [8]
Beclin-1 (BECN1) OT4X293M BECN1_HUMAN Increases Expression [8]
Sodium channel protein type 5 subunit alpha (SCN5A) OTGYZWR6 SCN5A_HUMAN Decreases Activity [48]
DNA replication licensing factor MCM6 (MCM6) OTKLIAWT MCM6_HUMAN Decreases Expression [7]
Interleukin-11 receptor subunit alpha (IL11RA) OTN6DBCJ I11RA_HUMAN Decreases Expression [16]
Structural maintenance of chromosomes protein 1A (SMC1A) OT9ZMRK9 SMC1A_HUMAN Decreases Expression [7]
Protein RRP5 homolog (PDCD11) OTS1NJK2 RRP5_HUMAN Increases Expression [9]
DNA replication complex GINS protein PSF1 (GINS1) OTVQZMMQ PSF1_HUMAN Increases Expression [6]
Major vault protein (MVP) OTJGHJRB MVP_HUMAN Decreases Expression [9]
Caspase-8 (CASP8) OTA8TVI8 CASP8_HUMAN Decreases Expression [16]
Prostaglandin reductase 1 (PTGR1) OTMAR351 PTGR1_HUMAN Increases Expression [11]
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein (HERPUD1) OT9EROL6 HERP1_HUMAN Increases Expression [28]
Metal cation symporter ZIP14 (SLC39A14) OTGR686L S39AE_HUMAN Increases Expression [11]
DNA polymerase delta subunit 3 (POLD3) OTEQEFQ2 DPOD3_HUMAN Decreases Expression [7]
Cyclin-dependent kinase 5 activator 1 (CDK5R1) OTJELWK0 CD5R1_HUMAN Decreases Expression [10]
Plectin (PLEC) OTU4XDEG PLEC_HUMAN Decreases Expression [9]
Pericentriolar material 1 protein (PCM1) OTFM133C PCM1_HUMAN Increases Expression [6]
Inorganic pyrophosphatase (PPA1) OTHZK1QB IPYR_HUMAN Increases Expression [9]
Poly(rC)-binding protein 1 (PCBP1) OTHN0TD7 PCBP1_HUMAN Increases Expression [9]
Angiopoietin-1 (ANGPT1) OTVZ1NG3 ANGP1_HUMAN Increases Secretion [27]
Ribosomal protein S6 kinase alpha-1 (RPS6KA1) OTDOTWU4 KS6A1_HUMAN Increases Expression [6]
Splicing factor 3A subunit 1 (SF3A1) OTI733D7 SF3A1_HUMAN Increases Expression [9]
Surfeit locus protein 1 (SURF1) OTAINRSS SURF1_HUMAN Decreases Expression [14]
RISC-loading complex subunit TARBP2 (TARBP2) OT1QQ8H3 TRBP2_HUMAN Decreases Expression [14]
Disks large homolog 2 (DLG2) OTQ3BD8U DLG2_HUMAN Increases Expression [9]
Mitochondrial import receptor subunit TOM34 (TOMM34) OTH6MITE TOM34_HUMAN Decreases Expression [9]
Sodium channel protein type 9 subunit alpha (SCN9A) OTGSKLL8 SCN9A_HUMAN Decreases Activity [48]
Nuclear factor erythroid 2-related factor 2 (NFE2L2) OT0HENJ5 NF2L2_HUMAN Increases Expression [14]
Mitogen-activated protein kinase 14 (MAPK14) OT5TCO3O MK14_HUMAN Decreases Expression [14]
Nuclear factor interleukin-3-regulated protein (NFIL3) OTQH9HM3 NFIL3_HUMAN Increases Expression [28]
Hypoxia-inducible factor 1-alpha (HIF1A) OTADSC03 HIF1A_HUMAN Increases Expression [54]
Cyclin-dependent kinase inhibitor 3 (CDKN3) OTBE3H07 CDKN3_HUMAN Decreases Expression [7]
Forkhead box protein D1 (FOXD1) OT80PRHS FOXD1_HUMAN Increases Expression [8]
Dual specificity protein phosphatase 5 (DUSP5) OTH96RA7 DUS5_HUMAN Increases Expression [8]
Histone H2A type 2-C (H2AC20) OTEIVLM1 H2A2C_HUMAN Increases Expression [9]
NADH dehydrogenase 1 alpha subcomplex subunit 9, mitochondrial (NDUFA9) OTMKQJJ8 NDUA9_HUMAN Decreases Expression [15]
Dual specificity protein phosphatase 6 (DUSP6) OT4H6RKW DUS6_HUMAN Increases Expression [8]
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2 (ST3GAL2) OT8WM21E SIA4B_HUMAN Decreases Expression [8]
Coiled-coil domain-containing protein 142 (CCDC142) OTYTFB46 CC142_HUMAN Decreases Expression [8]
Pancreatic lipase-related protein 3 (PNLIPRP3) OT7H4PSU LIPR3_HUMAN Increases Expression [8]
Mucin-like protein 3 (MUCL3) OTGAD3I0 MUCL3_HUMAN Increases Expression [6]
Protein MIX23 (MIX23) OTZ5O14U MIX23_HUMAN Increases Expression [6]
UMP-CMP kinase 2, mitochondrial (CMPK2) OTOG90R0 CMPK2_HUMAN Decreases Expression [33]
Caspase recruitment domain-containing protein 16 (CARD16) OT4NUHWB CAR16_HUMAN Decreases Expression [16]
BCL-6 corepressor-like protein 1 (BCORL1) OTPTFQN5 BCORL_HUMAN Increases Expression [6]
FYVE, RhoGEF and PH domain-containing protein 3 (FGD3) OTIH6283 FGD3_HUMAN Decreases Expression [8]
Centrosomal protein of 78 kDa (CEP78) OTTAI5S2 CEP78_HUMAN Increases Expression [6]
PCI domain-containing protein 2 (PCID2) OTF5LO98 PCID2_HUMAN Decreases Expression [6]
Long-chain fatty acid transport protein 3 (SLC27A3) OTXB60L7 S27A3_HUMAN Decreases Expression [8]
Alpha-tubulin N-acetyltransferase 1 (ATAT1) OTBE2LTI ATAT_HUMAN Decreases Expression [16]
Uncharacterized protein C6orf141 (C6ORF141) OTUS3SIQ CF141_HUMAN Increases Expression [8]
Late cornified envelope protein 1F (LCE1F) OTFSBZZF LCE1F_HUMAN Increases Expression [8]
CD276 antigen (CD276) OTKHTFVO CD276_HUMAN Increases Expression [16]
Spermatogenesis-associated protein 31H1 (SPATA31H1) OTN4HU1L S31H1_HUMAN Increases Expression [6]
Leukocyte-associated immunoglobulin-like receptor 1 (LAIR1) OTXIGC6I LAIR1_HUMAN Increases Expression [55]
Proline-rich protein 5-like (PRR5L) OTQ1Z0OU PRR5L_HUMAN Decreases Expression [8]
Large ribosomal subunit protein mL54 (MRPL54) OTWV3E31 RM54_HUMAN Increases Expression [14]
Glutathione hydrolase 6 (GGT6) OTAQWSCC GGT6_HUMAN Decreases Expression [8]
RNA polymerase-associated protein CTR9 homolog (CTR9) OTP151PZ CTR9_HUMAN Increases Expression [6]
Protein aurora borealis (BORA) OTV2ZPKP BORA_HUMAN Increases Expression [6]
Protein cornichon homolog 2 (CNIH2) OTT2ECCW CNIH2_HUMAN Decreases Expression [8]
Biogenesis of lysosome-related organelles complex 1 subunit 2 (BLOC1S2) OTUR3E76 BL1S2_HUMAN Increases Expression [6]
Serine protease FAM111B (FAM111B) OT9IQ9NV F111B_HUMAN Decreases Expression [8]
Aftiphilin (AFTPH) OTDUYPRS AFTIN_HUMAN Increases Expression [6]
CD109 antigen (CD109) OTDADBM4 CD109_HUMAN Decreases Expression [16]
Lysine-specific demethylase 7A (KDM7A) OT1VGYCX KDM7A_HUMAN Increases Expression [8]
Zinc finger protein basonuclin-2 (BNC2) OTU22H9Z BNC2_HUMAN Increases Expression [6]
Protein LIAT1 (LIAT1) OTOXIHJK LIAT1_HUMAN Increases Expression [6]
Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) OTMQXW7S RAPH1_HUMAN Increases Expression [14]
Probable ATP-dependent RNA helicase DDX46 (DDX46) OTB2X9TO DDX46_HUMAN Increases Expression [9]
Protein MCM10 homolog (MCM10) OTV0O3JN MCM10_HUMAN Decreases Expression [7]
STE20-related kinase adapter protein alpha (STRADA) OTG1Z6TY STRAA_HUMAN Decreases Expression [14]
#NAME? OTD229X7 MICA3_HUMAN Decreases Expression [14]
Probable helicase senataxin (SETX) OTG3JNOQ SETX_HUMAN Increases Expression [9]
E3 ubiquitin-protein ligase RBBP6 (RBBP6) OTTVG4HU RBBP6_HUMAN Increases Expression [6]
Notch-regulated ankyrin repeat-containing protein (NRARP) OTMYHUV2 NRARP_HUMAN Decreases Expression [8]
Uncharacterized protein C11orf96 (C11ORF96) OTEQU0V7 CK096_HUMAN Increases Expression [6]
Pleckstrin homology-like domain family B member 2 (PHLDB2) OTDKMB2G PHLB2_HUMAN Increases Expression [8]
NLR family member X1 (NLRX1) OTEJ7ROA NLRX1_HUMAN Decreases Expression [14]
Multidrug and toxin extrusion protein 2 (SLC47A2) OTF2CNRD S47A2_HUMAN Decreases Expression [8]
BLOC-2 complex member HPS6 (HPS6) OTXL5KQW HPS6_HUMAN Decreases Expression [8]
Leucine rich adaptor protein 1-like (LURAP1L) OTSJ29M5 LUR1L_HUMAN Increases Expression [8]
Tripartite motif-containing protein 59 (TRIM59) OT14I72L TRI59_HUMAN Decreases Expression [8]
Cell division cycle and apoptosis regulator protein 1 (CCAR1) OTUXLQZZ CCAR1_HUMAN Increases Expression [9]
Mitochondrial Rho GTPase 2 (RHOT2) OTV8WT2L MIRO2_HUMAN Increases Expression [14]
NAD-dependent protein deacetylase sirtuin-2 (SIRT2) OT5Q6SVK SIR2_HUMAN Decreases Expression [29]
Ribonucleoprotein PTB-binding 1 (RAVER1) OTMHBTLE RAVR1_HUMAN Decreases Expression [9]
Fanconi anemia group M protein (FANCM) OTNJG99Z FANCM_HUMAN Decreases Expression [7]
Lung adenoma susceptibility protein 2 (C18ORF54) OT4WJKTF LAS2_HUMAN Increases Expression [6]
Ribonuclease SLFN12 (SLFN12) OTTBXM25 SLN12_HUMAN Decreases Expression [8]
G-protein coupled receptor 135 (GPR135) OTXOY5NW GP135_HUMAN Decreases Expression [8]
Lysophosphatidylserine lipase ABHD12 (ABHD12) OTDP4F02 ABD12_HUMAN Increases Expression [6]
Metallothionein-1M (MT1M) OTVT8PLU MT1M_HUMAN Increases Expression [28]
Bardet-Biedl syndrome 5 protein (BBS5) OTFWF9N1 BBS5_HUMAN Increases Expression [6]
Homologous recombination OB-fold protein (HROB) OTMKZZU7 HROB_HUMAN Increases Expression [6]
EP300-interacting inhibitor of differentiation 2 (EID2) OTK0KCN4 EID2_HUMAN Decreases Expression [8]
Acyl-coenzyme A diphosphatase FITM2 (FITM2) OTED0W1S FITM2_HUMAN Decreases Expression [8]
Probable E3 ubiquitin-protein ligase TRIML2 (TRIML2) OT5QWTD2 TRIMM_HUMAN Increases Expression [8]
Fanconi anemia group B protein (FANCB) OTMZTXB5 FANCB_HUMAN Decreases Expression [7]
Diacylglycerol lipase-beta (DAGLB) OT1S9869 DGLB_HUMAN Decreases Expression [6]
Carbohydrate sulfotransferase 14 (CHST14) OT3FLH7U CHSTE_HUMAN Decreases Expression [8]
Transient receptor potential cation channel subfamily V member 1 (TRPV1) OTHHDR03 TRPV1_HUMAN Increases Activity [56]
Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe (LFNG) OTPSUBN2 LFNG_HUMAN Decreases Expression [8]
Transient receptor potential cation channel subfamily V member 3 (TRPV3) OTC57YC6 TRPV3_HUMAN Increases Expression [8]
Delta and Notch-like epidermal growth factor-related receptor (DNER) OT2GH2E5 DNER_HUMAN Increases Expression [6]
Semaphorin-6D (SEMA6D) OTU0UAZS SEM6D_HUMAN Increases Expression [6]
DNA helicase B (HELB) OT769EC5 HELB_HUMAN Increases Expression [6]
Endonuclease 8-like 3 (NEIL3) OTBCI2NS NEIL3_HUMAN Decreases Expression [7]
Prostamide/prostaglandin F synthase (PRXL2B) OTY5G543 PXL2B_HUMAN Decreases Expression [8]
Signal peptide peptidase-like 2A (SPPL2A) OTCVF6MM SPP2A_HUMAN Increases Expression [5]
Solute carrier family 2, facilitated glucose transporter member 14 (SLC2A14) OTBFIOVY GTR14_HUMAN Increases Expression [11]
Transcription factor Sp7 (SP7) OT07ETZT SP7_HUMAN Increases Expression [27]
#NAME? OTJEDVWA MICA1_HUMAN Decreases Expression [14]
Partitioning defective 3 homolog B (PARD3B) OTGZ43YI PAR3L_HUMAN Increases Expression [14]
Phospholipase ABHD3 (ABHD3) OTH8P977 ABHD3_HUMAN Increases Expression [6]
Pleckstrin homology-like domain family A member 1 (PHLDA1) OTFTWMIQ PHLA1_HUMAN Increases Expression [8]
Fatty acyl-CoA reductase 1 (FAR1) OTLHTYIE FACR1_HUMAN Increases Expression [9]
Palladin (PALLD) OTZ2MUJZ PALLD_HUMAN Decreases Expression [8]
ATR-interacting protein (ATRIP) OT78O9LF ATRIP_HUMAN Decreases Expression [7]
Microprocessor complex subunit DGCR8 (DGCR8) OT62LXE4 DGCR8_HUMAN Decreases Expression [8]
Zinc transporter SLC39A7 (SLC39A7) OTYMA1VB S39A7_HUMAN Increases Expression [11]
Histone H1.10 (H1-10) OTBWDA4E H1X_HUMAN Decreases Expression [16]
Nicastrin (NCSTN) OT5QBTA4 NICA_HUMAN Decreases Expression [10]
Acidic leucine-rich nuclear phosphoprotein 32 family member B (ANP32B) OT3SQMLU AN32B_HUMAN Increases Expression [6]
DNA repair and recombination protein RAD54-like (RAD54L) OTEGMAKG RAD54_HUMAN Decreases Expression [7]
Type II iodothyronine deiodinase (DIO2) OTGPNSLH IOD2_HUMAN Decreases Expression [8]
Hyaluronan synthase 2 (HAS2) OTTD3PAL HYAS2_HUMAN Increases Expression [8]
Bcl2-associated agonist of cell death (BAD) OT63ERYM BAD_HUMAN Decreases Expression [16]
F-box only protein 32 (FBXO32) OTUE978R FBX32_HUMAN Increases Expression [28]
Oxysterol-binding protein 2 (OSBP2) OTDGLB4J OSBP2_HUMAN Increases Expression [8]
Ribosome-releasing factor 2, mitochondrial (GFM2) OT51TIMY RRF2M_HUMAN Increases Expression [9]
Transcription factor E2F7 (E2F7) OTWW358N E2F7_HUMAN Increases Expression [7]
Crossover junction endonuclease EME1 (EME1) OTD9RKD9 EME1_HUMAN Decreases Expression [7]
Arrestin domain-containing protein 3 (ARRDC3) OTAKW7R9 ARRD3_HUMAN Increases Expression [8]
Gamma-secretase subunit APH-1A (APH1A) OT97F1TU APH1A_HUMAN Decreases Expression [10]
Leucine-rich repeat-containing protein 45 (LRRC45) OTAAMYQO LRC45_HUMAN Decreases Expression [8]
CAP-Gly domain-containing linker protein 3 (CLIP3) OTGJEGIB CLIP3_HUMAN Decreases Expression [5]
Microspherule protein 1 (MCRS1) OT8K2X8P MCRS1_HUMAN Decreases Expression [6]
Sororin (CDCA5) OTZLCQ5U CDCA5_HUMAN Decreases Expression [7]
Aurora kinase B (AURKB) OTIY4VHU AURKB_HUMAN Increases Expression [6]
Serine/threonine-protein kinase greatwall (MASTL) OTQ7YKK5 GWL_HUMAN Increases Expression [6]
Serine/threonine-protein phosphatase PGAM5, mitochondrial (PGAM5) OT6Q5M0C PGAM5_HUMAN Decreases Expression [9]
Splicing factor 45 (RBM17) OT9ROJCL SPF45_HUMAN Decreases Expression [9]
Histone H2A type 1-H (H2AC12) OTLXVB97 H2A1H_HUMAN Decreases Expression [8]
Rho-related GTP-binding protein RhoV (RHOV) OTW4N3QN RHOV_HUMAN Increases Expression [8]
Coiled-coil domain-containing protein 7 (CCDC7) OTNCL9JR CCDC7_HUMAN Decreases Expression [7]
FYVE, RhoGEF and PH domain-containing protein 4 (FGD4) OTYXJQCW FGD4_HUMAN Increases Expression [6]
Uncharacterized protein C5orf34 (C5ORF34) OTT2ESR4 CE034_HUMAN Increases Expression [6]
NACHT, LRR and PYD domains-containing protein 3 (NLRP3) OTZM6MHU NLRP3_HUMAN Decreases Expression [16]
Serine/threonine-protein phosphatase 1 regulatory subunit 10 (PPP1R10) OT7GE3BN PP1RA_HUMAN Decreases Expression [8]
DEP domain-containing protein 7 (DEPDC7) OT62C942 DEPD7_HUMAN Increases Expression [6]
ATPase family AAA domain-containing protein 5 (ATAD5) OTI8ABKF ATAD5_HUMAN Decreases Expression [8]
Tribbles homolog 3 (TRIB3) OTG5OS7X TRIB3_HUMAN Increases Expression [28]
Tribbles homolog 1 (TRIB1) OTPEO17G TRIB1_HUMAN Increases Expression [8]
LysM and putative peptidoglycan-binding domain-containing protein 1 (LYSMD1) OTTLKELW LYSM1_HUMAN Decreases Expression [8]
Protein IWS1 homolog (IWS1) OTF96EYX IWS1_HUMAN Increases Expression [6]
Mitochondrial tRNA methylthiotransferase CDK5RAP1 (CDK5RAP1) OTDEJXD0 CK5P1_HUMAN Decreases Expression [6]
Proheparin-binding EGF-like growth factor (HBEGF) OTLU00JS HBEGF_HUMAN Increases Expression [11]
Sodium channel protein type 2 subunit alpha (SCN2A) OTUSYE4Z SCN2A_HUMAN Decreases Activity [48]
Sortilin (SORT1) OTFCQ4B1 SORT_HUMAN Increases Expression [9]
Transcription termination factor 1, mitochondrial (MTERF1) OT3EIK39 MTEF1_HUMAN Increases Expression [14]
Krueppel-like factor 6 (KLF6) OTQY9S7F KLF6_HUMAN Increases Expression [8]
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (PKMYT1) OTYRXD2T PMYT1_HUMAN Decreases Expression [7]
Succinate dehydrogenase cytochrome b560 subunit, mitochondrial (SDHC) OTC8G2MX C560_HUMAN Increases Expression [14]
Monoglyceride lipase (MGLL) OT5ES4IE MGLL_HUMAN Decreases Expression [6]
Cell division control protein 6 homolog (CDC6) OTX93FE7 CDC6_HUMAN Decreases Expression [7]
Mitogen-activated protein kinase kinase kinase 3 (MAP3K3) OT53LJGW M3K3_HUMAN Increases Expression [5]
Transmembrane 9 superfamily member 2 (TM9SF2) OTA0C202 TM9S2_HUMAN Decreases Expression [9]
Protein smoothened (SMO) OTXXE208 SMO_HUMAN Decreases Expression [8]
Myeloid differentiation primary response protein MyD88 (MYD88) OTB4D6FL MYD88_HUMAN Decreases Expression [16]
Histone H2A type 1-J (H2AC14) OT5Y4MMC H2A1J_HUMAN Decreases Expression [8]
Forkhead box protein C2 (FOXC2) OT83P1E0 FOXC2_HUMAN Increases Expression [6]
Growth/differentiation factor 15 (GDF15) OTWQN50N GDF15_HUMAN Increases Expression [28]
Target of rapamycin complex 2 subunit MAPKAP1 (MAPKAP1) OTYKB9G3 SIN1_HUMAN Increases Expression [14]
B-cell CLL/lymphoma 7 protein family member B (BCL7B) OT8DQQRD BCL7B_HUMAN Decreases Expression [6]
Junctophilin-2 (JPH2) OTL9YH7V JPH2_HUMAN Decreases Expression [8]
Partner of Y14 and mago (PYM1) OTEZ2WUO PYM1_HUMAN Increases Expression [9]
Cilia- and flagella-associated protein 300 (CFAP300) OTJWZZIO CF300_HUMAN Increases Expression [6]
Migration and invasion enhancer 1 (MIEN1) OTCQ8DAD MIEN1_HUMAN Decreases Expression [16]
Polycomb group RING finger protein 1 (PCGF1) OTHOU68T PCGF1_HUMAN Decreases Expression [6]
Mitochondrial ribosome-associated GTPase 1 (MTG1) OTC9U1LI MTG1_HUMAN Increases Expression [14]
Death-inducer obliterator 1 (DIDO1) OT9PB547 DIDO1_HUMAN Decreases Expression [8]
Histone H2A.J (H2AJ) OTVA4XTW H2AJ_HUMAN Increases Expression [9]
Glutathione-specific gamma-glutamylcyclotransferase 1 (CHAC1) OTJGE772 CHAC1_HUMAN Increases Expression [28]
Enoyl- reductase, mitochondrial (MECR) OTJQ5XKQ MECR_HUMAN Increases Expression [14]
Sister chromatid cohesion protein DCC1 (DSCC1) OTPUVLZT DCC1_HUMAN Decreases Expression [8]
Protein FAM174C (FAM174C) OTK2U1QO F174C_HUMAN Increases Expression [6]
Fanconi anemia group J protein (BRIP1) OT38QBD4 FANCJ_HUMAN Decreases Expression [7]
Bcl-2-like protein 13 (BCL2L13) OT2VRFTM B2L13_HUMAN Decreases Expression [16]
AP-1 complex subunit mu-1 (AP1M1) OT1IR6CD AP1M1_HUMAN Decreases Expression [9]
EKC/KEOPS complex subunit GON7 (GON7) OT36YA7Q GON7_HUMAN Increases Expression [6]
Fanconi anemia group D2 protein (FANCD2) OTVEB5LF FACD2_HUMAN Decreases Expression [7]
Actin-related protein T3 (ACTRT3) OT2U08K8 ACTT3_HUMAN Decreases Expression [8]
NF-kappa-B inhibitor zeta (NFKBIZ) OTU728KS IKBZ_HUMAN Increases Expression [8]
Hydroperoxide isomerase ALOXE3 (ALOXE3) OT76J52A LOXE3_HUMAN Increases Expression [8]
Sulfiredoxin-1 (SRXN1) OTYDBO4L SRXN1_HUMAN Increases Expression [11]
Kinetochore protein Nuf2 (NUF2) OTOOQL35 NUF2_HUMAN Increases Expression [6]
STE20-related kinase adapter protein beta (STRADB) OTUSF1A0 STRAB_HUMAN Decreases Expression [14]
Protein MIS12 homolog (MIS12) OT90D4M0 MIS12_HUMAN Increases Expression [6]
Sharpin (SHARPIN) OTU1J2KH SHRPN_HUMAN Decreases Expression [5]
Coiled-coil domain-containing protein 8 (CCDC8) OTO295IH CCDC8_HUMAN Decreases Expression [8]
Epsin-3 (EPN3) OTNNYDT6 EPN3_HUMAN Decreases Expression [8]
DNA replication factor Cdt1 (CDT1) OTVY53VG CDT1_HUMAN Decreases Expression [8]
Sphingosine 1-phosphate receptor 5 (S1PR5) OTQF1R0U S1PR5_HUMAN Decreases Expression [8]
Phosducin-like protein 3 (PDCL3) OTD3WGV1 PDCL3_HUMAN Decreases Expression [16]
Centromere protein H (CENPH) OTPOO9LK CENPH_HUMAN Increases Expression [6]
5-azacytidine-induced protein 2 (AZI2) OT61Q7Q8 AZI2_HUMAN Increases Expression [6]
5' exonuclease Apollo (DCLRE1B) OT2LFW7A DCR1B_HUMAN Decreases Expression [7]
5'-nucleotidase domain-containing protein 2 (NT5DC2) OTPDRGGN NT5D2_HUMAN Decreases Expression [8]
Protein ECT2 (ECT2) OTQDUCT6 ECT2_HUMAN Increases Expression [6]
Actin-related protein 5 (ACTR5) OT7L2KS6 ARP5_HUMAN Decreases Expression [9]
Large ribosomal subunit protein mL44 (MRPL44) OT27ZC26 RM44_HUMAN Increases Expression [14]
E3 ubiquitin-protein ligase SMURF2 (SMURF2) OT3TRVL7 SMUF2_HUMAN Increases Expression [5]
Calcyclin-binding protein (CACYBP) OTJMZD2T CYBP_HUMAN Increases Expression [6]
Transient receptor potential cation channel subfamily V member 4 (TRPV4) OTPZKQLX TRPV4_HUMAN Affects Activity [57]
Plasminogen receptor (PLGRKT) OT5ITHAW PLRKT_HUMAN Decreases Expression [16]
Solute carrier family 38 member 10 (SLC38A10) OTXPUL6S S38AA_HUMAN Decreases Expression [8]
Chromobox protein homolog 8 (CBX8) OT4U5V1T CBX8_HUMAN Increases Expression [6]
ATP-binding cassette sub-family B member 6 (ABCB6) OTPGZFES ABCB6_HUMAN Decreases Expression [8]
Tumor necrosis factor receptor superfamily member 12A (TNFRSF12A) OT5V52LN TNR12_HUMAN Decreases Expression [16]
Sodium- and chloride-dependent transporter XTRP3 (SLC6A20) OTHRD4XO S6A20_HUMAN Increases Expression [11]
Transcription and mRNA export factor ENY2 (ENY2) OTTNU8RK ENY2_HUMAN Decreases Expression [6]
Exosome complex component RRP41 (EXOSC4) OTG4TICP EXOS4_HUMAN Increases Expression [9]
Synembryn-A (RIC8A) OT4YZOWE RIC8A_HUMAN Decreases Expression [9]
Ubiquitin carboxyl-terminal hydrolase CYLD (CYLD) OT37FKH0 CYLD_HUMAN Increases Expression [5]
Diablo IAP-binding mitochondrial protein (DIABLO) OTHJ9MCZ DBLOH_HUMAN Decreases Expression [14]
Sphingosine kinase 2 (SPHK2) OTNFG52M SPHK2_HUMAN Increases Expression [6]
Platelet-derived growth factor C (PDGFC) OT3ZJ0XU PDGFC_HUMAN Decreases Expression [6]
DNA polymerase epsilon subunit 3 (POLE3) OTOELRF6 DPOE3_HUMAN Decreases Expression [7]
Glutaredoxin-2, mitochondrial (GLRX2) OT4LIRBC GLRX2_HUMAN Increases Expression [14]
Tumor necrosis factor receptor superfamily member 19 (TNFRSF19) OTTVT4MB TNR19_HUMAN Decreases Expression [16]
Protein FAM217B (FAM217B) OTDB4M8G F217B_HUMAN Decreases Expression [8]
SERTA domain-containing protein 4 (SERTAD4) OTZ1GUD9 SRTD4_HUMAN Decreases Expression [8]
tRNA:m(4)X modification enzyme TRM13 homolog (TRMT13) OT2H0MCE TRM13_HUMAN Decreases Expression [9]
Fanconi anemia group I protein (FANCI) OTW8E3SC FANCI_HUMAN Decreases Expression [7]
ATP-dependent RNA helicase DDX18 (DDX18) OTKB9C3S DDX18_HUMAN Increases Expression [6]
Arginine and glutamate-rich protein 1 (ARGLU1) OTRVRZ4Z ARGL1_HUMAN Increases Expression [6]
Uncharacterized protein C14orf119 (C14ORF119) OT0T836C CN119_HUMAN Increases Expression [6]
Uncharacterized protein C2orf42 (C2ORF42) OTN1MSWZ CB042_HUMAN Increases Expression [6]
DNA damage-inducible transcript 4 protein (DDIT4) OTHY8SY4 DDIT4_HUMAN Increases Expression [28]
Nuclear distribution protein nudE homolog 1 (NDE1) OT2N8Q17 NDE1_HUMAN Increases Expression [6]
Sodium channel protein type 3 subunit alpha (SCN3A) OT4C2LCB SCN3A_HUMAN Decreases Activity [48]
G2 and S phase-expressed protein 1 (GTSE1) OTPP742Z GTSE1_HUMAN Decreases Expression [7]
Endoplasmic reticulum aminopeptidase 1 (ERAP1) OT72S99B ERAP1_HUMAN Decreases Expression [9]
Gamma-secretase subunit PEN-2 (PSENEN) OTJ7M7G9 PEN2_HUMAN Decreases Expression [10]
Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3) OT0DZGY4 E2AK3_HUMAN Increases Phosphorylation [15]
Opioid growth factor receptor (OGFR) OTROS6RJ OGFR_HUMAN Decreases Expression [6]
Dentin sialophosphoprotein (DSPP) OT1TYNDN DSPP_HUMAN Increases Expression [34]
Very-long-chain (HACD3) OTISMCAF HACD3_HUMAN Increases Expression [9]
Origin recognition complex subunit 3 (ORC3) OTYQWB6B ORC3_HUMAN Increases Expression [6]
DnaJ homolog subfamily B member 9 (DNAJB9) OT38EQT6 DNJB9_HUMAN Increases Expression [28]
Protein DBF4 homolog A (DBF4) OTBL7JHQ DBF4A_HUMAN Decreases Expression [7]
DnaJ homolog subfamily B member 4 (DNAJB4) OTUD01BK DNJB4_HUMAN Increases Expression [28]
Kelch-like protein 3 (KLHL3) OTEJ6850 KLHL3_HUMAN Decreases Expression [8]
Prenylcysteine oxidase 1 (PCYOX1) OT8FBKY0 PCYOX_HUMAN Decreases Expression [8]
DNA helicase MCM8 (MCM8) OTC93H3S MCM8_HUMAN Decreases Expression [7]
ERBB receptor feedback inhibitor 1 (ERRFI1) OT7VZ2IZ ERRFI_HUMAN Increases Expression [8]
Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial (SLC25A13) OTTZVSK6 S2513_HUMAN Decreases Expression [9]
Peroxisomal carnitine O-octanoyltransferase (CROT) OTWK68MM OCTC_HUMAN Decreases Expression [8]
CASP8-associated protein 2 (CASP8AP2) OTTWT68S C8AP2_HUMAN Decreases Expression [8]
Nuclear pore complex protein Nup50 (NUP50) OTOZ98K3 NUP50_HUMAN Increases Expression [9]
Protein CDV3 homolog (CDV3) OTUA175T CDV3_HUMAN Increases Expression [6]
Plexin-B3 (PLXNB3) OTXRKPOO PLXB3_HUMAN Decreases Expression [6]
Transcription factor MafF (MAFF) OT9B7MX0 MAFF_HUMAN Increases Expression [11]
Apoptosis-associated speck-like protein containing a CARD (PYCARD) OT67RON3 ASC_HUMAN Decreases Expression [16]
Inhibitor of growth protein 4 (ING4) OT0VVG4V ING4_HUMAN Decreases Expression [16]
AP-4 complex subunit epsilon-1 (AP4E1) OT4DUNVU AP4E1_HUMAN Increases Expression [6]
Cystine/glutamate transporter (SLC7A11) OTKJ6PXW XCT_HUMAN Increases Expression [11]
Exonuclease 1 (EXO1) OTI87RS5 EXO1_HUMAN Decreases Expression [7]
Sodium channel protein type 8 subunit alpha (SCN8A) OT0JGIZN SCN8A_HUMAN Decreases Activity [48]
C-Jun-amino-terminal kinase-interacting protein 1 (MAPK8IP1) OTDAWAUZ JIP1_HUMAN Increases Expression [6]
Protein phosphatase 1 regulatory subunit 3C (PPP1R3C) OTEU05TX PPR3C_HUMAN Increases Expression [28]
Calcium/calmodulin-dependent protein kinase type II subunit alpha (CAMK2A) OTJGX19T KCC2A_HUMAN Decreases Expression [10]
Chromodomain Y-like protein (CDYL) OTCUK5KZ CDYL_HUMAN Increases Expression [6]
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 (PIN4) OT403QC1 PIN4_HUMAN Decreases Expression [6]
DNA replication complex GINS protein PSF2 (GINS2) OT974IYI PSF2_HUMAN Decreases Expression [8]
Dexamethasone-induced Ras-related protein 1 (RASD1) OT2BAJHK RASD1_HUMAN Increases Expression [8]
Caspase recruitment domain-containing protein 8 (CARD8) OTXXZYWU CARD8_HUMAN Decreases Expression [16]
Small ribosomal subunit protein bS1m (MRPS28) OT8CLJ6M RT28_HUMAN Increases Expression [14]
MOB-like protein phocein (MOB4) OTOQRMAS PHOCN_HUMAN Increases Expression [9]
Small ribosomal subunit protein bS18m (MRPS18C) OTL868QS RT18C_HUMAN Increases Expression [14]
Mitochondrial fission 1 protein (FIS1) OT2HL10J FIS1_HUMAN Decreases Expression [14]
Serine-threonine kinase receptor-associated protein (STRAP) OTT3T7QT STRAP_HUMAN Increases Expression [5]
Talin-2 (TLN2) OT10QQBC TLN2_HUMAN Decreases Expression [9]
Mitochondrial import inner membrane translocase subunit Tim9 (TIMM9) OTK7PDNN TIM9_HUMAN Increases Expression [14]
Mitochondrial import inner membrane translocase subunit Tim8 B (TIMM8B) OTGZO1MT TIM8B_HUMAN Increases Expression [14]
Origin recognition complex subunit 6 (ORC6) OTKQN3KP ORC6_HUMAN Decreases Expression [7]
Cysteine sulfinic acid decarboxylase (CSAD) OT3I2G0A CSAD_HUMAN Decreases Expression [6]
Phosphoserine aminotransferase (PSAT1) OTVV1YV9 SERC_HUMAN Increases Expression [28]
Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase (ALG6) OTZRVUH4 ALG6_HUMAN Decreases Expression [8]
Calcineurin-binding protein cabin-1 (CABIN1) OT4G5CIK CABIN_HUMAN Decreases Expression [14]
Proton-coupled zinc antiporter SLC30A1 (SLC30A1) OTY8J0S4 ZNT1_HUMAN Increases Expression [8]
Lymphocyte antigen 96 (LY96) OTN4HXA2 LY96_HUMAN Decreases Expression [16]
Cytochrome P450 2J2 (CYP2J2) OTJBTEH8 CP2J2_HUMAN Increases Metabolism [58]
------------------------------------------------------------------------------------
⏷ Show the Full List of 739 DOT(s)
Indication(s) of Clobazam - Lundbeck
Disease Entry ICD 11 Status REF
Anxiety disorder 6B00-6B0Z Approved [4]
Epilepsy 8A60-8A68 Approved [4]
Clobazam - Lundbeck Interacts with 2 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
GABA(A) receptor gamma-3 (GABRG3) TTEX6LM GBRG3_HUMAN Modulator [59]
GABA(A) receptor alpha-1 (GABRA1) TT1MPAY GBRA1_HUMAN Antagonist [60]
------------------------------------------------------------------------------------
Clobazam - Lundbeck Interacts with 1 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [61]
------------------------------------------------------------------------------------
Clobazam - Lundbeck Interacts with 4 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [62]
Cytochrome P450 2C18 (CYP2C18) DEZMWRE CP2CI_HUMAN Metabolism [62]
Cytochrome P450 2B6 (CYP2B6) DEPKLMQ CP2B6_HUMAN Metabolism [62]
Mephenytoin 4-hydroxylase (CYP2C19) DEGTFWK CP2CJ_HUMAN Metabolism [63]
------------------------------------------------------------------------------------
Clobazam - Lundbeck Interacts with 2 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Cytochrome P450 2C19 (CYP2C19) OTFMJYYE CP2CJ_HUMAN Increases ADR [62]
Apolipoprotein E (APOE) OTFOWL2H APOE_HUMAN Increases ADR [64]
------------------------------------------------------------------------------------

References

1 ClinicalTrials.gov (NCT02564952) An Open-label Extension Study to Investigate Possible Drug-drug Interactions Between Clobazam and Cannabidiol
2 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89.
3 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7149).
5 Transcriptomic Analysis of Stem Cells Treated with Moringin or Cannabidiol: Analogies and Differences in Inflammation Pathways. Int J Mol Sci. 2019 Nov 30;20(23):6039. doi: 10.3390/ijms20236039.
6 Cannabidiol Activates Neuronal Precursor Genes in Human Gingival Mesenchymal Stromal Cells. J Cell Biochem. 2017 Jun;118(6):1531-1546. doi: 10.1002/jcb.25815. Epub 2016 Dec 29.
7 Cannabidiol-induced transcriptomic changes and cellular senescence in human Sertoli cells. Toxicol Sci. 2023 Feb 17;191(2):227-238. doi: 10.1093/toxsci/kfac131.
8 Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma. Sci Rep. 2020 Nov 26;10(1):20622. doi: 10.1038/s41598-020-77674-y.
9 Cannabidiol Displays Proteomic Similarities to Antipsychotics in Cuprizone-Exposed Human Oligodendrocytic Cell Line MO3.13. Front Mol Neurosci. 2021 May 28;14:673144. doi: 10.3389/fnmol.2021.673144. eCollection 2021.
10 Cannabidiol Modulates the Expression of Alzheimer's Disease-Related Genes in Mesenchymal Stem Cells. Int J Mol Sci. 2016 Dec 23;18(1):26. doi: 10.3390/ijms18010026.
11 Cannabidiol induces antioxidant pathways in keratinocytes by targeting BACH1. Redox Biol. 2020 Jan;28:101321. doi: 10.1016/j.redox.2019.101321. Epub 2019 Sep 5.
12 Cannabidiol upregulates melanogenesis through CB1 dependent pathway by activating p38 MAPK and p42/44 MAPK. Chem Biol Interact. 2017 Aug 1;273:107-114. doi: 10.1016/j.cbi.2017.06.005. Epub 2017 Jun 7.
13 In vitro effects of cannabidiol and its main metabolites in mouse and human Sertoli cells. Food Chem Toxicol. 2022 Jan;159:112722. doi: 10.1016/j.fct.2021.112722. Epub 2021 Dec 3.
14 Gingival Stromal Cells as an In Vitro Model: Cannabidiol Modulates Genes Linked With Amyotrophic Lateral Sclerosis. J Cell Biochem. 2017 Apr;118(4):819-828. doi: 10.1002/jcb.25757. Epub 2016 Nov 28.
15 Cannabidiol promotes apoptosis via regulation of XIAP/Smac in gastric cancer. Cell Death Dis. 2019 Nov 7;10(11):846. doi: 10.1038/s41419-019-2001-7.
16 Cannabidiol Modulates the Immunophenotype and Inhibits the Activation of the Inflammasome in Human Gingival Mesenchymal Stem Cells. Front Physiol. 2016 Nov 24;7:559. doi: 10.3389/fphys.2016.00559. eCollection 2016.
17 (-)-Cannabidiol antagonizes cannabinoid receptor agonists and noradrenaline in the mouse vas deferens. Eur J Pharmacol. 2002 Dec 5;456(1-3):99-106.
18 KEGG: new perspectives on genomes, pathways, diseases and drugs. Nucleic Acids Res. 2017 Jan 4;45(D1):D353-D361. (dg:DG01665)
19 Molecular targets of cannabidiol in neurological disorders. Neurotherapeutics. 2015 Oct;12(4):699-730.
20 Exogenous cannabinoids as substrates, inhibitors, and inducers of human drug metabolizing enzymes: a systematic review. Drug Metab Rev. 2014 Feb;46(1):86-95.
21 Characterization of the structural determinants required for potent mechanism-based inhibition of human cytochrome P450 1A1 by cannabidiol. Chem Biol Interact. 2014 May 25;215:62-8.
22 Cannabidiol, a major phytocannabinoid, as a potent atypical inhibitor for CYP2D6. Drug Metab Dispos. 2011 Nov;39(11):2049-56. doi: 10.1124/dmd.111.041384. Epub 2011 Aug 5.
23 TRPV2 is activated by cannabidiol and mediates CGRP release in cultured rat dorsal root ganglion neurons. J Neurosci. 2008 Jun 11;28(24):6231-8.
24 Interaction of plant cannabinoids with the multidrug transporter ABCC1 (MRP1). Eur J Pharmacol. 2008 Sep 4;591(1-3):128-31.
25 COX-2 and PPAR-gama confer cannabidiol-induced apoptosis of human lung cancer cells. Mol Cancer Ther. 2013 Jan;12(1):69-82.
26 Cannabidiol regulates CB1-pSTAT3 signaling for neurite outgrowth, prolongs lifespan, and improves health span in Caenorhabditis elegans of A pathology models. FASEB J. 2021 May;35(5):e21537. doi: 10.1096/fj.202002724R.
27 Cannabidiol induces osteoblast differentiation via angiopoietin1 and p38 MAPK. Environ Toxicol. 2020 Dec;35(12):1318-1325. doi: 10.1002/tox.22996. Epub 2020 Jul 13.
28 Inhibiting Heat Shock Proteins Can Potentiate the Cytotoxic Effect of Cannabidiol in Human Glioma Cells. Anticancer Res. 2015 Nov;35(11):5827-37.
29 Role of miRNA in the regulation of cannabidiol-mediated apoptosis in neuroblastoma cells. Oncotarget. 2019 Jan 1;10(1):45-59. doi: 10.18632/oncotarget.26534. eCollection 2019 Jan 1.
30 Liprin alfa 2 gene expression is increased by cannabis use and associated with neuropsychological function. Eur Neuropsychopharmacol. 2019 May;29(5):643-652. doi: 10.1016/j.euroneuro.2019.03.004. Epub 2019 Mar 15.
31 Cytotoxic Effects of Cannabinoids on Human HT-29 Colorectal Adenocarcinoma Cells: Different Mechanisms of THC, CBD, and CB83. Int J Mol Sci. 2020 Aug 1;21(15):5533. doi: 10.3390/ijms21155533.
32 Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1. FASEB J. 2012 Apr;26(4):1535-48. doi: 10.1096/fj.11-198184. Epub 2011 Dec 23.
33 CBD Promotes Oral Ulcer Healing via Inhibiting CMPK2-Mediated Inflammasome. J Dent Res. 2022 Feb;101(2):206-215. doi: 10.1177/00220345211024528. Epub 2021 Jul 16.
34 Investigation of in vitro odonto/osteogenic capacity of cannabidiol on human dental pulp cell. J Dent. 2021 Jun;109:103673. doi: 10.1016/j.jdent.2021.103673. Epub 2021 Apr 16.
35 Cannabidiol and Oxygen-Ozone Combination Induce Cytotoxicity in Human Pancreatic Ductal Adenocarcinoma Cell Lines. Cancers (Basel). 2020 Sep 27;12(10):2774. doi: 10.3390/cancers12102774.
36 Cannabidiol induces expression of human cytochrome P450 1A1 that is possibly mediated through aryl hydrocarbon receptor signaling in HepG2 cells. Life Sci. 2015 Sep 1;136:87-93. doi: 10.1016/j.lfs.2015.07.007. Epub 2015 Jul 15.
37 Decrease of plasminogen activator inhibitor-1 may contribute to the anti-invasive action of cannabidiol on human lung cancer cells. Pharm Res. 2010 Oct;27(10):2162-74. doi: 10.1007/s11095-010-0219-2. Epub 2010 Jul 29.
38 Inhibition of autophagic flux differently modulates cannabidiol-induced death in 2D and 3D glioblastoma cell cultures. Sci Rep. 2020 Feb 14;10(1):2687. doi: 10.1038/s41598-020-59468-4.
39 Ca(2+) Signaling and IL-8 Secretion in Human Testicular Peritubular Cells Involve the Cation Channel TRPV2. Int J Mol Sci. 2018 Sep 19;19(9):2829. doi: 10.3390/ijms19092829.
40 HU-331 and Oxidized Cannabidiol Act as Inhibitors of Human Topoisomerase II and . Chem Res Toxicol. 2018 Feb 19;31(2):137-144. doi: 10.1021/acs.chemrestox.7b00302. Epub 2018 Jan 8.
41 Cannabidiol (CBD) but not tetrahydrocannabinol (THC) dysregulate in vitro decidualization of human endometrial stromal cells by disruption of estrogen signaling. Reprod Toxicol. 2020 Apr;93:75-82. doi: 10.1016/j.reprotox.2020.01.003. Epub 2020 Jan 14.
42 Inhibition of interleukin-1-induced endothelial tissue factor expression by the synthetic cannabinoid WIN 55,212-2. Oncotarget. 2016 Sep 20;7(38):61438-61457. doi: 10.18632/oncotarget.11367.
43 Effects of non-euphoric plant cannabinoids on muscle quality and performance of dystrophic mdx mice. Br J Pharmacol. 2019 May;176(10):1568-1584. doi: 10.1111/bph.14460. Epub 2018 Sep 9.
44 Cannabidiol Effectively Promoted Cell Death in Bladder Cancer and the Improved Intravesical Adhesion Drugs Delivery Strategy Could Be Better Used for Treatment. Pharmaceutics. 2021 Sep 7;13(9):1415. doi: 10.3390/pharmaceutics13091415.
45 Cannabinoids synergize with carfilzomib, reducing multiple myeloma cells viability and migration. Oncotarget. 2016 Nov 22;7(47):77543-77557. doi: 10.18632/oncotarget.12721.
46 Novel mechanism of cannabidiol-induced apoptosis in breast cancer cell lines. Breast. 2018 Oct;41:34-41. doi: 10.1016/j.breast.2018.06.009. Epub 2018 Jun 22.
47 hiPSC-Based Model of Prenatal Exposure to Cannabinoids: Effect on Neuronal Differentiation. Front Mol Neurosci. 2020 Jul 6;13:119. doi: 10.3389/fnmol.2020.00119. eCollection 2020.
48 Inhibitory effects of cannabidiol on voltage-dependent sodium currents. J Biol Chem. 2018 Oct 26;293(43):16546-16558. doi: 10.1074/jbc.RA118.004929. Epub 2018 Sep 14.
49 Effects of cannabidiol on the function of 7-nicotinic acetylcholine receptors. Eur J Pharmacol. 2013 Nov 15;720(1-3):310-9. doi: 10.1016/j.ejphar.2013.10.011. Epub 2013 Oct 18.
50 Targeting multiple cannabinoid anti-tumour pathways with a resorcinol derivative leads to inhibition of advanced stages of breast cancer. Br J Pharmacol. 2014 Oct;171(19):4464-77. doi: 10.1111/bph.12803. Epub 2014 Sep 5.
51 Palmitoylethanolamide and Cannabidiol Prevent Inflammation-induced Hyperpermeability of the Human Gut In Vitro and In Vivo-A Randomized, Placebo-controlled, Double-blind Controlled Trial. Inflamm Bowel Dis. 2019 May 4;25(6):1006-1018. doi: 10.1093/ibd/izz017.
52 Cannabidiol Reduces Leukemic Cell Size - But Is It Important?. Front Pharmacol. 2017 Mar 24;8:144. doi: 10.3389/fphar.2017.00144. eCollection 2017.
53 Cannabidiol Induces Cell Cycle Arrest and Cell Apoptosis in Human Gastric Cancer SGC-7901 Cells. Biomolecules. 2019 Jul 25;9(8):302. doi: 10.3390/biom9080302.
54 Cannabidiol disrupts apoptosis, autophagy and invasion processes of placental trophoblasts. Arch Toxicol. 2021 Oct;95(10):3393-3406. doi: 10.1007/s00204-021-03122-z. Epub 2021 Jul 24.
55 A novel mechanism of cannabidiol in suppressing ovarian cancer through LAIR-1 mediated mitochondrial dysfunction and apoptosis. Environ Toxicol. 2023 May;38(5):1118-1132. doi: 10.1002/tox.23752. Epub 2023 Feb 22.
56 Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide. Br J Pharmacol. 2001 Oct;134(4):845-52. doi: 10.1038/sj.bjp.0704327.
57 Cannabidiol inhibits human glioma by induction of lethal mitophagy through activating TRPV4. Autophagy. 2021 Nov;17(11):3592-3606. doi: 10.1080/15548627.2021.1885203. Epub 2021 Feb 25.
58 Cross-talk of cannabinoid and endocannabinoid metabolism is mediated via human cardiac CYP2J2. J Inorg Biochem. 2018 Jul;184:88-99. doi: 10.1016/j.jinorgbio.2018.03.016. Epub 2018 Apr 7.
59 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
60 DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6.
61 Tarascon Pocket Pharmacopoeia 2018 Classic Shirt-Pocket Edition.
62 In vitro characterization of clobazam metabolism by recombinant cytochrome P450 enzymes: importance of CYP2C19. Drug Metab Dispos. 2004 Nov;32(11):1279-86.
63 A major influence of CYP2C19 genotype on the steady-state concentration of N-desmethylclobazam. Brain Dev. 2004 Dec;26(8):530-4.
64 Apolipoprotein E gene polymorphisms are associated with psoriasis but do not determine disease response to acitretin. Br J Dermatol. 2006 Feb;154(2):345-52. doi: 10.1111/j.1365-2133.2005.06950.x.