Details of the Drug Combinations

General Information of This Drug (ID: DM0C9IL)

Drug Name

Ranolazine DM0C9IL

Synonyms

RANOLAZINE; 95635-55-5; Ranexa; N-(2,6-dimethylphenyl)-2-(4-(2-hydroxy-3-(2-methoxyphenoxy)propyl)piperazin-1-yl)acetamide; CVT-303; (-)-Ranolazine; Ranolazine (Ranexa); Ranolazine 2HCl; RS-43285-003; 142387-99-3; N-(2,6-dimethylphenyl)-2-[4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl]acetamide; CHEBI:87690; N-(2,6-dimethylphenyl)-2-{4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl}acetamide; C24H33N3O4; NCGC00015897-02; DSSTox_RID_80743; DSSTox_CID_25196; DSSTox_GSID_45196; Ran4; CVT 303; Latixa; RAN D; Latixa; Ranolazine dihydrochloride; KEG-1295; RS-43285; Ranexa (TN); Ranexa, Ranolazine; Ranolazine (USAN/INN); Ranolazine extended-release; Ranolazine/Dronedarone Fixed-Dose Combination

Indication

Disease Entry	ICD 11	Status	REF
Acute coronary syndrome	BA41	Approved	[1]
Angina pectoris	BA40	Approved	[1]
Chronic/stable angina	BA40.1	Approved	[2]
Diarrhea-predominant irritable bowel syndrome	DD91.01	Approved	[1]
Paroxysmal atrial fibrillation	BC81.30	Phase 2	[3]
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Therapeutic Class

Analgesics

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

3 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Ranolazine + Metformin	DC90236	Metformin	Type 2 Diabetes Mellitus	[4]
Ranolazine + Dronedarone	DCH3PCS	Dronedarone	Atrial Fibrillation	[5]
Ranolazine + Glimepiride	DCQ6TIP	Glimepiride	Type 2 Diabetes Mellitus	[6]
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References

1	Ranolazine FDA Label
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7291).
3	Clinical pipeline report, company report or official report of Gilead.
4	ClinicalTrials.gov (NCT01546558) Single Cohort, 2-Period Study to Assess Pharmacokinetics of Metformin Alone and in Combination With Ranolazine 500 mg
5	ClinicalTrials.gov (NCT01522651) Study to Evaluate the Effect of Ranolazine and Dronedarone When Given Alone and in Combination in Patients With Paroxysmal Atrial Fibrillation
6	ClinicalTrials.gov (NCT01494987) Ranolazine When Added to Glimepiride in Subjects With Type 2 Diabetes Mellitus