Details of the Drug Combinations

General Information of This Drug (ID: DM1FW0C)

Drug Name

AZD7762 DM1FW0C

Synonyms

AZD7762; 860352-01-8; AZD-7762; (S)-5-(3-Fluorophenyl)-N-(piperidin-3-yl)-3-ureidothiophene-2-carboxamide; AZD 7762; UNII-5D822Y3L1H; 3-(Carbamoylamino)-5-(3-Fluorophenyl)-N-[(3s)-Piperidin-3-Yl]thiophene-2-Carboxamide; CHEMBL2041933; 5D822Y3L1H; J-502468; 5-(3-Fluorophenyl)-N-[(3s)-3-Piperidyl]-3-Ureido-Thiophene-2-Carboxamide; IAYGCINLNONXHY-LBPRGKRZSA-N; YDJ; AZD7762 hydrochloride; 5-(3-Fluorophenyl)-3-ureidothiophene-N-[(S)-piperidin-3-yl]-2-carboxamide; SCHEMBL1127614; GTPL7713; AOB1915; QCR-261; CHEBI:131156

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Phase 1	[1]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

4 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
AZD7762 + Ruxolitinib	DCNLIKY	Ruxolitinib	Hodgkin lymphoma (Cell Line: L-1236)	[2]
AZD7762 + Panobinostat	DC7O7IS	Panobinostat	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
AZD7762 + Pralatrexate	DC8Q85E	Pralatrexate	Ewing sarcoma (Cell Line: TC-71)	[2]
AZD7762 + Mitomycin	DCT3C7W	Mitomycin	Diffuse large B cell lymphoma (Cell Line: TMD8)	[2]
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2 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
AZD7762 + Gemcitabine	DCAR403	Gemcitabine	Cancer	[3]
AZD7762 + Irinotecan	DCKP75R	Irinotecan	Advanced Solid Tumors	[4]
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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7713).
2	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3	ClinicalTrials.gov (NCT00937664) Safety and Tolerability Study of AZD7762 in Combination With Gemcitabine
4	ClinicalTrials.gov (NCT00473616) Phase I Single Ascending Dose/Multiple Ascending Dose in Patients Treated With AZD7762 and Irinotecan