Details of the Drug Combinations

General Information of This Drug (ID: DM1Z74X)

Drug Name

Tacedinaline DM1Z74X

Synonyms

Acetyldinaline; Tacedinalina; Goe 5549; PD 123654; Ci-994; Goe-5549; PD-123654; Tacedinalina [INN-Spanish]; Tacedinaline [USAN:INN]; C.I. 994; Tacedinaline (USAN/INN); 4-(Acetylamino)-N-(2-aminophenyl)benzamide; 4-acetamido-N-(2-aminophenyl)benzamide; 4-acetamido-n-(2-aminophenyl)benzamid; 4-acetylamino-N-(2'-aminophenyl)benzamide

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Discontinued in Phase 2	[1]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

3 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Tacedinaline + Panobinostat	DCUFKKM	Panobinostat	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
Tacedinaline + Idarubicin	DC56CG0	Idarubicin	Glioblastoma? (Cell Line: T98G)	[2]
Tacedinaline + Ruxolitinib	DCZFDS2	Ruxolitinib	Hodgkin lymphoma (Cell Line: L-1236)	[3]
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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8367).
2	CheMBL Affinity Phenotypic Cellular Interaction Assay ID: CHEMBL1125966
3	CheMBL Affinity Phenotypic Cellular Interaction Assay ID: CHEMBL1125976