Details of the Drug Combinations

General Information of This Drug (ID: DM3Q1HL)

Drug Name
T-3.5   DM3Q1HL
Synonyms
Hemozoin formation inhibitors (malaria); T3.5; Antimalarials, Oregon Health & Science University; Acridones (malaria), Oregon Health & Science University; Endochin-like quinolones, Oregon Health & Science University; Hemozoin formation inhibitors (malaria), Oregon Health & Science University; Modified acridone anti-malaria drugs, DesignMedix/Portland State University; SYNAC series of modified acridones (malaria), DesignMedix/Portland State University; T2 (malaria), Oregon Health & Science University; X5 (malaria), Oregon Health &Science University; T-3.5, DesignMedix/Portland State University
Indication
Disease Entry ICD 11 Status REF
Malaria 1F40-1F45 Investigative [1]
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

19 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Dihydroergotamine + T-3.5 DC9X1NR Dihydroergotamine Hepatoblastoma (Cell Line: HB3) [2]
Ivermectin + T-3.5 DC5RXX5 Ivermectin Hepatoblastoma (Cell Line: HB3) [2]
JTC-801 + T-3.5 DC1EGRK JTC-801 DD2 (Cell Line: DD2) [2]
JTC-801 + T-3.5 DC49GJH JTC-801 Hepatoblastoma (Cell Line: HB3) [2]
Miconazole + T-3.5 DCNHUW7 Miconazole Hepatoblastoma (Cell Line: HB3) [3]
Nitisinone + T-3.5 DCN58EC Nitisinone DD2 (Cell Line: DD2) [2]
Nitisinone + T-3.5 DCFXAK7 Nitisinone Hepatoblastoma (Cell Line: HB3) [2]
Omacetaxine mepesuccinate + T-3.5 DCTDLWZ Omacetaxine mepesuccinate DD2 (Cell Line: DD2) [2]
Omacetaxine mepesuccinate + T-3.5 DC3HE5A Omacetaxine mepesuccinate Hepatoblastoma (Cell Line: HB3) [3]
Pyrimethamine + T-3.5 DC13WUT Pyrimethamine DD2 (Cell Line: DD2) [2]
SB 228357 + T-3.5 DCVQUGZ SB 228357 Hepatoblastoma (Cell Line: HB3) [3]
Sorafenib + T-3.5 DCOVVS7 Sorafenib DD2 (Cell Line: DD2) [2]
Sorafenib + T-3.5 DCZP6W7 Sorafenib Hepatoblastoma (Cell Line: HB3) [2]
T-3.5 + MK-4815 DCCCO03 MK-4815 DD2 (Cell Line: DD2) [2]
T-3.5 + Atovaquone DCP4CIA Atovaquone DD2 (Cell Line: DD2) [2]
T-3.5 + NITD609 DCFFYR4 NITD609 Hepatoblastoma (Cell Line: HB3) [3]
T-3.5 + MK-4815 DC39677 MK-4815 Hepatoblastoma (Cell Line: HB3) [3]
Vorinostat + T-3.5 DCA4M8G Vorinostat Hepatoblastoma (Cell Line: HB3) [2]
ZM-447439 + T-3.5 DCPSAE6 ZM-447439 DD2 (Cell Line: DD2) [2]
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⏷ Show the Full List of 19 DrugCom(s)

References

1 The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
2 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.