Details of the Drug Combinations

General Information of This Drug (ID: DM5CBNY)

Drug Name
BIX-01294   DM5CBNY
Synonyms BIX01294; BIX 01294
Indication
Disease Entry ICD 11 Status REF
Breast cancer 2C60-2C65 Preclinical [1]
Drug Type
Small molecular drug
Structure
3D MOL is unavailable 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

24 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Artemether + BIX-01294 DC7USAS Artemether DD2 (Cell Line: DD2) [2]
Artemisinin + BIX-01294 DCPRUEK Artemisinin DD2 (Cell Line: DD2) [2]
Artemisinin + BIX-01294 DCQJFWT Artemisinin Hepatoblastoma (Cell Line: HB3) [2]
BGT226 + BIX-01294 DCDC56N BGT226 DD2 (Cell Line: DD2) [2]
BIX-01294 + Clindamycin DCB5LFJ Clindamycin DD2 (Cell Line: DD2) [2]
BIX-01294 + Ruxolitinib DCVIHG2 Ruxolitinib T-cell leukemia/lymphoma (Cell Line: ED-40515) [2]
BIX-01294 + THAPSIGARGIN DCTL2VR THAPSIGARGIN Ewing sarcoma (Cell Line: TC-71) [2]
BIX-01294 + Marizomib DCEHEQV Marizomib Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
BIX-01294 + ABT-263 DCWJ0FM ABT-263 Ewing sarcoma (Cell Line: TC-71) [2]
BIX-01294 + Artemisinin DCXKFWT Artemisinin DD2 (Cell Line: DD2) [2]
BIX-01294 + Clomiphene citrate DCO3RAA Clomiphene citrate DD2 (Cell Line: DD2) [2]
BIX-01294 + Chloroquine DCGA57W Chloroquine DD2 (Cell Line: DD2) [2]
BIX-01294 + Naltrexone DCRGPAS Naltrexone DD2 (Cell Line: DD2) [2]
BIX-01294 + Piperaquine DCRFU87 Piperaquine DD2 (Cell Line: DD2) [2]
BIX-01294 + Mefloquine DCMEIA2 Mefloquine DD2 (Cell Line: DD2) [2]
BIX-01294 + Clindamycin DC6961M Clindamycin Hepatoblastoma (Cell Line: HB3) [3]
BIX-01294 + Ruxolitinib DCECH1I Ruxolitinib Hodgkin lymphoma (Cell Line: L-1236) [3]
BIX-01294 + THAPSIGARGIN DCEJJHR THAPSIGARGIN Hodgkin lymphoma (Cell Line: U-HO1) [3]
BIX-01294 + Artemisinin DCP46F0 Artemisinin Hepatoblastoma (Cell Line: HB3) [3]
BIX-01294 + Clomiphene citrate DCOT2WS Clomiphene citrate Hepatoblastoma (Cell Line: HB3) [3]
BIX-01294 + Mefloquine DCZ51Q1 Mefloquine Hepatoblastoma (Cell Line: HB3) [3]
NVP-AUY922 + BIX-01294 DCQH7NC NVP-AUY922 Hepatoblastoma (Cell Line: HB3) [3]
Tranylcypromine + BIX-01294 DCMS5SX Tranylcypromine DD2 (Cell Line: DD2) [2]
Tranylcypromine + BIX-01294 DCRJQ73 Tranylcypromine Hepatoblastoma (Cell Line: HB3) [2]
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⏷ Show the Full List of 24 DrugCom(s)

References

1 Epigenetics and beyond: targeting writers of protein lysine methylation to treat disease. Nat Rev Drug Discov. 2021 Apr;20(4):265-286.
2 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.