Details of the Drug

General Information of Drug (ID: DM5CBNY)

• Drug Name: BIX-01294
• Synonyms: BIX01294; BIX 01294

Indication

Disease Entry	ICD 11	Status	REF
Breast cancer	2C60-2C65	Preclinical	[1]

• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 0:
  Molecular Weight (mw); 490.6
  Logarithm of the Partition Coefficient (xlogp); 4.5
  Rotatable Bond Count (rotbonds); 7
  Hydrogen Bond Donor Count (hbonddonor); 1
  Hydrogen Bond Acceptor Count (hbondacc); 8
• Chemical Identifiers:
  Formula: C28H38N6O2
  IUPAC Name: N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amine
  Canonical SMILES: CN1CCCN(CC1)C2=NC3=CC(=C(C=C3C(=N2)NC4CCN(CC4)CC5=CC=CC=C5)OC)OC
  InChI: InChI=1S/C28H38N6O2/c1-32-12-7-13-34(17-16-32)28-30-24-19-26(36-3)25(35-2)18-23(24)27(31-28)29-22-10-14-33(15-11-22)20-21-8-5-4-6-9-21/h4-6,8-9,18-19,22H,7,10-17,20H2,1-3H3,(H,29,30,31)
  InChIKey: OSXFATOLZGZLSK-UHFFFAOYSA-N
• Cross-matching ID:
  PubChem CID: 25150857
  ChEBI ID: CHEBI:93986
  CAS Number: 935693-62-2
  TTD ID: D06PPL

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Euchromatic histone-lysine N-methyltransferase 1 (EHMT1)	TTOFXD7	EHMT1_HUMAN	Inhibitor	[2]
Histone-lysine N-methyltransferase EHMT2 (EHMT2)	TTS6RZT	EHMT2_HUMAN	Inhibitor	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Interferon alpha-2 (IFNA2)	OT4GII73	IFNA2_HUMAN	Protein Interaction/Cellular Processes	[3]
Interferon regulatory factor 7 (IRF7)	OTC1A2PQ	IRF7_HUMAN	Gene/Protein Processing	[3]

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 150 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
MEC1	CTRP2	1.7879	3.0852	1.7832	21.7111
JM1	CTRP2	1.1096	4.2211	0.9437	26.779
OCI-Ly19	CTRP2	-0.7067	5.8793	-1.4783	40.1606
SU-DHL-5	CTRP1	0.2837	1.2801	0.2837	68.1693
PL21	CTRP2; CTRP1	0.3695	2.5852	0.3504	31.2749
Granta-519	CTRP2	0.49	5.058	0.0703	31.7203
NCO2	CTRP2	0.6072	3.7066	0.4908	40.7196
GA-10	CTRP2	0.6293	2.3619	0.6235	29.4333
OCI-Ly10	CTRP2; CTRP1	0.7885	3.36	0.7291	28.6216
OCI-AML-3	CTRP2; CTRP1	0.8529	2.2004	0.8517	27.9978
Hs 611.T	CTRP2	0.8933	2.5646	0.8868	27.6769
697	CTRP2	0.9059	2.2391	0.9046	27.5757
KE-97	CTRP2; CTRP1	0.9171	3.3271	0.868	27.7316
NU-DUL-1	CTRP2; CTRP1	0.9396	2.8924	0.9225	27.474
HuT 78	CTRP2	1.0269	4.4589	0.8049	27.5217
EoL-1	CTRP2	1.032	2.1909	1.0314	26.7332
SU-DHL-8	CTRP2	1.1119	3.7575	1.0233	26.4985
MOTN-1	CTRP2	1.1276	2.2096	1.1272	26.0955
NALM-6	CTRP2	1.1332	3.1072	1.1103	26.1337
DND-41	CTRP2	1.1509	3.904	1.0436	26.3029
Reh	CTRP2	1.1718	3.0715	1.1524	25.8649
PF-382	CTRP2	1.1967	4.141	1.053	26.1233
ST486	CTRP2	1.2101	2.6227	1.2068	25.5554
DoHH2	CTRP2	1.2123	3.2892	1.18	34.9486
Daudi	CTRP2	1.2231	2.5059	1.2214	25.4638
EB1	CTRP2	1.2467	3.4317	1.2039	25.4449
NU-DHL-1	CTRP2	1.3172	2.984	1.3061	24.8681
JVM-3	CTRP2	1.3609	3.7595	1.2886	24.7847
MOLP-8	CTRP2	1.3731	2.1171	1.3731	24.4585
KHM-1B	CTRP2	1.3795	3.5643	1.3309	24.5798
KMS-11	CTRP2; CTRP1	1.4411	3.7664	1.3739	24.3061
EJM	CTRP2; CTRP1	1.4639	4.8385	1.1934	24.8609
SUP-T1	CTRP2	1.4685	3.7686	1.402	24.0481
THP-1	CTRP2; CTRP1	1.4842	2.8841	1.4795	23.8077
KE-37	CTRP2	1.4844	2.9467	1.4781	32.3627
Karpas-422	CTRP2	1.5006	3.0164	1.4926	23.636
TALL-1 [Human adult T-ALL]	CTRP2	1.5264	3.4803	1.493	23.5498
A3/Kawakami	CTRP2	1.5292	3.4034	1.502	23.5102
Ki-JK	CTRP2	1.537	3.793	1.4717	32.1508
A4/Fukuda	CTRP2	1.5484	2.7009	1.5471	23.2953
Kasumi-1	CTRP2	1.5561	2.9679	1.5505	23.2585
Ku812	CTRP2; CTRP1	1.5837	3.5144	1.5507	23.2408
HH [Human lymphoma]	CTRP2	1.6099	3.7589	1.5532	23.0726
SUP-T11	CTRP2	1.6132	3.1502	1.6029	22.8938
KMS-20	CTRP2	1.6263	2.8911	1.6233	22.7818
MOLT-16	CTRP2	1.6814	3.4827	1.6547	22.4943
HuNS1	CTRP2	1.7374	3.3629	1.7207	22.0874
Pfeiffer	CTRP2	1.7442	3.8483	1.685	22.1867
MOLT-3	CTRP2	1.755	3.9554	1.6827	22.1597
Peer	CTRP2	1.7819	3.9574	1.7111	29.9555
M-07e	CTRP2	1.7965	3.0653	1.7923	21.6519
U266B1	CTRP2	1.7987	3.2378	1.7895	21.654
MHH-CALL-4	CTRP2	1.8215	4.1969	1.7171	21.8275
SU-DHL-6	CTRP2	1.8564	3.9366	1.7932	21.453
OPM-2	CTRP2	1.8726	4.2417	1.7644	21.5005
SET-2	CTRP2	1.8855	2.9901	1.8836	21.0513
Ci-1	CTRP2	1.9091	3.0601	1.9065	20.8964
P3HR-1	CTRP2; CTRP1	1.9239	3.4131	1.9107	20.9095
Mino	CTRP2	1.9428	3.1559	1.9388	20.6764
SKM-1	CTRP2; CTRP1	1.9624	3.3995	1.951	20.6474
CML-T1	CTRP2	1.988	3.6953	1.9582	27.8963
WSU-DLCL2	CTRP2; CTRP1	1.9941	3.2958	1.9874	27.8297
Kasumi-2	CTRP2	2.0218	5.1291	1.7222	21.1858
KM-H2	CTRP2	2.1042	4.4905	1.9682	20.0549
KO52	CTRP2	2.1279	4.0588	2.0665	19.6383
KMS-26	CTRP2	2.1673	3.7173	2.1438	19.2468
RS4;11	CTRP2	2.2234	4.4229	2.1105	19.1806
RPMI-8402	CTRP2	2.2424	4.3816	2.1386	25.9313
SEM	CTRP2	2.2806	3.7717	2.2578	18.4894
HL-60	CTRP2	2.3298	4.2144	2.2603	18.3212
KMS-12-BM	CTRP2	2.333	3.6215	2.3216	18.1022
MM1.S	CTRP2	2.3356	3.6428	2.3232	18.088
NCI-H929	CTRP2	2.3563	3.5972	2.3467	17.9409
BL-70	CTRP2; CTRP1	2.3637	4.2781	2.288	18.1959
KMS-21-BM	CTRP2	2.3778	3.9311	2.346	24.3657
OCI-AML-2	CTRP2	2.3958	3.5637	2.3886	17.6692
MOLT-13	CTRP2	2.401	5.188	2.1191	18.6012
Karpas-299	CTRP2	2.4126	3.1022	2.4125	17.5336
MOLM-6	CTRP2	2.4728	3.9	2.4485	17.214
NB4	CTRP2	2.4789	2.9376	2.4789	17.0914
ME1	CTRP2	2.5125	4.2031	2.4572	17.0552
Mono-Mac-1	CTRP2	2.5455	4.5919	2.4262	17.058
SU-DHL-1	CTRP2	2.5516	2.9832	2.5516	22.6412
HT	CTRP2; CTRP1	2.5696	3.9077	2.5494	22.6715
JJN-3	CTRP2	2.6061	4.7785	2.451	16.7812
LP-1	CTRP2; CTRP1	2.6119	3.835	2.5983	16.332
DB	CTRP2	2.6227	4.3678	2.5507	16.3788
ALL-SIL	CTRP2	2.6274	4.2973	2.5666	22.2339
AMO1	CTRP2; CTRP1	2.6524	3.8128	2.6414	16.0536
Namalwa	CTRP2	2.6707	5.2758	2.3872	16.8146
L-363	CTRP2	2.7117	3.2532	2.7116	15.5411
MV4-11	CTRP2	2.7204	5.0906	2.4954	16.2712
SR	CTRP2	2.739	3.8661	2.7276	15.397
P12-Ichikawa	CTRP2	2.7394	3.8569	2.7286	20.9847
HDLM-2	CTRP2	2.7508	5.0927	2.528	16.0611
Jurkat	CTRP2	2.7626	3.5253	2.7616	15.205
NOMO-1	CTRP2; CTRP1	2.7725	3.8143	2.7649	15.2428
RCH-ACV	CTRP2	2.7745	4.5805	2.6767	15.4578
CA46	CTRP2	2.7749	5.204	2.5222	16.0094
SUP-HD1	CTRP2	2.8194	5.5453	2.463	16.0949
EHEB	CTRP2	2.8201	4.1021	2.7948	20.3181
Ri-1	CTRP2	2.8269	4.577	2.7341	15.0915
SUP-B15	CTRP2	2.8624	5.524	2.5169	15.7693
KMS-27	CTRP2	2.9038	3.8666	2.8972	14.2831
P31/FUJ	CTRP2	2.9188	3.7143	2.9167	19.3154
JURL-MK1	CTRP2	2.947	4.0719	2.9302	19.1263
RPMI-8226	CTRP2; CTRP1	2.9571	3.8952	2.951	14.0092
HPB-ALL	CTRP2	2.9779	5.3232	2.7073	14.7253
DEL	CTRP2	2.9877	3.7402	2.986	18.6873
OCI-Ly3	CTRP2	2.9974	8.4787	1.4221	19.6083
L-540	CTRP2	2.9977	4.0708	2.9832	13.6841
MC116	CTRP2; CTRP1	3.0217	3.9455	3.0151	13.5812
RPMI-6666	CTRP2	3.0422	4.6404	2.9549	13.6384
AML-193	CTRP2	3.0523	4.4073	3.0054	13.4307
MOLM-13	CTRP2	3.0674	4.3365	3.0309	18.1248
MOLP-2	CTRP2	3.1735	4.2988	3.1476	12.5518
SUP-M2	CTRP2	3.1905	6.2741	2.5902	14.562
RL	CTRP2	3.1918	5.7343	2.7997	13.7586
Raji	CTRP2	3.1967	4.6766	3.1152	12.5893
KMS-28BM	CTRP2	3.2931	4.9807	3.1502	12.1655
U-937	CTRP2; CTRP1	3.3115	3.9241	3.3104	11.6337
OCI-AML-5	CTRP2	3.3437	4.5191	3.3009	11.4755
MOLM-16	CTRP2; CTRP1	3.3503	4.5958	3.2972	11.5526
KYO-1	CTRP2	3.386	4.1864	3.3784	11.074
BV-173	CTRP2	3.4147	4.9348	3.2945	11.2751
EM-2	CTRP2	3.4238	4.152	3.4189	14.7415
F-36P	CTRP2	3.4419	5.2744	3.2277	11.4351
KMS-34	CTRP2	3.4439	4.2678	3.4336	10.6973
K-562	CTRP2	3.4459	4.9141	3.3337	11.0389
SU-DHL-4	CTRP2; CTRP1	3.451	5.0119	3.3167	11.1697
LAMA-84	CTRP2	3.5132	4.1737	3.5095	10.2135
SU-DHL-10	CTRP2	3.5585	4.2365	3.5535	9.9161
HEL	CTRP2	3.576	4.1176	3.5748	9.7866
L-428	CTRP2	3.5879	5.0069	3.465	10.1321
KCL-22	CTRP2	3.6087	4.814	3.5339	9.8223
SK-MM-2	CTRP2	3.8428	5.6073	3.5456	9.0863
MHH-CALL-3	CTRP2	3.8459	6.671	3.0991	10.8282
BDCM	CTRP2	3.9475	5.2222	3.7945	7.8507
GDM-1	CTRP2; CTRP1	4.0402	6.1433	3.538	8.6683
JeKo-1	CTRP2	4.053	6.0111	3.6027	8.2924
TF-1	CTRP2	4.1304	5.0141	4.055	6.3519
HD-MY-Z	CTRP2	4.2376	5.1415	4.1356	5.7356
KMS-18	CTRP2	4.2407	5.2925	4.089	5.8996
HEL 92.1.7	CTRP2	4.4131	4.8786	4.3926	4.2754
KMM-1	CTRP2	4.4617	10.109	2.0115	18.5758
OCI-M1	CTRP2	4.4798	5.0288	4.4324	3.927
CMK	CTRP2	4.5353	5	4.5003	3.5129
Toledo	CTRP2	4.7881	5.7773	4.4473	3.0525
Karpas-620	CTRP2	4.8232	6.3577	4.1954	4.02
REC-1	CTRP2	6.7777	13.7842	2.0212	9.6156

Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Oesophagus Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
TE8	CTRP2	3.9525	8.0841	2.5404	12.8338
TE15	CTRP2	4.2971	6.0113	3.8528	6.6664
TE-5	CTRP2	2.2501	4.8352	2.0493	19.3131
KYSE-140	CTRP2; CTRP1	2.3852	4.4967	2.2731	18.1791
KYSE-450	CTRP2; CTRP1	2.7825	3.7955	2.7759	15.1728
OE21	CTRP2	3.1633	4.6497	3.0842	12.8033
TE-11	CTRP2	3.3151	4.5761	3.2613	11.7045
TE-4	CTRP2	3.3719	6.4092	2.7253	13.5453
TE-14	CTRP2	3.5482	5.549	3.2504	11.0407
TE-10	CTRP2	3.6373	4.7647	3.5752	9.5873
KYSE-70	CTRP2	3.7537	5.2091	3.2289	4.6026
TE-1	CTRP2	3.7644	5.2925	3.5726	9.2103
KYSE-410	CTRP2; CTRP1	3.9145	5.6104	3.6255	8.6679
TE-6	CTRP2	3.9677	5.1127	3.8501	7.5868
COLO 680N	CTRP2	3.981	5.5032	3.7328	10.8858
KYSE-180	CTRP2	4.0788	4.9857	4.0061	6.6857
TE-9	CTRP2	4.1521	5.3363	3.9778	6.5719
KYSE-520	CTRP2	4.1938	6.6425	3.4597	8.5077
OE33	CTRP2	4.2057	7.2711	3.1731	9.6494
OE19	CTRP2	4.2975	6.3744	3.6871	7.3321
KYSE-30	CTRP2	4.5819	6.2338	4.0309	5.2457
EC-GI-10	CTRP2	4.8749	6.2463	4.2969	3.4851
KYSE-510	CTRP2	5.5689	6.999	4.4621	1.6011
KYSE-150	CTRP2	5.6002	7.002	4.481	1.4859

Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Pancreas Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
N2a-PK1	CTRP2	4.3201	5.5406	4.0792	5.7142
PaTu 8988s	CTRP2	-0.6944	11.2547	-3.5679	43.0026
Panc 02.03	CTRP2	0.7906	2.6954	-3.5502	0.1652
QGP-1	CTRP2; CTRP1	2.2512	3.8302	2.2228	25.5973
Panc 10.05	CTRP1	2.4779	3.8697	2.4567	37.0126
Panc 03.27	CTRP2; CTRP1	2.5134	3.7807	2.4996	16.9881
CFPAC-1	CTRP2; CTRP1	2.5718	3.7065	2.5635	22.5969
KP-3	CTRP2; CTRP1	2.7318	4.364	2.6697	15.6996
HuP-T4	CTRP2; CTRP1	2.8765	4.7603	2.7516	14.9562
PaTu 8902	CTRP2; CTRP1	2.8822	4.0417	2.8654	14.5438
MIA PaCa-2	CTRP2	2.9004	4.3164	2.8557	14.4351
Hs 766T	CTRP2	3.2515	4.4995	3.2051	12.1021
SNU-213	CTRP2	3.2765	3.8959	3.2754	16.0617
Panc 05.04	CTRP2	3.3467	3.9984	3.3448	11.3165
BxPC-3	CTRP2	3.372	4.2327	3.3611	15.2394
YAPC	CTRP2	3.4532	4.4878	3.4222	10.7055
SNU-410	CTRP2	3.6349	5.4025	3.3954	10.2472
PK-45H	CTRP2	3.6609	8.8834	1.8777	16.1947
HPAC	CTRP2; CTRP1	3.7148	4.3908	3.7071	8.9717
Panc 08.13	CTRP2	3.8249	5.1435	3.6852	8.6166
PK-59	CTRP2	3.8606	5.0802	3.7426	8.3005
AsPC-1	CTRP2	3.9367	5.3605	3.7365	8.098
PaTu 8988t	CTRP2	3.9427	5.1616	3.8082	7.8146
HuP-T3	CTRP2	3.945	5.8484	3.5586	8.7537
SUIT-2	CTRP2; CTRP1	4.0105	5.4167	3.8003	7.7343
TCC-Pan2	CTRP2	4.0758	6.6064	2.8183	5.7221
Capan-1	CTRP2	4.2641	5.2976	4.1123	5.7447
SW1990	CTRP2	4.3663	5.7786	4.0266	5.7971
SU.86.86	CTRP2	4.5011	5.8087	4.1504	4.9571
Panc 04.03	CTRP2	4.5133	5.7636	4.1831	4.7958
PSN1	CTRP2	4.5311	5.2027	4.4342	3.768
DAN-G	CTRP2	4.5954	5.2508	4.4859	3.3894
KP-2	CTRP2	4.6225	5.2319	4.522	3.1757
L3.3	CTRP2	4.7213	5.5288	4.4991	3.0027
Capan-2	CTRP2; CTRP1	4.7633	6.5747	4.0424	4.8749
KP-4	CTRP2	4.8462	6.0663	4.3601	4.4758
HPAF-II	CTRP2	5.037	6.4639	4.3285	3.0234

Cancer Drug Sensitivity Data Curated from 50 Cell Line(s) in Skin Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
SH4	CTRP2	1.468	2.6279	1.4668	23.8306
Hs 936.T	CTRP2; CTRP1	1.2836	1.7297	1.2836	25.1273
Hs 940.T	CTRP2	1.458	2.2854	1.4579	23.8932
Hs 852.T	CTRP2; CTRP1	1.4999	2.4545	1.4997	23.6884
UACC-257	CTRP2	1.5046	1.9761	1.5046	23.5826
Hs 934.T	CTRP2	1.5491	1.9356	1.5491	23.286
IGR-1	CTRP2	1.6093	12.5911	-1.8698	33.318
A2058	CTRP2	1.6603	2.1425	1.6603	22.5456
COLO 792	CTRP2	1.9359	3.5769	1.913	20.7859
Malme-3M	CTRP2	1.9437	6.877	1.0294	23.9368
COLO 741	CTRP2; CTRP1	2.0705	3.8048	2.0355	27.2667
G-361	CTRP2; CTRP1	2.3584	3.3513	2.3561	17.9811
A-375	CTRP2; CTRP1	2.4963	4.3699	2.4158	17.3302
SK-MEL-5	CTRP2; CTRP1	2.517	3.0252	2.517	16.918
RPMI-7951	CTRP2	2.6571	3.2579	2.657	21.6829
IPC-298	CTRP2	2.6624	3.0456	2.6624	15.8693
SK-MEL-1	CTRP2; CTRP1	2.7594	3.5282	2.7584	15.3078
Hs 688(A).T	CTRP2	2.969	3.6693	2.9681	13.8296
Hs 944.T	CTRP2; CTRP1	3.1048	3.7755	3.1038	13.0091
IGR-37	CTRP2	3.1136	4.3962	3.0724	13.003
MDA-MB-435S	CTRP2	3.1878	4.0457	3.1812	12.3909
K029AX	CTRP2	3.255	4.0411	3.2503	11.9369
COLO 800	CTRP2	3.2591	4.6528	3.1873	12.1395
Mel Ho	CTRP2	3.274	3.886	3.273	11.7979
LOX-IMVI	CTRP2	3.3016	4.7239	3.2194	11.8931
MeWo	CTRP2	3.3038	4.7195	3.2227	11.8746
WM793	CTRP2	3.3138	4.0611	3.3096	11.5437
IGR-39	CTRP2	3.3295	4.6671	3.2607	11.6604
WM983B	CTRP2	3.3384	5.6074	3.0033	12.5717
Hs 294T	CTRP2	3.4479	4.5728	3.4045	10.7837
Mel JuSo	CTRP2	3.5252	4.0025	3.5248	10.1226
SK-MEL-3	CTRP2	3.5484	4.0298	3.548	9.9678
SK-MEL-30	CTRP2	3.5557	3.9403	3.5556	9.9183
WM1799	CTRP2	3.5966	4.0056	3.5964	9.6462
WM115	CTRP2	3.6444	4.0936	3.644	9.3282
SK-MEL-24	CTRP2	3.6575	5.339	3.4412	10.0111
SK-MEL-28	CTRP2; CTRP1	3.8146	4.331	3.8123	8.2894
SK-MEL-31	CTRP2	4.0483	4.9601	3.9791	6.8763
HT-144	CTRP2	4.1113	4.8419	4.0733	6.3465
SK-MEL-2	CTRP2	4.1408	9.3542	2.0968	14.2104
COLO 829	CTRP2	4.1726	5.9121	3.769	7.3219
Hs 895.T	CTRP2	4.177	4.8675	4.1395	5.9072
WT2-iPS	CTRP2	4.32	4.9639	4.2743	4.984
A101D	CTRP2	4.44	6.1042	3.9536	5.9024
WM88	CTRP2	4.4515	5.001	4.4087	4.0987
CJM [Human melanoma]	CTRP2	4.4867	4.9977	4.4478	3.8503
RVH-421	CTRP2	4.5861	4.9702	4.5623	3.1352
UACC-62	CTRP2	4.5996	4.9434	4.5823	3.0227
WM266-4	CTRP2	4.6071	4.9469	4.5898	2.9723
Hs 839.T	CTRP2	4.6666	4.9953	4.6444	2.5938

Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
COLO 684	CTRP2	3.017	17.0332	-2.7134	31.5265

Cancer Drug Sensitivity Data Curated from 14 Cell Line(s) in Autonomic Ganglia Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
NH-6	CTRP2	0.6512	3.1521	0.6042	29.4254
SK-N-DZ	CTRP2	1.1294	2.2096	1.1291	26.0833
IMR-32	CTRP2	1.5102	3.5234	1.4723	23.6728
SK-N-AS	CTRP2	1.5942	3.2782	1.5774	23.0422
SK-N-FI	CTRP2	1.6292	2.8882	1.6262	22.7626
SK-N-SH	CTRP2	1.7183	3.0907	1.7123	22.1789
Kelly	CTRP2	2.4624	3.2191	2.462	17.2031
CHP-126	CTRP2	2.4795	3.1856	2.4793	17.0886
MHH-NB-11	CTRP2	2.5323	3.1909	2.5322	22.8164
KP-N-SI9s	CTRP2	3.5573	4.3051	3.5488	9.9359
SK-N-BE(2)	CTRP2	3.7775	4.7717	3.7255	8.6185
NB1	CTRP2	3.926	5.4105	3.7074	8.2376
KP-N-YN	CTRP2	4.0729	6.0174	3.6206	8.1694
CHP-212	CTRP2	4.0816	5.3785	3.8866	7.1171

Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Biliary Tract Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
SNU-1079	CTRP2	2.7282	3.5889	2.7261	21.0461
SNU-869	CTRP2	2.9072	5.5167	2.5678	15.4491
HuH-28	CTRP2	2.9556	4.3858	2.905	14.0877
SNU-478	CTRP2	3.4787	4.5468	3.4414	10.5575
SNU-308	CTRP2	3.6996	4.3878	3.6912	8.9872
SNU-1196	CTRP2	4.4837	5.8214	4.1271	6.9455

Cancer Drug Sensitivity Data Curated from 15 Cell Line(s) in Bone Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
A-673	CTRP2	1.1132	2.7318	1.1061	26.214
Hs 888.T	CTRP2	1.6131	2.1962	1.6131	22.8596
Hs 822.T	CTRP2	2.2425	2.9922	2.2423	18.6672
SK-ES-1	CTRP2	2.9402	4.4851	2.873	14.2475
MHH-ES-1	CTRP2	3.0478	4.2769	3.0171	13.4053
SK-N-MC	CTRP2	3.1459	4.7085	3.0536	12.9654
U2OS	CTRP1	3.2065	4.8824	3.0826	27.3705
CAL-78	CTRP2	3.3637	4.1743	3.356	11.2229
SaOS-2	CTRP2	3.6339	4.3639	3.6245	9.4283
SW1353	CTRP2	3.6683	4.1527	3.6674	12.5024
SJSA-1	CTRP2	3.9091	5.0775	3.7963	7.9592
MG-63	CTRP2	3.932	5.2289	3.7755	7.9667
G-292 clone A141B1	CTRP2	4.0752	5.0823	3.976	6.8051
HOS	CTRP2	4.4808	5.5155	4.2582	4.5828
TC71	CTRP2	4.588	5.0912	4.5328	3.2352

Cancer Drug Sensitivity Data Curated from 68 Cell Line(s) in Breast Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
CAL-148	CTRP2	1.3256	3.9162	1.229	25.103
MDA-MB-468	CTRP2	1.5619	3.2399	1.5461	23.2536
DU4475	CTRP2	1.9504	3.8287	1.9057	20.7635
MCF-7	CTRP2; CTRP1	2.0717	4.3382	1.9635	27.5951
CAL-85-1	CTRP2	2.4301	4.3927	2.3392	17.7272
BT-474	CTRP2	2.7913	3.7128	2.7875	15.0232
HCC202	CTRP2	2.8213	5.7776	2.3848	16.3811
BT-549	CTRP2	2.9214	5.8723	2.4585	15.8173
Hs 578Bst	CTRP2	2.9365	3.9402	2.9275	14.0732
HCC1500	CTRP2	2.9459	5.4375	2.6359	15.0832
MDA-MB-453	CTRP2	3.0188	4.1258	3.001	13.5545
HCC1395	CTRP2	3.1303	4.0834	3.1199	12.7869
CAL-51	CTRP2	3.2406	4.0416	3.2355	12.0343
HDQ-P1	CTRP2	3.3538	4.566	3.3046	15.5835
CAMA-1	CTRP2	3.3813	7.5927	2.2128	21.0759
KPL-1	CTRP2	3.3842	4.0629	3.3814	15.0916
ZR-75-1	CTRP2	3.5344	4.3833	3.3834	4.5248
CAL-120	CTRP2	3.5764	4.0486	3.576	13.3347
HCC2218	CTRP2	3.6111	4.7424	3.5511	9.7546
HMC-1-8	CTRP2	3.6265	4.0148	3.6264	9.4464
T-47D	CTRP2	3.6408	4.4178	3.6277	9.3948
HCC1428	CTRP2	3.6953	5.7517	3.3328	10.3116
HCC38	CTRP2	3.7506	5.8307	3.3605	10.0517
SK-BR-3	CTRP2	3.9153	5.2053	3.7647	8.056
HCC1143	CTRP2	3.9388	5.4921	3.6915	8.2611
HCC1806	CTRP2	3.9648	5.1033	3.8496	7.5975
MDA-MB-231	CTRP2	3.998	5.6025	3.7131	8.0124
JIMT-1	CTRP2	4.0061	5.3683	3.8088	10.3976
HCC1954	CTRP2	4.0225	6.5823	3.3173	9.5073
HCC1419	CTRP2	4.0999	5.5333	3.8485	7.21
MDA-MB-361	CTRP2	4.2809	5.3482	4.1122	5.6972
HCC1937	CTRP2	4.3495	6.8433	3.516	7.9047
MDA-MB-157	CTRP2	4.6905	5.5513	4.458	3.2453
BT-20	CTRP2	5.2549	7.662	3.9066	4.3912
BT 416	CTRP2	1.8455	4.6327	1.6566	21.9633
BT 330	CTRP2	1.9561	2.9083	1.9554	20.5772
BT 286	CTRP2	2.2674	4.2316	2.1907	18.7616
BT164	CTRP2	2.6411	4.7114	2.5045	16.4824
BT 239	CTRP2	2.6876	4.4831	2.601	15.9976
BT 112	CTRP2	3.1026	4.7314	3.0018	13.2836
BT 271	CTRP2	3.1359	4.5634	3.0704	12.9383
BT 228	CTRP2	3.3933	4.4449	3.3638	11.0997
BT 159	CTRP2	3.3951	3.8795	3.3949	10.9886
BT147	CTRP2	3.4187	4.0879	3.4158	10.8403
BT 440	CTRP2	3.4289	4.0999	3.4258	10.773
BT 131	CTRP2	3.4308	4.0836	3.4282	10.7587
BT 248	CTRP2	3.4665	4.229	3.4592	10.5367
BT 231	CTRP2	3.5082	4.7537	3.4373	10.4779
BT 428	CTRP2	3.5345	4.3717	3.5202	10.1072
BT 504	CTRP2	3.54	3.9107	3.5399	10.0228
BT 333	CTRP2	3.5949	4.1484	3.5933	9.6623
BT 232	CTRP2	3.5988	4.0816	3.5982	9.6325
BT 359	CTRP2	3.6281	4.2886	3.6227	9.4536
BT 172	CTRP2	3.6354	4.1268	3.6346	9.3895
BT 482	CTRP2	3.6407	4.4386	3.6258	9.4017
BT 245	CTRP2	3.679	4.3655	3.6712	9.1226
BT 139	CTRP2	3.7042	4.1541	3.7036	8.9303
BT 498	CTRP2	3.7102	4.5645	3.6858	8.9713
BT 187	CTRP2	3.7132	4.5499	3.6908	8.9442
BT 444	CTRP2	3.7148	4.2398	3.713	8.8641
BT 216	CTRP2	3.7615	5.3514	3.5499	9.3028
BT 422	CTRP2	3.7941	4.2444	3.7932	8.3324
BT 340	CTRP2	3.7993	4.2291	3.7986	8.2971
BT 179	CTRP2	4.0027	4.926	3.9375	7.1655
BT 224	CTRP2	4.1896	5.8241	3.8244	7.0591
BT 145	CTRP2	4.3599	5.0756	4.2886	4.8108
BT 328	CTRP2	4.7324	5.4882	4.5288	2.8557
BT 320	CTRP2	5.0474	5.8791	4.6296	1.7378

Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Tongue Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
YD-38	CTRP2	3.2519	4.0378	3.2471	11.9579

Cancer Drug Sensitivity Data Curated from 42 Cell Line(s) in Central Nervous System Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
Hs 683	CTRP2	1.5716	1.9799	1.5716	23.1364
DK-MG	CTRP2	1.6141	2.6902	1.6132	22.8561
LN-229	CTRP2; CTRP1	2.259	2.886	2.259	18.6352
SNU-466	CTRP2	2.6489	3.103	2.6489	15.9589
LN-18	CTRP2	2.7315	3.1495	2.7315	15.4086
KNS-81	CTRP2	3.1952	4.0777	3.1872	12.3465
SF268	CTRP2	3.2212	4.566	3.162	12.3484
GOS-3	CTRP2	3.2239	4.0616	3.2175	12.1496
GaMG	CTRP2; CTRP1	3.24	3.8712	3.239	12.1091
U-87MG ATCC	CTRP2	3.2985	4.7302	3.2148	16.2494
GMS-10	CTRP2	3.3219	4.2053	3.311	11.5121
SNU-201	CTRP2	3.3406	4.0304	3.3379	15.4869
SF539	CTRP2	3.3684	4.2049	3.3592	11.1967
U-118MG	CTRP2	3.4276	4.7737	3.3458	11.053
M059K	CTRP2	3.4398	4.6964	3.3746	10.9134
42-MG-BA	CTRP2	3.4558	4.0695	3.4539	10.59
SW1088	CTRP2	3.4871	4.3651	3.4712	10.4283
SNU-1105	CTRP2	3.5027	4.0026	3.5021	14.0051
ONS-76	CTRP2	3.5756	4.2231	3.5716	13.3585
KNS-60	CTRP2	3.6416	4.0818	3.6412	9.347
KG-1-C	CTRP2	3.6717	4.0407	3.6716	9.1452
KALS-1	CTRP2	3.7157	4.6164	3.6848	8.957
SNB-75	CTRP2	3.7247	4.804	3.6619	9.0079
SNU-626	CTRP2	3.7541	4.3162	3.7508	11.7338
CCF-STTG1	CTRP2	3.811	4.919	3.7304	8.4966
YKG-1	CTRP2	3.8822	4.8191	3.8298	7.9226
KNS-42	CTRP2	3.9719	4.7303	3.9423	7.246
Daoy	CTRP2	3.9804	5.117	3.8626	7.5029
SNU-489	CTRP2	4.0656	5.0025	3.9874	9.2613
GB-1	CTRP2	4.0701	5.2405	3.9217	7.0195
U-251MG	CTRP2	4.0823	5.2843	3.9203	6.989
YH-13	CTRP2	4.3004	5.2232	4.1775	5.3958
TM-31	CTRP2	4.3803	7.4246	3.2638	8.8728
SF295	CTRP2; CTRP1	4.5227	5.1813	4.4362	3.8773
DBTRG-05MG	CTRP2	4.5903	5.7598	4.2623	4.2836
SW1783	CTRP2	4.7035	9.0584	2.7467	10.3287
Becker	CTRP2	4.8144	6.0792	4.3248	3.5
SNU-738	CTRP2	4.8652	5.9941	4.4131	4.1186
SF126	CTRP2	4.9741	6.6914	4.1616	3.8487
8-MG-BA	CTRP2	5.0604	6.1542	4.5028	2.2458
A-172	CTRP2	6.5739	16.4164	0.5773	15.2891
T98G	CTRP2	10.3885	24.3123	-0.5829	13.4415

Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Endometrium Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
MFE-319	CTRP2; CTRP1	1.2975	2.1674	1.2974	25.035
HEC-6	CTRP2; CTRP1	2.2064	4.5605	2.0665	19.466
HEC-265	CTRP2; CTRP1	2.8721	4.362	2.8203	14.7303
JHUEM-2	CTRP2; CTRP1	2.9843	4.3793	2.9377	13.966
HEC-151	CTRP2; CTRP1	3.0885	4.5123	3.0293	13.3158
RL95-2	CTRP2	3.46	4.0576	3.4584	14.3974
EN	CTRP2	3.5918	4.531	3.5641	9.7713
JHUEM-1	CTRP2	3.61	4.3713	3.5992	9.5924
HEC-1-B	CTRP2	3.6707	5.7682	3.3001	14.3217
ESS-1	CTRP2	3.7353	5.2736	3.5472	9.3901
HEC-50B	CTRP2	3.8572	5.2017	3.7027	8.4563
HEC-251	CTRP2; CTRP1	3.8918	5.5968	3.6064	8.8044
HEC-1-A	CTRP2	3.9339	5.1571	3.7999	7.8712
MFE-296	CTRP2	3.9456	4.7923	3.9035	7.4644
JHUEM-3	CTRP2	4.2459	8.2541	2.7336	11.3677
HEC-108	CTRP2; CTRP1	4.2811	4.937	4.24	5.318
JHUEM-7	CTRP2	4.3219	5.5066	4.0948	5.6491
KLE	CTRP2; CTRP1	4.407	5.6778	4.1181	5.4192
EFE-184	CTRP2	4.4703	5.0787	4.4082	4.0432
AN3-CA	CTRP2	4.7489	6.0782	4.2644	3.8972
HEC-59	CTRP2; CTRP1	4.8534	6.4269	4.1969	4.0366
Ishikawa (Heraklio) 02 ER-	CTRP2; CTRP1	3.7383	5.3972	3.5129	9.5951

Cancer Drug Sensitivity Data Curated from 19 Cell Line(s) in Kidney Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
CAL-54	CTRP2	2.1093	3.9483	2.0606	19.7186
UO-31	CTRP2	2.2809	3.6174	2.2681	18.4534
KMRC-3	CTRP2	2.4285	3.4542	2.4251	17.4386
KMRC-2	CTRP2	2.6754	3.9452	2.6566	15.8457
VMRC-RCW	CTRP2; CTRP1	3.3453	6.0517	2.8479	13.2264
KMRC-20	CTRP2	3.3625	4.0994	3.358	15.2964
RCC10RGB	CTRP2; CTRP1	3.5552	4.1294	3.5535	10.0137
TUHR10TKB	CTRP2	3.7988	4.5265	3.7837	8.3494
TUHR4TKB	CTRP2	3.886	4.6366	3.8637	10.6241
Caki-1	CTRP2	3.9212	5.5005	3.6696	8.3937
786-O	CTRP2	4.2595	6.2264	3.7174	7.3042
KMRC-1	CTRP2	4.3127	5.0794	4.2361	5.1439
769-P	CTRP2	4.3718	5.1343	4.284	4.792
OS-RC-2	CTRP2	4.3965	5.9516	3.9802	8.0491
ACHN	CTRP2	4.5284	9.267	2.489	11.7631
TUHR14TKB	CTRP2	4.5304	6.0256	4.0796	5.1702
VMRC-RCZ	CTRP2	4.6163	5.1483	4.5453	3.1059
SNU-1272	CTRP2	5.0379	6.2478	4.4373	2.5646
Caki-2	CTRP2	5.1319	8.2074	3.5352	6.1768

Cancer Drug Sensitivity Data Curated from 53 Cell Line(s) in Large Intestine Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
SW1417	CTRP2	0.4715	7.8905	-0.934	34.6309
LS180	CTRP2; CTRP1	0.7238	2.5217	0.7157	28.8799
LS513	CTRP2; CTRP1	1.3378	2.2738	1.3376	33.7531
SW48	CTRP2; CTRP1	1.3407	4.1749	1.2038	34.3228
CL-40	CTRP1	1.4013	3.0437	1.3902	52.21
CL-34	CTRP1	1.5729	3.4148	1.547	49.8067
SNU-C5	CTRP2; CTRP1	1.881	3.7701	1.8394	21.2913
SNU-81	CTRP1	1.986	4.1357	1.9048	44.24
C2BBe1	CTRP2; CTRP1	1.9912	4.392	1.8667	20.8436
COLO205	CTRP2; CTRP1	2.0685	3.7556	2.0379	27.2642
COLO 320	CTRP1	2.0727	9.268	-0.342	42.8064
KM12	CTRP2; CTRP1	2.0984	4.2406	2.009	20.0083
HT115	CTRP2; CTRP1	2.1979	3.3707	2.1929	19.0584
GP2d	CTRP2; CTRP1	2.2948	3.9032	2.262	18.5073
HCT 15	CTRP2	2.3981	4.0435	2.3556	17.7734
RKO	CTRP2; CTRP1	2.5143	3.4068	2.5127	16.9414
SW948	CTRP2; CTRP1	2.5268	4.2957	2.4603	17.0785
COLO 678	CTRP2; CTRP1	2.5616	5.7477	2.1186	18.2058
T84	CTRP2	2.5764	4.3281	2.5074	16.6769
SNU-C2A	CTRP2; CTRP1	2.5933	4.5172	2.4943	16.7488
LS411N	CTRP2; CTRP1	2.6132	6.5533	1.8726	25.7513
SNU-C4	CTRP2; CTRP1	2.7386	5.1512	2.5009	16.2766
SNU-175	CTRP2; CTRP1	2.7862	5.0195	2.5893	21.549
NCI-H716	CTRP2	2.7957	5.4143	2.4802	16.1013
CW-2	CTRP2; CTRP1	2.8361	4.4382	2.77	15.0191
SK-CO-1	CTRP2; CTRP1	2.9224	4.1132	2.9017	19.4738
SNU-1033	CTRP2	2.9932	5.3666	2.7102	14.6696
OUMS-23	CTRP2	3.0235	3.7842	3.0215	18.3639
LS1034	CTRP2	3.0346	5.1876	2.8104	14.1789
RCM-1 [Human ESC]	CTRP2; CTRP1	3.0487	5.5221	2.7231	14.5408
HCT 116	CTRP2; CTRP1	3.0546	4.1404	3.0378	13.3962
SNU-61	CTRP2; CTRP1	3.1834	5.2728	2.9499	13.3073
CL-11	CTRP2	3.1932	4.4335	3.1523	12.4717
CCK-81	CTRP2	3.2064	4.7028	3.1205	12.5402
HT-29	CTRP2; CTRP1	3.2307	5.0627	3.0627	12.7551
MDST8	CTRP2; CTRP1	3.2587	3.8546	3.258	11.9836
SW1116	CTRP2	3.306	4.4704	3.2676	11.7118
NCI-H747	CTRP2	3.5332	5.1039	3.3786	10.6107
HT-55	CTRP2; CTRP1	3.5562	6.0209	3.0837	11.7382
NCI-H508	CTRP2; CTRP1	3.633	5.0412	3.5075	9.9283
LoVo	CTRP2; CTRP1	3.7161	8.0324	2.345	14.268
COLO201	CTRP2	3.7965	4.2627	3.7953	8.3174
SNU-C1	CTRP2	3.9078	5.7987	3.5397	8.9284
SNU-407	CTRP2	3.9415	5.3054	3.7606	7.9942
SW403	CTRP1	4.2816	9.2212	2.2991	26.3331
HCC-56	CTRP2	4.3297	4.972	4.283	4.9231
DLD-1	CTRP2; CTRP1	4.4002	5.8285	4.0454	7.8007
SNU-1040	CTRP1	4.4034	4.9432	4.3715	9.5997
SNU-503	CTRP2	4.5905	5.2733	4.472	3.4561
LS123	CTRP2; CTRP1	4.7807	7.9478	3.3765	7.6197
HCT 8	CTRP2; CTRP1	5.131	6.1645	4.565	1.9392
SW620	CTRP2; CTRP1	5.5753	7.7687	4.1065	3.1065
SW480	CTRP1	6.1796	9.6323	3.6253	8.8255

Cancer Drug Sensitivity Data Curated from 20 Cell Line(s) in Liver Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
JHH-1	CTRP2	0.4305	1.7359	-3.3563	0.0289
HuH-6	CTRP2	2.1948	3.6136	2.1793	19.0362
SNU-182	CTRP2	2.2402	4.7342	2.0629	19.2954
JHH-6	CTRP2; CTRP1	2.2599	3.8818	2.2273	18.7389
Hep-G2	CTRP2; CTRP1	2.9414	4.345	2.8966	14.2448
Hep 3B2.1-7	CTRP2	3.24	5.0162	3.0828	17.1366
SNU-761	CTRP2	3.2932	4.8729	3.1772	12.0687
SNU-398	CTRP2; CTRP1	3.5649	5.4871	3.2943	10.9133
SNU-423	CTRP2	3.9976	4.9112	3.9354	7.189
SNU-878	CTRP2	4.0851	5.6113	3.8023	10.1266
SNU-387	CTRP2	4.1113	6.1448	3.6042	8.1341
JHH-5	CTRP2	4.1439	7.3062	3.0969	10.1071
Li-7	CTRP2	4.1629	5.5436	3.9116	9.2606
JHH-4	CTRP2	4.2168	5.249	4.0781	6.0093
SNU-449	CTRP2; CTRP1	4.3447	4.876	4.3208	4.8349
SK-HEP-1	CTRP2	4.4013	9.2354	2.3915	12.4364
SNU-886	CTRP2	4.5884	6.3426	2.4434	0.8367
PLC/PRF/5	CTRP2	5.0429	7.2176	3.9565	4.5755
SNU-475	CTRP2	5.2169	6.2334	4.5868	1.6151
JHH-2	CTRP2	5.5993	9.7055	3.1586	6.9151

Cancer Drug Sensitivity Data Curated from 157 Cell Line(s) in Lung Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
SCLC-21H	CTRP2; CTRP1	-1.0316	2.1944	-1.0773	40.6676
NCI-H146	CTRP2	0.0833	2.8999	0.0309	33.2244
NCI-H1963	CTRP1	0.6102	2.049	0.6088	63.3749
NCI-H1693	CTRP2	1.0731	4.045	0.9366	26.9209
SK-MES-1	CTRP2	1.2342	3.2064	1.2088	25.469
COR-L47	CTRP2	1.2345	6.0636	0.5695	27.6749
NCI-H2141	CTRP2; CTRP1	1.2415	5.0618	0.8921	26.6103
NCI-H810	CTRP2; CTRP1	1.2657	3.0494	1.2507	25.2966
COR-L88	CTRP2; CTRP1	1.2723	6.2631	0.5447	27.7099
HCC33	CTRP1	1.499	2.3984	1.4988	50.8522
SHP-77	CTRP2; CTRP1	1.5449	2.0299	1.5449	31.874
DMS 273	CTRP2; CTRP1	1.6133	3.6616	1.5681	23.0848
NCI-H2081	CTRP2; CTRP1	1.6177	4.3544	1.4696	23.4103
NCI-H2029	CTRP2; CTRP1	1.6207	3.4908	1.5912	22.9824
KNS-62	CTRP2; CTRP1	1.6282	2.6742	1.6275	22.8361
COR-L279	CTRP1	1.633	3.8964	1.5615	49.0061
VMRC-LCD	CTRP2; CTRP1	1.6776	4.3065	1.5436	22.9629
NCI-H1836	CTRP1	1.696	3.3463	1.6792	48.0777
NCI-H23	CTRP2; CTRP1	1.7601	5.7126	1.2613	23.7128
COLO 668	CTRP2; CTRP1	1.7778	3.7043	1.7372	21.9746
NCI-H211	CTRP2	1.7974	3.6542	1.762	21.7511
COR-L95	CTRP2	1.8046	3.266	1.7945	21.6178
NCI-H1694	CTRP2; CTRP1	1.928	3.5049	1.91	20.8986
DMS 114	CTRP2	1.9472	2.7759	1.947	20.6346
COR-L51	CTRP2; CTRP1	2.0391	3.8413	1.9988	20.2345
NCI-H1105	CTRP2; CTRP1	2.0529	4.0815	1.9844	20.2392
NCI-H1944	CTRP2; CTRP1	2.0723	3.6531	2.05	19.9525
DMS 79	CTRP2	2.0725	4.6899	1.8906	20.428
Calu-6	CTRP2; CTRP1	2.1116	3.5291	2.0983	19.6608
NCI-H69	CTRP2	2.1227	5.226	1.8044	20.5828
NCI-H1666	CTRP2; CTRP1	2.1236	4.2677	2.0317	19.8493
NCI-H1437	CTRP1	2.165	5.0287	1.909	42.4762
NCI-H1435	CTRP2; CTRP1	2.1804	3.4573	2.1723	19.1854
NCI-H82	CTRP1	2.1845	3.089	2.1838	41.0648
HCC78	CTRP2; CTRP1	2.2166	3.4776	2.2086	25.8174
HCC1833	CTRP2; CTRP1	2.2213	4.3527	2.1224	19.2238
NCI-H1792	CTRP2; CTRP1	2.2326	3.6921	2.214	18.8734
NCI-H520	CTRP2	2.2663	3.8444	2.2369	18.6071
NCI-H522	CTRP2; CTRP1	2.2678	4.315	2.179	18.8793
LCLC-97TM1	CTRP2; CTRP1	2.3697	3.7453	2.3529	17.9548
NCI-H446	CTRP2	2.3744	3.2677	2.3733	17.7915
NCI-H1573	CTRP1	2.3814	4.596	2.249	39.0274
COLO 699	CTRP2; CTRP1	2.3914	4.2112	2.3277	17.9701
EBC-1	CTRP2; CTRP1	2.3978	3.9061	2.3699	17.8052
NCI-H727	CTRP2; CTRP1	2.4357	4.1552	2.3828	24.0375
DMS 454	CTRP2	2.4761	4.284	2.4066	17.3468
NCI-H1373	CTRP2; CTRP1	2.4912	3.4459	2.4888	17.0977
T3M-10	CTRP2; CTRP1	2.5404	4.1156	2.4989	16.9025
NCI-H596	CTRP1	2.5467	3.6606	2.5396	35.9383
NCI-H1568	CTRP2; CTRP1	2.5761	4.9419	2.3804	17.2056
NCI-H2106	CTRP2	2.5875	5.6003	2.1931	24.21
HCC2935	CTRP2; CTRP1	2.5934	3.927	2.5728	16.4787
NCI-H2126	CTRP2; CTRP1	2.6128	4.0501	2.5824	16.3825
RERF-LC-Ad2	CTRP2	2.6346	4.6412	2.5126	16.4741
HARA [Human squamous cell lung carcinoma]	CTRP2; CTRP1	2.6405	4.138	2.6024	22.1116
CAL-12T	CTRP2; CTRP1	2.6436	3.8942	2.6275	16.1294
BEN	CTRP2; CTRP1	2.6856	3.5686	2.6834	21.5366
NCI-H1975	CTRP2; CTRP1	2.7391	4.3118	2.6851	21.2912
NCI-H2087	CTRP2	2.751	4.4177	2.6806	15.5189
HCC1359	CTRP1	2.8126	3.6661	2.8102	32.1071
NCI-H1048	CTRP1	2.8599	4.7549	2.7347	32.2914
NCI-H1734	CTRP2	2.8867	4.6203	2.7904	14.7053
SW1271	CTRP2	2.8951	10.6719	0.2866	23.9593
NCI-H1092	CTRP2	2.9245	6.3456	2.2802	16.4871
EPLC-272H	CTRP2; CTRP1	2.9723	4.1554	2.9504	13.9614
NCI-H2122	CTRP2; CTRP1	3.0375	3.928	3.032	13.4721
HCC1588	CTRP2	3.06	3.8615	3.0568	13.2308
NCI-H1184	CTRP2	3.0669	4.095	3.0534	13.2197
NCI-H2405	CTRP2; CTRP1	3.0737	4.1991	3.0529	18.1021
LC-1/sq-SF	CTRP2; CTRP1	3.1225	4.2439	3.1	12.9639
Sq-1	CTRP2; CTRP1	3.187	4.1453	3.1753	12.4978
NCI-H2291	CTRP2	3.2344	5.7317	2.8465	13.4602
NCI-H441	CTRP2; CTRP1	3.235	6.3577	2.6082	14.4525
NCI-H526	CTRP2	3.2518	4.0777	3.2455	11.9635
NCI-H1793	CTRP2; CTRP1	3.2788	4.5439	3.2288	12.0178
NCI-H647	CTRP2	3.2896	6.4092	2.6391	14.1026
NCI-H1876	CTRP1	3.3008	5.3874	3.0414	27.0404
NCI-H1915	CTRP2; CTRP1	3.3055	5.6356	2.9618	12.906
NCI-H2342	CTRP2; CTRP1	3.3084	5.2245	3.1009	12.3823
SK-LU-1	CTRP2; CTRP1	3.3132	4.3751	3.2878	11.7044
NCI-H1838	CTRP2	3.3365	4.5984	3.2806	11.5687
Calu-3	CTRP2; CTRP1	3.3512	4.6537	3.2882	11.581
HCC1195	CTRP2; CTRP1	3.3881	4.2361	3.3781	11.1536
NCI-H358	CTRP2; CTRP1	3.3957	5.9237	2.9515	17.2907
LXF 289	CTRP2; CTRP1	3.4303	4.3875	3.41	10.9077
LCLC-103H	CTRP2; CTRP1	3.4359	4.02	3.4347	14.7264
NCI-H292	CTRP2	3.4574	4.9392	3.34	10.9808
ChaGo-K-1	CTRP2; CTRP1	3.4919	5.1666	3.3182	11.0404
HCC44	CTRP2; CTRP1	3.4985	4.3583	3.4842	10.4334
NCI-H1355	CTRP2; CTRP1	3.5173	5.1948	3.3375	10.894
NCI-H1155	CTRP2	3.5302	5.1181	3.3713	14.514
NCI-H889	CTRP2	3.5433	4.1714	3.5404	10.0101
NCI-H2228	CTRP2	3.549	6.9407	2.6771	13.27
NCI-H196	CTRP2	3.5903	4.2453	3.5858	9.7027
HCC95	CTRP2	3.628	4.793	3.5593	13.1865
RERF-LC-KJ	CTRP1	3.6286	4.4871	3.609	20.5734
NCI-H1581	CTRP2	3.6421	4.9081	3.549	13.1762
NCI-H2073	CTRP1	3.6474	4.6964	3.6002	20.5098
NCI-H2030	CTRP2; CTRP1	3.6538	7.7756	2.4052	14.1772
NCI-H3255	CTRP1	3.6589	4.5105	3.6385	20.1471
HOP-92	CTRP2	3.6934	4.7865	3.6316	9.2129
NCI-H2009	CTRP2; CTRP1	3.735	6.9442	2.8701	16.486
DV-90	CTRP2; CTRP1	3.7486	5.406	3.5211	9.5347
LK2	CTRP2	3.7581	4.2001	3.7575	8.5715
HCC4006	CTRP2; CTRP1	3.8015	5.4035	3.5792	9.1649
A-549	CTRP2; CTRP1	3.812	6.5003	3.1471	10.8085
NCI-H661	CTRP2; CTRP1	3.8574	4.9855	3.767	8.3107
NCI-H2196	CTRP2	3.8897	5.0177	3.7915	8.0355
HCC366	CTRP2	3.8994	5.0678	3.7884	10.9299
NCI-H1623	CTRP2	3.906	6.3488	3.3042	9.8568
Lu-65	CTRP2; CTRP1	3.908	4.9223	3.8374	7.9036
COR-L23	CTRP1	3.9257	5.5964	3.6428	18.3911
NCI-H1930	CTRP1	3.9605	5.0782	3.8548	16.4839
Lu-99	CTRP2; CTRP1	3.9742	5.6378	3.6787	11.3085
NCI-H650	CTRP2; CTRP1	3.9897	6.549	3.3059	13.2461
MOR/CPR	CTRP2	3.9946	4.9405	3.9253	7.2338
HCC15	CTRP2; CTRP1	4.0113	5.3464	3.826	10.4066
NCI-H2085	CTRP2	4.0424	6.2286	3.4967	8.7392
NCI-H2023	CTRP2; CTRP1	4.0702	5.3611	3.8845	7.2472
NCI-H322	CTRP2	4.1833	5.1773	4.0653	6.1555
HOP-62	CTRP2	4.1905	5.2932	4.0344	6.2492
NCI-H841	CTRP2; CTRP1	4.2164	5.1822	4.1031	6.0087
HCC1438	CTRP2	4.2464	4.932	4.2014	5.4717
NCI-H2170	CTRP2	4.2599	7.6115	3.0601	9.9885
NCI-H2172	CTRP2; CTRP1	4.319	5.5049	4.0973	5.7373
HCC2279	CTRP2	4.4081	6.0082	3.9661	5.9316
NCI-H1869	CTRP2	4.4226	7.1159	3.4537	7.9917
NCI-H1299	CTRP2; CTRP1	4.4492	5.3169	4.3088	4.5664
NCI-H1781	CTRP1	4.4691	5.1133	4.3995	8.9519
LUDLU-1	CTRP2	4.4695	5.1905	4.3718	4.1795
NCI-H2444	CTRP2	4.5106	5.2347	4.4006	3.9531
IA-LM	CTRP2	4.5124	6.6652	3.7569	6.5344
NCI-H1339	CTRP2	4.521	5.0128	4.4815	3.6245
RERF-LC-MS	CTRP2	4.5242	5.2093	4.4244	3.8246
NCI-H1703	CTRP2	4.5362	12.2519	1.0088	17.5967
NCI-H1755	CTRP2; CTRP1	4.5676	6.6796	3.8099	6.276
SBC-5	CTRP2	4.5856	5.6256	4.3184	4.0708
HCC2108	CTRP2; CTRP1	4.5873	5.7522	4.2693	4.353
NCI-H838	CTRP2	4.6037	5.7683	4.2717	4.2124
LOU-NH91	CTRP2	4.6506	5.8212	4.2935	4.0089
SW1573	CTRP2	4.6895	5.6911	4.3926	3.5119
NCI-H1395	CTRP2	4.7969	8.8941	2.9096	9.4582
RERF-LC-A1	CTRP2	4.9119	6.5693	4.1689	3.944
HCC1171	CTRP2	4.9362	6.6877	4.1309	4.0537
NCI-H1650	CTRP2	4.9433	6.6351	4.1633	3.9033
PC-14	CTRP2	4.9824	6.8972	4.0659	4.2344
RERF-LC-Ad1	CTRP2	5.0054	6.6212	4.2233	3.5274
NCI-H2286	CTRP2; CTRP1	5.0365	5.9595	4.5898	2.0135
NCI-H460	CTRP2; CTRP1	5.0638	5.6828	4.751	1.2832
EKVX	CTRP2	5.0881	7.4155	3.8951	4.7473
Calu-1	CTRP2	5.1333	6.1149	4.5813	1.7818
HCC827	CTRP2; CTRP1	5.2215	7.9573	3.7429	5.2206
COR-L105	CTRP2	5.3916	15.4917	0.1072	19.0269
NCI-H226	CTRP2	5.4816	8.3144	3.758	4.6199
NCI-H1563	CTRP2	5.4824	8.0462	3.891	4.0656
NCI-H2110	CTRP2; CTRP1	5.9424	10.8161	2.8793	7.5722
Hs 888.Lu	CTRP2	4.3028	5.0985	4.2196	5.2336

Cancer Drug Sensitivity Data Curated from 23 Cell Line(s) in Soft Tissue Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
Aska-SS	CTRP2	1.8614	2.9675	1.8596	21.2113
Yamato-SS	CTRP2	3.246	4.0224	3.2417	11.9957
TE 441.T	CTRP2	1.3073	1.9715	1.3073	24.8967
Hs 729.T	CTRP2	1.6028	2.8447	1.6003	22.9367
G-401	CTRP2; CTRP1	1.7906	3.5669	1.7627	21.8465
TE 617.T	CTRP2	1.7984	4.02	1.7199	21.8919
RD	CTRP2	2.3125	5.6277	1.8855	19.7198
TTC-709	CTRP2	2.4281	4.0557	2.3859	17.5727
Rh18	CTRP2	2.5661	3.3945	2.565	16.5143
SW982	CTRP2	2.7052	3.6433	2.7017	15.5957
RKN	CTRP2; CTRP1	2.7062	3.5962	2.7038	15.6666
A-204	CTRP2	2.9506	4.4543	2.8892	14.1584
BT-16	CTRP2	2.9903	4.2428	2.9601	13.7867
Rh41	CTRP2	3.1154	4.3117	3.0847	17.6615
KYM-1	CTRP2	3.1586	3.8807	3.1565	12.5707
Tm87-16	CTRP2	3.2427	4.6339	3.1731	12.2416
GCT	CTRP2	3.4979	4.5187	3.4657	10.4122
G-402	CTRP2	3.6261	5.1961	3.4526	10.0617
BT-12	CTRP2	3.6261	3.9548	3.626	9.4493
HT-1080	CTRP2; CTRP1	3.6698	4.4706	3.654	9.2986
SK-LMS-1	CTRP2	4.5546	5.7962	4.2098	4.5842
MES-SA	CTRP2	4.6028	4.9575	4.5831	3.0094
SK-UT-1	CTRP2	13.099	29.89	-1.4802	12.7935

Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Thigh Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
P-STS	CTRP2	1.9532	4.0455	1.8819	20.8359
SYO-1	CTRP2	2.4774	3.2251	2.4771	17.1028
H-STS	CTRP2	3.3028	5.0465	3.1432	12.1611

Cancer Drug Sensitivity Data Curated from 44 Cell Line(s) in Ovary Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
2004	CTRP2	2.3861	4.4125	2.2882	18.0449
COV434	CTRP2; CTRP1	1.3254	3.7255	1.256	25.0833
OVCAR-4	CTRP2; CTRP1	1.669	3.3988	1.6481	22.6321
OVCAR-8	CTRP2; CTRP1	1.8034	3.8445	1.7492	21.8506
OVK18	CTRP2; CTRP1	1.9508	3.0893	1.9483	20.6949
COV644	CTRP2; CTRP1	1.9921	4.2956	1.8853	20.776
RMG-I	CTRP2; CTRP1	2.3613	4.998	2.1313	18.7563
OVKATE	CTRP1	2.6092	4.5159	2.5118	35.6455
RMUG-S	CTRP1	2.6686	6.5944	1.9148	38.2303
TYK-nu	CTRP2; CTRP1	2.8183	4.2827	2.7736	15.0637
FU-OV-1	CTRP2	2.9574	5.2905	2.6951	14.8311
JHOS-2	CTRP2	3.0359	5.2252	2.8006	14.2108
SNU-119	CTRP2	3.1171	5.55	2.7841	14.032
SNU-8	CTRP2	3.2539	3.9757	3.2511	16.2752
COV362	CTRP2; CTRP1	3.3317	5.4239	3.063	12.4525
OVMANA	CTRP1	3.3569	4.0139	3.3549	24.3266
OV-90	CTRP2; CTRP1	3.358	4.8036	3.2657	11.6386
Caov-3	CTRP2; CTRP1	3.4245	4.326	3.4095	10.9284
OAW28	CTRP2	3.4396	7.1976	2.4509	14.4498
JHOC-5	CTRP2; CTRP1	3.4569	4.6048	3.4103	10.821
OC 314	CTRP2	3.482	3.9931	3.4815	10.4105
JHOS-4	CTRP1	3.4915	4.5806	3.4512	22.6828
SK-OV-3	CTRP2; CTRP1	3.5162	5.1128	3.3602	10.8146
OAW42	CTRP2; CTRP1	3.6094	4.4107	3.5959	9.6925
OV7	CTRP2; CTRP1	3.6127	4.5595	3.5837	9.7235
COV318	CTRP1	3.6139	4.8532	3.533	21.239
EFO-27	CTRP2; CTRP1	3.7775	5.3994	3.5546	9.3263
A2780	CTRP2; CTRP1	3.8509	4.7901	3.803	8.204
OVSAHO	CTRP2	3.9501	5.67	3.6357	11.509
IGROV-1	CTRP2; CTRP1	4.0448	5.2656	3.8896	7.3019
ES2	CTRP2	4.1413	5.1609	4.0247	6.4294
DOV13	CTRP2	4.1922	5.2733	4.0432	6.2111
JHOM-1	CTRP2; CTRP1	4.2854	5.4823	4.0706	5.933
HEY A8	CTRP2; CTRP1	4.3014	6.9463	3.428	8.4643
Kuramochi	CTRP2	4.3486	5.9674	3.9247	8.518
MCAS	CTRP2	4.3942	5.2165	4.2813	4.7362
SNU-840	CTRP2; CTRP1	4.3952	6.3078	3.8215	6.6354
OVCAR-5	CTRP2	4.4	6.2268	3.8571	6.3915
ONCO-DG-1	CTRP2	4.4426	5.9426	4.0307	7.6141
OVTOKO	CTRP2	4.4516	5.5865	4.1977	6.6772
EFO-21	CTRP2; CTRP1	4.4575	5.6442	4.1849	5.0232
OV56	CTRP2	4.5587	4.9808	4.5302	3.3341
TOV-112D	CTRP2	4.5826	5.2625	4.4677	3.4948
OVISE	CTRP2	4.9429	6.0611	4.4492	2.7049

Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Clivus Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
U-CH1	CTRP2	4.4511	5.5071	4.2306	4.7707

Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Pleura Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
MPP 89	CTRP2	2.4173	4.0206	2.3785	17.6328
NCI-H28	CTRP2; CTRP1	3.2996	5.0525	3.1407	16.7141
IST-Mes1	CTRP2	3.4824	5.1075	3.3221	10.9693
MSTO-211H	CTRP2; CTRP1	3.5391	5.056	3.4011	10.5972
ACC-MESO-1	CTRP2	4.066	6.293	3.492	11.8565
NCI-H2052	CTRP2; CTRP1	4.3024	5.8452	3.9377	6.4041
NCI-H2452	CTRP2	4.704	7.2368	3.6531	6.5401
JL-1	CTRP2	8.8388	16.2603	2.1943	6.2498

Cancer Drug Sensitivity Data Curated from 4 Cell Line(s) in Prostate Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
22Rv1	CTRP2	2.8115	4.6675	2.6991	15.2627
PaCa-3	CTRP2; CTRP1	3.0487	8.3878	1.5219	19.1695
LNCaP clone FGC	CTRP2	3.4155	5.4094	3.1552	11.7812
DU145	CTRP2	5.0103	7.6669	3.7046	5.6975

Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Salivary Gland Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
YD-15	CTRP2	3.7823	4.4591	3.7723	8.4419
A-253	CTRP2	4.3401	6.0448	3.8812	6.4437

Cancer Drug Sensitivity Data Curated from 34 Cell Line(s) in Stomach Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
ECC10	CTRP2	1.3784	2.7738	1.3745	24.4365
IM95	CTRP2	1.6077	6.7383	0.7256	26.0006
SNU-16	CTRP2	1.7646	3.2475	1.7542	21.885
OCUM-1	CTRP2	1.9283	4.3213	1.8103	21.1636
SNU-1	CTRP2	2.21	4.5747	2.0656	19.3803
AGS	CTRP2; CTRP1	2.2501	3.6351	2.2356	18.743
GSS	CTRP2	2.3583	3.1282	2.358	24.3979
NUGC-4	CTRP2; CTRP1	2.4429	3.4173	2.4405	17.4193
Hs 746.T	CTRP2	2.5386	4.317	2.4685	16.9327
HuG1-N	CTRP2	2.615	5.6837	2.1946	17.6892
MKN7	CTRP2; CTRP1	3.0079	5.2643	2.7613	14.5205
NUGC-3	CTRP2	3.1166	4.1329	3.1025	12.8907
Fu97	CTRP2; CTRP1	3.1542	4.4925	3.103	12.851
KATO III	CTRP2	3.2652	5.9591	2.794	13.5725
SNU-719	CTRP2	3.3226	5.0297	3.1694	12.0063
SNU-5	CTRP2	3.3611	4.263	3.3477	11.2593
HGC-27	CTRP2	3.4595	4.6713	3.4004	10.7611
NCI-N87	CTRP2	3.4882	5.4255	3.2286	11.2959
SH-10-TC	CTRP2; CTRP1	3.5827	4.3832	3.5703	9.8668
23132/87	CTRP2	3.602	4.2224	3.5986	13.116
GSU	CTRP2	3.6403	3.9085	3.6403	12.7529
SNU-620	CTRP2	3.7431	5.4498	3.496	13.0297
KE-39	CTRP2	3.8658	5.9628	3.4282	9.475
SNU-216	CTRP2	3.868	4.9528	3.7844	8.1274
SNU-601	CTRP2	3.9537	5.0399	3.8553	7.6104
SNU-668	CTRP2	3.9726	5.0384	3.8763	7.4771
MKN74	CTRP2; CTRP1	4.1931	5.3939	4.0053	6.4409
LMSU	CTRP2	4.4817	8.4928	2.8315	10.4435
ECC12	CTRP2	4.6838	6.1754	4.156	6.1263
MKN1	CTRP2	4.7753	6.55	4.057	6.4083
MKN45	CTRP2	5.2799	6.7864	4.361	3.3382
SNU-685	CTRP2	3.6866	5.7174	3.3366	10.3214
SNG-M	CTRP2; CTRP1	4.5458	5.2729	4.4287	3.839
SNU-1077	CTRP2	5.445	6.7592	4.4935	2.2451

Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Thyroid Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
SW579	CTRP2	1.5178	1.9067	1.5178	23.4947
BHT-101	CTRP2	3.0088	3.7032	3.0078	13.5651
8305C	CTRP2	3.054	3.7963	3.0522	18.0858
8505C	CTRP2	3.1156	4.2134	3.095	12.9192
B-CPAP	CTRP2	3.3508	4.3081	3.3333	15.4626
CAL-62	CTRP2	3.4325	4.0615	3.4305	14.6491
ML-1 [Human leukemia]	CTRP2	3.4759	4.7187	3.4093	10.6781
TT	CTRP2	3.4867	4.1286	3.4839	10.3871
CGTH-W-1	CTRP2	3.5503	4.174	3.5473	13.5837
TT2609-C02	CTRP2	4.6036	5.5691	4.3619	3.851
FTC-133	CTRP2	5.1835	6.2372	4.5596	1.7845

Cancer Drug Sensitivity Data Curated from 28 Cell Line(s) in Upper Aerodigestive Tract Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
SCC-25	CTRP2	2.7159	3.8919	2.7023	15.5585
BICR 18	CTRP2	2.7225	4.6361	2.6091	15.859
BHY	CTRP2	3.1267	4.02	3.1195	17.4506
HSC-3	CTRP2	3.161	4.217	3.1422	17.1921
YD-10B	CTRP2	3.1797	4.6173	3.1081	12.6679
Detroit 562	CTRP2	3.198	4.5601	3.1379	17.0495
SCC-9	CTRP2; CTRP1	3.2556	5.8654	2.8239	13.5683
HSC-2	CTRP2; CTRP1	3.3102	4.6108	3.2516	11.8386
BICR 22	CTRP2	3.3298	4.994	3.1867	11.922
YD-8	CTRP2	3.4098	4.3735	3.3892	10.9592
SNU-1214	CTRP2	3.475	5.7747	3.0886	11.861
BICR 16	CTRP2	3.4908	4.2123	3.485	10.3696
BICR 31	CTRP2	3.5403	5.3296	3.3171	10.815
SNU-899	CTRP2	3.5787	4.1272	3.5773	9.7696
SNU-1076	CTRP2	3.5981	4.0278	3.5978	13.1372
CAL-33	CTRP2	3.7229	5.0579	3.5984	9.2399
PE/CA-PJ15	CTRP2	3.7957	7.2467	2.785	12.2163
BICR 6	CTRP2	3.9197	6.5046	3.2487	10.0423
SNU-1066	CTRP2	4.0114	5.1502	3.8864	9.9838
PE/CA-PJ49	CTRP2	4.2525	7.4274	3.1423	9.6669
PE/CA-PJ34 (clone C12)	CTRP2	4.2982	5.1859	4.1874	5.3655
FaDu	CTRP2	4.4005	5.0263	4.3466	4.4778
PE/CA-PJ41 (clone D2)	CTRP2	4.4391	5.2006	4.3354	4.4036
SNU-46	CTRP2	4.6412	7.4243	3.5037	7.2988
SCC-4	CTRP2	4.7883	5.4748	4.5909	2.466
HSC-4	CTRP2	4.8938	5.5364	4.6639	1.9161
SNU-1041	CTRP2	5.3103	6.3034	4.6203	1.8132
BICR 56	CTRP2	6.9974	8.198	4.658	0.1007

Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Urinary Tract Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
RT-4	CTRP2; CTRP1	2.0623	4.2875	1.9623	20.2852
U-BLC1	CTRP2	3.116	4.6764	3.0277	13.1505
JMSU-1	CTRP2	3.1558	4.6791	3.0703	17.5531
KMBC-2	CTRP2; CTRP1	3.2208	5.083	3.0463	12.8443
253J-BV	CTRP2	3.2998	4.1192	3.2929	15.8771
639V	CTRP2	3.4247	3.9363	3.4242	14.7133
CAL-29	CTRP2	3.4414	4.1699	3.4362	14.5828
253J	CTRP2	3.4587	4.1129	3.4559	14.4148
BFTC-905	CTRP2	3.6194	4.4633	3.6011	13.0265
VM-CUB-1	CTRP2	3.987	4.9138	3.9234	9.9035
TCCSUP	CTRP2	3.9875	4.8834	3.9306	7.2376
BC-3C	CTRP2	4.0151	4.9125	3.9542	7.0677
T24	CTRP2	4.0527	4.9954	3.9751	6.8767
5637	CTRP2; CTRP1	4.1104	5.2811	3.9556	6.865
UM-UC-1	CTRP2	4.3017	7.1419	3.3268	8.7936
HT-1197	CTRP2	4.3096	8.6961	2.575	24.322
RT-112	CTRP2	4.5454	6.0511	4.0823	5.1226
SW1710	CTRP2	4.6759	6.0219	4.2226	4.2382
HT-1376	CTRP2; CTRP1	4.8561	6.8997	3.9644	5.0024
UM-UC-3	CTRP2; CTRP1	5.2244	6.2204	4.6096	1.5904
KU-19-19	CTRP2	5.5089	7.5839	4.1379	4.0925
J82	CTRP2	7.9239	20.6054	-0.4864	16.5498

Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Urogenital System Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
HeLa	CTRP2	4.1322	4.7948	4.1042	6.1725

References

• [1] Epigenetics and beyond: targeting writers of protein lysine methylation to treat disease. Nat Rev Drug Discov. 2021 Apr;20(4):265-286.
• [2] Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase. Mol Cell. 2007 Feb 9;25(3):473-81.
• [3] Inhibition of euchromatic histone methyltransferase 1 and 2 sensitizes chronic myeloid leukemia cells to interferon treatment. PLoS One. 2014 Jul 31;9(7):e103915. doi: 10.1371/journal.pone.0103915. eCollection 2014.