Details of the Drug Combinations

General Information of This Drug (ID: DM5PCS7)

Drug Name

Bupropion DM5PCS7

Synonyms

bupropion; Amfebutamone; 34911-55-2; Amfebutamon; 2-(tert-butylamino)-1-(3-chlorophenyl)propan-1-one; amfebutamonum; Amfebutamona; (+-)-Bupropion; Wellbatrin; Bupropion [INN:BAN]; 34841-39-9; Elontril; Amfebutamonum [INN-Latin]; Zyban; Amfebutamona [INN-Spanish]; Bupropion SR; AMFEBUTAMONE HCl; alpha-(tert-butylamino)-m-chloropropiophenone; CHEMBL894; BRN 2101062; (+-)-1-(3-chlorophenyl)-2-((1,1-dimethylethyl)amino)-1-propanone; CHEBI:3219; SNPPWIUOZRMYNY-UHFFFAOYSA-N; 1-(3-chlorophenyl)-2-[(1,1-dimethylethyl)amino]propan-1-one; Amfebutamon; Amfebutamonum; Elont; Bupropion Hcl; Bupropion hydrocloride; Bupropion (INN); Bupropion (Old RN); Bupropion (USAN); Alpha-(tert-Butylamino)-m-chloropropiophenone; Alpha-(tert-butylamino)-m-chloropropiophenone; (-)-2-(tert-Butylamino)-3'-chloropropiophenone; (-)-2-(tert-Butylamino)-3'-chlorpropiophenon; 1-Propanone; 2-(Tert-Butylamino)-3'-chloropropiophenone

Indication

Disease Entry	ICD 11	Status	REF
Depression	6A70-6A7Z	Approved	[1]
Lung cancer	2C25.0	Approved	[1]
Major depressive disorder	6A70.3	Approved	[1]
Obesity	5B81	Approved	[1]
Seasonal affective disorder	N.A.	Approved	[1]
Smoking dependence	6C4A.2	Approved	[2]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

18 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Bupropion + Armodafinil	DCS8X9W	Armodafinil	Non Small Cell Lung Cancer	[3]
Bupropion + Varenicline	DCY0TDX	Varenicline	Nicotine Dependence	[4]
Bupropion + Nicotine	DC45HM2	Nicotine	Cigarette Smoking	[5]
Bupropion + Curcumin	DC4HV40	Curcumin	Non Small Cell Lung Cancer	[3]
Bupropion + Varenicline	DC6MWBZ	Varenicline	Nicotine Dependence	[6]
Bupropion + Eszopiclone	DCDKOQP	Eszopiclone	Insomnia	[7]
Bupropion + Armodafinil	DCGCVBI	Armodafinil	Non Small Cell Lung Cancer	[3]
Bupropion + Naltrexone	DCQFAHU	Naltrexone	Smoking	[8]
Bupropion + Escitalopram	DCQVJ7Z	Escitalopram	Depression	[9]
Bupropion + Naltrexone	DCEVL3P	Naltrexone	Obesity	[10]
Rivoceranib + Bupropion	DCERO03	Rivoceranib	Advanced Solid Tumor	[11]
Bupropion + Naltrexone	DC6OC31	Naltrexone	Binge Drinking	[12]
Bupropion + Varenicline	DCSWZ7S	Varenicline	Smoking Cessation	[13]
Zonisamide + Bupropion	DC2HOHA	Zonisamide	Smoking Cessation	[14]
Aripiprazole + Bupropion	DCFRTWC	Aripiprazole	Major Depressive Disorder	[15]
Bupropion + Varenicline	DCVB53E	Varenicline	Smoking Cessation	[16]
Citalopram + Bupropion	DCZ31IN	Citalopram	Depressive Illness	[17]
Sertraline + Bupropion	DCSROKR	Sertraline	Major Depressive Disorder	[18]
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References

1	Bupropion FDA Label
2	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
3	ClinicalTrials.gov (NCT01048983) Reducing Symptom Burden - Non Small Cell Lung Cancer (NSCLC)
4	ClinicalTrials.gov (NCT01406223) Mechanistic Evaluations of Pre-Cessation Therapies for Smoking Cessation
5	ClinicalTrials.gov (NCT01560507) Tailored Smoking Cessation Treatment for LIVE FOR LIFE Participants
6	ClinicalTrials.gov (NCT00749658) Human Laboratory Study of Varenicline and Bupropion for Nicotine Dependence
7	ClinicalTrials.gov (NCT00511134) Study of Lunesta Versus Placebo for Sleep Problems Related to Smoking Cessation and Zyban
8	ClinicalTrials.gov (NCT00129246) Low-Dose Naltrexone Combined With Bupropion to Stop Smoking With Less Weight Gain
9	ClinicalTrials.gov (NCT00917059) Personalized Indicators for Predicting Response to SSRI Treatment in Major Depression (The PRISE-MD Study)
10	A randomized, phase 3 trial of naltrexone SR/bupropion SR on weight and obesity-related risk factors (COR-II). Obesity (Silver Spring). 2013 May;21(5):935-43.
11	ClinicalTrials.gov (NCT04457180) A Pharmacokinetic Interaction Study Between Apatinib Mesylate and Repaglinide or Bupropion in Advanced Solid Tumor Subjects
12	ClinicalTrials.gov (NCT02842073) An Open Label Trial of Bupropion and Naltrexone for Binge Drinking
13	ClinicalTrials.gov (NCT03897439) Individualizing Pharmacotherapy for African American Smokers
14	ClinicalTrials.gov (NCT04388319) Zonisamide/Bupropion Effects on Switching to Electronic Cigarettes
15	ClinicalTrials.gov (NCT01942187) A Comparison of Medication Augmentation and PST in the Treatment of Depression in Older Adults
16	ClinicalTrials.gov (NCT01330043) Extended Treatment for Smoking Cessation
17	ClinicalTrials.gov (NCT03278938) Add-on to Cognitive, Event-Related Potentials (ERP) and Electroencephalogram (EEG) Asymmetry in Affective Disorders
18	ClinicalTrials.gov (NCT05537584) SMART Trial to Predict Anhedonia Response to Antidepressant Treatment