Details of the Drug Combinations

General Information of This Drug (ID: DM5YF4M)

Drug Name

Droxidopa DM5YF4M

Synonyms

droxidopa; 23651-95-8; L-DOPS; Northera; (2S,3R)-2-amino-3-(3,4-dihydroxyphenyl)-3-hydroxypropanoic acid; threo-Dopaserine; 3916-18-5; DOPS; DL-threo-DOPS; L-Threodops; DL-threo-3,4-Dihydroxyphenylserine; DL-threo-Droxidopa; DL-threo-Dihydroxyphenylserine; UNII-J7A92W69L7; SM 5688; CHEBI:31524; Droxidopa (L-DOPS); threo-beta,3-Dihydroxy-DL-tyrosine; EINECS 223-480-5; beta,3-Dihydroxy-DL-tyrosine threo-; BRN 2852792; L-threo-dihydroxyphenylserine; DL-threo-3-(3,4-Dihydroxyphenyl)serine; Serine, 3-(3,4-dihydroxyphenyl)-, DL-threo-

Indication

Disease Entry	ICD 11	Status	REF
Chronic fatigue syndrome	8E49	Approved	[1]
Neurogenic orthostatic hypotension	8D87.0Y	Approved	[2]
Pure autonomic failure	N.A.	Approved	[1]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

2 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Droxidopa + Pyridostigmine	DCHO64D	Pyridostigmine	Orthostatic Hypotension	[3]
Droxidopa + Carbidopa	DC8YVY0	Carbidopa	Parkinson Disease	[4]
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References

1	Droxidopa FDA Label
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7391).
3	ClinicalTrials.gov (NCT01370512) Droxidopa / Pyridostigmine in Orthostatic Hypotension
4	ClinicalTrials.gov (NCT00547911) Augmenting Effects of L-DOPS With Carbidopa and Entacapone