Details of the Drug Combinations

General Information of This Drug (ID: DM6T924)

• Drug Name: Gabapentin (DM6T924)
• Synonyms: Aclonium; GBN; Gabapen; Gabapentina; Gabapentine; Gabapentinium; Gabapentino; Gabapentinum; Gabapetin; Neurontin; Serada; Vultin; Apotex brand of gabapentin; Aventis brand of gabapentin; Gabapentin GR; Gabapentin Hexal; Gabapentin Stada; Gabapentino [Spanish]; Hexal brand of gabapentin; Novopharm brand of gabapentin; Parke Davis brand of gabapentin; Pfizer brand of gabapentin; Pharmascience brand of gabapentin; Ratiopharm brand of gabapentin; Stadapharm brand of gabapentin; GOE 2450; Go 3450; Apo-Gabapentin; DDS-2003; DM-1796; DM-5689; G-154; Gabapentin (Neurontin); Gabapentin-ratiopharm; Gabapentine [INN-French]; Gabapentino [INN-Spanish]; Gabapentinum [INN-Latin]; Goe-3450; Neurontin (TN); Novo-Gabapentin; PMS-Gabapentin; Warner-Lambert brand of gabapentin; Gabapentin [USAN:INN:BAN]; [1-(AMINOMETHYL)CYCLOHEXYL]ACETIC ACID; Gabapentin (JAN/USAN/INN); 1-(Aminomethyl)-cyclohexaneacetic acid; 1-(Aminomethyl)cyclohexaneacetic acid; 2-[1-(aminomethyl)cyclohexyl]acetic acid

Indication

Complex partial seizure; ICD 11: 8A68.0; Status: Approved [1]; Postherpetic neuralgia; ICD 11: 1E91.5; Status: Approved [2]; Solid tumour/cancer; ICD 11: 2A00-2F9Z; Status: Phase 3 [1]

• Therapeutic Class: Analgesics
• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

1 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Gabapentin + NVP-AUY922	DCDS0BL	NVP-AUY922	Hepatoblastoma (Cell Line: HB3)	[3]

15 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Clonidine + Gabapentin	DC6OIUO	Clonidine	Shoulder Arthroscopy	[4]
Gabapentin + Famciclovir	DCRRWHR	Famciclovir	Herpes Zoster	[5]
Gabapentin + Ropivacaine	DC2FM0H	Ropivacaine	Total Knee Arthroplasty	[6]
Gabapentin + Duloxetine	DC93237	Duloxetine	Diabetic Neuropathic Pain	[7]
Gabapentin + Morphine	DCKAE4Y	Morphine	Postoperative Pain	[8]
Gabapentin + Famciclovir	DCO532N	Famciclovir	Herpes Zoster	[5]
Ketamine + Gabapentin	DCBTL8M	Ketamine	Head and Neck Cancer	[9]
Dexamethasone + Gabapentin	DCUQGVM	Dexamethasone	Postoperative Nausea and Vomiting	[10]
Ketamine + Gabapentin	DC0QGDX	Ketamine	Pain	[11]
Celecoxib + Gabapentin	DC36DRN	Celecoxib	Pain Management	[12]
Celecoxib + Gabapentin	DC9UEN0	Celecoxib	Colorectal Disorders	[13]
Celecoxib + Gabapentin	DCELKQ4	Celecoxib	Colorectal Disorders	[13]
Gabapentin + Ibuprofen	DCFX6J6	Ibuprofen	Pain	[14]
Gabapentin + Ketorolac	DC1JR7L	Ketorolac	Pain	[15]
Gabapentin + Valproic Acid	DC69F6S	Valproic Acid	Alcohol Withdrawal Syndrome	[16]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5483).
• [2] Gabapentin FDA Label
• [3] Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
• [4] ClinicalTrials.gov (NCT01112878) Oral Clonidine & Gabapentin: Improving Recovery and Pain Management After Outpatient With Major Orthopedic Surgery
• [5] ClinicalTrials.gov (NCT03120962) Effect of Early Use of Oxycodone During the Acute Phase of Herpes Zoster on Preventing Postherpetic Neuralgia
• [6] ClinicalTrials.gov (NCT01489631) Analgesia After Total Knee Replacement Surgery
• [7] ClinicalTrials.gov (NCT00619983) Three Way Interaction Between Gabapentin, Duloxetine, and Donepezil in Patients With Diabetic Neuropathy
• [8] ClinicalTrials.gov (NCT00726999) Perioperative Use of Gabapentin To Decrease Narcotic Requirements in Spinal Fusion
• [9] ClinicalTrials.gov (NCT05156060) Gabapentin & Ketamine for Prevention/Treatment of Acute/Chronic Pain in Locally Advanced Head and Neck Cancer
• [10] ClinicalTrials.gov (NCT02525848) Aprepitant Versus Gabapentin Prophylaxis for Postoperative Nausea and Vomiting in Laparoscopic Gynecological Surgeries
• [11] ClinicalTrials.gov (NCT02815111) Evaluation of Ketamine and Multi-modal Analgesics
• [12] ClinicalTrials.gov (NCT03121963) Pain Management in Head and Neck Surgery Patients
• [13] ClinicalTrials.gov (NCT02351934) Early Diuresis Following Colorectal Surgery
• [14] ClinicalTrials.gov (NCT02076893) Postoperative Tramadol/Gabapentin/Ibuprofen Versus Tramadol/Placebo/Ibuprofen
• [15] ClinicalTrials.gov (NCT02867176) Pain Management in Corneal Collagen Crosslinking for Keratoconus
• [16] ClinicalTrials.gov (NCT03012815) Gabapentin for Alcohol Withdrawal Syndrome