Details of the Drug Combinations

General Information of This Drug (ID: DM6VZFQ)

Drug Name
Pirfenidone   DM6VZFQ
Synonyms
Deskar; Esbriet; Pirespa; Pirfenidona; Pirfenidonum; AMR 69; P 2116; AMR-69; F-647; KS-5041; Pirfenidona [INN-Spanish]; Pirfenidone (Deskar); Pirfenidone [USAN:INN]; Pirfenidonum [INN-Latin]; S-7701; Pirfenidone (JAN/USAN/INN); 5-Methyl-1-phenyl-1H-pyridin-2-one; 5-Methyl-1-phenyl-2(1H)-pyridone; 5-Methyl-1-phenyl-2-(1H)-pyridone; 5-methyl-1-phenylpyridin-2(1H)-one; 5-methyl-1-phenylpyridin-2-one
Indication
Disease Entry ICD 11 Status REF
Idiopathic pulmonary fibrosis CB03.4 Approved [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

6 Clinical Trial Drug Combination(s) Consisting of This drug
DrugCom Name DrugCom ID Component Drug Indication REF
Pirfenidone + Nintedanib DCTN4WO Nintedanib Pulmonary Fibrosis [2]
Pirfenidone + Carboplatin DCJ5RWE Carboplatin Lung Cancer [3]
Vismodegib + Pirfenidone DCVI973 Vismodegib Idiopathic Pulmonary Fibrosis [4]
Pirfenidone + Acetylcysteine DCEF05R Acetylcysteine Idiopathic Pulmonary Fibrosis [5]
Sildenafil + Pirfenidone DCJOTCU Sildenafil Idiopathic Pulmonary Fibrosis [6]
Pirfenidone + Nintedanib DC7YVGZ Nintedanib Idiopathic Pulmonary Fibrosis [7]
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⏷ Show the Full List of 6 DrugCom(s)

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7532).
2 ClinicalTrials.gov (NCT01417156) Safety and PK Study of BIBF 1120 in Japanese Patients With IPF: Follow up Study From 1199.31(NCT01136174)
3 ClinicalTrials.gov (NCT03177291) Pirfenidone Combined With Standard First-Line Chemotherapy in Advanced-Stage Lung NSCLC
4 ClinicalTrials.gov (NCT02648048) A Study of Oral Vismodegib in Combination With Pirfenidone in Participants With Idiopathic Pulmonary Fibrosis
5 ClinicalTrials.gov (NCT02707640) A Study to Assess the Safety and Tolerability of N-Acetylcysteine When Administered With Pirfenidone to Participants With Idiopathic Pulmonary Fibrosis (IPF)
6 ClinicalTrials.gov (NCT02951429) Efficacy, Safety, and Tolerability Study of Pirfenidone in Combination With Sildenafil in Participants With Advanced Idiopathic Pulmonary Fibrosis (IPF) and Intermediate or High Probability of Group 3 Pulmonary Hypertension
7 ClinicalTrials.gov (NCT02606877) A Study to Compare the Amount of Nintedanib and Pirfenidone in the Blood When Nintedanib and Pirfenidone Are Given Separately or in Combination