Details of the Drug Combinations

General Information of This Drug (ID: DM783CH)

• Drug Name: Levobupivacaine (DM783CH)
• Synonyms: Novabupi; Chirocaine (TN); Levobupivacaine (INN); Levobupivacaine [INN:BAN]; Novabupi (TN); L(-)-Bupivacaine; L-(-)-bupivacaine; L-(-)-1-Butyl-2',6'-pipecoloxylidide; (2S)-1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide; (S)-1-Butyl-2',6'-pipecoloxylidide; (S)-bupivacaine

Indication

Anaesthesia; ICD 11: 9A78.6; Status: Approved [1]

• Therapeutic Class: Anesthetics
• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

15 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Clonidine + Levobupivacaine	DCSSXSU	Clonidine	Knee Osteoarthritis	[2]
Epinephrine + Levobupivacaine	DCD8QCR	Epinephrine	Pain, Postoperative	[3]
Levobupivacaine + Diclofenac	DC2EF2A	Diclofenac	Pain, Postoperative	[4]
Levobupivacaine + Morphine	DC51BUZ	Morphine	Reconstruction Breast Surgery	[5]
Levobupivacaine + Sufentanil	DCAGNA0	Sufentanil	Pregnancy	[6]
Levobupivacaine + Ropivacaine	DCJ48K2	Ropivacaine	Pain Insensitivity, Congenital	[7]
Dexamethasone + Levobupivacaine	DC1EILQ	Dexamethasone	Effects of; Anesthesia, in Labor and Delivery	[8]
Ketamine + Levobupivacaine	DCQWMOV	Ketamine	Analgesia	[9]
Levobupivacaine + Magnesium Sulfate	DCEKPM8	Magnesium Sulfate	Analgesia	[9]
Levobupivacaine + Fentanyl	DCR3QSU	Fentanyl	Anesthesia	[10]
Clonidine + Levobupivacaine	DCARI40	Clonidine	Anesthesia, Epidural	[11]
Levobupivacaine + Ketorolac	DCX6GZ8	Ketorolac	Total Knee Arthroplasty	[12]
Levobupivacaine + Phenylephrine	DCKMRGW	Phenylephrine	Hypotension	[13]
Levobupivacaine + Fentanyl	DCKWQO1	Fentanyl	Epidural Analgesia	[14]
Levobupivacaine + Tramadol	DCWMSM7	Tramadol	Heart Surgery Via Sternotomy	[15]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7211).
• [2] ClinicalTrials.gov (NCT02695654) Effectiveness of Ultrasound Guided Adductor Canal Block on Chronic Pain in Knee Osteoarthritis
• [3] ClinicalTrials.gov (NCT04020133) the Role of Popliteal Plexus Block in Pain Management After Anterior Cruciate Ligament Reconstruction.
• [4] ClinicalTrials.gov (NCT02556970) A Study Investigating Pain Following Single-port or Multi-port Video Assisted Thoracoscopic Surgery
• [5] ClinicalTrials.gov (NCT02677571) PVB vs PECS Block in Breast Surgery
• [6] ClinicalTrials.gov (NCT01856166) PIEB-PCEA Versus CEI-PCEA for Labor Analgesia in Nulliparous
• [7] ClinicalTrials.gov (NCT02513433) Comparison of Levobupivacaine, Ropivacaine and Bupivacaine in Epidural Anaesthesia
• [8] ClinicalTrials.gov (NCT02588417) Intrathecal Dexamethasone and Labor Analgesia
• [9] ClinicalTrials.gov (NCT04275661) Ketamine Versus Magnesium Sulphate as Adjuvants for ESPB in Breast Cancer Surgery
• [10] ClinicalTrials.gov (NCT02430090) Comparison of Intratechal Levobupivacaine and Adding With Sufetanil and Fentanyl in Ceserean Section
• [11] ClinicalTrials.gov (NCT02563821) Programmed Intermittent Epidural Bolus Versus Continuous Epidural Infusion for Third Trimester Medical Termination of Pregnancy Analgesia : a Randomized Study. (PCEA-IMG)
• [12] ClinicalTrials.gov (NCT02082067) Total Knee Prosthesis With Continuous Block of Adductor Canal and Outcome
• [13] ClinicalTrials.gov (NCT02802683) Hemodynamic Impact of Hyperbaric Versus Isobaric for Spinal Anesthesia During Cesarean Delivery
• [14] ClinicalTrials.gov (NCT04397406) Dexmedetomidine or Fentanyl as Additives to Epidural Levobupivacaine in Painless Labor
• [15] ClinicalTrials.gov (NCT02851394) Advantage of Tramadol in Local Analgesia Post-Sternotomy