Details of the Drug Combinations

General Information of This Drug (ID: DM8WI3R)

Drug Name

Alogliptin DM8WI3R

Synonyms

850649-61-5; UNII-JHC049LO86; alogliptina; 2-({6-[(3r)-3-Aminopiperidin-1-Yl]-3-Methyl-2,4-Dioxo-3,4-Dihydropyrimidin-1(2h)-Yl}methyl)benzonitrile; SYR-322; JHC049LO86; (R)-2-((6-(3-aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile; CHEBI:72323; AK322010; 2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl}methyl)benzonitrile; vipidia; Alogliptin [INN]; Alogliptin (SYR-322); alogliptinum; alogliptine; HSDB 8203; UNII-JHC049LO86

Indication

Disease Entry	ICD 11	Status	REF
Type-2 diabetes	5A11	Approved	[1]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

3 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Alogliptin + Sitagliptin	DC1333J	Sitagliptin	Type 2 Diabetes Mellitus	[2]
Alogliptin + Metformin	DC8SIBJ	Metformin	Type 2 Diabetes Mellitus	[3]
Alogliptin + Metformin	DCW2VQ9	Metformin	Diabetes Mellitus, Type 2	[4]
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2 Approved Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Alogliptin + Metformin	DCHJ3N7	Metformin	Type-2 diabetes	[5]
Alogliptin + Pioglitazone	DCLZAYY	Pioglitazone	Type-2 diabetes	[5]
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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6319).
2	ClinicalTrials.gov (NCT01588587) DPP-IV Inhibitors Underlying Mechanism of Cancer in Diabetic Patients
3	ClinicalTrials.gov (NCT00856284) Efficacy and Safety of Alogliptin Plus Metformin Compared to Glipizide Plus Metformin in Patients With Type 2 Diabetes Mellitus
4	ClinicalTrials.gov (NCT01023581) Efficacy and Safety of Alogliptin Plus Metformin in Patients With Type 2 Diabetes
5	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015