Details of the Drug Combinations

General Information of This Drug (ID: DM9BQTX)

Drug Name

PIK-75 DM9BQTX

Synonyms

PIK75; PIK 75; imidazopyridine derivative 8c [PMID 17601739]

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]
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Drug Type

Small molecular drug

Structure

3D MOL is unavailable

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

2 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
PIK-75 + Ruxolitinib	DCYOP5J	Ruxolitinib	Hodgkin lymphoma (Cell Line: L-1236)	[2]
PIK-75 + Marizomib	DC71HZJ	Marizomib	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
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References

1	Isoform-selective inhibition of phosphoinositide 3-kinase: identification of a new region of nonconserved amino acids critical for p110alpha inhibition. Mol Pharmacol. 2011 Oct;80(4):657-64.
2	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.