Details of the Drug Combinations

General Information of This Drug (ID: DMB8MNU)

Drug Name

CHIR-99021 DMB8MNU

Synonyms

CHIR99021; CHIR 99021; CT-99021; CT99021

Indication

Disease Entry	ICD 11	Status	REF
Allergic inflammation	4A80-4A85	Patented	[1]
Graft rejection	NE84	Patented	[1]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

1 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
CHIR-99021 + Ruxolitinib	DCUDI3Z	Ruxolitinib	Hodgkin lymphoma (Cell Line: L-1236)	[2]
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References

1	Glycogen synthase kinase 3 (GSK-3) inhibitors: a patent update (2014-2015).Expert Opin Ther Pat. 2017 Jun;27(6):657-666.
2	Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.