Details of the Drug Combinations

General Information of This Drug (ID: DMBR01X)

Drug Name
Brilinta   DMBR01X
Synonyms
Ticagrelor; 274693-27-5; Brilique; AZD-6140; AZD6140; AZD 6140; AR-C126532XX; UNII-GLH0314RVC; [14C]-Ticagrelor; GLH0314RVC; CHEBI:68558; (1S,2S,3R,5S)-3-[7-[[(1R,2S)-2-(3,4-DIFLUOROPHENYL)CYCLOPROPYL]AMINO]-5-(PROPYLTHIO)-3H-1,2,3-TRIAZOLO[4,5-D]PYRIMIDIN-3-YL]-5-(2-HYDROXYETHOXY)-1,2-CYCLOPENTANEDIOL; (1S,2S,3R,5S)-3-(7-(((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol; Brilique; AR-C126532; Ticagrelor (USAN/INN); Brilinta/Brilique
Indication
Disease Entry ICD 11 Status REF
Acute coronary syndrome BA41 Approved [1]
Thrombosis DB61-GB90 Approved [2]
Arterial thrombosis DB61-DD30 Phase 3 [3]
Myocardial infarction BA41-BA43 Phase 3 [3]
Peripheral vascular disease BD4Z Investigative [4]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

24 Clinical Trial Drug Combination(s) Consisting of This drug
DrugCom Name DrugCom ID Component Drug Indication REF
Brilinta + Aspirin DCIVTKZ Aspirin De Novo Stenosis [5]
Brilinta + Aspirin DCSMUT0 Aspirin Antiplatelet Drug [6]
Brilinta + Aspirin DC1YHVU Aspirin Inhibition on Platelet Aggregation [7]
Brilinta + Aspirin DCD2Z4H Aspirin Coronary Artery Disease [8]
Brilinta + Clopidogrel DCKADAS Clopidogrel Coronary Artery Disease [9]
Brilinta + Rosuvastatin DC9WTUP Rosuvastatin Pharmacokinetics [10]
Cangrelor + Brilinta DC3BWX5 Cangrelor Coronary Artery Disease [11]
Prasugrel + Brilinta DCH6MMX Prasugrel ST-Elevation Myocardial Infarction [12]
Brilinta + Eptifibatide DCKSI5R Eptifibatide Acute Coronary Syndrome [13]
Brilinta + Rivaroxaban DCWW9VB Rivaroxaban Acute Coronary Syndrome [14]
Brilinta + Aspirin DCUMZH1 Aspirin Coronary Artery Disease (CAD) [15]
Brilinta + Colchicine DC55FQF Colchicine Stroke [16]
Brilinta + Rivaroxaban DC5WOHZ Rivaroxaban Atrial Fibrillation [17]
Brilinta + Clopidogrel DC6WLZ2 Clopidogrel Coronary Artery Disease [18]
Prasugrel + Brilinta DC7RF5D Prasugrel Atrial Fibrillation [19]
Brilinta + Aspirin DC1FNAS Aspirin Stable Coronary Syndrome [20]
Brilinta + Morphine DC4U6GN Morphine Coronary Artery Disease [21]
Brilinta + Morphine DCKZ2UQ Morphine ST-segment Elevation Myocardial Infarction [22]
Brilinta + Atorvastatin DCWFSDG Atorvastatin Ischemia [23]
Fentanyl + Brilinta DC31888 Fentanyl Percutaneous Coronary Intervention [24]
Methotrexate + Brilinta DCFZS7F Methotrexate Rheumatoid Arthritis [25]
Prasugrel + Brilinta DC3EC39 Prasugrel Cardiovascular Diseases [26]
Prasugrel + Brilinta DCKXNMR Prasugrel Myocardial Infarction [27]
Prasugrel + Brilinta DC963XW Prasugrel Coronary Artery Disease [28]
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⏷ Show the Full List of 24 DrugCom(s)

References

1 Ticagrelor-Induced Syncope/Bradyarrhythmia. Cureus. 2021 Jan 23;13(1):e12874.
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1765).
3 ClinicalTrials.gov (NCT01732822) A Study Comparing Cardiovascular Effects of Ticagrelor and Clopidogrel in Patients With Peripheral Artery Disease. U.S. National Institutes of Health.
4 Antithrombotic Therapy for Symptomatic Peripheral Arterial Disease: A Systematic Review and Network Meta-Analysis. Drugs. 2022 Aug;82(12):1287-1302.
5 ClinicalTrials.gov (NCT05209412) Paclitaxel-Coated Balloon Versus Zotarolimus-Eluting Stent for Treatment of De Novo Coronary Artery Lesions
6 ClinicalTrials.gov (NCT04971356) 1-month DAPT Plus 5-month Ticagrelor Monotherapy Versus 12-month DAPT in Patients With Drug-coated Balloon
7 ClinicalTrials.gov (NCT01744288) Study to See if Platelet Transfusion Stop or Lessen the Effect of the Drug on Platelets
8 ClinicalTrials.gov (NCT00528411) A Study of the Onset and Offset of Antiplatelet Effects Comparing Ticagrelor, Clopidogrel, and Placebo With Aspirin
9 ClinicalTrials.gov (NCT01742117) Tailored Antiplatelet Therapy Following PCI
10 ClinicalTrials.gov (NCT05373277) KF2019#1-trial: Effects of a Thrombocyte Inhibitor on a Cholesterol-lowering Drug
11 ClinicalTrials.gov (NCT01766466) Cangrelor Ticagrelor Transition Study
12 ClinicalTrials.gov (NCT01531114) PraSugrel vs TicagrElor in ST-Elevation Myocardial Infarction paTients With Diabetes Mellitus
13 ClinicalTrials.gov (NCT01919723) Ticagrelor and Eptifibatide Bolus-Only Versus Ticagrelor and Eptifibatide Bolus Plus Abbreviated Infusion
14 ClinicalTrials.gov (NCT02293395) A Study to Compare the Safety of Rivaroxaban Versus Acetylsalicylic Acid in Addition to Either Clopidogrel or Ticagrelor Therapy in Participants With Acute Coronary Syndrome
15 ClinicalTrials.gov (NCT01813435) GLOBAL LEADERS: A Clinical Study Comparing Two Forms of Anti-platelet Therapy After Stent Implantation
16 ClinicalTrials.gov (NCT05476991) Evaluation of Low Dose Colchicine and Ticagrelor in Prevention of Ischemic Stroke in Patients With Stroke Due to Atherosclerosis
17 ClinicalTrials.gov (NCT03331484) The Safety and Efficacy Of Rivaroxaban and Ticagrelor for Patients With Atrial Fibrillation After Percutaneous Coronary Intervention
18 ClinicalTrials.gov (NCT01805596) Effect of Ticagrelor on Endothelial Function
19 ClinicalTrials.gov (NCT02866175) Edoxaban Treatment Versus Vitamin K Antagonist in Patients With Atrial Fibrillation Undergoing Percutaneous Coronary Intervention
20 ClinicalTrials.gov (NCT03224923) A Novel Strategy For Personalized Long-Term Dual Antiplatelet Therapy (RAPID EXTEND PILOT STUDY)
21 ClinicalTrials.gov (NCT02403830) Effect of Methylnaltrexone on the PK/PD Profiles of Ticagrelor in Patients Treated With Morphine
22 ClinicalTrials.gov (NCT02217878) Influence of Morphine on Pharmacokinetics and Pharmacodynamics of Ticagrelor in Patients With Acute Myocardial Infarction
23 ClinicalTrials.gov (NCT02910778) The Effect of Ticagrelor With or Without Atorvastatin on Endothelial Function in Healthy Males
24 ClinicalTrials.gov (NCT03476369) Fentanyl and Crushed Ticagrelor in Percutaneous Coronary Intervention
25 ClinicalTrials.gov (NCT02874092) Ticagrelor in Methotrexate-Resistant Rheumatoid Arthritis
26 ClinicalTrials.gov (NCT02587260) Hunting for the Off-Target Properties of Ticagrelor on Endothelial Function in Humans (HI-TECH)
27 ClinicalTrials.gov (NCT02545933) Vorapaxar in Patients With Prior Myocardial Infarction Treated With Prasugrel and Ticagrelor
28 ClinicalTrials.gov (NCT01957540) Differential Effect of Ticagrelor Versus Prasugrel Maintenance Dose on Endothelial Function of Peripheral Vessels in Patients With Coronary Artery Disease