Details of the Drug Combinations

General Information of This Drug (ID: DME2H5T)

• Drug Name: Cilastatin (DME2H5T)
• Synonyms: Cilastatina; Cilastatine; Cilastatinum; Cilastatin Monosodium Salt; Cilastatin acid; Cilastatina [Spanish]; Cilastatine [French]; Cilastatinum [Latin]; MK0791; Cilastatin (INN); Cilastatin [INN:BAN]; MK-791; (2Z)-7-{[(2R)-2-amino-2-carboxyethyl]sulfanyl}-2-({[(1S)-2,2-dimethylcyclopropyl]carbonyl}amino)hept-2-enoic acid; (Z)-(S)-6-carboxy-6-[(S)-2,2-dimethylcyclopropanecarboxamido]hex-5-enyl-L-cysteine; (Z)-7-[(2R)-2-amino-3-hydroxy-3-oxopropyl]sulfanyl-2-[[(1S)-2,2-dimethylcyclopropanecarbonyl]amino]hept-2-enoic acid

Indication

Bacteremia; ICD 11: 1A73; Status: Approved [1]; Bacterial infection; ICD 11: 1A00-1C4Z; Status: Approved [2]; Endometritis; ICD 11: N.A.; Status: Approved [1]; Peritonitis; ICD 11: N.A.; Status: Approved [1]; Pelvic inflammatory disease; ICD 11: GA05; Status: Investigative [1]

• Therapeutic Class: Antibiotics
• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

53 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Acetohydroxamic Acid + Cilastatin	DCQJZBE	Acetohydroxamic Acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amiloride + Cilastatin	DCBRLJ6	Amiloride	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Bortezomib + Cilastatin	DCOD46I	Bortezomib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Chlorzoxazone + Cilastatin	DCVDL5L	Chlorzoxazone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Cilastatin + Aprepitant	DCWZEW0	Aprepitant	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Cilastatin + Ribavirin-TP	DCNE9CW	Ribavirin-TP	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Cilastatin + Dantrolene	DCY85OW	Dantrolene	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Cilastatin + Dactinomycin	DC5VC9F	Dactinomycin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Cilastatin + Epinephrine	DC7YIPS	Epinephrine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Cilastatin + PMID28460551-Compound-2	DCCGTCT	PMID28460551-Compound-2	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Cilastatin + Triapine	DCYARBX	Triapine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Cilastatin + IT-141	DCJT254	IT-141	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Cilastatin + Testosterone cypionate	DC5K885	Testosterone cypionate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Cilastatin + Emetine	DC0MHP9	Emetine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Cilastatin + Pazopanib	DCIAJUM	Pazopanib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Cilastatin + Ciprofibrate	DCGTP2O	Ciprofibrate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Cilastatin + Naringenin	DCXYCN8	Naringenin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Cilastatin + Arfolitixorin	DC0Y50U	Arfolitixorin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Cilastatin + Fenoprofen	DC5E9UW	Fenoprofen	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Cilastatin + Methylene blue	DCB8BQ5	Methylene blue	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Cilastatin + Tropisetron	DCSS7A9	Tropisetron	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Cilastatin + Mesalazine	DCM9G2X	Mesalazine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Cilastatin + Trimethobenzamide	DCRS4YV	Trimethobenzamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Cilastatin + Maprotiline	DCNFGY1	Maprotiline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Cilastatin + Leflunomide	DC3HI7D	Leflunomide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Cilastatin + Brincidofovir	DCYIWQR	Brincidofovir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Cilastatin + Hyodeoxycholic acid	DCI9UNE	Hyodeoxycholic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Cilastatin + Chlormezanone	DCVFZ71	Chlormezanone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Cilastatin + Mycophenolic acid	DCSDAGJ	Mycophenolic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Cilastatin + Olmesartan medoxomil	DCRLQ2A	Olmesartan medoxomil	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Cilastatin + Auranofin	DCO2O66	Auranofin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Cilastatin + PMID28870136-Compound-43	DCULW21	PMID28870136-Compound-43	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Cilastatin + Cilostazol	DCTS0LP	Cilostazol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Cycloguanil + Cilastatin	DC6RUA8	Cycloguanil	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Diazoxide + Cilastatin	DC0CVKT	Diazoxide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Eptifibatide + Cilastatin	DCCP4ZH	Eptifibatide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Furazolidone + Cilastatin	DCM43D5	Furazolidone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Ibutilide + Cilastatin	DCEOLC7	Ibutilide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Imatinib + Cilastatin	DC2QPLY	Imatinib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
K-134 + Cilastatin	DCQCKRU	K-134	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Levamisole + Cilastatin	DCRECI6	Levamisole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Maprotiline + Cilastatin	DCMEBJX	Maprotiline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Mefloquine + Cilastatin	DC69FN6	Mefloquine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Methotrexate + Cilastatin	DCXFTM6	Methotrexate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Metyrosine + Cilastatin	DCCAIQO	Metyrosine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Mycophenolic acid + Cilastatin	DCAN8H3	Mycophenolic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Niclosamide + Cilastatin	DC16KTD	Niclosamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Oxyphenbutazone + Cilastatin	DC2N6WO	Oxyphenbutazone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Pentamidine + Cilastatin	DCTS2JW	Pentamidine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Pyrazinamide + Cilastatin	DCMTAGF	Pyrazinamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Terameprocol + Cilastatin	DCQZ17G	Terameprocol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Trihexyphenidyl + Cilastatin	DC8ZRBJ	Trihexyphenidyl	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Vinblastine + Cilastatin	DCLRQFQ	Vinblastine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]

1 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Linezolid + Cilastatin	DC5EN94	Linezolid	Bacterial Pneumonia	[4]

References

• [1] Cilastatin FDA Label
• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5166).
• [3] Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
• [4] ClinicalTrials.gov (NCT02493764) Imipenem/Relebactam/Cilastatin Versus Piperacillin/Tazobactam for Treatment of Participants With Bacterial Pneumonia (MK-7655A-014)