Details of the Drug Combinations

General Information of This Drug (ID: DMF0NQR)

Drug Name

Eplerenone DMF0NQR

Synonyms

Epoxymexrenone; Inspra; Selara; CGP-30083; Inspra (TN); SC-66110; Eplerenone (JAN/USAN/INN); Inspra, Epoxymexrenone, CGP30083, SC-66110,Eplerenone; 7alpha-methoxycarbonyl-3-oxo-9,11alpha-epoxy-17alpha-pregn-4-ene-21,17-carbolactone

Indication

Disease Entry	ICD 11	Status	REF
Heart failure	BD10-BD13	Approved	[1]
Coronavirus Disease 2019 (COVID-19)	1D6Y	Investigative	[2]
------------------------------------------------------------------------------------

Therapeutic Class

Antihypertensive Agents

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

3 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Amlodipine + Eplerenone	DCN0SAO	Amlodipine	Hypertension	[3]
Cinacalcet + Eplerenone	DCQ7FUV	Cinacalcet	Primary Hyperparathyroidism	[4]
Amlodipine + Eplerenone	DC6X9DN	Amlodipine	Metabolic Syndrome	[5]
------------------------------------------------------------------------------------

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2876).
2	Network-based drug repurposing for novel coronavirus 2019-nCoV/SARS-CoV-2. Cell Discov. 2020 Mar 16;6:14.
3	ClinicalTrials.gov (NCT01996449) The Role of Aldosterone on Augmented Exercise Pressor Reflex in Hypertension
4	ClinicalTrials.gov (NCT02525796) Evaluating Alternative Medical Therapies in Primary Hyperparathyroidism
5	ClinicalTrials.gov (NCT02034435) Endogenous Renin-Angiotensin-Aldosterone System and Glucose Metabolism