Details of the Drug Combinations

General Information of This Drug (ID: DMFP8WE)

Drug Name
ZM-447439   DMFP8WE
Synonyms
331771-20-1; ZM-447439; ZM447439; ZM 447439; N-[4-[[6-METHOXY-7-[3-(4-MORPHOLINYL)PROPOXY]-4-QUINAZOLINYL]AMINO]PHENYL]BENZAMIDE; TCMDC-125873; UNII-RSN3P9776R; CHEMBL202721; RSN3P9776R; N-(4-((6-methoxy-7-(3-morpholinopropoxy)quinazolin-4-yl)amino)phenyl)benzamide; C29H31N5O4; N-[4-({6-methoxy-7-[3-(morpholin-4-yl)propoxy]quinazolin-4-yl}amino)phenyl]benzamide; N-(4-{[6-Methoxy-7-(3-Morpholin-4-Ylpropoxy)quinazolin-4-Yl]amino}phenyl)benzamide
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

18 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Sorafenib + ZM-447439 DC8KSBK Sorafenib DD2 (Cell Line: DD2) [2]
ZM-447439 + OZ277 DCYHRMA OZ277 DD2 (Cell Line: DD2) [2]
ZM-447439 + Lumefantrine DCPAWN0 Lumefantrine DD2 (Cell Line: DD2) [2]
ZM-447439 + T-3.5 DCPSAE6 T-3.5 DD2 (Cell Line: DD2) [2]
ZM-447439 + Dihydroergotamine DCKEB13 Dihydroergotamine DD2 (Cell Line: DD2) [2]
ZM-447439 + Thiolactomycin DCYY8PA Thiolactomycin DD2 (Cell Line: DD2) [2]
ZM-447439 + Docetaxel DCFA09Q Docetaxel DD2 (Cell Line: DD2) [2]
ZM-447439 + Sarpogrelate DC8TF3N Sarpogrelate DD2 (Cell Line: DD2) [2]
ZM-447439 + Ivermectin DCCY6CT Ivermectin DD2 (Cell Line: DD2) [2]
ZM-447439 + SB 228357 DC2ZSXD SB 228357 DD2 (Cell Line: DD2) [2]
ZM-447439 + Epothilone B DCH8PO0 Epothilone B DD2 (Cell Line: DD2) [2]
ZM-447439 + Miconazole DC7C247 Miconazole DD2 (Cell Line: DD2) [2]
ZM-447439 + Omacetaxine mepesuccinate DCDAFQ5 Omacetaxine mepesuccinate DD2 (Cell Line: DD2) [2]
ZM-447439 + MK-4815 DCUGMA8 MK-4815 DD2 (Cell Line: DD2) [2]
ZM-447439 + Mefloquine DC4R0IA Mefloquine DD2 (Cell Line: DD2) [2]
ZM-447439 + Nitisinone DCGITW3 Nitisinone DD2 (Cell Line: DD2) [2]
ZM-447439 + Atovaquone DC5TBBZ Atovaquone DD2 (Cell Line: DD2) [2]
ZM-447439 + Thiolactomycin DCY6LK5 Thiolactomycin Hepatoblastoma (Cell Line: HB3) [3]
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⏷ Show the Full List of 18 DrugCom(s)

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8353).
2 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.