Details of the Drug Combinations

General Information of This Drug (ID: DMGEMB7)

Drug Name
Hydrocortisone   DMGEMB7
Synonyms
Acticort; Alacort; Algicirtis; Alphaderm; Amberin; Anflam; Anucort; Aquacort; Cetacort; Chronocort; Cleiton; Cobadex; Colocort; Corhydron; Cortanal; Cortef; Cortenema; Cortesal; Corticreme; Cortifair; Cortifan; Cortiment; Cortisol; Cortisolonum; Cortisporin; Cortispray; Cortolotion; Cortonema; Cortoxide; Cortril; Cremesone; Cutisol; Delacort; Dermacort; Dermaspray; Dermil; Dermocortal; Dermolate; Dihydrocostisone; Dioderm; Drotic; DuoCort; Efcorbin; Efcortelan; Efcortelin; Eldecort; Eldercort; Epicort; Epicortisol; Evacort; Ficortril; Fiocortril; Flexicort; Genacort; Glycort; Hidalone; Hycort; Hycortol; Hycortole; Hydracort; Hydrasson; Hydrocortal; Hydrocorticosterone; Hydrocortisyl; Hydrocortone; Hydroskin; Hydroxycortisone; Hytisone; Hytone; Idrocortisone; Kyypakkaus; Lactisona; Lubricort; Maintasone; Medicort; Meusicort; Mildison; Milliderm; Nutracort; Optef; Otocort; Penecort; Permicort; Prepcort; Proctocort; Protocort; Rectoid; Sanatison; Schericur; Sigmacort; Signef; Stiefcorcil; Synacort; Tarcortin; Texacort; Timocort; Traumaide; Uniderm; Vytone; Zenoxone; ACETASOL HC; Aeroseb HC; AnusolHC; Aquanil HC; Barseb HC; CaldeCORT Spray; Clear aid; Component of Lubricort; Component of Otalgine; Cortisol alcohol; Cortisporin Otico; Ef corlin; Epiderm H; Esiderm H; Foille Insetti; HYDROCORTISONE AND ACETIC ACID; HYDROCORTISONE IN ABSORBASE; Heb Cort; Hydrocortisone alcohol; Hydrocortisone base; Hydrocortisone free alcohol; Hydrocortisone solution; Hytone lotion; Idrocortisone [DCIT]; Komed HC; Lacticare HC; Nogenic HC; ORLEX HC; Pediotic Suspension; Polcort H; Preparation H Hydrocortisone Cream; Prevex HC; Proctozone HC; Remederm HC; Scalpicin Capilar; Scheroson F; Systral Hydrocort; Transderma H; VoSol HC; H 4001; Texacort lotion 25; [3H]cortisol; ACETIC ACID W/ HYDROCORTISONE; Acticort (TN); Aeroseb-HC; Ala-Cort; Ala-Scalp; Anti-inflammatory hormone; Anucort-HC; Anusol HC (TN); Balneol-hc; Basan-Corti; Beta-hc; COR-OTICIN; Colocort (TN); Cort-Dome; Cortef (TN); Cortisol, Hydrocortisone; Cremicort-H; Cyclodextrin-encapsulated hydrocortisone; Derm-Aid; Dome-cort; Domolene-HC; Genacort (lotion); Gyno-Cortisone; H-Cort; HC #1; HC #4; HC (HYDROCORTISONE); Heb-Cort; Hi-cor; Hidro-Colisona; Hidrocortisona [INN-Spanish]; Hydro-Adreson; Hydro-Colisona; Hydro-RX; Hydrocortisone-Water Soluble; Hydrocortisonum [INN-Latin]; Hytone (TN); Incortin-H; Incortin-hydrogen; Kendall's compound F; Lacticare-HC; Neo-Cortef; Neosporin-H Ear; Nystaform-HC; Otosone-F; Rectasol-HC; Reichstein's substance M; Scalp-Cort; Stie-cort; Component of Neo-Cort-Dome; Hydrocortisone [INN:BAN:JAN]; Hydrocortisone (JP15/USP/INN); 11-beta-Hydrocortisone; 11-beta-Hydroxycortisone; 11beta,17,21-Trihydroxyprogesterone; 11beta-Hydrocortisone; 11beta-Hydroxycortisone; 17-Hydroxycorticosterone; 17alpha-Hydroxycorticosterone
Indication
Disease Entry ICD 11 Status REF
Acne vulgaris ED80 Approved [1]
Acute adrenal insufficiency N.A. Approved [1]
Addison disease 5A74.0 Approved [1]
Allergic rhinitis CA08.0 Approved [1]
Angioedema 4A00.15 Approved [1]
Aspiration pneumonitis N.A. Approved [1]
Autoimmune haemolytic anaemia 3A20 Approved [1]
Blepharoconjunctivitis N.A. Approved [1]
Bursitis N.A. Approved [1]
Cerebral edema 8D60.1 Approved [1]
Corneal abrasion NA06.4 Approved [1]
Corneal ulcer 9A76 Approved [1]
Crohn disease DD70 Approved [1]
Dermatitis herpetiformis EB44 Approved [1]
Diamond-Blackfan anemia N.A. Approved [1]
Disorder of orbital region N.A. Approved [1]
Erythema multiforme N.A. Approved [1]
Exanthem N.A. Approved [1]
Gingival disorder N.A. Approved [1]
Granuloma annulare N.A. Approved [1]
Inflammation 1A00-CA43.1 Approved [2]
Inflammatory bowel disease DD72 Approved [1]
Keratitis N.A. Approved [1]
Malignant otitis externa caused by Pseudomonas aeruginosa N.A. Approved [1]
Multiple sclerosis 8A40 Approved [1]
Mycosis fungoides 2B01 Approved [1]
Primary cutaneous T-cell lymphoma N.A. Approved [1]
Proctitis DB33.Z Approved [1]
Psoriasis EA90 Approved [1]
Psoriatic arthritis FA21 Approved [1]
Rheumatic heart disease N.A. Approved [1]
Rosacea ED90.0 Approved [1]
Sarcoidosis 4B20.5 Approved [1]
Serum sickness N.A. Approved [1]
Severe asthma CA23 Approved [1]
Systemic lupus erythematosus 4A40.0 Approved [1]
Tinea corporis 1F28.Y Approved [1]
Tinea cruris 1F28.3 Approved [1]
Ulcerative colitis DD71 Approved [1]
Viral pneumonia N.A. Approved [1]
Coronavirus Disease 2019 (COVID-19) 1D6Y Phase 3 [3]
Congenital adrenal hyperplasia 5A71.01 Phase 2 [4]
Acquired thrombocytopenia N.A. Investigative [1]
Asthma CA23 Investigative [1]
Beta-thalassemia major N.A. Investigative [1]
Classic Hodgkin lymphoma N.A. Investigative [1]
Iridocyclitis N.A. Investigative [1]
Phobic disorder N.A. Investigative [1]
Rheumatoid arthritis FA20 Investigative [1]
Synovitis N.A. Investigative [1]
Tinea pedis 1F28.2 Investigative [1]
Trichinellosis N.A. Investigative [1]
Uveitis 9A96.Z Investigative [1]
⏷ Show the Full List of Indication(s)
Therapeutic Class
Antiinflammatory Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

1 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Hydrocortisone + PF-562271 DC48P9H PF-562271 Diffuse large B cell lymphoma (Cell Line: TMD8) [5]
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14 Clinical Trial Drug Combination(s) Consisting of This drug
DrugCom Name DrugCom ID Component Drug Indication REF
Dexamethasone + Hydrocortisone DC3BFC7 Dexamethasone Adrenal Hyperplasia, Congenital [6]
Hydrocortisone + Fludrocortisone DC55Y85 Fludrocortisone Renin Angiotensin [7]
Hydrocortisone + Cyclosporin A DC6OG7M Cyclosporin A Dry Eye Syndromes [8]
Hydrocortisone + Fludrocortisone DCJBBY2 Fludrocortisone Septic Shock [9]
Hydrocortisone + Ketoconazole DCKXM7K Ketoconazole Prostate Cancer [10]
Hydrocortisone + Mannitol DCNJU4C Mannitol Opioid Dependence [11]
Hydrocortisone + Dopamine DCZA04Q Dopamine Infant, Newborn [12]
Metyrapone + Hydrocortisone DC4W0T5 Metyrapone Glucocorticoid Effect [13]
Yohimbine + Hydrocortisone DCV6WK0 Yohimbine Cigarette Smoking [14]
ABIRATERONE + Hydrocortisone DCMLYR0 ABIRATERONE Congenital Adrenal Hyperplasia [15]
Ceftriaxone + Hydrocortisone DCCOFAU Ceftriaxone Severe Septic Syndrome (Severe Sepsis and Septic Shock) Diagnosed and Treated by Mobile Intensive Care Unit [16]
Hydrocortisone + Prednisolone DCQ5DOY Prednisolone Adrenal Insufficiency [17]
Caffeine + Hydrocortisone DCTSKEV Caffeine Post-Dural Puncture Headache [18]
Hydrocortisone + Azathioprine DCRSBCG Azathioprine Ulcerative Colitis [19]
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⏷ Show the Full List of 14 DrugCom(s)

References

1 Hydrocortisone FDA Label
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2868).
3 Hydrocortisone for COVID-19 and Severe Hypoxia (COVID STEROID)
4 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
5 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
6 ClinicalTrials.gov (NCT00621985) Dexamethasone Treatment of Congenital Adrenal Hyperplasia
7 ClinicalTrials.gov (NCT00673270) Effects of Fludrocortisone and Hydrocortisone in Healthy Volunteers With Aldosterone Induced Suppression
8 ClinicalTrials.gov (NCT04597762) Effect of Ciclosporin Eyedrops on Sjgren Syndrome
9 ClinicalTrials.gov (NCT00320099) Combination of Corticotherapy and Intensive Insulin Therapy for Septic Shock
10 ClinicalTrials.gov (NCT00895310) Use of Low Dose Ketoconazole in Prostate Cancer That Does Not Respond to Hormone Therapy and Prior Chemotherapy
11 ClinicalTrials.gov (NCT01718964) Acute Effects of Cortisol on Heroin Craving in Opioid Dependence (Ghost-Basel)
12 ClinicalTrials.gov (NCT00874393) Early Blood Pressure Management in Extremely Premature Infants
13 ClinicalTrials.gov (NCT05167084) Acute Consequences Of Food-induced Glucocorticoid Secretion In Healthy Individuals
14 ClinicalTrials.gov (NCT03670212) Investigation of Nicotine Seeking Behavior in Current Smokers
15 ClinicalTrials.gov (NCT03548246) Androgen Reduction in Congenital Adrenal Hyperplasia
16 ClinicalTrials.gov (NCT02473263) Samu Save Sepsis: Early Goal Directed Therapy in Pre Hospital Care of Patients With Severe Sepsis and/or Septic Shock
17 ClinicalTrials.gov (NCT03936517) Safety and Efficacy of Prednisolone in Adrenal Insufficiency Disease (PRED-AID Study)
18 ClinicalTrials.gov (NCT03910088) Pregabalin Versus Hydrocortisone for Postdural Puncture Headache After Spinal for Cesarean
19 ClinicalTrials.gov (NCT02425852) A Randomized, Multicenter Open Label Study Comparing Early Administration of Azathioprine Plus IFX to Steroids Plus Azathioprine for Acute Severe Colitis