Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
                                                                        
                                                    
                                | DrugCom Name | 
                                DrugCom ID | 
                                Component Drug | 
                                Indication | 
                                REF | 
                            
                                                        
                                | 
                                    ABIRATERONE + SY-1425
                                 | 
                                
                                    DC2HLXJ
                                 | 
                                
                                                                        ABIRATERONE
                                                                     | 
                                
                                                                        Adult acute myeloid leukemia (Cell Line: HL-60(TB))
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    ABIRATERONE + SY-1425
                                 | 
                                
                                    DCN52PI
                                 | 
                                
                                                                        ABIRATERONE
                                                                     | 
                                
                                                                        Childhood T acute lymphoblastic leukemia (Cell Line: CCRF-CEM)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    ABIRATERONE + SY-1425
                                 | 
                                
                                    DC26CJX
                                 | 
                                
                                                                        ABIRATERONE
                                                                     | 
                                
                                                                        Chronic myelogenous leukemia (Cell Line: K-562)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    ABIRATERONE + SY-1425
                                 | 
                                
                                    DCUW77F
                                 | 
                                
                                                                        ABIRATERONE
                                                                     | 
                                
                                                                        Plasma cell myeloma (Cell Line: RPMI-8226)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    ABIRATERONE + SY-1425
                                 | 
                                
                                    DC1XX9N
                                 | 
                                
                                                                        ABIRATERONE
                                                                     | 
                                
                                                                        Renal cell carcinoma (Cell Line: UO-31)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    ABIRATERONE + SY-1425
                                 | 
                                
                                    DCWAY8F
                                 | 
                                
                                                                        ABIRATERONE
                                                                     | 
                                
                                                                        Breast adenocarcinoma (Cell Line: MDA-MB-468)
                                                                     | 
                                
                                     [3]                                  | 
                            
                                                        
                                | 
                                    ABIRATERONE + SY-1425
                                 | 
                                
                                    DC1M1C9
                                 | 
                                
                                                                        ABIRATERONE
                                                                     | 
                                
                                                                        Adenocarcinoma (Cell Line: HT29)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    ABIRATERONE + SY-1425
                                 | 
                                
                                    DC6S94P
                                 | 
                                
                                                                        ABIRATERONE
                                                                     | 
                                
                                                                        High grade ovarian serous adenocarcinoma (Cell Line: OVCAR-8)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    ABIRATERONE + SY-1425
                                 | 
                                
                                    DCAEKCR
                                 | 
                                
                                                                        ABIRATERONE
                                                                     | 
                                
                                                                        Malignant melanoma (Cell Line: LOX IMVI)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    ABIRATERONE + SY-1425
                                 | 
                                
                                    DC73WH3
                                 | 
                                
                                                                        ABIRATERONE
                                                                     | 
                                
                                                                        Melanoma (Cell Line: MALME-3M)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    ABIRATERONE + SY-1425
                                 | 
                                
                                    DCSCE32
                                 | 
                                
                                                                        ABIRATERONE
                                                                     | 
                                
                                                                        Melanoma (Cell Line: SK-MEL-2)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    ABIRATERONE + SY-1425
                                 | 
                                
                                    DC8K94B
                                 | 
                                
                                                                        ABIRATERONE
                                                                     | 
                                
                                                                        Minimally invasive lung adenocarcinoma (Cell Line: NCI-H322M)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Amonafide + SY-1425
                                 | 
                                
                                    DC9H3DO
                                 | 
                                
                                                                        Amonafide
                                                                     | 
                                
                                                                        Glioma (Cell Line: SF-539)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Amonafide + SY-1425
                                 | 
                                
                                    DC4ULPP
                                 | 
                                
                                                                        Amonafide
                                                                     | 
                                
                                                                        Melanoma (Cell Line: MALME-3M)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Amonafide + SY-1425
                                 | 
                                
                                    DC9IN3P
                                 | 
                                
                                                                        Amonafide
                                                                     | 
                                
                                                                        Papillary renal cell carcinoma (Cell Line: ACHN)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Amonafide + SY-1425
                                 | 
                                
                                    DCV7YQD
                                 | 
                                
                                                                        Amonafide
                                                                     | 
                                
                                                                        Plasma cell myeloma (Cell Line: RPMI-8226)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Amonafide + SY-1425
                                 | 
                                
                                    DCXL28C
                                 | 
                                
                                                                        Amonafide
                                                                     | 
                                
                                                                        Carcinoma (Cell Line: MCF7)
                                                                     | 
                                
                                     [3]                                  | 
                            
                                                        
                                | 
                                    Amonafide + SY-1425
                                 | 
                                
                                    DCD01T0
                                 | 
                                
                                                                        Amonafide
                                                                     | 
                                
                                                                        Colon carcinoma (Cell Line: KM12)
                                                                     | 
                                
                                     [3]                                  | 
                            
                                                        
                                | 
                                    Amonafide + SY-1425
                                 | 
                                
                                    DCNRE8R
                                 | 
                                
                                                                        Amonafide
                                                                     | 
                                
                                                                        Invasive ductal carcinoma (Cell Line: HS 578T)
                                                                     | 
                                
                                     [3]                                  | 
                            
                                                        
                                | 
                                    Anastrozole + SY-1425
                                 | 
                                
                                    DCZLQU8
                                 | 
                                
                                                                        Anastrozole
                                                                     | 
                                
                                                                        Adenocarcinoma (Cell Line: DU-145)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Anastrozole + SY-1425
                                 | 
                                
                                    DC4XPSN
                                 | 
                                
                                                                        Anastrozole
                                                                     | 
                                
                                                                        Adenocarcinoma (Cell Line: HCT-15)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Anastrozole + SY-1425
                                 | 
                                
                                    DCQ4I6V
                                 | 
                                
                                                                        Anastrozole
                                                                     | 
                                
                                                                        Adenocarcinoma (Cell Line: HT29)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Anastrozole + SY-1425
                                 | 
                                
                                    DCWHTX7
                                 | 
                                
                                                                        Anastrozole
                                                                     | 
                                
                                                                        Amelanotic melanoma (Cell Line: MDA-MB-435)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Anastrozole + SY-1425
                                 | 
                                
                                    DCT65GT
                                 | 
                                
                                                                        Anastrozole
                                                                     | 
                                
                                                                        Clear cell renal cell carcinoma (Cell Line: A498)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Anastrozole + SY-1425
                                 | 
                                
                                    DCZKAZY
                                 | 
                                
                                                                        Anastrozole
                                                                     | 
                                
                                                                        Cutaneous melanoma (Cell Line: SK-MEL-5)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Anastrozole + SY-1425
                                 | 
                                
                                    DCN11GS
                                 | 
                                
                                                                        Anastrozole
                                                                     | 
                                
                                                                        Cutaneous melanoma (Cell Line: SK-MEL-28)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Anastrozole + SY-1425
                                 | 
                                
                                    DC17PO3
                                 | 
                                
                                                                        Anastrozole
                                                                     | 
                                
                                                                        High grade ovarian serous adenocarcinoma (Cell Line: OVCAR-5)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Anastrozole + SY-1425
                                 | 
                                
                                    DCDPON6
                                 | 
                                
                                                                        Anastrozole
                                                                     | 
                                
                                                                        Large cell lung carcinoma (Cell Line: NCI-H460)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Anastrozole + SY-1425
                                 | 
                                
                                    DC4ZRAJ
                                 | 
                                
                                                                        Anastrozole
                                                                     | 
                                
                                                                        Lung adenocarcinoma (Cell Line: HOP-62)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Anastrozole + SY-1425
                                 | 
                                
                                    DCNVP75
                                 | 
                                
                                                                        Anastrozole
                                                                     | 
                                
                                                                        Lung adenocarcinoma  (Cell Line: NCI-H522)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Anastrozole + SY-1425
                                 | 
                                
                                    DC2NCOS
                                 | 
                                
                                                                        Anastrozole
                                                                     | 
                                
                                                                        Melanoma (Cell Line: MALME-3M)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Anastrozole + SY-1425
                                 | 
                                
                                    DCNEI8T
                                 | 
                                
                                                                        Anastrozole
                                                                     | 
                                
                                                                        Melanoma (Cell Line: SK-MEL-2)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Anastrozole + SY-1425
                                 | 
                                
                                    DCTHLMQ
                                 | 
                                
                                                                        Anastrozole
                                                                     | 
                                
                                                                        Minimally invasive lung adenocarcinoma (Cell Line: NCI-H322M)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Anastrozole + SY-1425
                                 | 
                                
                                    DCPG4PL
                                 | 
                                
                                                                        Anastrozole
                                                                     | 
                                
                                                                        Plasma cell myeloma (Cell Line: RPMI-8226)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Arfolitixorin + SY-1425
                                 | 
                                
                                    DCFHK26
                                 | 
                                
                                                                        Arfolitixorin
                                                                     | 
                                
                                                                        Mixed endometrioid and clear cell carcinoma (Cell Line: IGROV1)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    BIO-300 + SY-1425
                                 | 
                                
                                    DCJHDKD
                                 | 
                                
                                                                        BIO-300
                                                                     | 
                                
                                                                        Melanoma (Cell Line: MALME-3M)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Bleomycin + SY-1425
                                 | 
                                
                                    DCSPRGX
                                 | 
                                
                                                                        Bleomycin
                                                                     | 
                                
                                                                        Glioma (Cell Line: SF-539)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Bleomycin + SY-1425
                                 | 
                                
                                    DCHM7B0
                                 | 
                                
                                                                        Bleomycin
                                                                     | 
                                
                                                                        Plasma cell myeloma (Cell Line: RPMI-8226)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Bleomycin + SY-1425
                                 | 
                                
                                    DCCPH30
                                 | 
                                
                                                                        Bleomycin
                                                                     | 
                                
                                                                        Melanoma (Cell Line: MALME-3M)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Bleomycin + SY-1425
                                 | 
                                
                                    DCUUD8W
                                 | 
                                
                                                                        Bleomycin
                                                                     | 
                                
                                                                        Mixed endometrioid and clear cell carcinoma (Cell Line: IGROV1)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Cabazitaxel + SY-1425
                                 | 
                                
                                    DCX1XS1
                                 | 
                                
                                                                        Cabazitaxel
                                                                     | 
                                
                                                                        Adenocarcinoma (Cell Line: DU-145)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Cabazitaxel + SY-1425
                                 | 
                                
                                    DCF5CKV
                                 | 
                                
                                                                        Cabazitaxel
                                                                     | 
                                
                                                                        Adenocarcinoma (Cell Line: A549)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Cabazitaxel + SY-1425
                                 | 
                                
                                    DCL69GJ
                                 | 
                                
                                                                        Cabazitaxel
                                                                     | 
                                
                                                                        Adenocarcinoma (Cell Line: HT29)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Cabazitaxel + SY-1425
                                 | 
                                
                                    DCVDJ6Q
                                 | 
                                
                                                                        Cabazitaxel
                                                                     | 
                                
                                                                        Adult acute myeloid leukemia (Cell Line: HL-60(TB))
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Cabazitaxel + SY-1425
                                 | 
                                
                                    DCDXUEZ
                                 | 
                                
                                                                        Cabazitaxel
                                                                     | 
                                
                                                                        Childhood T acute lymphoblastic leukemia (Cell Line: CCRF-CEM)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Cabazitaxel + SY-1425
                                 | 
                                
                                    DC7P54Z
                                 | 
                                
                                                                        Cabazitaxel
                                                                     | 
                                
                                                                        Chronic myelogenous leukemia (Cell Line: K-562)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Cabazitaxel + SY-1425
                                 | 
                                
                                    DC5UWNF
                                 | 
                                
                                                                        Cabazitaxel
                                                                     | 
                                
                                                                        Clear cell renal cell carcinoma  (Cell Line: CAKI-1)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Cabazitaxel + SY-1425
                                 | 
                                
                                    DCSJYHZ
                                 | 
                                
                                                                        Cabazitaxel
                                                                     | 
                                
                                                                        Cutaneous melanoma (Cell Line: SK-MEL-5)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Cabazitaxel + SY-1425
                                 | 
                                
                                    DCUYL3N
                                 | 
                                
                                                                        Cabazitaxel
                                                                     | 
                                
                                                                        Glioma (Cell Line: SF-539)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Cabazitaxel + SY-1425
                                 | 
                                
                                    DC3JC4U
                                 | 
                                
                                                                        Cabazitaxel
                                                                     | 
                                
                                                                        Large cell lung carcinoma (Cell Line: NCI-H460)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Cabazitaxel + SY-1425
                                 | 
                                
                                    DC3HIHL
                                 | 
                                
                                                                        Cabazitaxel
                                                                     | 
                                
                                                                        Lung adenocarcinoma  (Cell Line: NCI-H522)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Cabazitaxel + SY-1425
                                 | 
                                
                                    DCD82CM
                                 | 
                                
                                                                        Cabazitaxel
                                                                     | 
                                
                                                                        Malignant melanoma (Cell Line: UACC62)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Cabazitaxel + SY-1425
                                 | 
                                
                                    DCK05N1
                                 | 
                                
                                                                        Cabazitaxel
                                                                     | 
                                
                                                                        Malignant melanoma (Cell Line: LOX IMVI)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Cabazitaxel + SY-1425
                                 | 
                                
                                    DC8AXGT
                                 | 
                                
                                                                        Cabazitaxel
                                                                     | 
                                
                                                                        Melanoma (Cell Line: MALME-3M)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Cabazitaxel + SY-1425
                                 | 
                                
                                    DCLT4H1
                                 | 
                                
                                                                        Cabazitaxel
                                                                     | 
                                
                                                                        Mixed endometrioid and clear cell carcinoma (Cell Line: IGROV1)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Cabazitaxel + SY-1425
                                 | 
                                
                                    DCQS69I
                                 | 
                                
                                                                        Cabazitaxel
                                                                     | 
                                
                                                                        Papillary renal cell carcinoma (Cell Line: ACHN)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Cabazitaxel + SY-1425
                                 | 
                                
                                    DC0EZ50
                                 | 
                                
                                                                        Cabazitaxel
                                                                     | 
                                
                                                                        Plasma cell myeloma (Cell Line: RPMI-8226)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Cabazitaxel + SY-1425
                                 | 
                                
                                    DC8VA2B
                                 | 
                                
                                                                        Cabazitaxel
                                                                     | 
                                
                                                                        Pleural epithelioid mesothelioma (Cell Line: NCI-H226)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Cabazitaxel + SY-1425
                                 | 
                                
                                    DC4IIU3
                                 | 
                                
                                                                        Cabazitaxel
                                                                     | 
                                
                                                                        Renal cell carcinoma (Cell Line: SN12C)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Cabazitaxel + SY-1425
                                 | 
                                
                                    DCBKMGH
                                 | 
                                
                                                                        Cabazitaxel
                                                                     | 
                                
                                                                        Breast adenocarcinoma (Cell Line: MDA-MB-468)
                                                                     | 
                                
                                     [3]                                  | 
                            
                                                        
                                | 
                                    Cabazitaxel + SY-1425
                                 | 
                                
                                    DCEOQSM
                                 | 
                                
                                                                        Cabazitaxel
                                                                     | 
                                
                                                                        Carcinoma (Cell Line: RXF 393)
                                                                     | 
                                
                                     [3]                                  | 
                            
                                                        
                                | 
                                    Cabazitaxel + SY-1425
                                 | 
                                
                                    DCBG3DV
                                 | 
                                
                                                                        Cabazitaxel
                                                                     | 
                                
                                                                        Carcinoma (Cell Line: MCF7)
                                                                     | 
                                
                                     [3]                                  | 
                            
                                                        
                                | 
                                    Cabazitaxel + SY-1425
                                 | 
                                
                                    DC7KOX2
                                 | 
                                
                                                                        Cabazitaxel
                                                                     | 
                                
                                                                        Invasive ductal carcinoma (Cell Line: T-47D)
                                                                     | 
                                
                                     [3]                                  | 
                            
                                                        
                                | 
                                    Cabazitaxel + SY-1425
                                 | 
                                
                                    DC5L4VT
                                 | 
                                
                                                                        Cabazitaxel
                                                                     | 
                                
                                                                        Invasive ductal carcinoma (Cell Line: HS 578T)
                                                                     | 
                                
                                     [3]                                  | 
                            
                                                        
                                | 
                                    Crizotinib + SY-1425
                                 | 
                                
                                    DCSBEG4
                                 | 
                                
                                                                        Crizotinib
                                                                     | 
                                
                                                                        Adult acute myeloid leukemia (Cell Line: HL-60(TB))
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Crizotinib + SY-1425
                                 | 
                                
                                    DCRCFMU
                                 | 
                                
                                                                        Crizotinib
                                                                     | 
                                
                                                                        Melanoma (Cell Line: MALME-3M)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Crizotinib + SY-1425
                                 | 
                                
                                    DC4OIB1
                                 | 
                                
                                                                        Crizotinib
                                                                     | 
                                
                                                                        Papillary renal cell carcinoma (Cell Line: ACHN)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Dacarbazine + SY-1425
                                 | 
                                
                                    DCZVV6X
                                 | 
                                
                                                                        Dacarbazine
                                                                     | 
                                
                                                                        Adenocarcinoma (Cell Line: HCT116)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Dacarbazine + SY-1425
                                 | 
                                
                                    DC63T1C
                                 | 
                                
                                                                        Dacarbazine
                                                                     | 
                                
                                                                        Adenocarcinoma (Cell Line: HCT-15)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Dacarbazine + SY-1425
                                 | 
                                
                                    DCG9M0P
                                 | 
                                
                                                                        Dacarbazine
                                                                     | 
                                
                                                                        Amelanotic melanoma (Cell Line: MDA-MB-435)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Dacarbazine + SY-1425
                                 | 
                                
                                    DCUX4W7
                                 | 
                                
                                                                        Dacarbazine
                                                                     | 
                                
                                                                        Cutaneous melanoma (Cell Line: SK-MEL-28)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Dacarbazine + SY-1425
                                 | 
                                
                                    DCP60R3
                                 | 
                                
                                                                        Dacarbazine
                                                                     | 
                                
                                                                        Glioma (Cell Line: SF-539)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Dacarbazine + SY-1425
                                 | 
                                
                                    DCQW3GW
                                 | 
                                
                                                                        Dacarbazine
                                                                     | 
                                
                                                                        Non-small cell lung carcinoma (Cell Line: HOP-92)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Dacarbazine + SY-1425
                                 | 
                                
                                    DC0XDBZ
                                 | 
                                
                                                                        Dacarbazine
                                                                     | 
                                
                                                                        Ovarian serous cystadenocarcinoma (Cell Line: SK-OV-3)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Dactinomycin + SY-1425
                                 | 
                                
                                    DCIUD4E
                                 | 
                                
                                                                        Dactinomycin
                                                                     | 
                                
                                                                        Breast adenocarcinoma (Cell Line: MDA-MB-468)
                                                                     | 
                                
                                     [3]                                  | 
                            
                                                        
                                | 
                                    Dactinomycin + SY-1425
                                 | 
                                
                                    DCNFOEW
                                 | 
                                
                                                                        Dactinomycin
                                                                     | 
                                
                                                                        Colon adenocarcinoma (Cell Line: COLO 205)
                                                                     | 
                                
                                     [3]                                  | 
                            
                                                        
                                | 
                                    Dactinomycin + SY-1425
                                 | 
                                
                                    DCUXOTV
                                 | 
                                
                                                                        Dactinomycin
                                                                     | 
                                
                                                                        Invasive ductal carcinoma (Cell Line: T-47D)
                                                                     | 
                                
                                     [3]                                  | 
                            
                                                        
                                | 
                                    Dactinomycin + SY-1425
                                 | 
                                
                                    DC55DXY
                                 | 
                                
                                                                        Dactinomycin
                                                                     | 
                                
                                                                        Invasive ductal carcinoma (Cell Line: BT-549)
                                                                     | 
                                
                                     [3]                                  | 
                            
                                                        
                                | 
                                    Dactinomycin + SY-1425
                                 | 
                                
                                    DCN21WS
                                 | 
                                
                                                                        Dactinomycin
                                                                     | 
                                
                                                                        Adenocarcinoma (Cell Line: DU-145)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Dactinomycin + SY-1425
                                 | 
                                
                                    DCKGMRQ
                                 | 
                                
                                                                        Dactinomycin
                                                                     | 
                                
                                                                        Adenocarcinoma (Cell Line: SW-620)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Dactinomycin + SY-1425
                                 | 
                                
                                    DC168GN
                                 | 
                                
                                                                        Dactinomycin
                                                                     | 
                                
                                                                        Adult T acute lymphoblastic leukemia (Cell Line: MOLT-4)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Dactinomycin + SY-1425
                                 | 
                                
                                    DCQXDJH
                                 | 
                                
                                                                        Dactinomycin
                                                                     | 
                                
                                                                        Astrocytoma (Cell Line: SNB-19)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Dactinomycin + SY-1425
                                 | 
                                
                                    DCC5MD4
                                 | 
                                
                                                                        Dactinomycin
                                                                     | 
                                
                                                                        Childhood T acute lymphoblastic leukemia (Cell Line: CCRF-CEM)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Dactinomycin + SY-1425
                                 | 
                                
                                    DC0QJA8
                                 | 
                                
                                                                        Dactinomycin
                                                                     | 
                                
                                                                        Chronic myelogenous leukemia (Cell Line: K-562)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Dactinomycin + SY-1425
                                 | 
                                
                                    DCQJCIZ
                                 | 
                                
                                                                        Dactinomycin
                                                                     | 
                                
                                                                        Cutaneous melanoma (Cell Line: SK-MEL-28)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Dactinomycin + SY-1425
                                 | 
                                
                                    DCKSFV0
                                 | 
                                
                                                                        Dactinomycin
                                                                     | 
                                
                                                                        Glioblastoma (Cell Line: SNB-75)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Dactinomycin + SY-1425
                                 | 
                                
                                    DC5Z47D
                                 | 
                                
                                                                        Dactinomycin
                                                                     | 
                                
                                                                        High grade ovarian serous adenocarcinoma (Cell Line: OVCAR-4)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Dactinomycin + SY-1425
                                 | 
                                
                                    DCJ5Y9T
                                 | 
                                
                                                                        Dactinomycin
                                                                     | 
                                
                                                                        High grade ovarian serous adenocarcinoma (Cell Line: OVCAR-5)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Dactinomycin + SY-1425
                                 | 
                                
                                    DCYDGNI
                                 | 
                                
                                                                        Dactinomycin
                                                                     | 
                                
                                                                        High grade ovarian serous adenocarcinoma (Cell Line: NCI\\/ADR-RES)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Dactinomycin + SY-1425
                                 | 
                                
                                    DC6QL1K
                                 | 
                                
                                                                        Dactinomycin
                                                                     | 
                                
                                                                        Large cell lung carcinoma (Cell Line: NCI-H460)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Dactinomycin + SY-1425
                                 | 
                                
                                    DCNDPSH
                                 | 
                                
                                                                        Dactinomycin
                                                                     | 
                                
                                                                        Lung adenocarcinoma (Cell Line: MDA-MB-231)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Dactinomycin + SY-1425
                                 | 
                                
                                    DCWBDYY
                                 | 
                                
                                                                        Dactinomycin
                                                                     | 
                                
                                                                        Lung adenocarcinoma  (Cell Line: NCI-H522)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Dactinomycin + SY-1425
                                 | 
                                
                                    DCEIA8M
                                 | 
                                
                                                                        Dactinomycin
                                                                     | 
                                
                                                                        Malignant melanoma (Cell Line: UACC62)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Dactinomycin + SY-1425
                                 | 
                                
                                    DCDO6FU
                                 | 
                                
                                                                        Dactinomycin
                                                                     | 
                                
                                                                        Melanoma (Cell Line: UACC-257)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Dactinomycin + SY-1425
                                 | 
                                
                                    DCXME7S
                                 | 
                                
                                                                        Dactinomycin
                                                                     | 
                                
                                                                        Mixed endometrioid and clear cell carcinoma (Cell Line: IGROV1)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Dactinomycin + SY-1425
                                 | 
                                
                                    DC9E3D9
                                 | 
                                
                                                                        Dactinomycin
                                                                     | 
                                
                                                                        Non-small cell lung carcinoma (Cell Line: HOP-92)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Dactinomycin + SY-1425
                                 | 
                                
                                    DCS0N1N
                                 | 
                                
                                                                        Dactinomycin
                                                                     | 
                                
                                                                        Plasma cell myeloma (Cell Line: RPMI-8226)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Dactinomycin + SY-1425
                                 | 
                                
                                    DCWMNXP
                                 | 
                                
                                                                        Dactinomycin
                                                                     | 
                                
                                                                        Pleural epithelioid mesothelioma (Cell Line: NCI-H226)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Dactinomycin + SY-1425
                                 | 
                                
                                    DCEY2UY
                                 | 
                                
                                                                        Dactinomycin
                                                                     | 
                                
                                                                        Renal cell carcinoma (Cell Line: UO-31)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Dexrazoxane + SY-1425
                                 | 
                                
                                    DC57KXY
                                 | 
                                
                                                                        Dexrazoxane
                                                                     | 
                                
                                                                        Plasma cell myeloma (Cell Line: RPMI-8226)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Dexrazoxane + SY-1425
                                 | 
                                
                                    DCS7DJ2
                                 | 
                                
                                                                        Dexrazoxane
                                                                     | 
                                
                                                                        Colon carcinoma (Cell Line: KM12)
                                                                     | 
                                
                                     [3]                                  | 
                            
                                                        
                                | 
                                    Dexrazoxane + SY-1425
                                 | 
                                
                                    DCA03W0
                                 | 
                                
                                                                        Dexrazoxane
                                                                     | 
                                
                                                                        Amelanotic melanoma (Cell Line: MDA-MB-435)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Dexrazoxane + SY-1425
                                 | 
                                
                                    DCW2OML
                                 | 
                                
                                                                        Dexrazoxane
                                                                     | 
                                
                                                                        Ovarian serous cystadenocarcinoma (Cell Line: SK-OV-3)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    DFN-15 + SY-1425
                                 | 
                                
                                    DCGOOAU
                                 | 
                                
                                                                        DFN-15
                                                                     | 
                                
                                                                        Colon carcinoma (Cell Line: KM12)
                                                                     | 
                                
                                     [3]                                  | 
                            
                                                        
                                | 
                                    DFN-15 + SY-1425
                                 | 
                                
                                    DCYZOEB
                                 | 
                                
                                                                        DFN-15
                                                                     | 
                                
                                                                        Invasive ductal carcinoma (Cell Line: HS 578T)
                                                                     | 
                                
                                     [3]                                  | 
                            
                                                        
                                | 
                                    DFN-15 + SY-1425
                                 | 
                                
                                    DCKFZ16
                                 | 
                                
                                                                        DFN-15
                                                                     | 
                                
                                                                        Amelanotic melanoma (Cell Line: M14)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    DFN-15 + SY-1425
                                 | 
                                
                                    DC53O5U
                                 | 
                                
                                                                        DFN-15
                                                                     | 
                                
                                                                        Cutaneous melanoma (Cell Line: SK-MEL-5)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    DFN-15 + SY-1425
                                 | 
                                
                                    DCEPIN8
                                 | 
                                
                                                                        DFN-15
                                                                     | 
                                
                                                                        High grade ovarian serous adenocarcinoma (Cell Line: OVCAR-4)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    DFN-15 + SY-1425
                                 | 
                                
                                    DCBL4FV
                                 | 
                                
                                                                        DFN-15
                                                                     | 
                                
                                                                        High grade ovarian serous adenocarcinoma (Cell Line: OVCAR-5)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Digitoxin + SY-1425
                                 | 
                                
                                    DCLQ4Z1
                                 | 
                                
                                                                        Digitoxin
                                                                     | 
                                
                                                                        Malignant melanoma (Cell Line: UACC62)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Epirubicin + SY-1425
                                 | 
                                
                                    DC1M0E6
                                 | 
                                
                                                                        Epirubicin
                                                                     | 
                                
                                                                        Adult acute myeloid leukemia (Cell Line: HL-60(TB))
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Epirubicin + SY-1425
                                 | 
                                
                                    DCDVFYZ
                                 | 
                                
                                                                        Epirubicin
                                                                     | 
                                
                                                                        Adult T acute lymphoblastic leukemia (Cell Line: MOLT-4)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Epirubicin + SY-1425
                                 | 
                                
                                    DCWBAM2
                                 | 
                                
                                                                        Epirubicin
                                                                     | 
                                
                                                                        Childhood T acute lymphoblastic leukemia (Cell Line: CCRF-CEM)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Epirubicin + SY-1425
                                 | 
                                
                                    DCRUQ04
                                 | 
                                
                                                                        Epirubicin
                                                                     | 
                                
                                                                        Chronic myelogenous leukemia (Cell Line: K-562)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Epirubicin + SY-1425
                                 | 
                                
                                    DCWUH8A
                                 | 
                                
                                                                        Epirubicin
                                                                     | 
                                
                                                                        Clear cell renal cell carcinoma  (Cell Line: CAKI-1)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Epirubicin + SY-1425
                                 | 
                                
                                    DCSTMJI
                                 | 
                                
                                                                        Epirubicin
                                                                     | 
                                
                                                                        Glioblastoma (Cell Line: SNB-75)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Epirubicin + SY-1425
                                 | 
                                
                                    DC33ABV
                                 | 
                                
                                                                        Epirubicin
                                                                     | 
                                
                                                                        Glioma (Cell Line: SF-268)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Epirubicin + SY-1425
                                 | 
                                
                                    DCKYM26
                                 | 
                                
                                                                        Epirubicin
                                                                     | 
                                
                                                                        Renal cell carcinoma (Cell Line: UO-31)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Epirubicin + SY-1425
                                 | 
                                
                                    DCHDUAC
                                 | 
                                
                                                                        Epirubicin
                                                                     | 
                                
                                                                        Invasive ductal carcinoma (Cell Line: HS 578T)
                                                                     | 
                                
                                     [3]                                  | 
                            
                                                        
                                | 
                                    Epirubicin + SY-1425
                                 | 
                                
                                    DCFTIYS
                                 | 
                                
                                                                        Epirubicin
                                                                     | 
                                
                                                                        Invasive ductal carcinoma (Cell Line: BT-549)
                                                                     | 
                                
                                     [3]                                  | 
                            
                                                        
                                | 
                                    Epirubicin + SY-1425
                                 | 
                                
                                    DCACHRW
                                 | 
                                
                                                                        Epirubicin
                                                                     | 
                                
                                                                        Cutaneous melanoma (Cell Line: SK-MEL-28)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Epirubicin + SY-1425
                                 | 
                                
                                    DCS5CYD
                                 | 
                                
                                                                        Epirubicin
                                                                     | 
                                
                                                                        Cutaneous melanoma (Cell Line: SK-MEL-5)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Epirubicin + SY-1425
                                 | 
                                
                                    DC5NMBO
                                 | 
                                
                                                                        Epirubicin
                                                                     | 
                                
                                                                        High grade ovarian serous adenocarcinoma (Cell Line: OVCAR-5)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Epirubicin + SY-1425
                                 | 
                                
                                    DCIQLM3
                                 | 
                                
                                                                        Epirubicin
                                                                     | 
                                
                                                                        Lung adenocarcinoma  (Cell Line: NCI-H522)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Epirubicin + SY-1425
                                 | 
                                
                                    DCQDMVT
                                 | 
                                
                                                                        Epirubicin
                                                                     | 
                                
                                                                        Malignant melanoma (Cell Line: LOX IMVI)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Epirubicin + SY-1425
                                 | 
                                
                                    DCRN0KO
                                 | 
                                
                                                                        Epirubicin
                                                                     | 
                                
                                                                        Melanoma (Cell Line: UACC-257)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Epirubicin + SY-1425
                                 | 
                                
                                    DC3GDEX
                                 | 
                                
                                                                        Epirubicin
                                                                     | 
                                
                                                                        Pleural epithelioid mesothelioma (Cell Line: NCI-H226)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Gefitinib + SY-1425
                                 | 
                                
                                    DC47O85
                                 | 
                                
                                                                        Gefitinib
                                                                     | 
                                
                                                                        Adenocarcinoma (Cell Line: NCIH23)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Gefitinib + SY-1425
                                 | 
                                
                                    DCSC8VK
                                 | 
                                
                                                                        Gefitinib
                                                                     | 
                                
                                                                        Adenocarcinoma (Cell Line: A549)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Gefitinib + SY-1425
                                 | 
                                
                                    DC9A8E5
                                 | 
                                
                                                                        Gefitinib
                                                                     | 
                                
                                                                        Adenocarcinoma (Cell Line: HT29)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Gefitinib + SY-1425
                                 | 
                                
                                    DCHM3OE
                                 | 
                                
                                                                        Gefitinib
                                                                     | 
                                
                                                                        Cutaneous melanoma (Cell Line: SK-MEL-5)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Gefitinib + SY-1425
                                 | 
                                
                                    DCXVL5D
                                 | 
                                
                                                                        Gefitinib
                                                                     | 
                                
                                                                        Large cell lung carcinoma (Cell Line: NCI-H460)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Gefitinib + SY-1425
                                 | 
                                
                                    DCT6Y0B
                                 | 
                                
                                                                        Gefitinib
                                                                     | 
                                
                                                                        Melanoma (Cell Line: MALME-3M)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Gefitinib + SY-1425
                                 | 
                                
                                    DCISVSX
                                 | 
                                
                                                                        Gefitinib
                                                                     | 
                                
                                                                        Papillary renal cell carcinoma (Cell Line: ACHN)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Gefitinib + SY-1425
                                 | 
                                
                                    DCBC21J
                                 | 
                                
                                                                        Gefitinib
                                                                     | 
                                
                                                                        Plasma cell myeloma (Cell Line: RPMI-8226)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Indazole derivative 5 + SY-1425
                                 | 
                                
                                    DCEVVX6
                                 | 
                                
                                                                        Indazole derivative 5
                                                                     | 
                                
                                                                        Adult acute myeloid leukemia (Cell Line: HL-60(TB))
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Indazole derivative 5 + SY-1425
                                 | 
                                
                                    DCV3P1T
                                 | 
                                
                                                                        Indazole derivative 5
                                                                     | 
                                
                                                                        Carcinoma (Cell Line: MCF7)
                                                                     | 
                                
                                     [3]                                  | 
                            
                                                        
                                | 
                                    Indazole derivative 5 + SY-1425
                                 | 
                                
                                    DC1T48L
                                 | 
                                
                                                                        Indazole derivative 5
                                                                     | 
                                
                                                                        Invasive ductal carcinoma (Cell Line: BT-549)
                                                                     | 
                                
                                     [3]                                  | 
                            
                                                        
                                | 
                                    Indazole derivative 5 + SY-1425
                                 | 
                                
                                    DCDPZ9D
                                 | 
                                
                                                                        Indazole derivative 5
                                                                     | 
                                
                                                                        Adenocarcinoma (Cell Line: DU-145)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Indazole derivative 5 + SY-1425
                                 | 
                                
                                    DC0CYTT
                                 | 
                                
                                                                        Indazole derivative 5
                                                                     | 
                                
                                                                        Adenocarcinoma (Cell Line: HT29)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Indazole derivative 5 + SY-1425
                                 | 
                                
                                    DCJMRG8
                                 | 
                                
                                                                        Indazole derivative 5
                                                                     | 
                                
                                                                        High grade ovarian serous adenocarcinoma (Cell Line: OVCAR-8)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Indazole derivative 5 + SY-1425
                                 | 
                                
                                    DCR1ZDL
                                 | 
                                
                                                                        Indazole derivative 5
                                                                     | 
                                
                                                                        Prostate carcinoma (Cell Line: PC-3)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    JNK-IN-8 + SY-1425
                                 | 
                                
                                    DCSOY7Y
                                 | 
                                
                                                                        JNK-IN-8
                                                                     | 
                                
                                                                        Plasma cell myeloma (Cell Line: RPMI-8226)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    JNK-IN-8 + SY-1425
                                 | 
                                
                                    DCA31EE
                                 | 
                                
                                                                        JNK-IN-8
                                                                     | 
                                
                                                                        Ovarian serous cystadenocarcinoma (Cell Line: SK-OV-3)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Lenalidomide + SY-1425
                                 | 
                                
                                    DC8RGAV
                                 | 
                                
                                                                        Lenalidomide
                                                                     | 
                                
                                                                        Glioma (Cell Line: SF-268)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Lenalidomide + SY-1425
                                 | 
                                
                                    DCZQ3QT
                                 | 
                                
                                                                        Lenalidomide
                                                                     | 
                                
                                                                        Plasma cell myeloma (Cell Line: RPMI-8226)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Lenalidomide + SY-1425
                                 | 
                                
                                    DCG2BUY
                                 | 
                                
                                                                        Lenalidomide
                                                                     | 
                                
                                                                        Adenocarcinoma (Cell Line: OVCAR3)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Lenalidomide + SY-1425
                                 | 
                                
                                    DCTM58K
                                 | 
                                
                                                                        Lenalidomide
                                                                     | 
                                
                                                                        Adenocarcinoma (Cell Line: HT29)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Lenalidomide + SY-1425
                                 | 
                                
                                    DCDCI5I
                                 | 
                                
                                                                        Lenalidomide
                                                                     | 
                                
                                                                        Amelanotic melanoma (Cell Line: MDA-MB-435)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Lenalidomide + SY-1425
                                 | 
                                
                                    DC8CHOL
                                 | 
                                
                                                                        Lenalidomide
                                                                     | 
                                
                                                                        Cutaneous melanoma (Cell Line: SK-MEL-28)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Lenalidomide + SY-1425
                                 | 
                                
                                    DC36V8A
                                 | 
                                
                                                                        Lenalidomide
                                                                     | 
                                
                                                                        Large cell lung carcinoma (Cell Line: NCI-H460)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Lenalidomide + SY-1425
                                 | 
                                
                                    DC49LTE
                                 | 
                                
                                                                        Lenalidomide
                                                                     | 
                                
                                                                        Melanoma (Cell Line: SK-MEL-2)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Letrozole + SY-1425
                                 | 
                                
                                    DCGR1K3
                                 | 
                                
                                                                        Letrozole
                                                                     | 
                                
                                                                        Cutaneous melanoma (Cell Line: SK-MEL-5)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Letrozole + SY-1425
                                 | 
                                
                                    DC8HJPP
                                 | 
                                
                                                                        Letrozole
                                                                     | 
                                
                                                                        Lung adenocarcinoma (Cell Line: HOP-62)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Letrozole + SY-1425
                                 | 
                                
                                    DC58R1U
                                 | 
                                
                                                                        Letrozole
                                                                     | 
                                
                                                                        Plasma cell myeloma (Cell Line: RPMI-8226)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Letrozole + SY-1425
                                 | 
                                
                                    DCF2GUB
                                 | 
                                
                                                                        Letrozole
                                                                     | 
                                
                                                                        Invasive ductal carcinoma (Cell Line: HS 578T)
                                                                     | 
                                
                                     [3]                                  | 
                            
                                                        
                                | 
                                    LIAROZOLE + SY-1425
                                 | 
                                
                                    DC1BW8G
                                 | 
                                
                                                                        LIAROZOLE
                                                                     | 
                                
                                                                        High grade ovarian serous adenocarcinoma (Cell Line: OVCAR-4)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Mechlorethamine + SY-1425
                                 | 
                                
                                    DCFXASA
                                 | 
                                
                                                                        Mechlorethamine
                                                                     | 
                                
                                                                        Clear cell renal cell carcinoma (Cell Line: A498)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Mechlorethamine + SY-1425
                                 | 
                                
                                    DCP1CG5
                                 | 
                                
                                                                        Mechlorethamine
                                                                     | 
                                
                                                                        Clear cell renal cell carcinoma (Cell Line: 786-0)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Mechlorethamine + SY-1425
                                 | 
                                
                                    DCTI2GI
                                 | 
                                
                                                                        Mechlorethamine
                                                                     | 
                                
                                                                        Renal cell carcinoma (Cell Line: UO-31)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Mechlorethamine + SY-1425
                                 | 
                                
                                    DCLN6UZ
                                 | 
                                
                                                                        Mechlorethamine
                                                                     | 
                                
                                                                        Colon carcinoma (Cell Line: KM12)
                                                                     | 
                                
                                     [3]                                  | 
                            
                                                        
                                | 
                                    Mechlorethamine + SY-1425
                                 | 
                                
                                    DC4LPQP
                                 | 
                                
                                                                        Mechlorethamine
                                                                     | 
                                
                                                                        Adenocarcinoma (Cell Line: HT29)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Mechlorethamine + SY-1425
                                 | 
                                
                                    DC7YHX2
                                 | 
                                
                                                                        Mechlorethamine
                                                                     | 
                                
                                                                        Adenocarcinoma (Cell Line: HCC-2998)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Mechlorethamine + SY-1425
                                 | 
                                
                                    DCLGHCC
                                 | 
                                
                                                                        Mechlorethamine
                                                                     | 
                                
                                                                        Amelanotic melanoma (Cell Line: MDA-MB-435)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Mechlorethamine + SY-1425
                                 | 
                                
                                    DCH343O
                                 | 
                                
                                                                        Mechlorethamine
                                                                     | 
                                
                                                                        Cutaneous melanoma (Cell Line: SK-MEL-28)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Mechlorethamine + SY-1425
                                 | 
                                
                                    DCX8JCU
                                 | 
                                
                                                                        Mechlorethamine
                                                                     | 
                                
                                                                        High grade ovarian serous adenocarcinoma (Cell Line: OVCAR-8)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Mechlorethamine + SY-1425
                                 | 
                                
                                    DCJ5RJM
                                 | 
                                
                                                                        Mechlorethamine
                                                                     | 
                                
                                                                        Lung adenocarcinoma (Cell Line: HOP-62)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Mechlorethamine + SY-1425
                                 | 
                                
                                    DCYVPBH
                                 | 
                                
                                                                        Mechlorethamine
                                                                     | 
                                
                                                                        Melanoma (Cell Line: SK-MEL-2)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Mechlorethamine + SY-1425
                                 | 
                                
                                    DCT64U7
                                 | 
                                
                                                                        Mechlorethamine
                                                                     | 
                                
                                                                        Non-small cell lung carcinoma (Cell Line: HOP-92)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Mechlorethamine + SY-1425
                                 | 
                                
                                    DC4FUXX
                                 | 
                                
                                                                        Mechlorethamine
                                                                     | 
                                
                                                                        Ovarian serous cystadenocarcinoma (Cell Line: SK-OV-3)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Mechlorethamine + SY-1425
                                 | 
                                
                                    DCBFSEB
                                 | 
                                
                                                                        Mechlorethamine
                                                                     | 
                                
                                                                        Pleural epithelioid mesothelioma (Cell Line: NCI-H226)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Methotrexate + SY-1425
                                 | 
                                
                                    DC9DXF4
                                 | 
                                
                                                                        Methotrexate
                                                                     | 
                                
                                                                        Adult acute myeloid leukemia (Cell Line: HL-60(TB))
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Methotrexate + SY-1425
                                 | 
                                
                                    DC5TNHP
                                 | 
                                
                                                                        Methotrexate
                                                                     | 
                                
                                                                        Lung adenocarcinoma (Cell Line: HOP-62)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Picoplatin + SY-1425
                                 | 
                                
                                    DCUQD9C
                                 | 
                                
                                                                        Picoplatin
                                                                     | 
                                
                                                                        Colon carcinoma (Cell Line: KM12)
                                                                     | 
                                
                                     [3]                                  | 
                            
                                                        
                                | 
                                    Picoplatin + SY-1425
                                 | 
                                
                                    DCLIWEX
                                 | 
                                
                                                                        Picoplatin
                                                                     | 
                                
                                                                        Adenocarcinoma (Cell Line: HT29)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Picoplatin + SY-1425
                                 | 
                                
                                    DCSARLZ
                                 | 
                                
                                                                        Picoplatin
                                                                     | 
                                
                                                                        Cutaneous melanoma (Cell Line: SK-MEL-28)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Picoplatin + SY-1425
                                 | 
                                
                                    DC9ZSYU
                                 | 
                                
                                                                        Picoplatin
                                                                     | 
                                
                                                                        Melanoma (Cell Line: SK-MEL-2)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Picoplatin + SY-1425
                                 | 
                                
                                    DC4CTNN
                                 | 
                                
                                                                        Picoplatin
                                                                     | 
                                
                                                                        Non-small cell lung carcinoma (Cell Line: HOP-92)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Picoplatin + SY-1425
                                 | 
                                
                                    DCOUEIR
                                 | 
                                
                                                                        Picoplatin
                                                                     | 
                                
                                                                        Ovarian serous cystadenocarcinoma (Cell Line: SK-OV-3)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Raloxifene + SY-1425
                                 | 
                                
                                    DCDZ9EU
                                 | 
                                
                                                                        Raloxifene
                                                                     | 
                                
                                                                        Cutaneous melanoma (Cell Line: SK-MEL-28)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Raloxifene + SY-1425
                                 | 
                                
                                    DCEN7W2
                                 | 
                                
                                                                        Raloxifene
                                                                     | 
                                
                                                                        Melanoma (Cell Line: SK-MEL-2)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Ruxolitinib + SY-1425
                                 | 
                                
                                    DC1D4YS
                                 | 
                                
                                                                        Ruxolitinib
                                                                     | 
                                
                                                                        Adult acute myeloid leukemia (Cell Line: HL-60(TB))
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Ruxolitinib + SY-1425
                                 | 
                                
                                    DCITECP
                                 | 
                                
                                                                        Ruxolitinib
                                                                     | 
                                
                                                                        Chronic myelogenous leukemia (Cell Line: K-562)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Ruxolitinib + SY-1425
                                 | 
                                
                                    DC84DFM
                                 | 
                                
                                                                        Ruxolitinib
                                                                     | 
                                
                                                                        Papillary renal cell carcinoma (Cell Line: ACHN)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Ruxolitinib + SY-1425
                                 | 
                                
                                    DCNJSBO
                                 | 
                                
                                                                        Ruxolitinib
                                                                     | 
                                
                                                                        Lung adenocarcinoma  (Cell Line: NCI-H522)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Pentostatin
                                 | 
                                
                                    DCYBKX0
                                 | 
                                
                                                                        Pentostatin
                                                                     | 
                                
                                                                        Anaplastic large cell lymphoma (Cell Line: SR)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Pentostatin
                                 | 
                                
                                    DCMRBUI
                                 | 
                                
                                                                        Pentostatin
                                                                     | 
                                
                                                                        Renal cell carcinoma (Cell Line: SN12C)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Fulvestrant
                                 | 
                                
                                    DCMBB1M
                                 | 
                                
                                                                        Fulvestrant
                                                                     | 
                                
                                                                        Adult T acute lymphoblastic leukemia (Cell Line: MOLT-4)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Fulvestrant
                                 | 
                                
                                    DCS2ZVS
                                 | 
                                
                                                                        Fulvestrant
                                                                     | 
                                
                                                                        Astrocytoma (Cell Line: U251)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Fulvestrant
                                 | 
                                
                                    DC9NP7P
                                 | 
                                
                                                                        Fulvestrant
                                                                     | 
                                
                                                                        Clear cell renal cell carcinoma (Cell Line: TK-10)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Fulvestrant
                                 | 
                                
                                    DCR298D
                                 | 
                                
                                                                        Fulvestrant
                                                                     | 
                                
                                                                        Papillary renal cell carcinoma (Cell Line: ACHN)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Hepzato
                                 | 
                                
                                    DCGMUOJ
                                 | 
                                
                                                                        Hepzato
                                                                     | 
                                
                                                                        Papillary renal cell carcinoma (Cell Line: ACHN)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Ixabepilone
                                 | 
                                
                                    DCKB2OG
                                 | 
                                
                                                                        Ixabepilone
                                                                     | 
                                
                                                                        Adult acute myeloid leukemia (Cell Line: HL-60(TB))
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Panobinostat
                                 | 
                                
                                    DCOFH0H
                                 | 
                                
                                                                        Panobinostat
                                                                     | 
                                
                                                                        Diffuse intrinsic pontine glioma (Cell Line: DIPG25)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Isoniazid
                                 | 
                                
                                    DCI4Y6E
                                 | 
                                
                                                                        Isoniazid
                                                                     | 
                                
                                                                        Adult T acute lymphoblastic leukemia (Cell Line: MOLT-4)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Isoniazid
                                 | 
                                
                                    DCGXGTN
                                 | 
                                
                                                                        Isoniazid
                                                                     | 
                                
                                                                        Astrocytoma (Cell Line: U251)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Isoniazid
                                 | 
                                
                                    DCVA73C
                                 | 
                                
                                                                        Isoniazid
                                                                     | 
                                
                                                                        Childhood T acute lymphoblastic leukemia (Cell Line: CCRF-CEM)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Arsenic trioxide
                                 | 
                                
                                    DCUZ9FI
                                 | 
                                
                                                                        Arsenic trioxide
                                                                     | 
                                
                                                                        Adult acute myeloid leukemia (Cell Line: HL-60(TB))
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Plicamycin
                                 | 
                                
                                    DCS9RMN
                                 | 
                                
                                                                        Plicamycin
                                                                     | 
                                
                                                                        Adult T acute lymphoblastic leukemia (Cell Line: MOLT-4)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Plicamycin
                                 | 
                                
                                    DC798ED
                                 | 
                                
                                                                        Plicamycin
                                                                     | 
                                
                                                                        Astrocytoma (Cell Line: U251)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Plicamycin
                                 | 
                                
                                    DCJGGDS
                                 | 
                                
                                                                        Plicamycin
                                                                     | 
                                
                                                                        Chronic myelogenous leukemia (Cell Line: K-562)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Plicamycin
                                 | 
                                
                                    DC9U88D
                                 | 
                                
                                                                        Plicamycin
                                                                     | 
                                
                                                                        Glioblastoma (Cell Line: SNB-75)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Nilotinib
                                 | 
                                
                                    DCS19JV
                                 | 
                                
                                                                        Nilotinib
                                                                     | 
                                
                                                                        Clear cell renal cell carcinoma (Cell Line: TK-10)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Triapine
                                 | 
                                
                                    DCB5W11
                                 | 
                                
                                                                        Triapine
                                                                     | 
                                
                                                                        Clear cell renal cell carcinoma  (Cell Line: CAKI-1)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Triapine
                                 | 
                                
                                    DCQ8PEN
                                 | 
                                
                                                                        Triapine
                                                                     | 
                                
                                                                        Papillary renal cell carcinoma (Cell Line: ACHN)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + 10-hydroxycamptothecin
                                 | 
                                
                                    DCOCTM7
                                 | 
                                
                                                                        10-hydroxycamptothecin
                                                                     | 
                                
                                                                        Adult acute myeloid leukemia (Cell Line: HL-60(TB))
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + 10-hydroxycamptothecin
                                 | 
                                
                                    DCXM5N3
                                 | 
                                
                                                                        10-hydroxycamptothecin
                                                                     | 
                                
                                                                        Astrocytoma (Cell Line: U251)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Topetecan
                                 | 
                                
                                    DCWD7J7
                                 | 
                                
                                                                        Topetecan
                                                                     | 
                                
                                                                        Adult acute myeloid leukemia (Cell Line: HL-60(TB))
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Topetecan
                                 | 
                                
                                    DCAVXNM
                                 | 
                                
                                                                        Topetecan
                                                                     | 
                                
                                                                        Childhood T acute lymphoblastic leukemia (Cell Line: CCRF-CEM)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Topetecan
                                 | 
                                
                                    DCW8OER
                                 | 
                                
                                                                        Topetecan
                                                                     | 
                                
                                                                        Glioma (Cell Line: SF-539)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Terameprocol
                                 | 
                                
                                    DCUU5KG
                                 | 
                                
                                                                        Terameprocol
                                                                     | 
                                
                                                                        Astrocytoma (Cell Line: SNB-19)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Terameprocol
                                 | 
                                
                                    DCUQWIC
                                 | 
                                
                                                                        Terameprocol
                                                                     | 
                                
                                                                        Childhood T acute lymphoblastic leukemia (Cell Line: CCRF-CEM)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Terameprocol
                                 | 
                                
                                    DCHTK01
                                 | 
                                
                                                                        Terameprocol
                                                                     | 
                                
                                                                        Chronic myelogenous leukemia (Cell Line: K-562)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Terameprocol
                                 | 
                                
                                    DCWDG2S
                                 | 
                                
                                                                        Terameprocol
                                                                     | 
                                
                                                                        Glioma (Cell Line: SF-295)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Terameprocol
                                 | 
                                
                                    DC3O9QK
                                 | 
                                
                                                                        Terameprocol
                                                                     | 
                                
                                                                        Papillary renal cell carcinoma (Cell Line: ACHN)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Terameprocol
                                 | 
                                
                                    DCI4FN3
                                 | 
                                
                                                                        Terameprocol
                                                                     | 
                                
                                                                        Renal cell carcinoma (Cell Line: UO-31)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + SCH 727965
                                 | 
                                
                                    DCEN33R
                                 | 
                                
                                                                        SCH 727965
                                                                     | 
                                
                                                                        Glioblastoma (Cell Line: SNB-75)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Ifosfamide
                                 | 
                                
                                    DCWCQ26
                                 | 
                                
                                                                        Ifosfamide
                                                                     | 
                                
                                                                        Clear cell renal cell carcinoma (Cell Line: TK-10)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Docetaxel
                                 | 
                                
                                    DC97CPL
                                 | 
                                
                                                                        Docetaxel
                                                                     | 
                                
                                                                        Adult acute myeloid leukemia (Cell Line: HL-60(TB))
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Docetaxel
                                 | 
                                
                                    DCS4I3S
                                 | 
                                
                                                                        Docetaxel
                                                                     | 
                                
                                                                        Adult T acute lymphoblastic leukemia (Cell Line: MOLT-4)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Docetaxel
                                 | 
                                
                                    DCABU9S
                                 | 
                                
                                                                        Docetaxel
                                                                     | 
                                
                                                                        Anaplastic large cell lymphoma (Cell Line: SR)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Docetaxel
                                 | 
                                
                                    DC4ODWE
                                 | 
                                
                                                                        Docetaxel
                                                                     | 
                                
                                                                        Astrocytoma (Cell Line: U251)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Docetaxel
                                 | 
                                
                                    DCKKJVP
                                 | 
                                
                                                                        Docetaxel
                                                                     | 
                                
                                                                        Astrocytoma (Cell Line: SNB-19)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Docetaxel
                                 | 
                                
                                    DC9JMBK
                                 | 
                                
                                                                        Docetaxel
                                                                     | 
                                
                                                                        Childhood T acute lymphoblastic leukemia (Cell Line: CCRF-CEM)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Docetaxel
                                 | 
                                
                                    DC5FDQ7
                                 | 
                                
                                                                        Docetaxel
                                                                     | 
                                
                                                                        Chronic myelogenous leukemia (Cell Line: K-562)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Docetaxel
                                 | 
                                
                                    DCA2NMN
                                 | 
                                
                                                                        Docetaxel
                                                                     | 
                                
                                                                        Clear cell renal cell carcinoma (Cell Line: A498)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Docetaxel
                                 | 
                                
                                    DCG1TG7
                                 | 
                                
                                                                        Docetaxel
                                                                     | 
                                
                                                                        Clear cell renal cell carcinoma (Cell Line: TK-10)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Docetaxel
                                 | 
                                
                                    DC6LL9E
                                 | 
                                
                                                                        Docetaxel
                                                                     | 
                                
                                                                        Clear cell renal cell carcinoma  (Cell Line: CAKI-1)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Docetaxel
                                 | 
                                
                                    DCTEX0N
                                 | 
                                
                                                                        Docetaxel
                                                                     | 
                                
                                                                        Glioblastoma (Cell Line: SNB-75)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Docetaxel
                                 | 
                                
                                    DCWFJ67
                                 | 
                                
                                                                        Docetaxel
                                                                     | 
                                
                                                                        Glioma (Cell Line: SF-268)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Docetaxel
                                 | 
                                
                                    DCJ4UFM
                                 | 
                                
                                                                        Docetaxel
                                                                     | 
                                
                                                                        Glioma (Cell Line: SF-295)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Docetaxel
                                 | 
                                
                                    DCIEM4V
                                 | 
                                
                                                                        Docetaxel
                                                                     | 
                                
                                                                        Glioma (Cell Line: SF-539)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Docetaxel
                                 | 
                                
                                    DC1F8HA
                                 | 
                                
                                                                        Docetaxel
                                                                     | 
                                
                                                                        Papillary renal cell carcinoma (Cell Line: ACHN)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Docetaxel
                                 | 
                                
                                    DCG235K
                                 | 
                                
                                                                        Docetaxel
                                                                     | 
                                
                                                                        Plasma cell myeloma (Cell Line: RPMI-8226)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Docetaxel
                                 | 
                                
                                    DCUKN23
                                 | 
                                
                                                                        Docetaxel
                                                                     | 
                                
                                                                        Renal cell carcinoma (Cell Line: UO-31)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Docetaxel
                                 | 
                                
                                    DC3LJXB
                                 | 
                                
                                                                        Docetaxel
                                                                     | 
                                
                                                                        Renal cell carcinoma (Cell Line: SN12C)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Raloxifene
                                 | 
                                
                                    DC8PN8V
                                 | 
                                
                                                                        Raloxifene
                                                                     | 
                                
                                                                        Adult T acute lymphoblastic leukemia (Cell Line: MOLT-4)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Raloxifene
                                 | 
                                
                                    DCCHBKU
                                 | 
                                
                                                                        Raloxifene
                                                                     | 
                                
                                                                        Papillary renal cell carcinoma (Cell Line: ACHN)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Marizomib
                                 | 
                                
                                    DCJY3UW
                                 | 
                                
                                                                        Marizomib
                                                                     | 
                                
                                                                        Diffuse intrinsic pontine glioma (Cell Line: DIPG25)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Sirolimus
                                 | 
                                
                                    DCVYDUM
                                 | 
                                
                                                                        Sirolimus
                                                                     | 
                                
                                                                        Adult T acute lymphoblastic leukemia (Cell Line: MOLT-4)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Sirolimus
                                 | 
                                
                                    DCBCE1A
                                 | 
                                
                                                                        Sirolimus
                                                                     | 
                                
                                                                        Chronic myelogenous leukemia (Cell Line: K-562)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Sirolimus
                                 | 
                                
                                    DCND9UY
                                 | 
                                
                                                                        Sirolimus
                                                                     | 
                                
                                                                        Clear cell renal cell carcinoma (Cell Line: A498)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Sirolimus
                                 | 
                                
                                    DC3IJWZ
                                 | 
                                
                                                                        Sirolimus
                                                                     | 
                                
                                                                        Clear cell renal cell carcinoma (Cell Line: TK-10)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Sirolimus
                                 | 
                                
                                    DC8E3D4
                                 | 
                                
                                                                        Sirolimus
                                                                     | 
                                
                                                                        Glioma (Cell Line: SF-295)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Sirolimus
                                 | 
                                
                                    DC06STC
                                 | 
                                
                                                                        Sirolimus
                                                                     | 
                                
                                                                        Plasma cell myeloma (Cell Line: RPMI-8226)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Sirolimus
                                 | 
                                
                                    DC12XZ9
                                 | 
                                
                                                                        Sirolimus
                                                                     | 
                                
                                                                        Renal cell carcinoma (Cell Line: UO-31)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Mitomycin
                                 | 
                                
                                    DCKFP0G
                                 | 
                                
                                                                        Mitomycin
                                                                     | 
                                
                                                                        Glioma (Cell Line: SF-539)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Mitomycin
                                 | 
                                
                                    DC0CYUV
                                 | 
                                
                                                                        Mitomycin
                                                                     | 
                                
                                                                        Papillary renal cell carcinoma (Cell Line: ACHN)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Mitomycin
                                 | 
                                
                                    DCJ8C9O
                                 | 
                                
                                                                        Mitomycin
                                                                     | 
                                
                                                                        Renal cell carcinoma (Cell Line: UO-31)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Altretamine
                                 | 
                                
                                    DC3HT32
                                 | 
                                
                                                                        Altretamine
                                                                     | 
                                
                                                                        Clear cell renal cell carcinoma (Cell Line: TK-10)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Altretamine
                                 | 
                                
                                    DC2M5RT
                                 | 
                                
                                                                        Altretamine
                                                                     | 
                                
                                                                        Clear cell renal cell carcinoma  (Cell Line: CAKI-1)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + TEM
                                 | 
                                
                                    DCSSUD1
                                 | 
                                
                                                                        TEM
                                                                     | 
                                
                                                                        Adult T acute lymphoblastic leukemia (Cell Line: MOLT-4)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + TEM
                                 | 
                                
                                    DC8FGGC
                                 | 
                                
                                                                        TEM
                                                                     | 
                                
                                                                        Glioma (Cell Line: SF-268)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Idarubicin
                                 | 
                                
                                    DCBFXXZ
                                 | 
                                
                                                                        Idarubicin
                                                                     | 
                                
                                                                        Glioblastoma? (Cell Line: T98G)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Imatinib
                                 | 
                                
                                    DC4IB4Y
                                 | 
                                
                                                                        Imatinib
                                                                     | 
                                
                                                                        Anaplastic large cell lymphoma (Cell Line: SR)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Imatinib
                                 | 
                                
                                    DCC5LYY
                                 | 
                                
                                                                        Imatinib
                                                                     | 
                                
                                                                        Childhood T acute lymphoblastic leukemia (Cell Line: CCRF-CEM)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Bortezomib
                                 | 
                                
                                    DC188M0
                                 | 
                                
                                                                        Bortezomib
                                                                     | 
                                
                                                                        Papillary renal cell carcinoma (Cell Line: ACHN)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Valrubicin
                                 | 
                                
                                    DC0CDNZ
                                 | 
                                
                                                                        Valrubicin
                                                                     | 
                                
                                                                        Adult acute myeloid leukemia (Cell Line: HL-60(TB))
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Valrubicin
                                 | 
                                
                                    DCBQJVD
                                 | 
                                
                                                                        Valrubicin
                                                                     | 
                                
                                                                        Plasma cell myeloma (Cell Line: RPMI-8226)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Valrubicin
                                 | 
                                
                                    DC2JDXA
                                 | 
                                
                                                                        Valrubicin
                                                                     | 
                                
                                                                        Renal cell carcinoma (Cell Line: UO-31)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Chlorambucil
                                 | 
                                
                                    DCM66MY
                                 | 
                                
                                                                        Chlorambucil
                                                                     | 
                                
                                                                        Adult T acute lymphoblastic leukemia (Cell Line: MOLT-4)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Sorafenib
                                 | 
                                
                                    DCDIHX5
                                 | 
                                
                                                                        Sorafenib
                                                                     | 
                                
                                                                        Adult T acute lymphoblastic leukemia (Cell Line: MOLT-4)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Sorafenib
                                 | 
                                
                                    DCNEIOK
                                 | 
                                
                                                                        Sorafenib
                                                                     | 
                                
                                                                        Astrocytoma (Cell Line: U251)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Sorafenib
                                 | 
                                
                                    DCYS24P
                                 | 
                                
                                                                        Sorafenib
                                                                     | 
                                
                                                                        Astrocytoma (Cell Line: SNB-19)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Sorafenib
                                 | 
                                
                                    DC8OJG7
                                 | 
                                
                                                                        Sorafenib
                                                                     | 
                                
                                                                        Childhood T acute lymphoblastic leukemia (Cell Line: CCRF-CEM)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Sorafenib
                                 | 
                                
                                    DCWU39R
                                 | 
                                
                                                                        Sorafenib
                                                                     | 
                                
                                                                        Chronic myelogenous leukemia (Cell Line: K-562)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Sorafenib
                                 | 
                                
                                    DCXTLIK
                                 | 
                                
                                                                        Sorafenib
                                                                     | 
                                
                                                                        Clear cell renal cell carcinoma (Cell Line: TK-10)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Sorafenib
                                 | 
                                
                                    DCBTQSW
                                 | 
                                
                                                                        Sorafenib
                                                                     | 
                                
                                                                        Clear cell renal cell carcinoma (Cell Line: 786-0)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Sorafenib
                                 | 
                                
                                    DCIIU4G
                                 | 
                                
                                                                        Sorafenib
                                                                     | 
                                
                                                                        Clear cell renal cell carcinoma (Cell Line: A498)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Sorafenib
                                 | 
                                
                                    DCZWBTS
                                 | 
                                
                                                                        Sorafenib
                                                                     | 
                                
                                                                        Clear cell renal cell carcinoma  (Cell Line: CAKI-1)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Sorafenib
                                 | 
                                
                                    DCNTFMT
                                 | 
                                
                                                                        Sorafenib
                                                                     | 
                                
                                                                        Glioma (Cell Line: SF-295)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Sorafenib
                                 | 
                                
                                    DCVYY74
                                 | 
                                
                                                                        Sorafenib
                                                                     | 
                                
                                                                        Glioma (Cell Line: SF-268)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Sorafenib
                                 | 
                                
                                    DCSWX52
                                 | 
                                
                                                                        Sorafenib
                                                                     | 
                                
                                                                        Papillary renal cell carcinoma (Cell Line: ACHN)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Sorafenib
                                 | 
                                
                                    DC5K1UA
                                 | 
                                
                                                                        Sorafenib
                                                                     | 
                                
                                                                        Renal cell carcinoma (Cell Line: UO-31)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Pomalidomide
                                 | 
                                
                                    DCOHKL2
                                 | 
                                
                                                                        Pomalidomide
                                                                     | 
                                
                                                                        Clear cell renal cell carcinoma (Cell Line: A498)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Pomalidomide
                                 | 
                                
                                    DCMNJGV
                                 | 
                                
                                                                        Pomalidomide
                                                                     | 
                                
                                                                        Renal cell carcinoma (Cell Line: UO-31)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Vinflunine
                                 | 
                                
                                    DCMXQGT
                                 | 
                                
                                                                        Vinflunine
                                                                     | 
                                
                                                                        Adult acute myeloid leukemia (Cell Line: HL-60(TB))
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Vinflunine
                                 | 
                                
                                    DCNMWLG
                                 | 
                                
                                                                        Vinflunine
                                                                     | 
                                
                                                                        Adult T acute lymphoblastic leukemia (Cell Line: MOLT-4)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Vinflunine
                                 | 
                                
                                    DC0ZOL9
                                 | 
                                
                                                                        Vinflunine
                                                                     | 
                                
                                                                        Astrocytoma (Cell Line: U251)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Vinflunine
                                 | 
                                
                                    DC475S3
                                 | 
                                
                                                                        Vinflunine
                                                                     | 
                                
                                                                        Astrocytoma (Cell Line: SNB-19)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Vinflunine
                                 | 
                                
                                    DCA69Z7
                                 | 
                                
                                                                        Vinflunine
                                                                     | 
                                
                                                                        Childhood T acute lymphoblastic leukemia (Cell Line: CCRF-CEM)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Vinflunine
                                 | 
                                
                                    DCIM8MA
                                 | 
                                
                                                                        Vinflunine
                                                                     | 
                                
                                                                        Chronic myelogenous leukemia (Cell Line: K-562)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Vinflunine
                                 | 
                                
                                    DCKH99K
                                 | 
                                
                                                                        Vinflunine
                                                                     | 
                                
                                                                        Glioblastoma (Cell Line: SNB-75)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Vinflunine
                                 | 
                                
                                    DCSXPKQ
                                 | 
                                
                                                                        Vinflunine
                                                                     | 
                                
                                                                        Plasma cell myeloma (Cell Line: RPMI-8226)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Vinflunine
                                 | 
                                
                                    DCZ4DXJ
                                 | 
                                
                                                                        Vinflunine
                                                                     | 
                                
                                                                        Renal cell carcinoma (Cell Line: SN12C)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Taxol
                                 | 
                                
                                    DCUHV1X
                                 | 
                                
                                                                        Taxol
                                                                     | 
                                
                                                                        Adult acute myeloid leukemia (Cell Line: HL-60(TB))
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Taxol
                                 | 
                                
                                    DC46IBE
                                 | 
                                
                                                                        Taxol
                                                                     | 
                                
                                                                        Chronic myelogenous leukemia (Cell Line: K-562)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Taxol
                                 | 
                                
                                    DCEUG0B
                                 | 
                                
                                                                        Taxol
                                                                     | 
                                
                                                                        Clear cell renal cell carcinoma (Cell Line: A498)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Taxol
                                 | 
                                
                                    DCTY9JT
                                 | 
                                
                                                                        Taxol
                                                                     | 
                                
                                                                        Clear cell renal cell carcinoma (Cell Line: 786-0)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Taxol
                                 | 
                                
                                    DCK4XFJ
                                 | 
                                
                                                                        Taxol
                                                                     | 
                                
                                                                        Clear cell renal cell carcinoma  (Cell Line: CAKI-1)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Taxol
                                 | 
                                
                                    DCDPXWY
                                 | 
                                
                                                                        Taxol
                                                                     | 
                                
                                                                        Glioblastoma (Cell Line: SNB-75)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Taxol
                                 | 
                                
                                    DCIJ8WD
                                 | 
                                
                                                                        Taxol
                                                                     | 
                                
                                                                        Glioma (Cell Line: SF-295)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Taxol
                                 | 
                                
                                    DC9FD1U
                                 | 
                                
                                                                        Taxol
                                                                     | 
                                
                                                                        Glioma (Cell Line: SF-268)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Taxol
                                 | 
                                
                                    DCGF0X1
                                 | 
                                
                                                                        Taxol
                                                                     | 
                                
                                                                        Papillary renal cell carcinoma (Cell Line: ACHN)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Taxol
                                 | 
                                
                                    DCJMAX6
                                 | 
                                
                                                                        Taxol
                                                                     | 
                                
                                                                        Plasma cell myeloma (Cell Line: RPMI-8226)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Taxol
                                 | 
                                
                                    DCB5EZV
                                 | 
                                
                                                                        Taxol
                                                                     | 
                                
                                                                        Renal cell carcinoma (Cell Line: UO-31)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + FORMESTANE
                                 | 
                                
                                    DCNCTYE
                                 | 
                                
                                                                        FORMESTANE
                                                                     | 
                                
                                                                        Adult T acute lymphoblastic leukemia (Cell Line: MOLT-4)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + FORMESTANE
                                 | 
                                
                                    DCYO3LA
                                 | 
                                
                                                                        FORMESTANE
                                                                     | 
                                
                                                                        Childhood T acute lymphoblastic leukemia (Cell Line: CCRF-CEM)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + FORMESTANE
                                 | 
                                
                                    DCWZGUJ
                                 | 
                                
                                                                        FORMESTANE
                                                                     | 
                                
                                                                        Clear cell renal cell carcinoma (Cell Line: TK-10)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + FORMESTANE
                                 | 
                                
                                    DCZZBPH
                                 | 
                                
                                                                        FORMESTANE
                                                                     | 
                                
                                                                        Glioma (Cell Line: SF-295)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Busulfan
                                 | 
                                
                                    DC65S4M
                                 | 
                                
                                                                        Busulfan
                                                                     | 
                                
                                                                        Astrocytoma (Cell Line: U251)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Busulfan
                                 | 
                                
                                    DCG5IXA
                                 | 
                                
                                                                        Busulfan
                                                                     | 
                                
                                                                        Glioblastoma (Cell Line: SNB-75)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Dasatinib
                                 | 
                                
                                    DC7AK94
                                 | 
                                
                                                                        Dasatinib
                                                                     | 
                                
                                                                        Clear cell renal cell carcinoma  (Cell Line: CAKI-1)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Pentostatin
                                 | 
                                
                                    DCN7ATE
                                 | 
                                
                                                                        Pentostatin
                                                                     | 
                                
                                                                        Invasive ductal carcinoma (Cell Line: BT-549)
                                                                     | 
                                
                                     [3]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Fulvestrant
                                 | 
                                
                                    DCHQMHM
                                 | 
                                
                                                                        Fulvestrant
                                                                     | 
                                
                                                                        Carcinoma (Cell Line: RXF 393)
                                                                     | 
                                
                                     [3]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Fulvestrant
                                 | 
                                
                                    DCG1BA6
                                 | 
                                
                                                                        Fulvestrant
                                                                     | 
                                
                                                                        Invasive ductal carcinoma (Cell Line: HS 578T)
                                                                     | 
                                
                                     [3]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Fulvestrant
                                 | 
                                
                                    DCHP05W
                                 | 
                                
                                                                        Fulvestrant
                                                                     | 
                                
                                                                        Invasive ductal carcinoma (Cell Line: BT-549)
                                                                     | 
                                
                                     [3]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Dactinomycin
                                 | 
                                
                                    DCNXQAW
                                 | 
                                
                                                                        Dactinomycin
                                                                     | 
                                
                                                                        Invasive ductal carcinoma (Cell Line: HS 578T)
                                                                     | 
                                
                                     [3]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + PMID28460551-Compound-2
                                 | 
                                
                                    DCIHNRU
                                 | 
                                
                                                                        PMID28460551-Compound-2
                                                                     | 
                                
                                                                        Invasive ductal carcinoma (Cell Line: T-47D)
                                                                     | 
                                
                                     [3]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Arsenic trioxide
                                 | 
                                
                                    DCOINMX
                                 | 
                                
                                                                        Arsenic trioxide
                                                                     | 
                                
                                                                        Invasive ductal carcinoma (Cell Line: T-47D)
                                                                     | 
                                
                                     [3]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Nilotinib
                                 | 
                                
                                    DCPCYTY
                                 | 
                                
                                                                        Nilotinib
                                                                     | 
                                
                                                                        Breast adenocarcinoma (Cell Line: MDA-MB-468)
                                                                     | 
                                
                                     [3]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Triapine
                                 | 
                                
                                    DCX8AJH
                                 | 
                                
                                                                        Triapine
                                                                     | 
                                
                                                                        Carcinoma (Cell Line: RXF 393)
                                                                     | 
                                
                                     [3]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Pralatrexate
                                 | 
                                
                                    DC8I02X
                                 | 
                                
                                                                        Pralatrexate
                                                                     | 
                                
                                                                        Colon adenocarcinoma (Cell Line: COLO 205)
                                                                     | 
                                
                                     [3]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Terameprocol
                                 | 
                                
                                    DCKS5JY
                                 | 
                                
                                                                        Terameprocol
                                                                     | 
                                
                                                                        Invasive ductal carcinoma (Cell Line: T-47D)
                                                                     | 
                                
                                     [3]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Docetaxel
                                 | 
                                
                                    DC6Y8EZ
                                 | 
                                
                                                                        Docetaxel
                                                                     | 
                                
                                                                        Breast adenocarcinoma (Cell Line: MDA-MB-468)
                                                                     | 
                                
                                     [3]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Docetaxel
                                 | 
                                
                                    DCEY78C
                                 | 
                                
                                                                        Docetaxel
                                                                     | 
                                
                                                                        Carcinoma (Cell Line: RXF 393)
                                                                     | 
                                
                                     [3]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Docetaxel
                                 | 
                                
                                    DCVPKK3
                                 | 
                                
                                                                        Docetaxel
                                                                     | 
                                
                                                                        Colon adenocarcinoma (Cell Line: COLO 205)
                                                                     | 
                                
                                     [3]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Docetaxel
                                 | 
                                
                                    DC9GUBY
                                 | 
                                
                                                                        Docetaxel
                                                                     | 
                                
                                                                        Colon carcinoma (Cell Line: KM12)
                                                                     | 
                                
                                     [3]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Docetaxel
                                 | 
                                
                                    DCLEGSI
                                 | 
                                
                                                                        Docetaxel
                                                                     | 
                                
                                                                        Invasive ductal carcinoma (Cell Line: HS 578T)
                                                                     | 
                                
                                     [3]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Docetaxel
                                 | 
                                
                                    DCSOMJB
                                 | 
                                
                                                                        Docetaxel
                                                                     | 
                                
                                                                        Invasive ductal carcinoma (Cell Line: T-47D)
                                                                     | 
                                
                                     [3]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Docetaxel
                                 | 
                                
                                    DC23Z7Y
                                 | 
                                
                                                                        Docetaxel
                                                                     | 
                                
                                                                        Invasive ductal carcinoma (Cell Line: BT-549)
                                                                     | 
                                
                                     [3]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Sirolimus
                                 | 
                                
                                    DCV2VN6
                                 | 
                                
                                                                        Sirolimus
                                                                     | 
                                
                                                                        Breast adenocarcinoma (Cell Line: MDA-MB-468)
                                                                     | 
                                
                                     [3]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Sirolimus
                                 | 
                                
                                    DCCRUIC
                                 | 
                                
                                                                        Sirolimus
                                                                     | 
                                
                                                                        Invasive ductal carcinoma (Cell Line: HS 578T)
                                                                     | 
                                
                                     [3]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Sirolimus
                                 | 
                                
                                    DCU3MGL
                                 | 
                                
                                                                        Sirolimus
                                                                     | 
                                
                                                                        Invasive ductal carcinoma (Cell Line: T-47D)
                                                                     | 
                                
                                     [3]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Mitomycin
                                 | 
                                
                                    DCQEAK4
                                 | 
                                
                                                                        Mitomycin
                                                                     | 
                                
                                                                        Invasive ductal carcinoma (Cell Line: HS 578T)
                                                                     | 
                                
                                     [3]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + TEM
                                 | 
                                
                                    DC2X2FE
                                 | 
                                
                                                                        TEM
                                                                     | 
                                
                                                                        Colon adenocarcinoma (Cell Line: COLO 205)
                                                                     | 
                                
                                     [3]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + TEM
                                 | 
                                
                                    DCUPKHT
                                 | 
                                
                                                                        TEM
                                                                     | 
                                
                                                                        Invasive ductal carcinoma (Cell Line: T-47D)
                                                                     | 
                                
                                     [3]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Imatinib
                                 | 
                                
                                    DC1R6F0
                                 | 
                                
                                                                        Imatinib
                                                                     | 
                                
                                                                        Breast adenocarcinoma (Cell Line: MDA-MB-468)
                                                                     | 
                                
                                     [3]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Imatinib
                                 | 
                                
                                    DC7MNHT
                                 | 
                                
                                                                        Imatinib
                                                                     | 
                                
                                                                        Invasive ductal carcinoma (Cell Line: T-47D)
                                                                     | 
                                
                                     [3]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Bleomycin
                                 | 
                                
                                    DCJ8WMW
                                 | 
                                
                                                                        Bleomycin
                                                                     | 
                                
                                                                        Invasive ductal carcinoma (Cell Line: T-47D)
                                                                     | 
                                
                                     [3]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Valrubicin
                                 | 
                                
                                    DCFKA4U
                                 | 
                                
                                                                        Valrubicin
                                                                     | 
                                
                                                                        Carcinoma (Cell Line: MCF7)
                                                                     | 
                                
                                     [3]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Valrubicin
                                 | 
                                
                                    DCCJL8D
                                 | 
                                
                                                                        Valrubicin
                                                                     | 
                                
                                                                        Invasive ductal carcinoma (Cell Line: HS 578T)
                                                                     | 
                                
                                     [3]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Chlorambucil
                                 | 
                                
                                    DCV57AF
                                 | 
                                
                                                                        Chlorambucil
                                                                     | 
                                
                                                                        Colon adenocarcinoma (Cell Line: COLO 205)
                                                                     | 
                                
                                     [3]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Chlorambucil
                                 | 
                                
                                    DCSYR34
                                 | 
                                
                                                                        Chlorambucil
                                                                     | 
                                
                                                                        Invasive ductal carcinoma (Cell Line: T-47D)
                                                                     | 
                                
                                     [3]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Sorafenib
                                 | 
                                
                                    DCDRAJT
                                 | 
                                
                                                                        Sorafenib
                                                                     | 
                                
                                                                        Carcinoma (Cell Line: RXF 393)
                                                                     | 
                                
                                     [3]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Sorafenib
                                 | 
                                
                                    DCT06GQ
                                 | 
                                
                                                                        Sorafenib
                                                                     | 
                                
                                                                        Colon adenocarcinoma (Cell Line: COLO 205)
                                                                     | 
                                
                                     [3]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Sorafenib
                                 | 
                                
                                    DC8LVNY
                                 | 
                                
                                                                        Sorafenib
                                                                     | 
                                
                                                                        Colon carcinoma (Cell Line: KM12)
                                                                     | 
                                
                                     [3]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Sorafenib
                                 | 
                                
                                    DCKHLWP
                                 | 
                                
                                                                        Sorafenib
                                                                     | 
                                
                                                                        Invasive ductal carcinoma (Cell Line: BT-549)
                                                                     | 
                                
                                     [3]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Vinflunine
                                 | 
                                
                                    DC8N5UQ
                                 | 
                                
                                                                        Vinflunine
                                                                     | 
                                
                                                                        Carcinoma (Cell Line: MCF7)
                                                                     | 
                                
                                     [3]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Vinflunine
                                 | 
                                
                                    DCGHHUF
                                 | 
                                
                                                                        Vinflunine
                                                                     | 
                                
                                                                        Colon carcinoma (Cell Line: KM12)
                                                                     | 
                                
                                     [3]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Vinflunine
                                 | 
                                
                                    DCWKSPV
                                 | 
                                
                                                                        Vinflunine
                                                                     | 
                                
                                                                        Invasive ductal carcinoma (Cell Line: BT-549)
                                                                     | 
                                
                                     [3]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Taxol
                                 | 
                                
                                    DC4WN0A
                                 | 
                                
                                                                        Taxol
                                                                     | 
                                
                                                                        Breast adenocarcinoma (Cell Line: MDA-MB-468)
                                                                     | 
                                
                                     [3]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Taxol
                                 | 
                                
                                    DC60YAW
                                 | 
                                
                                                                        Taxol
                                                                     | 
                                
                                                                        Carcinoma (Cell Line: MCF7)
                                                                     | 
                                
                                     [3]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Taxol
                                 | 
                                
                                    DCSZ8BO
                                 | 
                                
                                                                        Taxol
                                                                     | 
                                
                                                                        Colon carcinoma (Cell Line: KM12)
                                                                     | 
                                
                                     [3]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Taxol
                                 | 
                                
                                    DCQP3LK
                                 | 
                                
                                                                        Taxol
                                                                     | 
                                
                                                                        Invasive ductal carcinoma (Cell Line: BT-549)
                                                                     | 
                                
                                     [3]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Taxol
                                 | 
                                
                                    DCAMS9D
                                 | 
                                
                                                                        Taxol
                                                                     | 
                                
                                                                        Invasive ductal carcinoma (Cell Line: HS 578T)
                                                                     | 
                                
                                     [3]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Taxol
                                 | 
                                
                                    DCK989Q
                                 | 
                                
                                                                        Taxol
                                                                     | 
                                
                                                                        Invasive ductal carcinoma (Cell Line: T-47D)
                                                                     | 
                                
                                     [3]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + FORMESTANE
                                 | 
                                
                                    DCQ2LX2
                                 | 
                                
                                                                        FORMESTANE
                                                                     | 
                                
                                                                        Carcinoma (Cell Line: RXF 393)
                                                                     | 
                                
                                     [3]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Pentostatin
                                 | 
                                
                                    DCOIA4L
                                 | 
                                
                                                                        Pentostatin
                                                                     | 
                                
                                                                        Ovarian serous cystadenocarcinoma (Cell Line: SK-OV-3)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Fulvestrant
                                 | 
                                
                                    DCAL07K
                                 | 
                                
                                                                        Fulvestrant
                                                                     | 
                                
                                                                        Adenocarcinoma (Cell Line: DU-145)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Fulvestrant
                                 | 
                                
                                    DC1WTFM
                                 | 
                                
                                                                        Fulvestrant
                                                                     | 
                                
                                                                        Adenocarcinoma (Cell Line: NCIH23)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Fulvestrant
                                 | 
                                
                                    DCIMQH4
                                 | 
                                
                                                                        Fulvestrant
                                                                     | 
                                
                                                                        Large cell lung carcinoma (Cell Line: NCI-H460)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Fulvestrant
                                 | 
                                
                                    DCV5FVJ
                                 | 
                                
                                                                        Fulvestrant
                                                                     | 
                                
                                                                        Malignant melanoma (Cell Line: LOX IMVI)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Fulvestrant
                                 | 
                                
                                    DCHJG58
                                 | 
                                
                                                                        Fulvestrant
                                                                     | 
                                
                                                                        Ovarian serous cystadenocarcinoma (Cell Line: SK-OV-3)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Hepzato
                                 | 
                                
                                    DC2VJ7T
                                 | 
                                
                                                                        Hepzato
                                                                     | 
                                
                                                                        Adenocarcinoma (Cell Line: DU-145)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Hepzato
                                 | 
                                
                                    DC4BELG
                                 | 
                                
                                                                        Hepzato
                                                                     | 
                                
                                                                        Adenocarcinoma (Cell Line: HT29)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Ixabepilone
                                 | 
                                
                                    DC1R8H9
                                 | 
                                
                                                                        Ixabepilone
                                                                     | 
                                
                                                                        Adenocarcinoma (Cell Line: HCC-2998)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Ixabepilone
                                 | 
                                
                                    DC6BDLS
                                 | 
                                
                                                                        Ixabepilone
                                                                     | 
                                
                                                                        Adenocarcinoma (Cell Line: HCT116)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Ixabepilone
                                 | 
                                
                                    DCS7K5U
                                 | 
                                
                                                                        Ixabepilone
                                                                     | 
                                
                                                                        Amelanotic melanoma (Cell Line: MDA-MB-435)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Ixabepilone
                                 | 
                                
                                    DCBE2A9
                                 | 
                                
                                                                        Ixabepilone
                                                                     | 
                                
                                                                        Cutaneous melanoma (Cell Line: SK-MEL-28)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Ixabepilone
                                 | 
                                
                                    DC3ZNQG
                                 | 
                                
                                                                        Ixabepilone
                                                                     | 
                                
                                                                        Lung adenocarcinoma  (Cell Line: NCI-H522)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Ixabepilone
                                 | 
                                
                                    DCDX2SK
                                 | 
                                
                                                                        Ixabepilone
                                                                     | 
                                
                                                                        Melanoma (Cell Line: MALME-3M)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Lapatinib
                                 | 
                                
                                    DC5ZACX
                                 | 
                                
                                                                        Lapatinib
                                                                     | 
                                
                                                                        Adenocarcinoma (Cell Line: HCT116)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Cyclophosphamide
                                 | 
                                
                                    DCL2VO0
                                 | 
                                
                                                                        Cyclophosphamide
                                                                     | 
                                
                                                                        Adenocarcinoma (Cell Line: DU-145)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Cyclophosphamide
                                 | 
                                
                                    DCBCB0P
                                 | 
                                
                                                                        Cyclophosphamide
                                                                     | 
                                
                                                                        Amelanotic melanoma (Cell Line: M14)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Cyclophosphamide
                                 | 
                                
                                    DCDSMTI
                                 | 
                                
                                                                        Cyclophosphamide
                                                                     | 
                                
                                                                        Lung adenocarcinoma  (Cell Line: NCI-H522)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Cyclophosphamide
                                 | 
                                
                                    DCM3Q7F
                                 | 
                                
                                                                        Cyclophosphamide
                                                                     | 
                                
                                                                        Non-small cell lung carcinoma (Cell Line: HOP-92)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Isoniazid
                                 | 
                                
                                    DCBZ8GW
                                 | 
                                
                                                                        Isoniazid
                                                                     | 
                                
                                                                        Adenocarcinoma (Cell Line: HCT116)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Isoniazid
                                 | 
                                
                                    DCCPNH1
                                 | 
                                
                                                                        Isoniazid
                                                                     | 
                                
                                                                        High grade ovarian serous adenocarcinoma (Cell Line: OVCAR-4)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Arsenic trioxide
                                 | 
                                
                                    DCGWJE7
                                 | 
                                
                                                                        Arsenic trioxide
                                                                     | 
                                
                                                                        Melanoma (Cell Line: MALME-3M)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Plicamycin
                                 | 
                                
                                    DC0GGED
                                 | 
                                
                                                                        Plicamycin
                                                                     | 
                                
                                                                        Adenocarcinoma (Cell Line: NCIH23)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Plicamycin
                                 | 
                                
                                    DCBE4ES
                                 | 
                                
                                                                        Plicamycin
                                                                     | 
                                
                                                                        Adenocarcinoma (Cell Line: A549)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Plicamycin
                                 | 
                                
                                    DC4JOOX
                                 | 
                                
                                                                        Plicamycin
                                                                     | 
                                
                                                                        Adenocarcinoma (Cell Line: HT29)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Plicamycin
                                 | 
                                
                                    DCYBDGA
                                 | 
                                
                                                                        Plicamycin
                                                                     | 
                                
                                                                        Adenocarcinoma (Cell Line: HCC-2998)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Plicamycin
                                 | 
                                
                                    DCGOD7P
                                 | 
                                
                                                                        Plicamycin
                                                                     | 
                                
                                                                        Cutaneous melanoma (Cell Line: SK-MEL-28)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Plicamycin
                                 | 
                                
                                    DCZYG5N
                                 | 
                                
                                                                        Plicamycin
                                                                     | 
                                
                                                                        Cutaneous melanoma (Cell Line: SK-MEL-5)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Plicamycin
                                 | 
                                
                                    DC7IXDX
                                 | 
                                
                                                                        Plicamycin
                                                                     | 
                                
                                                                        Lung adenocarcinoma  (Cell Line: NCI-H522)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Plicamycin
                                 | 
                                
                                    DC3C4I0
                                 | 
                                
                                                                        Plicamycin
                                                                     | 
                                
                                                                        Melanoma (Cell Line: MALME-3M)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Plicamycin
                                 | 
                                
                                    DCD05FH
                                 | 
                                
                                                                        Plicamycin
                                                                     | 
                                
                                                                        Melanoma (Cell Line: SK-MEL-2)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Plicamycin
                                 | 
                                
                                    DCYI6L3
                                 | 
                                
                                                                        Plicamycin
                                                                     | 
                                
                                                                        Prostate carcinoma (Cell Line: PC-3)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Nilotinib
                                 | 
                                
                                    DC35SRQ
                                 | 
                                
                                                                        Nilotinib
                                                                     | 
                                
                                                                        Adenocarcinoma (Cell Line: HT29)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Nilotinib
                                 | 
                                
                                    DCMY8DR
                                 | 
                                
                                                                        Nilotinib
                                                                     | 
                                
                                                                        Amelanotic melanoma (Cell Line: MDA-MB-435)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Nilotinib
                                 | 
                                
                                    DCXIA2A
                                 | 
                                
                                                                        Nilotinib
                                                                     | 
                                
                                                                        Lung adenocarcinoma (Cell Line: HOP-62)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Triapine
                                 | 
                                
                                    DC9P5VQ
                                 | 
                                
                                                                        Triapine
                                                                     | 
                                
                                                                        Adenocarcinoma (Cell Line: HCT116)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Triapine
                                 | 
                                
                                    DCT082D
                                 | 
                                
                                                                        Triapine
                                                                     | 
                                
                                                                        Cutaneous melanoma (Cell Line: SK-MEL-5)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Triapine
                                 | 
                                
                                    DCEYXXH
                                 | 
                                
                                                                        Triapine
                                                                     | 
                                
                                                                        High grade ovarian serous adenocarcinoma (Cell Line: OVCAR-5)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Triapine
                                 | 
                                
                                    DC5S843
                                 | 
                                
                                                                        Triapine
                                                                     | 
                                
                                                                        Melanoma (Cell Line: SK-MEL-2)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Triapine
                                 | 
                                
                                    DCZZVM5
                                 | 
                                
                                                                        Triapine
                                                                     | 
                                
                                                                        Ovarian serous cystadenocarcinoma (Cell Line: SK-OV-3)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Topetecan
                                 | 
                                
                                    DCL7S6G
                                 | 
                                
                                                                        Topetecan
                                                                     | 
                                
                                                                        Adenocarcinoma (Cell Line: A549)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Topetecan
                                 | 
                                
                                    DC0HM0C
                                 | 
                                
                                                                        Topetecan
                                                                     | 
                                
                                                                        Melanoma (Cell Line: MALME-3M)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Pralatrexate
                                 | 
                                
                                    DCK07QP
                                 | 
                                
                                                                        Pralatrexate
                                                                     | 
                                
                                                                        Adenocarcinoma (Cell Line: DU-145)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Pralatrexate
                                 | 
                                
                                    DCG4YN6
                                 | 
                                
                                                                        Pralatrexate
                                                                     | 
                                
                                                                        Prostate carcinoma (Cell Line: PC-3)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Terameprocol
                                 | 
                                
                                    DCSN8T0
                                 | 
                                
                                                                        Terameprocol
                                                                     | 
                                
                                                                        Adenocarcinoma (Cell Line: NCIH23)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Terameprocol
                                 | 
                                
                                    DCE49JO
                                 | 
                                
                                                                        Terameprocol
                                                                     | 
                                
                                                                        Adenocarcinoma (Cell Line: HCT116)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Terameprocol
                                 | 
                                
                                    DCAYAR2
                                 | 
                                
                                                                        Terameprocol
                                                                     | 
                                
                                                                        Adenocarcinoma (Cell Line: HCT-15)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Terameprocol
                                 | 
                                
                                    DC9OIZJ
                                 | 
                                
                                                                        Terameprocol
                                                                     | 
                                
                                                                        Adenocarcinoma (Cell Line: SW-620)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Terameprocol
                                 | 
                                
                                    DCK9XX9
                                 | 
                                
                                                                        Terameprocol
                                                                     | 
                                
                                                                        Cutaneous melanoma (Cell Line: SK-MEL-28)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Terameprocol
                                 | 
                                
                                    DCSFEFK
                                 | 
                                
                                                                        Terameprocol
                                                                     | 
                                
                                                                        Large cell lung carcinoma (Cell Line: NCI-H460)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Terameprocol
                                 | 
                                
                                    DC9AKQ7
                                 | 
                                
                                                                        Terameprocol
                                                                     | 
                                
                                                                        Mixed endometrioid and clear cell carcinoma (Cell Line: IGROV1)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Terameprocol
                                 | 
                                
                                    DCTGDSH
                                 | 
                                
                                                                        Terameprocol
                                                                     | 
                                
                                                                        Non-small cell lung carcinoma (Cell Line: HOP-92)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Terameprocol
                                 | 
                                
                                    DCN4GSL
                                 | 
                                
                                                                        Terameprocol
                                                                     | 
                                
                                                                        Prostate carcinoma (Cell Line: PC-3)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + SCH 727965
                                 | 
                                
                                    DC97LFY
                                 | 
                                
                                                                        SCH 727965
                                                                     | 
                                
                                                                        Adenocarcinoma (Cell Line: NCIH23)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + SCH 727965
                                 | 
                                
                                    DC8XE4Z
                                 | 
                                
                                                                        SCH 727965
                                                                     | 
                                
                                                                        Lung adenocarcinoma (Cell Line: HOP-62)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Ifosfamide
                                 | 
                                
                                    DC98KZP
                                 | 
                                
                                                                        Ifosfamide
                                                                     | 
                                
                                                                        Pleural epithelioid mesothelioma (Cell Line: NCI-H226)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Docetaxel
                                 | 
                                
                                    DCJ12EK
                                 | 
                                
                                                                        Docetaxel
                                                                     | 
                                
                                                                        Adenocarcinoma (Cell Line: DU-145)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Docetaxel
                                 | 
                                
                                    DCC2YML
                                 | 
                                
                                                                        Docetaxel
                                                                     | 
                                
                                                                        Adenocarcinoma (Cell Line: OVCAR3)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Docetaxel
                                 | 
                                
                                    DCHYXGA
                                 | 
                                
                                                                        Docetaxel
                                                                     | 
                                
                                                                        Adenocarcinoma (Cell Line: NCIH23)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Docetaxel
                                 | 
                                
                                    DC52BTU
                                 | 
                                
                                                                        Docetaxel
                                                                     | 
                                
                                                                        Adenocarcinoma (Cell Line: A549)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Docetaxel
                                 | 
                                
                                    DCJYFB2
                                 | 
                                
                                                                        Docetaxel
                                                                     | 
                                
                                                                        Adenocarcinoma (Cell Line: HCT116)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Docetaxel
                                 | 
                                
                                    DCHC3PZ
                                 | 
                                
                                                                        Docetaxel
                                                                     | 
                                
                                                                        Adenocarcinoma (Cell Line: SW-620)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Docetaxel
                                 | 
                                
                                    DCQK6JZ
                                 | 
                                
                                                                        Docetaxel
                                                                     | 
                                
                                                                        Adenocarcinoma (Cell Line: HT29)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Docetaxel
                                 | 
                                
                                    DCKU98Z
                                 | 
                                
                                                                        Docetaxel
                                                                     | 
                                
                                                                        Adenocarcinoma (Cell Line: HCC-2998)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Docetaxel
                                 | 
                                
                                    DCR78CI
                                 | 
                                
                                                                        Docetaxel
                                                                     | 
                                
                                                                        Amelanotic melanoma (Cell Line: MDA-MB-435)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Docetaxel
                                 | 
                                
                                    DCOF830
                                 | 
                                
                                                                        Docetaxel
                                                                     | 
                                
                                                                        Amelanotic melanoma (Cell Line: M14)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Docetaxel
                                 | 
                                
                                    DCAH8VO
                                 | 
                                
                                                                        Docetaxel
                                                                     | 
                                
                                                                        Cutaneous melanoma (Cell Line: SK-MEL-28)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Docetaxel
                                 | 
                                
                                    DCE1G93
                                 | 
                                
                                                                        Docetaxel
                                                                     | 
                                
                                                                        Cutaneous melanoma (Cell Line: SK-MEL-5)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Docetaxel
                                 | 
                                
                                    DCKMF5J
                                 | 
                                
                                                                        Docetaxel
                                                                     | 
                                
                                                                        High grade ovarian serous adenocarcinoma (Cell Line: OVCAR-8)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Docetaxel
                                 | 
                                
                                    DCNMOSH
                                 | 
                                
                                                                        Docetaxel
                                                                     | 
                                
                                                                        High grade ovarian serous adenocarcinoma (Cell Line: OVCAR-5)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Docetaxel
                                 | 
                                
                                    DCGMGB5
                                 | 
                                
                                                                        Docetaxel
                                                                     | 
                                
                                                                        High grade ovarian serous adenocarcinoma (Cell Line: OVCAR-4)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Docetaxel
                                 | 
                                
                                    DC4MXNY
                                 | 
                                
                                                                        Docetaxel
                                                                     | 
                                
                                                                        Large cell lung carcinoma (Cell Line: NCI-H460)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Docetaxel
                                 | 
                                
                                    DCYNU9Q
                                 | 
                                
                                                                        Docetaxel
                                                                     | 
                                
                                                                        Lung adenocarcinoma (Cell Line: EKVX)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Docetaxel
                                 | 
                                
                                    DCAAULM
                                 | 
                                
                                                                        Docetaxel
                                                                     | 
                                
                                                                        Lung adenocarcinoma (Cell Line: MDA-MB-231)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Docetaxel
                                 | 
                                
                                    DCF5W8G
                                 | 
                                
                                                                        Docetaxel
                                                                     | 
                                
                                                                        Lung adenocarcinoma  (Cell Line: NCI-H522)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Docetaxel
                                 | 
                                
                                    DCOOYOU
                                 | 
                                
                                                                        Docetaxel
                                                                     | 
                                
                                                                        Malignant melanoma (Cell Line: UACC62)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Docetaxel
                                 | 
                                
                                    DC6ZQYH
                                 | 
                                
                                                                        Docetaxel
                                                                     | 
                                
                                                                        Melanoma (Cell Line: MALME-3M)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Docetaxel
                                 | 
                                
                                    DCUN3GK
                                 | 
                                
                                                                        Docetaxel
                                                                     | 
                                
                                                                        Mixed endometrioid and clear cell carcinoma (Cell Line: IGROV1)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Docetaxel
                                 | 
                                
                                    DC5XVFL
                                 | 
                                
                                                                        Docetaxel
                                                                     | 
                                
                                                                        Ovarian serous cystadenocarcinoma (Cell Line: SK-OV-3)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Docetaxel
                                 | 
                                
                                    DCMQZOQ
                                 | 
                                
                                                                        Docetaxel
                                                                     | 
                                
                                                                        Pleural epithelioid mesothelioma (Cell Line: NCI-H226)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Docetaxel
                                 | 
                                
                                    DCPK13U
                                 | 
                                
                                                                        Docetaxel
                                                                     | 
                                
                                                                        Prostate carcinoma (Cell Line: PC-3)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Raloxifene
                                 | 
                                
                                    DCRQ2L8
                                 | 
                                
                                                                        Raloxifene
                                                                     | 
                                
                                                                        Amelanotic melanoma (Cell Line: M14)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Raloxifene
                                 | 
                                
                                    DCW9GMN
                                 | 
                                
                                                                        Raloxifene
                                                                     | 
                                
                                                                        High grade ovarian serous adenocarcinoma (Cell Line: OVCAR-5)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Raloxifene
                                 | 
                                
                                    DCPVXJ6
                                 | 
                                
                                                                        Raloxifene
                                                                     | 
                                
                                                                        Malignant melanoma (Cell Line: UACC62)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Sirolimus
                                 | 
                                
                                    DCY694H
                                 | 
                                
                                                                        Sirolimus
                                                                     | 
                                
                                                                        Adenocarcinoma (Cell Line: A549)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Sirolimus
                                 | 
                                
                                    DCD2356
                                 | 
                                
                                                                        Sirolimus
                                                                     | 
                                
                                                                        Adenocarcinoma (Cell Line: HCT116)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Sirolimus
                                 | 
                                
                                    DCQU3BW
                                 | 
                                
                                                                        Sirolimus
                                                                     | 
                                
                                                                        Large cell lung carcinoma (Cell Line: NCI-H460)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Sirolimus
                                 | 
                                
                                    DC1UB77
                                 | 
                                
                                                                        Sirolimus
                                                                     | 
                                
                                                                        Lung adenocarcinoma (Cell Line: MDA-MB-231)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Sirolimus
                                 | 
                                
                                    DCHHGA9
                                 | 
                                
                                                                        Sirolimus
                                                                     | 
                                
                                                                        Melanoma (Cell Line: MALME-3M)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Sirolimus
                                 | 
                                
                                    DC7BZYP
                                 | 
                                
                                                                        Sirolimus
                                                                     | 
                                
                                                                        Mixed endometrioid and clear cell carcinoma (Cell Line: IGROV1)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Mitomycin
                                 | 
                                
                                    DCCWQME
                                 | 
                                
                                                                        Mitomycin
                                                                     | 
                                
                                                                        Adenocarcinoma (Cell Line: HT29)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Mitomycin
                                 | 
                                
                                    DCE1IJV
                                 | 
                                
                                                                        Mitomycin
                                                                     | 
                                
                                                                        Lung adenocarcinoma  (Cell Line: NCI-H522)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Mitomycin
                                 | 
                                
                                    DC8L00U
                                 | 
                                
                                                                        Mitomycin
                                                                     | 
                                
                                                                        Ovarian serous cystadenocarcinoma (Cell Line: SK-OV-3)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Altretamine
                                 | 
                                
                                    DC2BP0F
                                 | 
                                
                                                                        Altretamine
                                                                     | 
                                
                                                                        Lung adenocarcinoma  (Cell Line: NCI-H522)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Altretamine
                                 | 
                                
                                    DCAKM5M
                                 | 
                                
                                                                        Altretamine
                                                                     | 
                                
                                                                        Ovarian serous cystadenocarcinoma (Cell Line: SK-OV-3)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + TEM
                                 | 
                                
                                    DCR954W
                                 | 
                                
                                                                        TEM
                                                                     | 
                                
                                                                        Adenocarcinoma (Cell Line: HCT116)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + TEM
                                 | 
                                
                                    DC80FIE
                                 | 
                                
                                                                        TEM
                                                                     | 
                                
                                                                        Amelanotic melanoma (Cell Line: MDA-MB-435)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + TEM
                                 | 
                                
                                    DCYFHO6
                                 | 
                                
                                                                        TEM
                                                                     | 
                                
                                                                        Non-small cell lung carcinoma (Cell Line: HOP-92)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Idarubicin
                                 | 
                                
                                    DCV2PN5
                                 | 
                                
                                                                        Idarubicin
                                                                     | 
                                
                                                                        Amelanotic melanoma (Cell Line: MDA-MB-435)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Idarubicin
                                 | 
                                
                                    DCNNJKT
                                 | 
                                
                                                                        Idarubicin
                                                                     | 
                                
                                                                        Cutaneous melanoma (Cell Line: SK-MEL-5)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Idarubicin
                                 | 
                                
                                    DCD6OLK
                                 | 
                                
                                                                        Idarubicin
                                                                     | 
                                
                                                                        High grade ovarian serous adenocarcinoma (Cell Line: OVCAR-4)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Imatinib
                                 | 
                                
                                    DCZKTVJ
                                 | 
                                
                                                                        Imatinib
                                                                     | 
                                
                                                                        Lung adenocarcinoma (Cell Line: HOP-62)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Imatinib
                                 | 
                                
                                    DCZ5SCR
                                 | 
                                
                                                                        Imatinib
                                                                     | 
                                
                                                                        Ovarian serous cystadenocarcinoma (Cell Line: SK-OV-3)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Bortezomib
                                 | 
                                
                                    DCC9Y88
                                 | 
                                
                                                                        Bortezomib
                                                                     | 
                                
                                                                        Cutaneous melanoma (Cell Line: SK-MEL-28)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Valrubicin
                                 | 
                                
                                    DCO10C3
                                 | 
                                
                                                                        Valrubicin
                                                                     | 
                                
                                                                        Adenocarcinoma (Cell Line: HCC-2998)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Valrubicin
                                 | 
                                
                                    DC7Y7N0
                                 | 
                                
                                                                        Valrubicin
                                                                     | 
                                
                                                                        Adenocarcinoma (Cell Line: HCT-15)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Valrubicin
                                 | 
                                
                                    DCMT95V
                                 | 
                                
                                                                        Valrubicin
                                                                     | 
                                
                                                                        Melanoma (Cell Line: MALME-3M)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Cisplatin
                                 | 
                                
                                    DC6TIZ8
                                 | 
                                
                                                                        Cisplatin
                                                                     | 
                                
                                                                        Lung adenocarcinoma (Cell Line: EKVX)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Chlorambucil
                                 | 
                                
                                    DCOW8BR
                                 | 
                                
                                                                        Chlorambucil
                                                                     | 
                                
                                                                        Adenocarcinoma (Cell Line: NCIH23)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Chlorambucil
                                 | 
                                
                                    DCH409P
                                 | 
                                
                                                                        Chlorambucil
                                                                     | 
                                
                                                                        Adenocarcinoma (Cell Line: A549)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Chlorambucil
                                 | 
                                
                                    DCKM2K1
                                 | 
                                
                                                                        Chlorambucil
                                                                     | 
                                
                                                                        Adenocarcinoma (Cell Line: HCT-15)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Chlorambucil
                                 | 
                                
                                    DCW1X1L
                                 | 
                                
                                                                        Chlorambucil
                                                                     | 
                                
                                                                        High grade ovarian serous adenocarcinoma (Cell Line: NCI\\/ADR-RES)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Chlorambucil
                                 | 
                                
                                    DCOY7KB
                                 | 
                                
                                                                        Chlorambucil
                                                                     | 
                                
                                                                        Ovarian serous cystadenocarcinoma (Cell Line: SK-OV-3)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Sorafenib
                                 | 
                                
                                    DCFQI14
                                 | 
                                
                                                                        Sorafenib
                                                                     | 
                                
                                                                        Adenocarcinoma (Cell Line: DU-145)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Sorafenib
                                 | 
                                
                                    DCQ879E
                                 | 
                                
                                                                        Sorafenib
                                                                     | 
                                
                                                                        Adenocarcinoma (Cell Line: OVCAR3)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Sorafenib
                                 | 
                                
                                    DCNXRGP
                                 | 
                                
                                                                        Sorafenib
                                                                     | 
                                
                                                                        Adenocarcinoma (Cell Line: NCIH23)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Sorafenib
                                 | 
                                
                                    DCUT485
                                 | 
                                
                                                                        Sorafenib
                                                                     | 
                                
                                                                        Adenocarcinoma (Cell Line: HT29)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Sorafenib
                                 | 
                                
                                    DCJ3MW0
                                 | 
                                
                                                                        Sorafenib
                                                                     | 
                                
                                                                        Adenocarcinoma (Cell Line: HCT-15)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Sorafenib
                                 | 
                                
                                    DCOAYAL
                                 | 
                                
                                                                        Sorafenib
                                                                     | 
                                
                                                                        Adenocarcinoma (Cell Line: HCC-2998)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Sorafenib
                                 | 
                                
                                    DCPY8OD
                                 | 
                                
                                                                        Sorafenib
                                                                     | 
                                
                                                                        Amelanotic melanoma (Cell Line: M14)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Sorafenib
                                 | 
                                
                                    DCDB5Z9
                                 | 
                                
                                                                        Sorafenib
                                                                     | 
                                
                                                                        Cutaneous melanoma (Cell Line: SK-MEL-28)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Sorafenib
                                 | 
                                
                                    DCQR7BS
                                 | 
                                
                                                                        Sorafenib
                                                                     | 
                                
                                                                        Cutaneous melanoma (Cell Line: SK-MEL-5)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Sorafenib
                                 | 
                                
                                    DC7PDZ1
                                 | 
                                
                                                                        Sorafenib
                                                                     | 
                                
                                                                        High grade ovarian serous adenocarcinoma (Cell Line: OVCAR-8)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Sorafenib
                                 | 
                                
                                    DCDZB03
                                 | 
                                
                                                                        Sorafenib
                                                                     | 
                                
                                                                        High grade ovarian serous adenocarcinoma (Cell Line: OVCAR-5)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Sorafenib
                                 | 
                                
                                    DCZNQ9H
                                 | 
                                
                                                                        Sorafenib
                                                                     | 
                                
                                                                        Lung adenocarcinoma (Cell Line: HOP-62)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Sorafenib
                                 | 
                                
                                    DCQT1RP
                                 | 
                                
                                                                        Sorafenib
                                                                     | 
                                
                                                                        Lung adenocarcinoma (Cell Line: EKVX)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Sorafenib
                                 | 
                                
                                    DCTGDMW
                                 | 
                                
                                                                        Sorafenib
                                                                     | 
                                
                                                                        Lung adenocarcinoma (Cell Line: MDA-MB-231)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Sorafenib
                                 | 
                                
                                    DCMQMV2
                                 | 
                                
                                                                        Sorafenib
                                                                     | 
                                
                                                                        Lung adenocarcinoma  (Cell Line: NCI-H522)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Sorafenib
                                 | 
                                
                                    DC2YUPY
                                 | 
                                
                                                                        Sorafenib
                                                                     | 
                                
                                                                        Malignant melanoma (Cell Line: UACC62)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Sorafenib
                                 | 
                                
                                    DCID5RW
                                 | 
                                
                                                                        Sorafenib
                                                                     | 
                                
                                                                        Malignant melanoma (Cell Line: LOX IMVI)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Sorafenib
                                 | 
                                
                                    DC2GSRR
                                 | 
                                
                                                                        Sorafenib
                                                                     | 
                                
                                                                        Melanoma (Cell Line: UACC-257)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Sorafenib
                                 | 
                                
                                    DCNJIUK
                                 | 
                                
                                                                        Sorafenib
                                                                     | 
                                
                                                                        Melanoma (Cell Line: SK-MEL-2)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Sorafenib
                                 | 
                                
                                    DCIWW5M
                                 | 
                                
                                                                        Sorafenib
                                                                     | 
                                
                                                                        Non-small cell lung carcinoma (Cell Line: HOP-92)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Sorafenib
                                 | 
                                
                                    DCF7PLC
                                 | 
                                
                                                                        Sorafenib
                                                                     | 
                                
                                                                        Pleural epithelioid mesothelioma (Cell Line: NCI-H226)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Sorafenib
                                 | 
                                
                                    DCH20XY
                                 | 
                                
                                                                        Sorafenib
                                                                     | 
                                
                                                                        Prostate carcinoma (Cell Line: PC-3)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + ER819762
                                 | 
                                
                                    DCT8LGX
                                 | 
                                
                                                                        ER819762
                                                                     | 
                                
                                                                        Adenocarcinoma (Cell Line: NCIH23)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + ER819762
                                 | 
                                
                                    DCHQY7Z
                                 | 
                                
                                                                        ER819762
                                                                     | 
                                
                                                                        Adenocarcinoma (Cell Line: A549)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + ER819762
                                 | 
                                
                                    DCXGV22
                                 | 
                                
                                                                        ER819762
                                                                     | 
                                
                                                                        Amelanotic melanoma (Cell Line: M14)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Azacitidine
                                 | 
                                
                                    DCUO7VZ
                                 | 
                                
                                                                        Azacitidine
                                                                     | 
                                
                                                                        Adenocarcinoma (Cell Line: HT29)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Pomalidomide
                                 | 
                                
                                    DCCC91R
                                 | 
                                
                                                                        Pomalidomide
                                                                     | 
                                
                                                                        Adenocarcinoma (Cell Line: HCT116)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Pomalidomide
                                 | 
                                
                                    DC1OP75
                                 | 
                                
                                                                        Pomalidomide
                                                                     | 
                                
                                                                        Non-small cell lung carcinoma (Cell Line: HOP-92)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Vinflunine
                                 | 
                                
                                    DC7IB28
                                 | 
                                
                                                                        Vinflunine
                                                                     | 
                                
                                                                        Adenocarcinoma (Cell Line: OVCAR3)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Vinflunine
                                 | 
                                
                                    DC5X5PH
                                 | 
                                
                                                                        Vinflunine
                                                                     | 
                                
                                                                        Adenocarcinoma (Cell Line: HT29)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Vinflunine
                                 | 
                                
                                    DCGHP7R
                                 | 
                                
                                                                        Vinflunine
                                                                     | 
                                
                                                                        Cutaneous melanoma (Cell Line: SK-MEL-5)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Vinflunine
                                 | 
                                
                                    DCUJYGX
                                 | 
                                
                                                                        Vinflunine
                                                                     | 
                                
                                                                        High grade ovarian serous adenocarcinoma (Cell Line: OVCAR-8)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Vinflunine
                                 | 
                                
                                    DC934VJ
                                 | 
                                
                                                                        Vinflunine
                                                                     | 
                                
                                                                        Lung adenocarcinoma (Cell Line: HOP-62)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Vinflunine
                                 | 
                                
                                    DC5FO64
                                 | 
                                
                                                                        Vinflunine
                                                                     | 
                                
                                                                        Malignant melanoma (Cell Line: LOX IMVI)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Vinflunine
                                 | 
                                
                                    DCED3UH
                                 | 
                                
                                                                        Vinflunine
                                                                     | 
                                
                                                                        Malignant melanoma (Cell Line: UACC62)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Vinflunine
                                 | 
                                
                                    DCVQRWN
                                 | 
                                
                                                                        Vinflunine
                                                                     | 
                                
                                                                        Non-small cell lung carcinoma (Cell Line: HOP-92)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Vinflunine
                                 | 
                                
                                    DCE77KE
                                 | 
                                
                                                                        Vinflunine
                                                                     | 
                                
                                                                        Pleural epithelioid mesothelioma (Cell Line: NCI-H226)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Taxol
                                 | 
                                
                                    DCAA956
                                 | 
                                
                                                                        Taxol
                                                                     | 
                                
                                                                        Adenocarcinoma (Cell Line: A549)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Taxol
                                 | 
                                
                                    DCCN6KQ
                                 | 
                                
                                                                        Taxol
                                                                     | 
                                
                                                                        Adenocarcinoma (Cell Line: HCC-2998)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Taxol
                                 | 
                                
                                    DCA89CV
                                 | 
                                
                                                                        Taxol
                                                                     | 
                                
                                                                        High grade ovarian serous adenocarcinoma (Cell Line: OVCAR-8)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Taxol
                                 | 
                                
                                    DCG9FXT
                                 | 
                                
                                                                        Taxol
                                                                     | 
                                
                                                                        Large cell lung carcinoma (Cell Line: NCI-H460)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Taxol
                                 | 
                                
                                    DCS6OK2
                                 | 
                                
                                                                        Taxol
                                                                     | 
                                
                                                                        Lung adenocarcinoma (Cell Line: MDA-MB-231)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Taxol
                                 | 
                                
                                    DCX9A17
                                 | 
                                
                                                                        Taxol
                                                                     | 
                                
                                                                        Melanoma (Cell Line: MALME-3M)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Taxol
                                 | 
                                
                                    DCDX22C
                                 | 
                                
                                                                        Taxol
                                                                     | 
                                
                                                                        Mixed endometrioid and clear cell carcinoma (Cell Line: IGROV1)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Taxol
                                 | 
                                
                                    DCKS9T0
                                 | 
                                
                                                                        Taxol
                                                                     | 
                                
                                                                        Prostate carcinoma (Cell Line: PC-3)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + PMID28870136-Compound-43
                                 | 
                                
                                    DCSASP4
                                 | 
                                
                                                                        PMID28870136-Compound-43
                                                                     | 
                                
                                                                        Non-small cell lung carcinoma (Cell Line: HOP-92)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Aminolevulinic Acid Hydrochloride
                                 | 
                                
                                    DCTA11M
                                 | 
                                
                                                                        Aminolevulinic Acid Hydrochloride
                                                                     | 
                                
                                                                        Adenocarcinoma (Cell Line: A549)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Aminolevulinic Acid Hydrochloride
                                 | 
                                
                                    DC55UYM
                                 | 
                                
                                                                        Aminolevulinic Acid Hydrochloride
                                                                     | 
                                
                                                                        Adenocarcinoma (Cell Line: HCC-2998)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Estramustine
                                 | 
                                
                                    DCIAIFB
                                 | 
                                
                                                                        Estramustine
                                                                     | 
                                
                                                                        Melanoma (Cell Line: MALME-3M)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Busulfan
                                 | 
                                
                                    DC9NX6I
                                 | 
                                
                                                                        Busulfan
                                                                     | 
                                
                                                                        Adenocarcinoma (Cell Line: OVCAR3)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Busulfan
                                 | 
                                
                                    DCDZJPP
                                 | 
                                
                                                                        Busulfan
                                                                     | 
                                
                                                                        Amelanotic melanoma (Cell Line: M14)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Busulfan
                                 | 
                                
                                    DCPKWER
                                 | 
                                
                                                                        Busulfan
                                                                     | 
                                
                                                                        Lung adenocarcinoma (Cell Line: MDA-MB-231)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Dasatinib
                                 | 
                                
                                    DC9XWF4
                                 | 
                                
                                                                        Dasatinib
                                                                     | 
                                
                                                                        Adenocarcinoma (Cell Line: NCIH23)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Dasatinib
                                 | 
                                
                                    DCO4BQW
                                 | 
                                
                                                                        Dasatinib
                                                                     | 
                                
                                                                        Adenocarcinoma (Cell Line: HCT116)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    SY-1425 + Dasatinib
                                 | 
                                
                                    DCJS7RU
                                 | 
                                
                                                                        Dasatinib
                                                                     | 
                                
                                                                        Ovarian serous cystadenocarcinoma (Cell Line: SK-OV-3)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Thioguanine + SY-1425
                                 | 
                                
                                    DC1M0RM
                                 | 
                                
                                                                        Thioguanine
                                                                     | 
                                
                                                                        Glioma (Cell Line: SF-539)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Thioguanine + SY-1425
                                 | 
                                
                                    DCUQGDE
                                 | 
                                
                                                                        Thioguanine
                                                                     | 
                                
                                                                        Glioma (Cell Line: SF-295)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Thioguanine + SY-1425
                                 | 
                                
                                    DC51Z44
                                 | 
                                
                                                                        Thioguanine
                                                                     | 
                                
                                                                        Colon carcinoma (Cell Line: KM12)
                                                                     | 
                                
                                     [3]                                  | 
                            
                                                        
                                | 
                                    Thioguanine + SY-1425
                                 | 
                                
                                    DCTM2QE
                                 | 
                                
                                                                        Thioguanine
                                                                     | 
                                
                                                                        Mixed endometrioid and clear cell carcinoma (Cell Line: IGROV1)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Thioguanine + SY-1425
                                 | 
                                
                                    DCNZ2PH
                                 | 
                                
                                                                        Thioguanine
                                                                     | 
                                
                                                                        Ovarian serous cystadenocarcinoma (Cell Line: SK-OV-3)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Topotecan + SY-1425
                                 | 
                                
                                    DCAE7XG
                                 | 
                                
                                                                        Topotecan
                                                                     | 
                                
                                                                        Carcinoma (Cell Line: MCF7)
                                                                     | 
                                
                                     [3]                                  | 
                            
                                                        
                                | 
                                    Topotecan + SY-1425
                                 | 
                                
                                    DCGVY8E
                                 | 
                                
                                                                        Topotecan
                                                                     | 
                                
                                                                        Adult T acute lymphoblastic leukemia (Cell Line: MOLT-4)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Topotecan + SY-1425
                                 | 
                                
                                    DCB5EJM
                                 | 
                                
                                                                        Topotecan
                                                                     | 
                                
                                                                        Amelanotic melanoma (Cell Line: MDA-MB-435)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Topotecan + SY-1425
                                 | 
                                
                                    DCNFOTE
                                 | 
                                
                                                                        Topotecan
                                                                     | 
                                
                                                                        Clear cell renal cell carcinoma  (Cell Line: CAKI-1)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Topotecan + SY-1425
                                 | 
                                
                                    DCSERC3
                                 | 
                                
                                                                        Topotecan
                                                                     | 
                                
                                                                        Cutaneous melanoma (Cell Line: SK-MEL-28)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Topotecan + SY-1425
                                 | 
                                
                                    DCCOIK3
                                 | 
                                
                                                                        Topotecan
                                                                     | 
                                
                                                                        Glioma (Cell Line: SF-268)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Topotecan + SY-1425
                                 | 
                                
                                    DCC740M
                                 | 
                                
                                                                        Topotecan
                                                                     | 
                                
                                                                        High grade ovarian serous adenocarcinoma (Cell Line: OVCAR-8)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Topotecan + SY-1425
                                 | 
                                
                                    DCF9089
                                 | 
                                
                                                                        Topotecan
                                                                     | 
                                
                                                                        Lung adenocarcinoma (Cell Line: EKVX)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Topotecan + SY-1425
                                 | 
                                
                                    DCIKAMH
                                 | 
                                
                                                                        Topotecan
                                                                     | 
                                
                                                                        Minimally invasive lung adenocarcinoma (Cell Line: NCI-H322M)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Topotecan + SY-1425
                                 | 
                                
                                    DCFMJ7K
                                 | 
                                
                                                                        Topotecan
                                                                     | 
                                
                                                                        Mixed endometrioid and clear cell carcinoma (Cell Line: IGROV1)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Topotecan + SY-1425
                                 | 
                                
                                    DCM7VUG
                                 | 
                                
                                                                        Topotecan
                                                                     | 
                                
                                                                        Non-small cell lung carcinoma (Cell Line: HOP-92)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Topotecan + SY-1425
                                 | 
                                
                                    DC5ZJES
                                 | 
                                
                                                                        Topotecan
                                                                     | 
                                
                                                                        Ovarian serous cystadenocarcinoma (Cell Line: SK-OV-3)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Topotecan + SY-1425
                                 | 
                                
                                    DCF5OWL
                                 | 
                                
                                                                        Topotecan
                                                                     | 
                                
                                                                        Pleural epithelioid mesothelioma (Cell Line: NCI-H226)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Topotecan + SY-1425
                                 | 
                                
                                    DCJ614X
                                 | 
                                
                                                                        Topotecan
                                                                     | 
                                
                                                                        Prostate carcinoma (Cell Line: PC-3)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Trifluridine + SY-1425
                                 | 
                                
                                    DCDT531
                                 | 
                                
                                                                        Trifluridine
                                                                     | 
                                
                                                                        Glioma (Cell Line: SF-539)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Trifluridine + SY-1425
                                 | 
                                
                                    DCPGK7B
                                 | 
                                
                                                                        Trifluridine
                                                                     | 
                                
                                                                        Plasma cell myeloma (Cell Line: RPMI-8226)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Trifluridine + SY-1425
                                 | 
                                
                                    DCSBDF5
                                 | 
                                
                                                                        Trifluridine
                                                                     | 
                                
                                                                        Carcinoma (Cell Line: MCF7)
                                                                     | 
                                
                                     [3]                                  | 
                            
                                                        
                                | 
                                    Trifluridine + SY-1425
                                 | 
                                
                                    DCCR74V
                                 | 
                                
                                                                        Trifluridine
                                                                     | 
                                
                                                                        Adenocarcinoma (Cell Line: HT29)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Trifluridine + SY-1425
                                 | 
                                
                                    DC906SI
                                 | 
                                
                                                                        Trifluridine
                                                                     | 
                                
                                                                        Lung adenocarcinoma (Cell Line: EKVX)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Uracil mustard + SY-1425
                                 | 
                                
                                    DCG571P
                                 | 
                                
                                                                        Uracil mustard
                                                                     | 
                                
                                                                        Melanoma (Cell Line: MALME-3M)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Vandetanib + SY-1425
                                 | 
                                
                                    DC2UXFS
                                 | 
                                
                                                                        Vandetanib
                                                                     | 
                                
                                                                        Carcinoma (Cell Line: MCF7)
                                                                     | 
                                
                                     [3]                                  | 
                            
                                                        
                                | 
                                    Vandetanib + SY-1425
                                 | 
                                
                                    DCZWPA5
                                 | 
                                
                                                                        Vandetanib
                                                                     | 
                                
                                                                        Adult acute myeloid leukemia (Cell Line: HL-60(TB))
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Vandetanib + SY-1425
                                 | 
                                
                                    DCHISNA
                                 | 
                                
                                                                        Vandetanib
                                                                     | 
                                
                                                                        Amelanotic melanoma (Cell Line: MDA-MB-435)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Vandetanib + SY-1425
                                 | 
                                
                                    DCLZLYI
                                 | 
                                
                                                                        Vandetanib
                                                                     | 
                                
                                                                        Amelanotic melanoma (Cell Line: M14)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Vandetanib + SY-1425
                                 | 
                                
                                    DCV7334
                                 | 
                                
                                                                        Vandetanib
                                                                     | 
                                
                                                                        Anaplastic large cell lymphoma (Cell Line: SR)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Vandetanib + SY-1425
                                 | 
                                
                                    DCP1B4R
                                 | 
                                
                                                                        Vandetanib
                                                                     | 
                                
                                                                        Chronic myelogenous leukemia (Cell Line: K-562)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Vandetanib + SY-1425
                                 | 
                                
                                    DCF7QU4
                                 | 
                                
                                                                        Vandetanib
                                                                     | 
                                
                                                                        Cutaneous melanoma (Cell Line: SK-MEL-28)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Vandetanib + SY-1425
                                 | 
                                
                                    DCX9MYL
                                 | 
                                
                                                                        Vandetanib
                                                                     | 
                                
                                                                        Melanoma (Cell Line: SK-MEL-2)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Vemurafenib + SY-1425
                                 | 
                                
                                    DCA0WQ6
                                 | 
                                
                                                                        Vemurafenib
                                                                     | 
                                
                                                                        Adenocarcinoma (Cell Line: HT29)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Vemurafenib + SY-1425
                                 | 
                                
                                    DCN5NOW
                                 | 
                                
                                                                        Vemurafenib
                                                                     | 
                                
                                                                        Adult acute myeloid leukemia (Cell Line: HL-60(TB))
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Vemurafenib + SY-1425
                                 | 
                                
                                    DC2MWY3
                                 | 
                                
                                                                        Vemurafenib
                                                                     | 
                                
                                                                        Anaplastic large cell lymphoma (Cell Line: SR)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Vemurafenib + SY-1425
                                 | 
                                
                                    DCOY3XQ
                                 | 
                                
                                                                        Vemurafenib
                                                                     | 
                                
                                                                        Childhood T acute lymphoblastic leukemia (Cell Line: CCRF-CEM)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Vemurafenib + SY-1425
                                 | 
                                
                                    DCVKSKH
                                 | 
                                
                                                                        Vemurafenib
                                                                     | 
                                
                                                                        Chronic myelogenous leukemia (Cell Line: K-562)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Vemurafenib + SY-1425
                                 | 
                                
                                    DCHPZ1D
                                 | 
                                
                                                                        Vemurafenib
                                                                     | 
                                
                                                                        Malignant melanoma (Cell Line: UACC62)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Vemurafenib + SY-1425
                                 | 
                                
                                    DCDACK7
                                 | 
                                
                                                                        Vemurafenib
                                                                     | 
                                
                                                                        Malignant melanoma (Cell Line: LOX IMVI)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Vemurafenib + SY-1425
                                 | 
                                
                                    DCC61HU
                                 | 
                                
                                                                        Vemurafenib
                                                                     | 
                                
                                                                        Melanoma (Cell Line: SK-MEL-2)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Vemurafenib + SY-1425
                                 | 
                                
                                    DCZ1ICY
                                 | 
                                
                                                                        Vemurafenib
                                                                     | 
                                
                                                                        Renal cell carcinoma (Cell Line: UO-31)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Vincristine + SY-1425
                                 | 
                                
                                    DC1ETZF
                                 | 
                                
                                                                        Vincristine
                                                                     | 
                                
                                                                        Adenocarcinoma (Cell Line: HCT-15)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Vincristine + SY-1425
                                 | 
                                
                                    DCA6IDN
                                 | 
                                
                                                                        Vincristine
                                                                     | 
                                
                                                                        High grade ovarian serous adenocarcinoma (Cell Line: OVCAR-4)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Vincristine + SY-1425
                                 | 
                                
                                    DCP883V
                                 | 
                                
                                                                        Vincristine
                                                                     | 
                                
                                                                        Minimally invasive lung adenocarcinoma (Cell Line: NCI-H322M)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Vincristine + SY-1425
                                 | 
                                
                                    DCU630R
                                 | 
                                
                                                                        Vincristine
                                                                     | 
                                
                                                                        Plasma cell myeloma (Cell Line: RPMI-8226)
                                                                     | 
                                
                                     [2]                                  | 
                            
                                                        
                                | 
                                    Vismodegib + SY-1425
                                 | 
                                
                                    DC47ESM
                                 | 
                                
                                                                        Vismodegib
                                                                     | 
                                
                                                                        Invasive ductal carcinoma (Cell Line: T-47D)
                                                                     | 
                                
                                     [3]                                  | 
                            
                                                        
                                | 
                                    Vismodegib + SY-1425
                                 | 
                                
                                    DC64GFT
                                 | 
                                
                                                                        Vismodegib
                                                                     | 
                                
                                                                        Adenocarcinoma (Cell Line: NCIH23)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Vismodegib + SY-1425
                                 | 
                                
                                    DC3K6RB
                                 | 
                                
                                                                        Vismodegib
                                                                     | 
                                
                                                                        Adult acute myeloid leukemia (Cell Line: HL-60(TB))
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Vismodegib + SY-1425
                                 | 
                                
                                    DC20KFI
                                 | 
                                
                                                                        Vismodegib
                                                                     | 
                                
                                                                        Anaplastic large cell lymphoma (Cell Line: SR)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Vismodegib + SY-1425
                                 | 
                                
                                    DC9SCRX
                                 | 
                                
                                                                        Vismodegib
                                                                     | 
                                
                                                                        Chronic myelogenous leukemia (Cell Line: K-562)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Vismodegib + SY-1425
                                 | 
                                
                                    DCY4JSZ
                                 | 
                                
                                                                        Vismodegib
                                                                     | 
                                
                                                                        Cutaneous melanoma (Cell Line: SK-MEL-5)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Vismodegib + SY-1425
                                 | 
                                
                                    DCI34HU
                                 | 
                                
                                                                        Vismodegib
                                                                     | 
                                
                                                                        Large cell lung carcinoma (Cell Line: NCI-H460)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Vismodegib + SY-1425
                                 | 
                                
                                    DCHUDOA
                                 | 
                                
                                                                        Vismodegib
                                                                     | 
                                
                                                                        Malignant melanoma (Cell Line: LOX IMVI)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Vismodegib + SY-1425
                                 | 
                                
                                    DCQZPQM
                                 | 
                                
                                                                        Vismodegib
                                                                     | 
                                
                                                                        Melanoma (Cell Line: MALME-3M)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Vismodegib + SY-1425
                                 | 
                                
                                    DC5RESX
                                 | 
                                
                                                                        Vismodegib
                                                                     | 
                                
                                                                        Minimally invasive lung adenocarcinoma (Cell Line: NCI-H322M)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Vismodegib + SY-1425
                                 | 
                                
                                    DCSA2CS
                                 | 
                                
                                                                        Vismodegib
                                                                     | 
                                
                                                                        Prostate carcinoma (Cell Line: PC-3)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | 
                                    Vismodegib + SY-1425
                                 | 
                                
                                    DC8YA03
                                 | 
                                
                                                                        Vismodegib
                                                                     | 
                                
                                                                        Renal cell carcinoma (Cell Line: UO-31)
                                                                     | 
                                
                                     [4]                                  | 
                            
                                                        
                                | ------------------------------------------------------------------------------------ | 
						         | 
                                 | 
                                 | 
                                 |