Details of the Drug Combinations

General Information of This Drug (ID: DMHJTR2)

Drug Name

XL880 DMHJTR2

Synonyms

GSK 089; GSK 1363089; GSK1363089; XL 880; GSK1363089, GSK089, foretinib, EXEL-2880, XL880; 88Z; MET inhibitors

Indication

Disease Entry	ICD 11	Status	REF
Breast cancer	2C60-2C65	Phase 2	[1]
Gastric adenocarcinoma	2B72	Phase 2	[2]
Renal cell carcinoma	2C90	Phase 2	[2]
Squamous head and neck cell carcinom	2D60.0	Phase 2	[2]
Solid tumour/cancer	2A00-2F9Z	Phase 1	[2]
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Therapeutic Class

Anticancer Agents

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

2 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
XL880 + Panobinostat	DC81AHX	Panobinostat	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[3]
XL880 + Mitomycin	DCFXZJP	Mitomycin	Diffuse large B cell lymphoma (Cell Line: TMD8)	[3]
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2 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Lapatinib + XL880	DCAHJZ9	Lapatinib	Breast Cancer	[4]
Erlotinib + XL880	DCU3AFM	Erlotinib	Cancer	[5]
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References

1	ClinicalTrials.gov (NCT01147484) A Study of Foretinib in Patients With Recurrent/Metastatic Breast Cancer (IND197). U.S. National Institutes of Health.
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5679).
3	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
4	ClinicalTrials.gov (NCT01138384) Study of Foretinib in Combination With Lapatinib in Patients With Metastatic Breast Cancer
5	ClinicalTrials.gov (NCT02034097) A Study to Evaluate Foretinib in Subjects With Non-Small-Cell Lung Cancer