Details of the Drug Combinations

General Information of This Drug (ID: DMHKZLF)

Drug Name
OSI-906   DMHKZLF
Synonyms
Linsitinib; 867160-71-2; OSI-906; Linsitinib(OSI-906); OSI906; OSI 906; OSI-906AA; OSI-906 (Linsitinib); UNII-15A52GPT8T; Kinome_3532; ASP-7487; 3-[8-amino-1-(2-phenylquinolin-7-yl)imidazo[1,5-a]pyrazin-3-yl]-1-methylcyclobutan-1-ol; 15A52GPT8T; CHEMBL1091644; MMV676605; cis-3-[8-Amino-1-(2-phenyl-7-quinolinyl)imidazo[1,5-a]pyrazin-3-yl]-1-methylcyclobutanol; C26H23N5O; cis-3-(8-amino-1-(2-phenyl-7-quinolinyl)imidazo(1,5-a)pyrazin-3-yl)-1-methylcyclobutanol; Linsitinib [USAN:INN]; OSI906/Linsitinib/; Linsitinib; OSI-906
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Phase 3 [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

35 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
(-)-englerin A + OSI-906 DC5JZBN (-)-englerin A Ewing sarcoma (Cell Line: TC-71) [2]
ABT-263 + OSI-906 DC4KDZK ABT-263 Ewing sarcoma (Cell Line: TC-71) [3]
AXL-1717 + OSI-906 DCCF3FM AXL-1717 Ewing sarcoma (Cell Line: TC-71) [2]
Cantharidin + OSI-906 DC0278D Cantharidin Ewing sarcoma (Cell Line: TC-71) [2]
Efaproxyn + OSI-906 DCQEXUW Efaproxyn Ewing sarcoma (Cell Line: TC-71) [2]
Epothilone D + OSI-906 DC0QFDA Epothilone D Ewing sarcoma (Cell Line: TC-71) [2]
Exherin + OSI-906 DC64Y23 Exherin Ewing sarcoma (Cell Line: TC-71) [2]
GDC-0084 + OSI-906 DC62X1V GDC-0084 Ewing sarcoma (Cell Line: TC-71) [2]
MK-1775 + OSI-906 DCSUMSL MK-1775 Ewing sarcoma (Cell Line: TC-71) [2]
Nintedanib + OSI-906 DCYUZ4D Nintedanib Ewing sarcoma (Cell Line: TC-71) [2]
NVP-AUY922 + OSI-906 DCSD8H7 NVP-AUY922 Ewing sarcoma (Cell Line: TC-71) [2]
Ombrabulin + OSI-906 DCS3ZB4 Ombrabulin Ewing sarcoma (Cell Line: TC-71) [2]
OSI-027 + OSI-906 DCWAMNX OSI-027 Ewing sarcoma (Cell Line: TC-71) [2]
OSI-906 + GSK461364 DCD7Z44 GSK461364 Ewing sarcoma (Cell Line: TC-71) [3]
OSI-906 + AT13387 DC1Y2O6 AT13387 Ewing sarcoma (Cell Line: TC-71) [3]
OSI-906 + Carfilzomib DCO46XR Carfilzomib Ewing sarcoma (Cell Line: TC-71) [3]
OSI-906 + Panobinostat DCSKYVR Panobinostat Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [3]
OSI-906 + Eltanexor oral DC018M0 Eltanexor oral Ewing sarcoma (Cell Line: TC-71) [3]
OSI-906 + Formononetin DCUV4MY Formononetin Ewing sarcoma (Cell Line: TC-71) [3]
OSI-906 + BN-2629 DCSOZB5 BN-2629 Ewing sarcoma (Cell Line: TC-71) [3]
OSI-906 + PMID25656651-Compound-5 DC4C2I5 PMID25656651-Compound-5 Ewing sarcoma (Cell Line: TC-71) [3]
OSI-906 + Lenvatinib DCPCA8D Lenvatinib Ewing sarcoma (Cell Line: TC-71) [3]
OSI-906 + LY2523355 DCWVOL1 LY2523355 Ewing sarcoma (Cell Line: TC-71) [3]
OSI-906 + Etoposide DCZS8ES Etoposide Ewing sarcoma (Cell Line: TC-71) [3]
OSI-906 + PHA-739358 DCSYQOR PHA-739358 Ewing sarcoma (Cell Line: TC-71) [3]
OSI-906 + Ispinesib DCLX8Z6 Ispinesib Ewing sarcoma (Cell Line: TC-71) [3]
OSI-906 + Lestaurtinib DCF263I Lestaurtinib Ewing sarcoma (Cell Line: TC-71) [3]
OSI-906 + CHS-828 DCVLYUG CHS-828 Ewing sarcoma (Cell Line: TC-71) [3]
Panobinostat + OSI-906 DC1F0NO Panobinostat Ewing sarcoma (Cell Line: TC-71) [2]
Pelitinib + OSI-906 DCO5Q6Q Pelitinib Ewing sarcoma (Cell Line: TC-71) [2]
Romidepsin + OSI-906 DC28PBR Romidepsin Ewing sarcoma (Cell Line: TC-71) [2]
SCH-900776 + OSI-906 DCDRFBW SCH-900776 Ewing sarcoma (Cell Line: TC-71) [2]
Steroid derivative 1 + OSI-906 DC9ITHJ Steroid derivative 1 Ewing sarcoma (Cell Line: TC-71) [2]
Verteporfin + OSI-906 DC4MXRC Verteporfin Ewing sarcoma (Cell Line: TC-71) [2]
Withaferin A + OSI-906 DCJABLV Withaferin A Ewing sarcoma (Cell Line: TC-71) [2]
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⏷ Show the Full List of 35 DrugCom(s)

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7423).
2 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.