Details of the Drug Combinations

General Information of This Drug (ID: DMHTEAO)

Drug Name

Carvedilol DMHTEAO

Synonyms

Artist; Carvedilolum; Coreg; Coropres; Coropress; Dibloc; Dilatrend; Eucardic; Kredex; Querto; Atlana Pharma brand of carvedilol; Carvedilolum [Latin]; Coreg CR; GlaxoSmithKline brand of carvedilol; Lakeside brand of carvedilol; Roche brand of carvedilol; BM 14190; DQ 2466; SKF 105517; Artist (TN); BM-14190; Carloc (TN); Coreg (TN); DQ-2466; Dilatrend (TN); EG-P042; Eucardic (TN); BM-14-190; BM-14.190; Carvedilol, 14C-labeled; SK&F-105517; Carvedilol (JAN/USAN/INN); Carvedilol [USAN:INN:BAN:JAN]; Carvedilol, (R)-isomer; Carvedilol, (S)-isomer; Carvedilol, (+-)-isomer; (+-)-1-(Carbazol-4-yloxy)-3-((2-(o-methoxyphenoxy)ethyl)amino)-2-propanol; (+-)-1-Carbazol-4-yloxy)-3-((2-(o-methoxyphenoxy)ethyl)amino)-2-propanol; (+/-)-1-(Carbazol-4-yloxy)-3-[[2-(o-methoxyphenoxy)ethyl]amino]-2-propanol; 1-(9H-Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol; 1-(9H-carbazol-4-yloxy)-3-[(2-{[2-(methyloxy)phenyl]oxy}ethyl)amino]propan-2-ol; 1-(9H-carbazol-4-yloxy)-3-[2-(2-methoxyphenoxy)ethylamino]propan-2-ol; 1-(9H-carbazol-4-yloxy)-3-{[2-(2-methoxyphenoxy)ethyl]amino}propan-2-ol

Indication

Disease Entry	ICD 11	Status	REF
Chronic heart failure	BD1Z	Approved	[1]
Congestive heart failure	BD10	Approved	[2]
Pulmonary hypertension	BB01	Approved	[1]
Coronavirus Disease 2019 (COVID-19)	1D6Y	Investigative	[3]
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Therapeutic Class

Vasodilator Agents

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

6 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Carvedilol + Lumefantrine	DCAGZZI	Lumefantrine	DD2 (Cell Line: DD2)	[4]
Carvedilol + Lumefantrine	DC6CHFJ	Lumefantrine	Hepatoblastoma (Cell Line: HB3)	[4]
Carvedilol + Idarubicin	DCUXCY2	Idarubicin	Glioblastoma? (Cell Line: T98G)	[4]
Carvedilol + Artemisinin	DCIK82N	Artemisinin	DD2 (Cell Line: DD2)	[4]
Carvedilol + Mefloquine	DCZH6RB	Mefloquine	DD2 (Cell Line: DD2)	[4]
NITD609 + Carvedilol	DC831EP	NITD609	DD2 (Cell Line: DD2)	[4]
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⏷ Show the Full List of 6 DrugCom(s)

6 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Carvedilol + Pentoxifylline	DCLHFWX	Pentoxifylline	Liver Cirrhosis	[5]
Ivabradine + Carvedilol	DCU667O	Ivabradine	Diastolic Dysfunction	[6]
Carvedilol + Rosuvastatin	DCPFYP9	Rosuvastatin	Cirrhosis	[7]
Lisinopril + Carvedilol	DCULCLN	Lisinopril	Breast Carcinoma	[8]
Berberine + Carvedilol	DCRIRHD	Berberine	Cirrhosis Due to Hepatitis B	[9]
Carvedilol + Metoprolol	DCR5LXX	Metoprolol	Pulmonary Disease, Chronic Obstructive	[10]
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⏷ Show the Full List of 6 DrugCom(s)

References

1	Carvedilol FDA Label
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 551).
3	Can beta-adrenergic blockers be used in the treatment of COVID-19 Med Hypotheses. 2020 May 5;142:109809.
4	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
5	ClinicalTrials.gov (NCT06041932) Pentoxifylline Plus Carvedilol vs Carvedilol Monotherapy in Preventing New Decompensation in Stable Cirrhotic Patients With Prior Decompensation
6	ClinicalTrials.gov (NCT02294292) Therapeutic Approach to Diastolic Dysfunction in Chronic Liver Disease Patients and Its Impact on Morbidity and Mortality
7	ClinicalTrials.gov (NCT03720067) Propranolol, Carvedilol and Rosuvastatin in the Prevention of Variceal Bleeding in Cirrhotic Portal Hypertension
8	ClinicalTrials.gov (NCT04190433) Autophagy Activation for the Alleviation of Cardiomyopathy Symptoms After Anthracycline Treatment, ATACAR Trial
9	ClinicalTrials.gov (NCT04543643) Endoscopic and Microbiological Assessment of the Effect of Carvedilol Combined With Berberine on GOV in Cirrhosis
10	ClinicalTrials.gov (NCT03370835) Tolerability of Metoprolol-Succinate-ER and Carvedilol in COPD