Details of the Drug Combinations

General Information of This Drug (ID: DMIJGT9)

Drug Name
INCB24360   DMIJGT9
Synonyms Epacadostat
Indication
Disease Entry ICD 11 Status REF
Urothelial carcinoma 2C92.0 Phase 3 [1]
Melanoma 2C30 Phase 2 [2]
Solid tumour/cancer 2A00-2F9Z Phase 2 [3]
B-cell lymphoma 2A86 Phase 1 [2]
Colorectal cancer 2B91.Z Phase 1 [2]
Head and neck cancer 2D42 Phase 1 [2]
Lung cancer 2C25.0 Phase 1 [2]
Lymphoma 2A80-2A86 Phase 1 [2]
Merkel cell carcinoma 2C34 Phase 1 [2]
Ovarian cancer 2C73 Phase 1 [2]
Recurrent glioblastoma 2A00.00 Phase 1 [4]
⏷ Show the Full List of Indication(s)
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

3 Clinical Trial Drug Combination(s) Consisting of This drug
DrugCom Name DrugCom ID Component Drug Indication REF
Cladribine + INCB24360 DCLMC3G Cladribine AML [5]
INCB039110 + INCB24360 DCGSCH2 INCB039110 Solid Tumors [6]
INCB24360 + Idarubicin DCYS7BQ Idarubicin AML [7]
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References

1 ClinicalTrials.gov (NCT03361865) Pembrolizumab in Combination With Epacadostat or Placebo in Cisplatin-ineligible Urothelial Carcinoma (KEYNOTE-672/ECHO-307). U.S. National Institutes of Health.
2 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8221).
4 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
5 ClinicalTrials.gov (NCT03491579) Epacadostat, Cladribine and Cytarabine (ECC) in AML
6 ClinicalTrials.gov (NCT02559492) Itacitinib Combined With INCB024360 and/or Itacitinib Combined With INCB050465 in Advanced Solid Tumors
7 ClinicalTrials.gov (NCT03444649) Epacadostat, Idarubicin and Cytarabine (EIC) in AML