Details of the Drug

General Information of Drug (ID: DMIJGT9)

Drug Name
INCB24360
Synonyms Epacadostat
Indication
Disease Entry ICD 11 Status REF
Urothelial carcinoma 2C92.0 Phase 3 [1]
Melanoma 2C30 Phase 2 [2]
Solid tumour/cancer 2A00-2F9Z Phase 2 [3]
B-cell lymphoma 2A86 Phase 1 [2]
Colorectal cancer 2B91.Z Phase 1 [2]
Head and neck cancer 2D42 Phase 1 [2]
Lung cancer 2C25.0 Phase 1 [2]
Lymphoma 2A80-2A86 Phase 1 [2]
Merkel cell carcinoma 2C34 Phase 1 [2]
Ovarian cancer 2C73 Phase 1 [2]
Recurrent glioblastoma 2A00.00 Phase 1 [4]
⏷ Show the Full List of Indication(s)
ATC Code
L01XX58: INCB24360
L01XX: Other antineoplastic agents
L01X: OTHER ANTINEOPLASTIC AGENTS
L01: ANTINEOPLASTIC AGENTS
L: ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 1 Molecular Weight (mw) 438.24
Logarithm of the Partition Coefficient (xlogp) 0.8
Rotatable Bond Count (rotbonds) 8
Hydrogen Bond Donor Count (hbonddonor) 5
Hydrogen Bond Acceptor Count (hbondacc) 11
Chemical Identifiers
Formula
C11H13BrFN7O4S
IUPAC Name
N'-(3-bromo-4-fluorophenyl)-N-hydroxy-4-[2-(sulfamoylamino)ethylamino]-1,2,5-oxadiazole-3-carboximidamide
Canonical SMILES
C1=CC(=C(C=C1N=C(C2=NON=C2NCCNS(=O)(=O)N)NO)Br)F
InChI
InChI=1S/C11H13BrFN7O4S/c12-7-5-6(1-2-8(7)13)17-11(18-21)9-10(20-24-19-9)15-3-4-16-25(14,22)23/h1-2,5,16,21H,3-4H2,(H,15,20)(H,17,18)(H2,14,22,23)
InChIKey
FBKMWOJEPMPVTQ-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
135564890
ChEBI ID
CHEMBL3545369
CAS Number
1204669-58-8
UNII
71596A9R13
DrugBank ID
DB11717
TTD ID
D0G7MV
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Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Indoleamine 2,3-dioxygenase 1 (IDO1) TTZJYKH I23O1_HUMAN Inhibitor [5]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

References

1 ClinicalTrials.gov (NCT03361865) Pembrolizumab in Combination With Epacadostat or Placebo in Cisplatin-ineligible Urothelial Carcinoma (KEYNOTE-672/ECHO-307). U.S. National Institutes of Health.
2 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8221).
4 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
5 Incyte. Product Development Pipeline.