Details of the Drug Combinations

General Information of This Drug (ID: DMM5ZX6)

Drug Name
Epothilone B   DMM5ZX6
Synonyms
Epothilone B; Patupilone; 152044-54-7; (-)-Epothilone B; Epo B; EpoB; EPO906; EPO 906; UNII-UEC0H0URSE; EPO 906A; GNF-PF-193; CHEBI:31550; UEC0H0URSE; AK163080; Epothilone B (EPO906, Patupilone); 7,11-DIHYDROXY-8,8,10,12,16-PENTAMETHYL-3-[1-METHYL-2-(2-METHYL-THIAZOL-4-YL)VINYL]-4,17-DIOXABICYCLO[14.1.0]HEPTADECANE-5,9-DIONE; Epothilon B; Patupilone [INN]; (1S,3S,7S,10R,11S,12S,16R)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-((E)-1-(2-methylthiazol-4-yl)prop-1-en-2-yl)-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Discontinued in Phase 3 [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

26 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Dactinomycin + Epothilone B DCPNKXG Dactinomycin Hepatoblastoma (Cell Line: HB3) [2]
Docetaxel + Epothilone B DCK11BY Docetaxel Hepatoblastoma (Cell Line: HB3) [3]
Epothilone B + Docetaxel DCED7KX Docetaxel DD2 (Cell Line: DD2) [3]
Epothilone B + OZ277 DCLDM8L OZ277 Hepatoblastoma (Cell Line: HB3) [2]
Epothilone B + Docetaxel DC0IMAN Docetaxel Hepatoblastoma (Cell Line: HB3) [2]
Epothilone B + Omacetaxine mepesuccinate DCQYJA7 Omacetaxine mepesuccinate Hepatoblastoma (Cell Line: HB3) [2]
Epothilone B + Atovaquone DCPIXWQ Atovaquone Hepatoblastoma (Cell Line: HB3) [2]
Lumefantrine + Epothilone B DCKCPWF Lumefantrine Hepatoblastoma (Cell Line: HB3) [3]
Mefloquine + Epothilone B DCLFS4N Mefloquine Hepatoblastoma (Cell Line: HB3) [3]
Miconazole + Epothilone B DC90YHX Miconazole Hepatoblastoma (Cell Line: HB3) [2]
MK-4815 + Epothilone B DCBD6H5 MK-4815 Hepatoblastoma (Cell Line: HB3) [2]
NITD609 + Epothilone B DC7QOXF NITD609 Hepatoblastoma (Cell Line: HB3) [2]
Nitisinone + Epothilone B DC7696Z Nitisinone Hepatoblastoma (Cell Line: HB3) [3]
Omacetaxine mepesuccinate + Epothilone B DCHUBZ0 Omacetaxine mepesuccinate DD2 (Cell Line: DD2) [3]
Omacetaxine mepesuccinate + Epothilone B DCXHPR3 Omacetaxine mepesuccinate Hepatoblastoma (Cell Line: HB3) [2]
Proguanil + Epothilone B DC7JAQW Proguanil Hepatoblastoma (Cell Line: HB3) [3]
Pyronaridine + Epothilone B DCK4HEP Pyronaridine Hepatoblastoma (Cell Line: HB3) [2]
Quinine + Epothilone B DC6TFIL Quinine Hepatoblastoma (Cell Line: HB3) [3]
Ritonavir + Epothilone B DCSJO2R Ritonavir DD2 (Cell Line: DD2) [3]
Ritonavir + Epothilone B DCHGV84 Ritonavir Hepatoblastoma (Cell Line: HB3) [3]
Sarpogrelate + Epothilone B DC9YWTO Sarpogrelate Hepatoblastoma (Cell Line: HB3) [2]
SB 228357 + Epothilone B DC7T2PG SB 228357 Hepatoblastoma (Cell Line: HB3) [2]
Thiolactomycin + Epothilone B DCWMNUU Thiolactomycin Hepatoblastoma (Cell Line: HB3) [2]
Verapamil + Epothilone B DCC92QV Verapamil Hepatoblastoma (Cell Line: HB3) [2]
Vorinostat + Epothilone B DC9U8MY Vorinostat Hepatoblastoma (Cell Line: HB3) [3]
ZM-447439 + Epothilone B DCH8PO0 ZM-447439 DD2 (Cell Line: DD2) [3]
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⏷ Show the Full List of 26 DrugCom(s)

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005849)
2 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
3 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.