Details of the Drug

General Information of Drug (ID: DMM5ZX6)

Drug Name
Epothilone B
Synonyms
Epothilone B; Patupilone; 152044-54-7; (-)-Epothilone B; Epo B; EpoB; EPO906; EPO 906; UNII-UEC0H0URSE; EPO 906A; GNF-PF-193; CHEBI:31550; UEC0H0URSE; AK163080; Epothilone B (EPO906, Patupilone); 7,11-DIHYDROXY-8,8,10,12,16-PENTAMETHYL-3-[1-METHYL-2-(2-METHYL-THIAZOL-4-YL)VINYL]-4,17-DIOXABICYCLO[14.1.0]HEPTADECANE-5,9-DIONE; Epothilon B; Patupilone [INN]; (1S,3S,7S,10R,11S,12S,16R)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-((E)-1-(2-methylthiazol-4-yl)prop-1-en-2-yl)-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Discontinued in Phase 3 [1]
Affected Organisms
Humans and other mammals
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 1 Molecular Weight (mw) 507.7
Logarithm of the Partition Coefficient (xlogp) 4.2
Rotatable Bond Count (rotbonds) 2
Hydrogen Bond Donor Count (hbonddonor) 2
Hydrogen Bond Acceptor Count (hbondacc) 8
Chemical Identifiers
Formula
C27H41NO6S
IUPAC Name
(1S,3S,7S,10R,11S,12S,16R)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[(E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione
Canonical SMILES
C[C@H]1CCC[C@@]2([C@@H](O2)C[C@H](OC(=O)C[C@@H](C(C(=O)[C@@H]([C@H]1O)C)(C)C)O)/C(=C/C3=CSC(=N3)C)/C)C
InChI
InChI=1S/C27H41NO6S/c1-15-9-8-10-27(7)22(34-27)12-20(16(2)11-19-14-35-18(4)28-19)33-23(30)13-21(29)26(5,6)25(32)17(3)24(15)31/h11,14-15,17,20-22,24,29,31H,8-10,12-13H2,1-7H3/b16-11+/t15-,17+,20-,21-,22-,24-,27+/m0/s1
InChIKey
QXRSDHAAWVKZLJ-PVYNADRNSA-N
Cross-matching ID
PubChem CID
448013
ChEBI ID
CHEBI:31550
CAS Number
152044-54-7
UNII
UEC0H0URSE
DrugBank ID
DB03010
TTD ID
D0CV7Z
INTEDE ID
DR1795
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Tubulin (TUB) TTML2WA NOUNIPROTAC Inhibitor [2]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4)
Main DME 		DE4LYSA CP3A4_HUMAN Substrate [3]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Solid tumour/cancer
ICD Disease Classification 2A00-2F9Z
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Tubulin (TUB) DTT NO-GeName 7.94E-02 0.35 0.43
Cytochrome P450 3A4 (CYP3A4) DME CYP3A4 2.96E-01 -3.35E-01 -1.10E+00
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 36 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC1 -7.4215 -4.1509 -7.9055 33.523
ES1 GDSC1 -11.0166 -9.4665 -11.0169 75.0975
HOS GDSC1 -10.5444 -9.5636 -10.5445 69.7088
ES4 GDSC1 -10.4071 -5.9156 -10.6743 63.3131
MHH-ES-1 GDSC1 -10.0672 -7.834 -10.0805 63.138
EW-16 GDSC1 -9.7744 -6.8811 -9.841 59.1317
EW-13 GDSC1 -9.6383 -7.0264 -9.684 57.8171
SK-PN-DW GDSC1 -9.4415 -5.6515 -9.6816 54.8714
EW-7 GDSC1 -9.356 -4.2266 -9.9775 53.3842
EW-1 GDSC1 -9.0687 -6.2189 -9.174 51.1741
ES8 GDSC1 -8.9799 -6.921 -9.0054 50.1721
SJSA-1 GDSC1 -8.6619 -5.8348 -8.7997 46.5284
NY GDSC1 -8.6429 -5.62 -8.8209 46.3852
EW-18 GDSC1 -8.4338 -5.0806 -8.7198 44.2662
A-673 GDSC1 -8.3683 -6.5614 -8.3941 42.6554
NOS-1 [Human HNSCC] GDSC1 -8.3094 -4.8266 -8.6537 43.0409
MG-63 GDSC1 -8.3046 2.6148 -11.8025 46.8464
SK-ES-1 GDSC1 -7.8042 -3.7384 -8.4678 38.6182
ES7 GDSC1 -7.6035 -2.5488 -8.7351 38.2373
ES6 GDSC1 -6.3495 3.3412 -10.3222 36.4349
TC-71 GDSC1 -5.1949 -3.7842 -5.7569 7.1218
EW-24 GDSC1 -4.3678 -0.5892 -6.6779 11.3417
EW-11 GDSC1 -4.2469 3.7905 -8.7602 23.388
CAL-72 GDSC1 -4.0747 5.0953 -9.2744 25.032
U2OS GDSC1 -1.1247 46.3231 -27.4837 41.0455
EW-3 GDSC1 -0.8861 5.659 -7.387 7.7946
CHSA0108 GDSC1 -0.8343 6.7937 -7.8637 10.2277
G-292 clone A141B1 GDSC1 -0.7403 5.459 -7.2205 6.6585
H-EMC-SS GDSC1 -0.6462 4.4998 -6.7674 4.1459
ES5 GDSC1 -0.4347 6.6574 -7.577 8.0401
CHSA0011 GDSC1 -0.276 2.5385 -5.87 0.4055
CHSA8926 GDSC1 -0.0368 13.8382 -10.6454 20.19
SaOS-2 GDSC1 0.0412 17.089 -12.1507 24.2649
HuO9 GDSC1 0.0496 3.9482 -6.2475 1.2615
CAL-78 GDSC1 0.0998 21.0618 -14.0376 28.141
HuO-3N1 GDSC1 0.3206 16.523 -11.6879 22.5726
⏷ Show the Full List of 36 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 146 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JM1 GDSC1 -7.2872 -3.3614 -8.065 33.4925
SIG-M5 GDSC1 -11.1533 -10.1408 -11.1533 77.2326
SU-DHL-5 GDSC1 -10.0589 -9.3125 -10.0589 63.6627
ST486 GDSC1 -9.9651 -8.0526 -9.9706 62.185
NB4 GDSC1 -9.9354 -8.9526 -9.9354 62.1139
OCI-Ly19 GDSC1 -9.8087 -7.4831 -9.8303 60.0188
QIMR-WIL GDSC1 -9.727 -8.1935 -9.7285 59.4406
P32/ISH GDSC1 -9.5833 -8.7686 -9.5833 57.7185
A4/Fukuda GDSC1 -9.5648 -7.1352 -9.5989 57.0788
SU-DHL-16 GDSC1 -9.5087 -7.5442 -9.5198 56.6243
BL-41 GDSC1 -9.4584 -8.1339 -9.4591 56.1393
Karpas-231 GDSC1 -9.4392 -7.2051 -9.4638 55.6824
ALL-PO GDSC1 -9.4118 -6.9076 -9.4569 55.2432
ALL-SIL GDSC1 -9.3964 -5.6832 -9.6258 54.4522
RPMI-6666 GDSC1 -9.3787 -3.2409 -10.3425 53.1676
KCL-22 GDSC1 -9.2932 -6.9884 -9.3265 53.9131
Karpas-620 GDSC1 -9.273 -7.675 -9.2769 53.808
MEG-01 GDSC1 -9.156 -5.5007 -9.4045 51.9834
Reh GDSC1 -9.1452 -7.7367 -9.1471 52.2338
MV4-11 GDSC1 -9.1352 -7.9737 -9.1356 52.1155
697 GDSC1 -9.0932 -7.489 -9.0983 51.5799
TUR GDSC1 -9.0554 -7.458 -9.0607 51.1116
NKM-1 GDSC1 -9.0355 -7.6393 -9.0376 50.8688
HL-60 GDSC1 -9.0298 -7.5017 -9.0338 50.7949
KE-37 GDSC1 -9.0048 -7.2722 -9.0142 50.4818
RS4;11 GDSC1 -8.9886 -4.9183 -9.369 50.2258
SUP-B15 GDSC1 -8.9399 -5.9111 -9.0862 49.7104
BC-1 GDSC1 -8.9213 -7.2808 -8.9287 49.4494
SU-DHL-6 GDSC1 -8.845 -7.2327 -8.8524 48.5029
NALM-6 GDSC1 -8.8006 -7.1236 -8.8105 47.9568
MOLT-4 GDSC1 -8.608 -5.9888 -8.7153 45.8329
ML-2 GDSC1 -8.598 -6.8294 -8.6154 45.4679
MOLP-8 GDSC1 -8.5978 -3.2648 -9.4961 46.8882
AMO1 GDSC1 -8.5799 -4.9992 -8.9009 45.945
WIL2 NS GDSC1 -8.5289 -4.9957 -8.8462 45.385
Ku812 GDSC1 -8.4339 -4.7578 -8.8094 44.4814
CCRF-CEM GDSC1 -8.3578 -5.9132 -8.4586 42.8255
RPMI-8226 GDSC1 -8.3242 -7.0101 -8.3285 42.0038
OCI-AML-2 GDSC1 -8.3214 -7.0526 -8.3249 41.9651
JSC-1 GDSC1 -8.2903 -5.5313 -8.4566 42.2559
CESS GDSC1 -8.2817 -6.5373 -8.3057 41.5726
EB2 GDSC1 -8.2549 -5.2733 -8.4762 42.0341
Loucy GDSC1 -8.2409 -5.4011 -8.4313 41.7604
OCI-AML-3 GDSC1 -8.1514 -7.3473 -8.1516 39.8215
SR GDSC1 -8.122 -1.8205 -9.5848 43.6722
Farage GDSC1 -8.0677 -6.5628 -8.0823 38.8589
ATN-1 GDSC1 -8.0512 -7.1023 -8.0519 38.5719
DEL GDSC1 -8.0463 -4.7171 -8.3987 40.1142
TK [Human B-cell lymphoma] GDSC1 -8.0445 -5.1986 -8.265 39.5624
Hs 445 GDSC1 -8.0027 -5.9378 -8.0741 38.3566
MOLT-16 GDSC1 -7.9924 -4.1933 -8.5079 40.1096
HEL GDSC1 -7.971 -4.5517 -8.3673 39.4295
GDM-1 GDSC1 -7.9613 -6.1373 -8.0051 37.6959
HC-1 GDSC1 -7.9315 -5.3422 -8.1079 38.0105
OCI-AML-5 GDSC1 -7.929 -6.3338 -7.9531 37.183
MC116 GDSC1 -7.8888 -5.5213 -8.0231 37.2825
EoL-1 GDSC1 -7.8777 -6.6548 -7.8836 36.435
KMS-12-BM GDSC1 -7.8394 -6.5091 -7.8498 35.9839
P30/OHK GDSC1 -7.8325 -6.14 -7.8689 36.052
GR-ST GDSC1 -7.7997 -4.5275 -8.1885 37.4409
WSU-NHL GDSC1 -7.786 -2.8784 -8.7876 39.589
H9 GDSC1 -7.7848 -4.7528 -8.1029 36.9409
JJN-3 GDSC1 -7.7755 -5.3303 -7.9408 36.0619
MHH-PREB-1 GDSC1 -7.7034 -6.0244 -7.7447 34.4719
HAL-01 GDSC1 -7.5917 -6.2834 -7.606 32.9135
BALL-1 GDSC1 -7.5885 -6.1917 -7.6087 32.9097
MOLM-13 GDSC1 -7.583 -5.3644 -7.7239 33.5659
CTV-1 GDSC1 -7.5726 -4.3052 -8.015 35.0671
RPMI-8402 GDSC1 -7.5502 -4.6843 -7.8678 34.1562
KG-1 GDSC1 -7.5074 -5.1389 -7.6942 32.9035
BV-173 GDSC1 -7.4892 -4.576 -7.8352 33.5821
DoHH2 GDSC1 -7.4755 -4.9807 -7.7006 32.7358
KM-H2 GDSC1 -7.4373 -6.3382 -7.4444 30.9388
DB GDSC1 -7.4128 -3.5651 -8.1164 34.5239
L-363 GDSC1 -7.4099 -6.2026 -7.4226 30.6311
BE-13 GDSC1 -7.4047 -5.8286 -7.4511 30.7773
NU-DUL-1 GDSC1 -7.3782 -5.7426 -7.4343 30.5078
NOMO-1 GDSC1 -7.3436 -5.8455 -7.3841 29.9771
Namalwa GDSC1 -7.3272 -5.031 -7.5254 30.7559
Karpas-45 GDSC1 -7.3253 -4.3941 -7.7169 31.8789
ARH-77 GDSC1 -7.2961 -2.3465 -8.5057 35.5065
SUP-M2 GDSC1 -7.2689 -4.6409 -7.5749 30.6964
K-562 GDSC1 -7.2572 -4.5232 -7.6 30.7744
MY-M12 GDSC1 -7.2557 -5.1114 -7.4267 29.7045
U-698-M GDSC1 -7.1926 -4.5973 -7.5058 29.8112
A3/Kawakami GDSC1 -7.1926 -4.3054 -7.6037 30.4027
KOPN-8 GDSC1 -7.1073 -3.2463 -7.9236 31.6886
P12-Ichikawa GDSC1 -7.081 -4.6272 -7.3748 28.3252
PL-21 GDSC1 -7.0745 -4.5056 -7.4074 28.4923
Ramos.2G6.4C10 GDSC1 -7.0124 -5.7029 -7.0496 25.8182
OCI-M1 GDSC1 -6.9895 -4.0842 -7.4651 28.3556
NK-92MI GDSC1 -6.9593 -5.0198 -7.1269 26.0039
Jiyoye GDSC1 -6.8345 -3.6797 -7.4584 27.4299
CTB-1 GDSC1 -6.8232 -3.4084 -7.5588 27.9845
PF-382 GDSC1 -6.7994 -3.3888 -7.5423 27.7519
BC-3 GDSC1 -6.7903 -3.8497 -7.3433 26.4523
SU-DHL-8 GDSC1 -6.7572 -2.3358 -7.9634 29.9203
VL51 GDSC1 -6.6677 -1.5427 -8.2422 30.8485
Sc-1 GDSC1 -6.6653 -4.0013 -7.1507 24.4958
HH [Human lymphoma] GDSC1 -6.4593 0.5764 -9.0623 33.2268
L-540 GDSC1 -6.4572 -3.8215 -7.0035 22.3771
U266B1 GDSC1 -6.4203 0.3146 -8.8982 32.4364
EJM GDSC1 -6.3829 -3.7659 -6.9491 21.6102
Karpas-422 GDSC1 -6.3446 -2.9692 -7.2604 23.5432
LC4-1 GDSC1 -6.2914 -3.1977 -7.1034 22.2136
SCC-3 GDSC1 -6.2749 -5.1445 -6.3499 16.8499
MLMA GDSC1 -6.18 -4.0346 -6.6247 18.259
JURL-MK1 GDSC1 -6.1785 -1.9112 -7.5926 24.8452
SUP-T1 GDSC1 -6.1531 -0.9636 -8.0258 27.2025
SUP-HD1 GDSC1 -6.1108 -0.8555 -8.0388 27.0725
Granta-519 GDSC1 -6.0818 -3.3107 -6.8409 19.3309
YT GDSC1 -6.0665 -2.3584 -7.2711 22.2529
Mono-Mac-6 GDSC1 -5.8888 -2.1963 -7.1789 20.8027
CA46 GDSC1 -5.7636 -1.182 -7.5577 22.7155
HT GDSC1 -5.7194 -2.3531 -6.9433 18.3901
OPM-2 GDSC1 -5.7183 2.8887 -9.5366 31.7196
SK-MM-2 GDSC1 -5.7169 -2.6341 -6.8045 17.3724
LAMA-84 GDSC1 -5.6958 -1.3074 -7.434 21.635
HDLM-2 GDSC1 -5.6463 -2.2912 -6.9053 17.7957
RPMI-8866 GDSC1 -5.6392 -3.3699 -6.3765 13.8209
Daudi GDSC1 -5.4619 -0.6255 -7.5621 21.4514
EHEB GDSC1 -5.3601 -0.9739 -7.2992 19.3357
SU-DHL-1 GDSC1 -5.2172 -0.6498 -7.3367 19.0116
SU-DHL-4 GDSC1 -5.1578 -1.6701 -6.7762 14.8449
VAL GDSC1 -5.1217 0.166 -7.6627 20.7072
THP-1 GDSC1 -5.0112 -0.1882 -7.3925 18.5817
KMOE-2 GDSC1 -4.9576 0.518 -7.7009 20.3127
L-428 GDSC1 -4.5597 -0.9171 -6.6625 11.8511
DG-75 GDSC1 -4.5156 -0.7271 -6.7227 12.1494
DND-41 GDSC1 -4.5038 1.4022 -7.7734 19.1131
RC-K8 GDSC1 -3.8708 1.7153 -7.4435 15.0395
ME1 GDSC1 -3.6656 4.0561 -8.4443 20.061
IM-9 GDSC1 -3.5737 7.0541 -9.8587 25.7273
Raji GDSC1 -3.4804 0.9991 -6.8196 9.7935
EM-2 GDSC1 -1.0178 13.529 -11.1654 23.7078
ROS-50 GDSC1 -0.9447 4.4783 -6.9073 5.288
Karpas-299 GDSC1 -0.7308 8.0783 -8.3874 12.6404
MN-60 GDSC1 -0.39 2.7235 -5.9758 0.6853
KY821 GDSC1 -0.359 4.0695 -6.4628 2.3918
LP-1 GDSC1 -0.3341 4.3302 -6.5537 2.7678
L-1236 GDSC1 -0.1519 4.8885 -6.6923 3.2097
JVM-2 GDSC1 -0.0694 3.3451 -6.0759 0.8096
WSU-DLCL2 GDSC1 -0.0632 1.3408 -5.4089 0.0037
P31/FUJ GDSC1 0.1538 2.0765 -5.5736 0.0314
JVM-3 GDSC1 0.1698 2.6382 -5.7503 0.1444
RL GDSC1 0.2977 5.0445 -6.5557 2.2064
⏷ Show the Full List of 146 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 4 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KYSE-50 GDSC1 -10.8813 -8.5599 -10.8891 72.2732
KYSE-220 GDSC1 -9.7263 -7.4739 -9.7458 59.0963
HCE-4 GDSC1 -9.123 -7.0308 -9.1469 51.9071
TE-12 GDSC1 -7.6792 -0.8722 -9.5565 40.9425
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC1 -7.1273 -1.6482 -8.6486 35.0928
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SJNB-13 GDSC1 -10.331 -7.3444 -10.3825 65.1051
NH-12 GDSC1 -9.815 -6.6936 -9.9056 59.3564
SK-N-SH GDSC1 -8.7494 -5.5376 -8.9541 47.6254
NB(TU)1 GDSC1 -8.6134 -5.1937 -8.8867 46.2256
IMR-5 GDSC1 -8.2996 -4.6257 -8.7024 43.0964
SK-N-MC-IXC GDSC1 -8.1992 -6.9835 -8.2024 40.4365
MHH-NB-11 GDSC1 -8.1672 -4.8146 -8.502 41.4208
KP-N-YS GDSC1 -8.1466 -5.2275 -8.3693 40.7748
Kelly GDSC1 -7.7255 -4.9904 -7.9708 35.876
CHP-212 GDSC1 -7.5245 -3.1237 -8.4119 36.5369
GI-ME-N GDSC1 -7.3224 -0.86 -9.2064 38.0517
SK-N-DZ GDSC1 -6.8828 -2.0966 -8.1986 31.7912
SJNB-14 GDSC1 -6.7709 0.5226 -9.3289 35.5896
NB69 GDSC1 -6.7038 -3.0737 -7.579 27.4497
SJNB-5 GDSC1 -6.5366 -3.0601 -7.414 25.5325
SJNB-7 GDSC1 -6.4333 0.8732 -9.1833 33.5329
SJNB-10 GDSC1 -6.2433 -1.1126 -8.0386 27.6993
TGW GDSC1 -6.2344 -4.0379 -6.6804 18.9388
NB1 GDSC1 -6.1176 -1.8955 -7.5417 24.2395
SJNB-6 GDSC1 -5.7408 -0.9164 -7.6678 23.2902
SiMa GDSC1 -5.5619 -1.561 -7.1873 19.4188
SJNB-12 GDSC1 -4.4251 0.1934 -7.1098 14.602
KP-N-YN GDSC1 -4.333 1.1363 -7.5069 16.908
GOTO GDSC1 -3.9843 1.4572 -7.4005 15.1143
CHP-126 GDSC1 -3.6653 9.6802 -11.2352 30.0674
SK-N-BE(2)-M17 GDSC1 -1.9966 7.5316 -8.9466 17.9749
LA-N-6 GDSC1 -0.6431 5.9416 -7.3778 7.3392
SK-N-FI GDSC1 -0.2887 4.3544 -6.543 2.6754
SK-N-AS GDSC1 -0.0903 3.2864 -6.0629 0.784
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC1 -8.3438 -3.0217 -9.3192 44.7427
Cancer Drug Sensitivity Data Curated from 50 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MCF-7 GDSC1 -11.8318 -6.1491 -12.1721 71.93
CAL-85-1 GDSC1 -10.3786 -7.5135 -10.419 65.8149
JIMT-1 GDSC1 -10.2637 -7.2059 -10.3242 64.2735
MRK-nu-1 GDSC1 -10.0609 -6.7942 -10.1545 61.8197
OCUB-M GDSC1 -9.8475 -7.5661 -9.8662 60.5106
HCC1806 GDSC1 -9.5252 -4.8456 -9.9749 55.1246
HCC2157 GDSC1 -9.3791 -5.5127 -9.6446 54.195
CAL-51 GDSC1 -9.0371 -5.5557 -9.2628 50.7587
MDA-MB-468 GDSC1 -8.9624 -5.8956 -9.1133 49.9626
DU4475 GDSC1 -8.8814 -6.2384 -8.9708 49.019
EFM-192A GDSC1 -8.4241 -6.0066 -8.5151 43.5897
AU565 GDSC1 -7.9199 -4.7245 -8.2587 38.61
HCC38 GDSC1 -7.8344 2.3794 -11.2366 44.2882
HCC70 GDSC1 -7.7226 -4.6091 -8.0788 36.3936
CAL-148 GDSC1 -7.4938 -5.4026 -7.6188 32.3693
BT-20 GDSC1 -7.4684 -4.5204 -7.8304 33.4215
BT-549 GDSC1 -7.0374 -4.1956 -7.4754 28.6989
HCC1954 GDSC1 -6.9075 -3.89 -7.4518 27.8015
HCC1599 GDSC1 -6.8721 -5.3525 -6.9548 24.3601
EFM-19 GDSC1 -6.6592 0.0282 -8.984 33.8956
CAL-120 GDSC1 -6.4481 -3.8588 -6.9785 22.1554
HCC1569 GDSC1 -6.3903 -0.4337 -8.5062 30.6766
CAMA-1 GDSC1 -6.2066 -4.3217 -6.5375 17.7728
HCC1187 GDSC1 -6.1845 -2.942 -7.1127 21.7474
ZR-75-30 GDSC1 -5.9724 -2.0864 -7.3113 22.0787
MDA-MB-361 GDSC1 -5.8526 -1.2937 -7.5847 23.2798
MDA-MB-436 GDSC1 -5.7877 -1.5289 -7.4094 21.881
MDA-MB-415 GDSC1 -5.6702 -2.744 -6.7071 16.4475
COLO 824 GDSC1 -5.4104 -1.2735 -7.1944 18.8335
MDA-MB-231 GDSC1 -5.357 3.8198 -9.6887 30.8625
HCC202 GDSC1 -5.2228 0.5736 -7.9524 22.7952
Evsa-T GDSC1 -4.9948 -0.3794 -7.2832 17.7976
HCC1419 GDSC1 -4.9182 -2.8938 -5.9624 7.687
HCC2218 GDSC1 -4.8723 10.095 -12.4184 35.7851
UACC-893 GDSC1 -4.7483 0.2171 -7.3783 17.5192
HCC1937 GDSC1 -4.4953 0.7806 -7.4569 17.1385
BT-474 GDSC1 -4.3655 1.9786 -7.9513 19.6695
MDA-MB-453 GDSC1 -4.1602 2.6183 -8.1091 19.8628
HCC1395 GDSC1 -3.703 0.6714 -6.814 10.3516
HDQ-P1 GDSC1 -3.4631 8.444 -10.4632 27.3927
Hs 578T GDSC1 -2.4745 5.6846 -8.3849 16.4934
MDA-MB-330 GDSC1 -1.5847 10.1934 -9.9461 21.0187
HCC1500 GDSC1 -0.8319 7.6366 -8.246 12.1518
MDA-MB-175-VII GDSC1 -0.541 5.8745 -7.294 6.7347
MFM-223 GDSC1 0.1317 3.4452 -6.0365 0.6278
BT-483 GDSC1 0.1783 2.5275 -5.7112 0.1082
MDA-MB-157 GDSC1 0.2013 6.5487 -7.2001 5.2059
UACC-812 GDSC1 0.2315 3.378 -5.9773 0.467
HCC1428 GDSC1 0.7797 27.0167 -16.4582 30.8108
T-47D GDSC1 0.907 14.077 -10.1515 16.8208
⏷ Show the Full List of 50 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 52 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Daoy GDSC1 -14.1542 -7.2783 -14.4699 81.6355
D-566MG GDSC1 -12.0192 -2.5099 -13.4505 65.9444
GB-1 GDSC1 -10.2945 -3.1648 -11.3563 59.0233
H4 GDSC1 -9.9741 -6.7767 -10.0644 60.9864
SK-MG-1 GDSC1 -9.944 -8.3614 -9.9454 62.1022
Hs 683 GDSC1 -9.5952 -7.14 -9.6301 57.4195
MOG-G-UVW GDSC1 -9.5436 -6.0158 -9.7192 56.0996
NMC-G1 GDSC1 -9.4211 0.5572 -11.9621 52.3547
KS-1 [Human Krukenberg tumour] GDSC1 -9.4166 -3.6384 -10.2409 53.6089
SW1783 GDSC1 -9.4078 -6.29 -9.5267 54.8947
GaMG GDSC1 -9.3148 -6.5598 -9.3906 54.0137
M059J GDSC1 -9.1756 -6.8347 -9.2158 52.5024
YKG-1 GDSC1 -9.1343 -4.7785 -9.5676 51.612
SF295 GDSC1 -9.0832 -5.6606 -9.2904 51.2584
GI-1 GDSC1 -8.9211 -6.4556 -8.9853 49.4721
A-172 GDSC1 -8.8711 -3.7283 -9.6199 49.1792
SF539 GDSC1 -8.8215 -5.8954 -8.9611 48.3669
SNB-75 GDSC1 -8.7885 -1.9629 -10.2178 48.7424
8-MG-BA GDSC1 -8.6304 -3.9368 -9.2868 46.9277
LN-18 GDSC1 -8.5733 -6.2527 -8.6406 45.3166
Becker GDSC1 -8.291 -6.1264 -8.3562 41.8733
SF126 GDSC1 -8.1368 -4.3965 -8.5971 41.4965
KNS-42 GDSC1 -8.0787 -1.9084 -9.5021 43.2485
ONS-76 GDSC1 -8.0521 -0.6451 -10.0347 43.9477
KALS-1 GDSC1 -7.9975 -4.7991 -8.3214 39.4432
SF268 GDSC1 -7.8735 -1.3516 -9.5361 42.0374
D-423MG GDSC1 -7.4679 -4.2097 -7.9347 33.9735
MOG-G-CCM GDSC1 -7.4656 -4.2225 -7.9278 33.9224
Onda 10 GDSC1 -7.4263 -3.2066 -8.2747 35.3341
SW1088 GDSC1 -7.3355 0.0064 -9.6249 39.229
DBTRG-05MG GDSC1 -7.234 -4.3444 -7.635 30.8401
LN-229 GDSC1 -6.9018 -4.6192 -7.1825 26.0344
AM-38 GDSC1 -6.7299 -1.5457 -8.3018 31.456
U-251MG GDSC1 -6.4028 -3.0114 -7.3 24.1015
LNZTA3WT4 GDSC1 -6.3183 -2.8199 -7.3024 23.6888
YH-13 GDSC1 -6.2123 -0.6816 -8.2185 28.4745
PFSK-1 GDSC1 -6.1945 -3.2084 -7.0007 21.0178
U-118MG GDSC1 -5.9344 -2.4688 -7.0913 20.4084
T98G GDSC1 -5.5951 -0.8408 -7.5736 22.0831
U-87MG ATCC GDSC1 -5.4494 -0.3285 -7.6988 22.2363
CAS-1 GDSC1 -5.4241 2.204 -8.9394 28.3575
Onda 11 GDSC1 -5.339 1.1398 -8.3349 25.2793
DK-MG GDSC1 -5.1217 10.8987 -13.0283 37.4102
KINGS-1 GDSC1 -5.098 -0.8279 -7.1459 17.2582
D-392MG GDSC1 -5.0599 4.4098 -9.7322 29.951
D-263MG GDSC1 -4.686 7.8503 -11.1422 32.6951
42-MG-BA GDSC1 -4.0741 6.6268 -10.0367 27.7855
KNS-81-FD GDSC1 -3.8911 2.9519 -8.0686 18.7866
D283 Med GDSC1 -1.7808 5.0934 -7.6539 10.9822
D-502MG GDSC1 -0.6333 9.9362 -9.1898 16.041
LN-405 GDSC1 -0.5877 8.8798 -8.6693 13.6784
D-542MG GDSC1 0.1652 6.9611 -7.3908 6.1862
⏷ Show the Full List of 52 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ETK-1 GDSC1 -9.7008 -6.9318 -9.7583 58.4128
TGBC24TKB GDSC1 -8.373 -6.691 -8.3906 42.6771
TGBC1TKB GDSC1 -4.8468 0.0998 -7.4002 18.0188
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
AN3-CA GDSC1 -10.6645 -6.1482 -10.9066 65.5338
MFE-319 GDSC1 -10.3956 -8.0505 -10.4087 66.8057
ESS-1 GDSC1 -9.175 -7.0361 -9.2005 52.5302
MFE-296 GDSC1 -8.4776 -4.4732 -8.9434 45.1317
EN GDSC1 -6.0687 -1.4295 -7.7202 25.0893
KLE GDSC1 -4.6968 1.0263 -7.7408 19.5971
MFE-280 GDSC1 -3.9129 2.0103 -7.6199 16.2622
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 25 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
786-O GDSC1 -12.9755 -10.8823 -12.9759 91.809
VMRC-RCZ GDSC1 -12.1948 -3.8644 -13.1811 68.6518
HA7-RCC GDSC1 -10.9475 -1.794 -12.5689 60.8914
ACHN GDSC1 -10.9184 -1.782 -12.5426 60.7529
VMRC-RCW GDSC1 -10.7526 -8.4999 -10.7598 70.9795
769-P GDSC1 -10.3389 -7.6432 -10.3693 65.6512
BB65-RCC GDSC1 -10.2273 -4.7224 -10.7761 60.3332
OS-RC-2 GDSC1 -9.8476 -0.0967 -12.112 54.644
LB1047-RCC GDSC1 -9.6626 -4.3074 -10.2854 55.8609
BFTC-909 GDSC1 -9.1233 -3.6922 -9.9051 51.3174
TK-10 GDSC1 -8.8307 -2.7221 -9.9544 48.9593
UO-31 GDSC1 -8.2069 -4.7407 -8.5668 41.9485
RXF 393L GDSC1 -8.101 -3.163 -9.0057 42.3573
SW13 GDSC1 -7.9237 -5.8397 -8.0041 37.4293
LB2241-RCC GDSC1 -7.5323 -1.4782 -9.1333 39.0334
LB996-RCC GDSC1 -7.4951 -2.6836 -8.5651 36.9497
SN12C GDSC1 -6.8162 -4.2886 -7.2036 25.6857
A-704 GDSC1 -6.4126 0.6429 -9.0514 32.9718
RCC10RGB GDSC1 -5.6524 10.8021 -13.429 39.3559
SW156 GDSC1 -5.5914 2.3576 -9.1611 29.888
KMRC-20 GDSC1 -4.4302 2.0652 -8.0455 20.4137
Caki-1 GDSC1 -0.579 42.2332 -25.0165 39.4378
A-498 GDSC1 -0.3838 13.0336 -10.4928 20.3687
CAL-54 GDSC1 -0.3314 13.697 -10.7747 21.1655
KMRC-1 GDSC1 -0.3065 20.2693 -13.9425 28.6639
⏷ Show the Full List of 25 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
T84 GDSC1 -11.4032 -9.3934 -11.4048 78.5742
RKO GDSC1 -11.3769 -10.6206 -11.3769 80.0968
HT-29 GDSC1 -10.6062 -8.3831 -10.6139 69.3813
COLO205 GDSC1 -10.5893 -8.7472 -10.5914 69.7087
HCC2998 GDSC1 -10.573 -6.1747 -10.8025 64.951
LS180 GDSC1 -10.5213 -4.6354 -11.122 62.1059
SW620 GDSC1 -10.4863 -4.6465 -11.0807 61.9066
HCT 15 GDSC1 -10.4393 -5.7007 -10.7557 63.1919
LS1034 GDSC1 -10.0554 -3.912 -10.84 58.2975
LoVo GDSC1 -9.1885 -6.2669 -9.2952 52.5211
LS123 GDSC1 -9.0926 -2.1713 -10.4519 50.8901
SW626 GDSC1 -9.0554 -4.9919 -9.4218 50.8888
CCK-81 GDSC1 -8.7944 -5.573 -8.9953 48.121
KM12 GDSC1 -8.655 -6.7424 -8.6798 46.1949
NCI-H747 GDSC1 -8.509 0.2274 -10.8909 47.3501
GP5d GDSC1 -8.3504 -6.5224 -8.3784 42.4432
COLO 320HSR GDSC1 -8.0987 -4.8497 -8.4172 40.5842
SNU-C2B GDSC1 -7.7387 -4.3199 -8.1901 37.0223
SW48 GDSC1 -7.6408 -5.7384 -7.7163 33.8968
LS411N GDSC1 -7.631 1.6697 -10.7016 42.7041
HCT 116 GDSC1 -7.5938 -4.9785 -7.8303 34.2393
RCM-1 [Human ESC] GDSC1 -5.8862 -2.6824 -6.9427 19.138
SW837 GDSC1 -5.8471 0.7996 -8.6123 28.6843
SW948 GDSC1 -5.7438 -0.4148 -7.9183 24.7599
CaR-1 GDSC1 -5.7208 -2.5399 -6.8538 17.7491
C2BBe1 GDSC1 -5.2767 -0.441 -7.4922 20.2566
MDST8 GDSC1 -5.2224 -1.4522 -6.9407 16.2967
LS513 GDSC1 -4.9536 -0.985 -6.946 15.3073
HT115 GDSC1 -4.9385 -0.6927 -7.0797 16.1965
SW1463 GDSC1 -4.3157 3.6239 -8.7316 23.4822
SNU-C1 GDSC1 -4.0464 2.3402 -7.8837 18.2395
HT-55 GDSC1 -0.5322 11.542 -9.8816 18.5454
SW1417 GDSC1 -0.3662 4.7511 -6.7364 3.6532
CL-11 GDSC1 -0.2439 5.2427 -6.8783 4.1967
COLO 678 GDSC1 -0.118 3.1567 -6.0274 0.7036
CW-2 GDSC1 0.1341 2.2571 -5.638 0.0614
NCI-H716 GDSC1 0.2032 3.5567 -6.0493 0.6312
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC1 0.0373 4.113 -6.313 1.4912
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-398 GDSC1 -13.2143 -6.8754 -13.5274 78.5336
HLE GDSC1 -11.1751 -9.6769 -11.1753 77.0221
JHH-7 GDSC1 -10.8833 -9.3904 -10.8836 73.5833
SK-HEP-1 GDSC1 -9.9254 -6.2801 -10.0845 59.9354
SNU-423 GDSC1 -8.9181 -2.0861 -10.3029 49.6622
JHH-4 GDSC1 -8.4159 -5.0265 -8.7146 44.099
Hep 3B2.1-7 GDSC1 -8.3801 -4.5214 -8.8221 44.0592
JHH-6 GDSC1 -8.3245 -4.2942 -8.8344 43.6347
SNU-449 GDSC1 -8.182 -3.5647 -8.9379 42.7826
Hep-G2/C3A GDSC1 -8.0593 -1.6463 -9.596 43.2941
SNU-387 GDSC1 -7.6287 -3.7345 -8.2813 36.6737
JHH-1 GDSC1 -7.4329 -1.8808 -8.8518 37.5843
Huh-7 GDSC1 -7.1446 -4.4549 -7.5004 29.4887
HuH-1 GDSC1 -5.8584 -3.4764 -6.5415 16.0695
JHH-2 GDSC1 -5.2486 -3.1261 -6.1308 10.2625
SNU-475 GDSC1 -4.497 0.4324 -7.2848 16.0251
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 168 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LC-2/ad GDSC1 -12.5976 -9.5946 -12.6078 85.7667
NCI-H460 GDSC1 -11.5142 -10.6747 -11.5142 81.7498
CAL-12T GDSC1 -11.4936 -6.3571 -11.7638 70.8566
Lu-135 GDSC1 -11.2163 -10.1096 -11.2163 77.939
NCI-H2122 GDSC1 -11.2118 -9.4128 -11.2126 76.944
NCI-H2228 GDSC1 -10.9537 -6.8071 -11.1055 68.8366
LCLC-97TM1 GDSC1 -10.9109 -8.6041 -10.9182 72.6259
NCI-H810 GDSC1 -10.888 -4.9217 -11.4409 64.6925
IA-LM GDSC1 -10.8294 -5.3203 -11.2717 65.0472
LXF 289 GDSC1 -10.8173 -6.7653 -10.9656 67.8312
HCC44 GDSC1 -10.7944 -8.9764 -10.7958 72.1425
NCI-H2342 GDSC1 -10.567 -8.3423 -10.575 68.9332
NCI-H522 GDSC1 -10.4112 -7.3341 -10.4674 65.8036
NCI-H847 GDSC1 -10.3321 -6.9032 -10.4292 64.3849
LCLC-103H GDSC1 -10.2618 -6.3211 -10.4399 62.8567
NCI-H2009 GDSC1 -10.2503 -6.1726 -10.454 62.534
NCI-H1770 GDSC1 -10.1404 -8.0304 -10.1491 64.1199
NCI-H1299 GDSC1 -10.0118 -5.2205 -10.4052 59.3876
NCI-H1437 GDSC1 -10.0003 -8.2901 -10.0027 62.7329
SBC-5 GDSC1 -9.9706 -8.041 -9.9765 62.2404
NCI-H3122 GDSC1 -9.9393 -6.9908 -10.0037 60.9039
NCI-H2030 GDSC1 -9.9217 -5.9564 -10.1396 59.5207
SK-LU-1 GDSC1 -9.9146 -3.5852 -10.7979 57.0838
A-427 GDSC1 -9.8447 -3.3621 -10.8007 56.4526
NCI-H1355 GDSC1 -9.7557 -6.1167 -9.9299 58.207
NCI-H1648 GDSC1 -9.713 -7.8305 -9.7197 59.1443
EPLC-272H GDSC1 -9.5349 -6.611 -9.6181 56.4252
HCC15 GDSC1 -9.4064 -4.7108 -9.8839 54.0321
SK-MES-1 GDSC1 -9.4062 -6.9159 -9.4504 55.1841
COR-L23 GDSC1 -9.342 -7.4837 -9.3515 54.6171
SBC-3 GDSC1 -9.336 -7.1158 -9.3624 54.4509
NCI-H727 GDSC1 -9.3237 -2.5829 -10.5331 52.5617
Calu-3 GDSC1 -9.3183 -3.2132 -10.2879 52.7159
DMS 273 GDSC1 -9.158 -7.5221 -9.1633 52.3797
NCI-H1975 GDSC1 -9.1523 -5.6198 -9.3741 51.9731
ABC-1 GDSC1 -9.1514 -6.4751 -9.2274 52.1522
NCI-H292 GDSC1 -9.1084 -6.3117 -9.203 51.6347
HOP-62 GDSC1 -9.0592 -4.087 -9.7006 50.8272
NCI-H1568 GDSC1 -8.9928 -4.3943 -9.5289 50.2504
NCI-H211 GDSC1 -8.8894 -6.9763 -8.9084 49.0642
NCI-H2110 GDSC1 -8.8372 -6.0446 -8.9527 48.5257
NCI-H2170 GDSC1 -8.8235 -6.7427 -8.8552 48.2732
NCI-H1944 GDSC1 -8.655 -5.4754 -8.8651 46.5789
NCI-H2369 GDSC1 -8.5948 -5.5518 -8.7829 45.8563
LB647-SCLC GDSC1 -8.582 -6.187 -8.6582 45.4453
NCI-H441 GDSC1 -8.4922 -5.4658 -8.6902 44.7062
NCI-H358 GDSC1 -8.4463 -4.4469 -8.9176 44.8178
NCI-H650 GDSC1 -8.4155 6.8789 -13.9618 48.0773
EBC-1 GDSC1 -8.3769 -5.0228 -8.673 43.6577
NCI-H520 GDSC1 -8.2321 -5.6482 -8.37 41.4562
NCI-H2087 GDSC1 -8.1826 -3.8631 -8.8291 42.5141
SHP-77 GDSC1 -8.1493 -7.0934 -8.1506 39.8013
NCI-H647 GDSC1 -8.1487 -3.5377 -8.9122 42.4729
HARA [Human squamous cell lung carcinoma] GDSC1 -8.1331 -3.6837 -8.8411 42.1745
RERF-LC-KJ GDSC1 -8.0707 -4.6406 -8.4484 40.4844
NCI-H3255 GDSC1 -8.0408 -4.9598 -8.3233 39.7767
PC-14 GDSC1 -7.9985 -6.1131 -8.0471 38.1843
NCI-H1651 GDSC1 -7.981 -5.4622 -8.1353 38.5033
HCC78 GDSC1 -7.781 1.9727 -10.9908 43.7758
NCI-H2804 GDSC1 -7.7611 -0.4764 -9.8198 41.941
Lu-99A GDSC1 -7.7301 2.2652 -11.0819 43.6479
NCI-H1048 GDSC1 -7.5327 -5.0341 -7.7488 33.3818
LK-2 GDSC1 -7.4698 -2.6758 -8.5422 36.7054
NCI-H1915 GDSC1 -7.4625 -3.3252 -8.2646 35.5184
NCI-H290 GDSC1 -7.4586 -3.3312 -8.2581 35.4655
PaCa-3 GDSC1 -7.4139 -1.2471 -9.1192 38.3085
NCI-H2595 GDSC1 -7.3312 -4.2505 -7.7727 32.2315
Calu-6 GDSC1 -7.2879 -5.6213 -7.3558 29.4552
NCI-H1703 GDSC1 -7.2878 -5.199 -7.4402 29.9852
SW1271 GDSC1 -7.1707 -1.8729 -8.5899 35.1093
NCI-H1792 GDSC1 -7.0919 -4.5253 -7.4198 28.6736
IST-SL2 GDSC1 -7.0198 -4.3871 -7.3884 28.0515
NCI-H64 GDSC1 -6.9795 -5.7715 -7.007 25.3458
NCI-H526 GDSC1 -6.9649 -3.6094 -7.6244 29.1808
A-549 GDSC1 -6.9531 -1.9262 -8.3469 32.8656
IST-SL1 GDSC1 -6.8974 -2.5684 -8.0004 30.8848
ChaGo-K-1 GDSC1 -6.7131 -2.7861 -7.7157 28.3097
NCI-H2085 GDSC1 -6.7081 -1.4854 -8.3088 31.3738
NCI-H2171 GDSC1 -6.7056 -3.2693 -7.4959 26.9504
NCI-H1650 GDSC1 -6.6905 -1.7063 -8.1879 30.7055
NCI-H1436 GDSC1 -6.6208 -3.5213 -7.3002 25.2447
Ms-1 GDSC1 -6.5742 -1.2101 -8.3086 30.6828
NCI-H838 GDSC1 -6.5599 -4.4475 -6.8702 22.0061
CPC-N GDSC1 -6.4781 -3.0959 -7.3384 24.7399
NCI-H1963 GDSC1 -6.4191 -2.9234 -7.3562 24.552
NCI-H510A GDSC1 -6.4141 -3.7479 -6.9892 22.0521
NCI-H596 GDSC1 -6.3286 -2.8203 -7.3125 23.8069
LC-1/sq GDSC1 -6.3259 -2.0923 -7.6492 25.9093
NCI-H2405 GDSC1 -6.2969 7.1758 -12.1787 39.6359
COR-L105 GDSC1 -6.271 2.2903 -9.7317 34.5611
NCI-H2141 GDSC1 -6.2377 -1.7771 -7.7136 25.8577
NCI-H524 GDSC1 -6.2165 -3.9407 -6.7019 19.0005
SW1573 GDSC1 -6.0947 -2.5609 -7.2024 21.9251
NCI-H69 GDSC1 -6.0688 -3.7195 -6.6442 17.8413
NCI-H2722 GDSC1 -6.0289 0.6175 -8.6863 29.798
NCI-H1781 GDSC1 -6.02 -3.0127 -6.917 19.5798
NCI-H1734 GDSC1 -5.9825 -0.807 -7.9432 25.9626
NCI-H1623 GDSC1 -5.927 -2.1944 -7.2161 21.2312
Lu-134-A GDSC1 -5.8909 0.4122 -8.46 28.1796
NCI-H1304 GDSC1 -5.794 -0.9751 -7.6874 23.642
NCI-H661 GDSC1 -5.7202 -1.0469 -7.5847 22.692
NCI-H2023 GDSC1 -5.7191 -2.4913 -6.8758 17.9022
NCI-H1793 GDSC1 -5.7116 -1.5904 -7.3092 20.8877
NCI-H209 GDSC1 -5.605 -2.6735 -6.6802 15.9625
NCI-H446 GDSC1 -5.589 -3.8338 -6.1086 11.556
BEN GDSC1 -5.5816 1.937 -8.943 28.9927
NCI-H1435 GDSC1 -5.4552 0.3183 -8.0259 24.1351
Lu-65 GDSC1 -5.436 -1.3453 -7.1814 18.8508
NCI-H23 GDSC1 -5.4043 -3.219 -6.227 11.6517
HCC827 GDSC1 -5.3954 -0.4215 -7.6052 21.4446
NCI-H841 GDSC1 -5.3425 -1.2341 -7.1542 18.281
NCI-H1688 GDSC1 -5.255 -2.7256 -6.3351 11.8769
NCI-H2135 GDSC1 -5.1374 9.5787 -12.3815 36.4564
NCI-H1693 GDSC1 -5.127 -3.8102 -5.6828 6.2674
EKVX GDSC1 -5.1138 -2.9229 -6.113 9.5938
NCI-H1573 GDSC1 -4.9555 3.5849 -9.2326 27.7895
NCI-H82 GDSC1 -4.9495 -1.2143 -6.828 14.438
NCI-H2347 GDSC1 -4.9465 -0.7057 -7.0798 16.227
HCC33 GDSC1 -4.9389 2.0556 -8.4541 24.339
NCI-H1563 GDSC1 -4.8496 -2.7007 -6.003 7.7664
SBC-1 GDSC1 -4.8364 -1.6956 -6.4944 11.5348
UMC-11 GDSC1 -4.8258 -2.5045 -6.0818 8.302
COLO 668 GDSC1 -4.7894 0.2512 -7.4288 17.9946
NCI-H1581 GDSC1 -4.7753 -0.6834 -6.9504 14.6909
NCI-H196 GDSC1 -4.7621 -3.2844 -5.6434 4.65
NCI-H1836 GDSC1 -4.7433 -1.1391 -6.697 12.7331
NCI-H748 GDSC1 -4.7404 -0.6091 -6.9593 14.6306
NCI-H226 GDSC1 -4.7254 3.7773 -9.1387 26.6155
NCI-H2081 GDSC1 -4.6349 2.8682 -8.6106 24.0009
DMS 114 GDSC1 -4.5763 -0.5866 -6.8399 13.206
Lu-139 GDSC1 -4.5759 2.2071 -8.2327 21.9203
RERF-LC-MS GDSC1 -4.5419 3.1382 -8.6702 23.9583
COR-L88 GDSC1 -4.5067 1.3619 -7.7557 19.0181
NCI-H1155 GDSC1 -4.4057 -0.1439 -6.9273 13.2646
NCI-H1755 GDSC1 -4.3215 1.2795 -7.5691 17.2581
NCI-H2869 GDSC1 -4.2233 18.9843 -16.3278 39.0835
NCI-H1694 GDSC1 -4.0664 2.6208 -8.0381 19.1717
NCI-H1092 GDSC1 -4.0492 0.3308 -6.8944 11.9128
LOU-NH91 GDSC1 -3.9369 1.6494 -7.46 15.3453
NCI-H2196 GDSC1 -3.8773 1.7066 -7.444 15.0621
Lu-165 GDSC1 -3.7034 1.7982 -7.3622 14.0241
HOP-92 GDSC1 -3.1934 7.1947 -9.6395 23.8753
NCI-H1993 GDSC1 -2.9706 6.8072 -9.2836 21.8782
NCI-H2803 GDSC1 -2.2402 5.4348 -8.1076 14.4918
NCI-H1869 GDSC1 -1.3339 8.3455 -8.8926 16.2273
RERF-LC-Sq1 GDSC1 -1.0488 4.4301 -6.9408 5.6258
DMS 79 GDSC1 -0.842 8.4342 -8.6203 13.9583
NCI-H2731 GDSC1 -0.7418 10.4753 -9.5137 17.5737
COR-L95 GDSC1 -0.6163 4.8784 -6.9097 4.8353
NCI-H2373 GDSC1 -0.5125 23.2016 -15.5324 31.5439
NCI-H1838 GDSC1 -0.5055 3.4479 -6.2868 1.7884
DMS 53 GDSC1 -0.4772 3.1171 -6.1514 1.2648
NCI-H2444 GDSC1 -0.4308 5.299 -6.9929 5.0105
NCI-H513 GDSC1 -0.369 5.1148 -6.8861 4.3909
NCI-H2795 GDSC1 -0.3462 4.4097 -6.5905 2.9466
NCI-H345 GDSC1 -0.2123 1.771 -5.5938 0.0581
NCI-H2291 GDSC1 -0.2054 4.2975 -6.4843 2.3443
NCI-H1876 GDSC1 -0.2001 4.8895 -6.7148 3.3652
NCI-H1666 GDSC1 -0.1677 2.7587 -5.907 0.4466
NCI-H720 GDSC1 -0.0801 2.1152 -5.6621 0.0936
NCI-H2818 GDSC1 -0.063 2.0707 -5.642 0.0776
NCI-H322M GDSC1 0.0459 2.5311 -5.7565 0.1672
NCI-H187 GDSC1 0.1406 2.633 -5.7583 0.1563
NCI-H2591 GDSC1 0.1433 17.2255 -12.1462 24.0687
NCI-H2172 GDSC1 0.2146 2.0761 -5.554 0.0234
NCI-H2461 GDSC1 0.2491 18.4492 -12.6636 25.1013
NCI-H2029 GDSC1 0.38 3.3783 -5.9251 0.335
NCI-H2227 GDSC1 0.3875 8.4037 -7.8926 8.3022
⏷ Show the Full List of 168 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC1 -3.7414 2.0921 -7.5336 15.2126
Cancer Drug Sensitivity Data Curated from 23 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KYSE-510 GDSC1 -12.9623 -10.1352 -12.9674 88.8622
TE-15 GDSC1 -12.267 -6.2588 -12.6216 73.9507
TE-8 GDSC1 -12.1186 -8.056 -12.1943 78.5615
T.T GDSC1 -11.4689 -8.5113 -11.4902 76.6382
KYSE-270 GDSC1 -10.8592 -7.9899 -10.8876 70.8799
KYSE-180 GDSC1 -10.5188 -9.4453 -10.5188 69.372
KYSE-450 GDSC1 -10.4615 -5.9111 -10.7343 63.6971
TE-10 GDSC1 -10.1607 -6.7741 -10.2632 62.6943
KYSE-150 GDSC1 -9.9616 -5.9708 -10.18 59.8797
KYSE-410 GDSC1 -9.8004 -7.1957 -9.8399 59.6898
TE-11 GDSC1 -9.6288 -7.1244 -9.6662 57.7807
KYSE-140 GDSC1 -9.4358 0.588 -11.9907 52.4206
TE-9 GDSC1 -9.099 -4.7557 -9.5356 51.2761
TE-1 GDSC1 -8.9504 -6.5183 -9.0093 49.8172
TE-5 GDSC1 -8.5362 -2.8504 -9.591 46.5214
OE19 GDSC1 -8.2489 -0.2761 -10.4003 45.5179
OE21 GDSC1 -8.1151 -3.938 -8.7295 41.7317
COLO 680N GDSC1 -7.1048 -2.8627 -8.0838 32.4919
OE33 GDSC1 -7.0581 -1.7764 -8.5206 34.1954
KYSE-70 GDSC1 -6.952 -3.5739 -7.6253 29.1116
KYSE-520 GDSC1 -6.5043 -3.0325 -7.3934 25.2316
TE-6 GDSC1 -5.6347 0.7057 -8.3766 26.6878
EC-GI-10 GDSC1 -4.8407 -0.8178 -6.9365 14.8266
⏷ Show the Full List of 23 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 25 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
IGROV-1 GDSC1 -11.1668 -6.4543 -11.3926 69.3301
TOV-112D GDSC1 -10.7209 -9.1355 -10.7214 71.5495
OVCAR-8 GDSC1 -10.4455 -7.2162 -10.5145 65.8918
OC 314 GDSC1 -9.9499 -8.0711 -9.9549 62.0227
SK-OV-3 GDSC1 -9.6819 27.998 -25.526 51.0391
A2780 GDSC1 -9.5765 -6.8448 -9.636 57.0249
OVCAR-4 GDSC1 -9.3605 -2.8689 -10.4621 52.906
OAW42 GDSC1 -9.1833 -0.6123 -11.2033 51.2831
EFO-27 GDSC1 -9.1353 -3.4295 -10.0119 51.3709
OVCAR-5 GDSC1 -8.3065 -4.4891 -8.7521 43.2842
OVCAR-3 GDSC1 -7.8462 -4.2916 -8.3162 38.3192
OVTOKO GDSC1 -7.4786 -1.787 -8.9402 38.1407
Kuramochi GDSC1 -7.2438 -4.4882 -7.5969 30.6739
OAW28 GDSC1 -6.9783 -4.2565 -7.3898 27.8185
EFO-21 GDSC1 -6.5693 -1.0376 -8.3862 31.0178
Caov-3 GDSC1 -6.1548 -0.8683 -8.0738 27.464
FU-OV-1 GDSC1 -5.1443 -1.7615 -6.719 14.3678
RMG-I GDSC1 -5.0045 -0.8418 -7.0601 16.3059
ES-2 GDSC1 -4.6242 0.2452 -7.2924 16.5143
TYK-nu GDSC1 -4.3897 5.3615 -9.6576 27.4669
OVISE GDSC1 -4.0909 4.4264 -8.9542 23.7501
OV-90 GDSC1 -4.0797 6.3061 -9.8814 27.2844
Caov-4 GDSC1 -3.8682 5.0542 -9.093 23.6529
TOV-21G GDSC1 -0.2729 3.1766 -6.093 0.9575
OVKATE GDSC1 -0.107 2.0219 -5.6406 0.0801
⏷ Show the Full List of 25 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 30 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PSN1 GDSC1 -12.8012 -7.9684 -12.9226 80.6643
Panc 03.27 GDSC1 -12.789 -4.213 -13.7204 71.2321
KP-4 GDSC1 -10.3973 -8.1093 -10.4085 66.9039
MZ-PC-1 GDSC1 -10.3896 -7.204 -10.4568 65.3904
CFPAC-1 GDSC1 -9.8888 -5.5825 -10.1834 58.8179
HPAC GDSC1 -9.7316 -6.3588 -9.8634 58.2123
MIA PaCa-2 GDSC1 -9.6473 -5.8914 -9.8551 56.9917
KP-2 GDSC1 -9.626 -5.448 -9.9286 56.433
BxPC-3 GDSC1 -9.5888 -2.602 -10.808 54.3306
Panc 10.05 GDSC1 -9.5053 -6.1259 -9.6582 55.7967
PaTu 8988t GDSC1 -9.3504 -7.0009 -9.3853 54.5806
SUIT-2 GDSC1 -9.2595 -5.8582 -9.4416 53.1537
KP-1N GDSC1 -8.9056 -5.3858 -9.1584 49.3622
HuP-T4 GDSC1 -8.5435 -3.4422 -9.3712 46.3262
HuP-T3 GDSC1 -8.0581 -2.8914 -9.0687 42.2066
Capan-1 GDSC1 -7.7661 -4.5908 -8.1319 36.9464
KP-3 GDSC1 -7.4281 -4.3591 -7.8401 33.215
SU.86.86 GDSC1 -6.5127 -1.1117 -8.2962 30.3141
Panc 02.03 GDSC1 -6.12 1.8235 -9.3645 32.7739
PL4 GDSC1 -5.9411 -2.4866 -7.0892 20.4245
PaTu 8902 GDSC1 -5.5811 -0.9956 -7.4844 21.4626
HPAF-II GDSC1 -5.1368 5.6296 -10.4067 32.2465
Capan-2 GDSC1 -5.1104 0.935 -8.0376 22.8302
SW1990 GDSC1 -5.103 -1.7597 -6.6846 13.9529
Panc 04.03 GDSC1 -5.0786 3.7516 -9.4188 28.9261
Panc 08.13 GDSC1 -5.0218 1.2972 -8.1441 23.068
YAPC GDSC1 -1.6589 3.3321 -6.7908 5.757
AsPC-1 GDSC1 -0.9795 8.5026 -8.7386 14.7817
DAN-G GDSC1 0.1763 2.2113 -5.6095 0.0448
Hs 766T GDSC1 0.2887 4.3984 -6.3178 1.3483
⏷ Show the Full List of 30 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MPP 89 GDSC1 -6.811 -1.5708 -8.3699 32.1972
NCI-H28 GDSC1 -4.9911 5.4052 -10.1724 31.0968
NCI-H2052 GDSC1 -4.5694 -1.9698 -6.1476 7.9675
IST-Mes1 GDSC1 -2.7834 13.0732 -12.2373 30.2261
NCI-H2452 GDSC1 -0.2653 10.1489 -9.0575 14.7616
MSTO-211H GDSC1 0.0287 3.0252 -5.9285 0.4309
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
DU145 GDSC1 -10.4336 -7.8963 -10.4537 66.9464
LNCaP clone FGC GDSC1 -7.4825 -3.3959 -8.2573 35.6141
VCaP GDSC1 -7.2561 -3.5067 -7.9735 32.8424
22Rv1 GDSC1 -6.9758 -3.3721 -7.7335 29.8783
PC-3 GDSC1 -5.5374 -1.3537 -7.2678 19.8608
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC1 -6.5128 -3.1685 -7.3416 24.9416
Cancer Drug Sensitivity Data Curated from 56 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-431 GDSC1 -12.0861 -11.06 -12.0861 88.178
A101D GDSC1 -11.4965 -1.2092 -13.3816 62.493
A-375 GDSC1 -10.8563 -8.2494 -10.8728 71.4192
A2058 GDSC1 -10.3156 -9.0024 -10.3158 66.7859
IGR-1 GDSC1 -10.2593 -8.6069 -10.2606 65.9231
CHL-1 GDSC1 -10.1904 -8.3116 -10.1942 64.9236
Mel JuSo GDSC1 -10.1294 -7.1916 -10.1845 63.0012
G-361 GDSC1 -9.9395 -5.6796 -10.2168 59.3482
A-388 GDSC1 -9.9082 -5.086 -10.3272 58.44
IGR-37 GDSC1 -9.8346 -5.8747 -10.0615 58.6711
RPMI-7951 GDSC1 -9.7291 -6.604 -9.8257 58.4168
COLO 679 GDSC1 -9.4159 -4.4619 -9.9687 53.9876
WM793 GDSC1 -9.2401 -3.3097 -10.1684 52.1585
WM35 GDSC1 -8.9355 -5.227 -9.2296 49.6858
Hs 940.T GDSC1 -8.9249 -3.6794 -9.6953 49.6499
Mel Ho GDSC1 -8.9037 -1.8742 -10.3754 49.5695
HT-144 GDSC1 -8.7625 -5.5263 -8.9708 47.775
451Lu GDSC1 -8.4295 -2.6714 -9.5497 45.6987
WM1552C GDSC1 -8.3686 -3.8517 -9.0338 44.419
HMV-II GDSC1 -8.3087 0.1308 -10.6459 46.0795
DJM-1 GDSC1 -8.2119 -5.496 -8.3789 41.3288
IST-MEL1 GDSC1 -8.1751 -1.4443 -9.8033 44.3515
MZ-MEL-2 GDSC1 -7.9177 -4.0361 -8.4818 39.4719
SK-MEL-30 GDSC1 -7.7176 0.7385 -10.3433 42.6005
IPC-298 GDSC1 -7.5192 -2.7537 -8.5605 37.0838
SK-MEL-2 GDSC1 -7.2644 -3.0194 -8.1827 33.9171
SH-4 GDSC1 -6.8661 1.7425 -10.0106 37.8816
CP66-MEL GDSC1 -6.4546 -3.5123 -7.1317 23.2423
GAK GDSC1 -6.1162 -2.5824 -7.2133 22.1023
WM278 GDSC1 -6.0929 -1.4835 -7.7168 25.1834
CP50-MEL-B GDSC1 -6.0898 -2.6372 -7.1617 21.6249
RVH-421 GDSC1 -6.0161 -2.986 -6.9256 19.6232
MZ-MEL-7 GDSC1 -5.7591 6.7751 -11.5098 36.803
LB373-MEL-D GDSC1 -5.7585 -2.1437 -7.0818 19.5444
SK-MEL-3 GDSC1 -5.7199 3.4381 -9.8116 32.6019
LB2518-MEL GDSC1 -5.5496 -0.5903 -7.6573 22.4041
COLO 800 GDSC1 -5.2768 -2.631 -6.4015 12.4773
M14 GDSC1 -5.1553 -1.8967 -6.661 13.9767
UACC-257 GDSC1 -5.108 0.1854 -7.6608 20.6428
MMAc-SF GDSC1 -4.9136 8.1309 -11.4706 34.103
SK-MEL-5 GDSC1 -4.8268 0.0352 -7.3514 17.6269
WM115 GDSC1 -4.7246 -2.7895 -5.86 6.2251
UACC-62 GDSC1 -4.5436 1.6217 -7.9147 20.0707
Hs 938.T GDSC1 -4.1746 -0.6789 -6.4909 9.3687
COLO 792 GDSC1 -0.8347 4.4255 -6.8294 4.7162
SK-MEL-24 GDSC1 -0.5971 5.1207 -7.0017 5.2861
VMRC-MELG GDSC1 -0.4016 4.5372 -6.6667 3.3605
MeWo GDSC1 -0.3988 3.149 -6.132 1.1506
LOX-IMVI GDSC1 -0.3716 6.4401 -7.4482 7.2727
G-mel GDSC1 -0.2317 10.6436 -9.2664 15.5669
SK-MEL-28 GDSC1 -0.1447 4.2421 -6.437 2.0962
SK-MEL-1 GDSC1 0.0924 2.4265 -5.7066 0.113
COLO 829 GDSC1 0.1913 3.0216 -5.8703 0.2906
COLO 783 GDSC1 0.2485 2.4944 -5.6774 0.0775
WT2-iPS GDSC1 0.4916 4.8495 -6.4029 1.5059
EquiPSC Line K2 GDSC1 -3.8525 4.7082 -8.9092 22.8119
⏷ Show the Full List of 56 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC1 -11.3003 -10.0866 -11.3003 78.851
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MFH-ino GDSC1 -11.5764 -10.0053 -11.5765 81.4368
Hs 633.T GDSC1 -10.5613 -9.413 -10.5613 69.879
SK-LMS-1 GDSC1 -10.5223 -7.7466 -10.553 67.5179
SK-UT-1 GDSC1 -10.2461 -7.1342 -10.3126 64.0027
HT-1080 GDSC1 -10.1901 -8.7728 -10.1905 65.1983
EW-8 GDSC1 -10.155 -7.8028 -10.1717 64.0347
SW872 GDSC1 -10.1365 -7.6777 -10.1584 63.6974
SW982 GDSC1 -10.1054 -5.6708 -10.3992 60.6731
G-401 GDSC1 -9.1893 -1.4969 -10.8316 51.4424
MES-SA GDSC1 -8.7165 -4.0307 -9.3478 47.7132
A-204 GDSC1 -8.3622 -3.938 -8.9964 44.2939
RD GDSC1 -8.2297 -4.6184 -8.6284 42.3212
VA-ES-BJ GDSC1 -7.62 1.3755 -10.5506 42.433
G-402 GDSC1 -7.5228 -3.3237 -8.3289 36.1824
KYM-1 GDSC1 -7.52 -4.9886 -7.7471 33.2902
STS-0421 GDSC1 -7.4983 -3.8816 -8.0863 34.9287
GCT GDSC1 -7.2308 -2.9172 -8.1911 33.7537
Rh30 GDSC1 -6.3272 -2.4638 -7.4761 24.8529
Rh41 GDSC1 -5.6267 -3.3138 -6.3912 13.8766
TE 441.T GDSC1 -5.3171 -1.3149 -7.0916 17.7438
RKN GDSC1 -0.2611 11.4296 -9.6527 17.1516
SW684 GDSC1 0.3067 2.3737 -5.6196 0.0432
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 25 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HGC-27 GDSC1 -11.4479 -10.3847 -11.4479 80.7699
MKN28 GDSC1 -10.8061 -6.0327 -11.0831 66.2403
NUGC-3 GDSC1 -9.7946 -6.2473 -9.9492 58.7006
TMK-1 GDSC1 -8.5048 -7.2948 -8.5065 44.2462
IM95 GDSC1 -8.3628 -5.5537 -8.5306 43.1153
MKN1 GDSC1 -8.3378 -4.3672 -8.8251 43.7202
AGS GDSC1 -8.3192 -4.8659 -8.6533 43.1206
23132/87 GDSC1 -7.9879 -5.955 -8.0559 38.1563
RF-48 GDSC1 -7.947 -5.608 -8.0692 37.9322
NUGC-4 GDSC1 -7.9091 -4.7606 -8.2363 38.4348
MKN45 GDSC1 -7.7748 0.9896 -10.5176 43.1438
TGBC11TKB GDSC1 -7.4905 -3.2674 -8.3175 35.9268
ECC10 GDSC1 -7.454 -0.633 -9.4422 39.4126
GCIY GDSC1 -7.4117 -3.3385 -8.2056 34.9325
RERF-GC-1B GDSC1 -6.6119 -3.367 -7.3569 25.5659
OCUM-1 GDSC1 -5.845 -4.0316 -6.2777 14.0435
SNU-5 GDSC1 -5.0196 -2.6282 -6.1798 9.7619
NCI-N87 GDSC1 -4.9918 0.663 -7.8019 21.0421
SNU-16 GDSC1 -4.9867 -3.3731 -5.7796 6.4942
HSC-39 GDSC1 -4.5035 -1.3962 -6.3815 9.5543
SNU-1 GDSC1 -4.0046 7.2664 -10.3004 28.4158
MKN7 GDSC1 -3.9462 -0.573 -6.3815 7.9143
Fu97 GDSC1 -0.2569 4.4784 -6.5775 2.7976
SCH GDSC1 0.2251 3.9118 -6.1664 0.9219
SNG-M GDSC1 -10.7306 -8.8502 -10.7326 71.3151
⏷ Show the Full List of 25 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TT2609-C02 GDSC1 -11.3842 -10.1964 -11.3842 79.877
IHH-4 GDSC1 -11.3418 -10.8054 -11.3418 79.6957
CAL-62 GDSC1 -10.6857 -7.4254 -10.7472 68.2739
B-CPAP GDSC1 -10.2952 -8.0095 -10.3075 65.733
8505C GDSC1 -10.1963 -7.3842 -10.2386 63.9086
ML-1 [Human leukemia] GDSC1 -9.9743 -1.6783 -11.582 56.0885
KMH-2 GDSC1 -9.8311 -8.2782 -9.8326 60.7217
BHT-101 GDSC1 -9.7884 -3.2537 -10.7788 56.0067
ASH-3 GDSC1 -9.2015 -0.5454 -11.2511 51.3787
8305C GDSC1 -8.9707 -5.3382 -9.2407 50.0519
CGTH-W-1 GDSC1 -8.306 -5.1446 -8.5638 42.744
HTC-C3 GDSC1 -7.9838 -5.454 -8.1401 38.5462
K5 GDSC1 -7.6851 -2.982 -8.6389 38.4328
FTC-133 GDSC1 -0.7131 21.6114 -14.8982 30.9506
TT GDSC1 -0.1444 1.8209 -5.5878 0.0509
WRO GDSC1 0.6282 21.9989 -14.1185 27.4141
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 41 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KON GDSC1 -11.8855 -9.7763 -11.8869 83.1329
PCI-06A GDSC1 -11.7344 -10.1835 -11.7345 83.1876
JHU-011 GDSC1 -11.5065 -9.7005 -11.5071 80.1547
Ca9-22 GDSC1 -11.3663 -8.3815 -11.3905 75.5981
PCI-04B GDSC1 -11.0148 -8.1618 -11.0392 72.5045
BHY GDSC1 -11.0143 -7.125 -11.1268 69.9765
HSC-2 GDSC1 -10.9623 -7.7495 -11.01 71.1188
BB30-HNC GDSC1 -10.9614 -9.675 -10.9614 74.7106
CAL-27 GDSC1 -10.4482 -9.6096 -10.4482 68.5231
HSC-3 GDSC1 -10.3295 -5.3964 -10.7076 61.9512
OSC-19 GDSC1 -10.0612 -6.5768 -10.1839 61.5295
OSC-20 GDSC1 -10.0243 -7.3154 -10.0643 62.1272
KOSC-2 GDSC1 -10.0185 -5.943 -10.2472 60.3255
SCC-4 GDSC1 -9.9119 -6.1738 -10.0883 59.6893
JHU-029 GDSC1 -9.548 -3.4995 -10.4317 54.5085
SCC-25 GDSC1 -9.419 -5.898 -9.6066 54.7935
Detroit 562 GDSC1 -9.219 -7.2793 -9.2331 53.0963
CAL-33 GDSC1 -9.2129 -6.9037 -9.2493 52.9539
HO-1-N-1 GDSC1 -9.0485 -6.6943 -9.0949 50.9859
BICR 31 GDSC1 -8.9458 -3.2444 -9.8764 49.838
NCI-H3118 GDSC1 -8.7268 -6.1511 -8.8179 47.2046
PCI-38 GDSC1 -8.3867 -5.3208 -8.6086 43.56
PCI-15A GDSC1 -7.9833 -2.7297 -9.056 41.6635
HO-1-u-1 GDSC1 -7.6714 -1.4125 -9.3037 40.3059
SCC-15 GDSC1 -7.1798 -2.4151 -8.3564 34.1966
LB771-HNC GDSC1 -6.9282 -3.2242 -7.7461 29.6775
UPCI-SCC-090 GDSC1 -6.8372 -1.353 -8.4976 32.8961
SCC-9 GDSC1 -6.7522 1.3343 -9.7054 36.5924
BICR 78 GDSC1 -6.7084 -3.462 -7.4166 26.4685
BICR 22 GDSC1 -5.9889 0.5307 -8.6072 29.2778
BICR 10 GDSC1 -5.4209 0.0024 -7.8386 22.9428
HSC-4 GDSC1 -5.1952 2.1609 -8.7221 26.5466
FaDu GDSC1 -4.9697 1.0398 -7.9718 21.9317
PE/CA-PJ15 GDSC1 -3.8408 0.8115 -6.979 11.8843
SAT [Human HNSCC] GDSC1 -3.4906 6.1524 -9.3484 23.583
DOK GDSC1 -3.3662 7.3382 -9.8409 25.0835
BB49-HNC GDSC1 -0.0029 18.2759 -12.7554 25.7538
SAS GDSC1 0.0777 4.5389 -6.4561 1.9922
JHU-022 GDSC1 0.1866 8.2968 -7.9551 8.9175
SKN-3 GDSC1 0.2461 12.8925 -10.015 17.5259
PCI-30 GDSC1 0.7527 3.1575 -5.7273 0.0734
⏷ Show the Full List of 41 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SW1710 GDSC1 -13.9971 -9.6046 -14.0402 88.5736
639V GDSC1 -11.9516 -10.5631 -11.9516 85.8765
BFTC-905 GDSC1 -11.5141 -8.964 -11.5223 78.2527
5637 GDSC1 -10.4416 -8.7048 -10.4431 68.0597
RT-112 GDSC1 -10.326 -8.6067 -10.3277 66.6837
J82 GDSC1 -9.282 -6.9271 -9.3195 53.7653
UM-UC-3 GDSC1 -9.1493 -5.8791 -9.3184 52.0015
647V GDSC1 -8.3824 -5.2147 -8.6295 43.5835
TCCSUP GDSC1 -7.5994 -4.8851 -7.8624 34.4523
CAL-29 GDSC1 -6.6673 -3.3358 -7.4276 26.315
T24 GDSC1 -5.6334 -0.3865 -7.8331 23.7997
RT-4 GDSC1 -2.824 9.1331 -10.3196 25.2645
HT-1197 GDSC1 -1.1283 22.7751 -15.7824 32.8994
HT-1376 GDSC1 -1.1258 7.3713 -8.3035 13.0233
KU-19-19 GDSC1 0.3347 2.0999 -5.5232 0.0137
SW780 GDSC1 0.6948 2.9387 -5.6756 0.0499
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SW954 GDSC1 -11.2829 -9.9313 -11.2829 78.4807
CAL-39 GDSC1 -10.9039 -7.2664 -10.9931 69.5575
KGN GDSC1 -10.891 -6.6548 -11.0617 68.0857
BPH-1 GDSC1 -10.8329 -8.4907 -10.8416 71.7035
PA-1 GDSC1 -10.4104 -9.0248 -10.4107 67.9235
NT2-D1 GDSC1 -10.185 -7.3502 -10.2294 63.7522
DoTc2 4510 GDSC1 -10.0817 -3.3963 -11.0445 57.9827
HeLa GDSC1 -10.0732 -6.8235 -10.1639 61.9722
SW962 GDSC1 -9.7037 -5.7439 -9.9466 57.3794
NCC-IT GDSC1 -8.448 -5.6371 -8.606 44.0847
C-33 A GDSC1 -8.2355 -4.9108 -8.5493 42.1218
C-4-I GDSC1 -8.029 -5.3864 -8.204 39.1776
OVMIU GDSC1 -8.0214 -4.4162 -8.4652 40.1723
SiSo GDSC1 -7.9468 -5.6762 -8.0563 37.8654
NEC8 GDSC1 -7.9433 -4.6662 -8.3018 38.9619
Ca Ski GDSC1 -7.8379 -3.2076 -8.7089 39.6887
LB831-BLC GDSC1 -7.6689 -2.0299 -9.0271 39.554
MS751 GDSC1 -7.6158 -2.9163 -8.5933 37.82
JEG-3 GDSC1 -7.5836 -5.4846 -7.6995 33.4265
ME-180 GDSC1 -7.1244 -4.648 -7.4154 28.8392
SKN GDSC1 -7.0735 -2.0406 -8.4159 33.842
HEC-1 GDSC1 -6.6548 -2.1664 -7.9388 29.2414
HT-3 GDSC1 -5.9867 -3.4125 -6.699 17.8414
SKG-IIIa GDSC1 -4.9896 -1.0824 -6.9274 15.3076
JAR GDSC1 -4.9811 -2.0942 -6.4144 11.4423
OMC-1 [Human cervical carcinoma] GDSC1 -4.8498 4.718 -9.7113 29.1613
SiHa GDSC1 -4.8044 -1.5666 -6.5329 11.7149
SW756 GDSC1 -4.7988 4.9409 -9.7807 29.2238
DSH1 GDSC1 -0.7146 6.3981 -7.6181 8.7292
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005849)
2 Emerging therapies for multiple myeloma. Expert Opin Emerg Drugs. 2009 Mar;14(1):99-127.
3 The effect of ketoconazole on the pharmacokinetics and pharmacodynamics of ixabepilone: a first in class epothilone B analogue in late-phase clinical development. Clin Cancer Res. 2008 May 1;14(9):2701-9.