Details of the Drug Combinations

General Information of This Drug (ID: DMN3E57)

• Drug Name: Levodopa (DMN3E57)
• Synonyms: Levodopa (optimized formulation, Parkinson's disease); More effective levodopa (Parkinson's disease), Orion; Levodopa (optimized formulation, Parkinson's disease), Orion

Indication

Parkinson disease; ICD 11: 8A00.0; Status: Approved [1]; Parkinsonian disorder; ICD 11: N.A.; Status: Approved [2]; Postencephalitic Parkinson disease; ICD 11: N.A.; Status: Approved [2]

• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

5 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Dextroamphetamine + Levodopa	DCCWNKU	Dextroamphetamine	Cocaine Abuse	[3]
Levodopa + Rotigotine	DC1M73G	Rotigotine	Idiopathic Parkinson's Disease	[4]
Levodopa + Cabergoline	DCLC64B	Cabergoline	Parkinson's Disease	[5]
Opicapone + Levodopa	DCIUC7C	Opicapone	Parkinson Disease	[6]
Tozadenant + Levodopa	DCFJTXD	Tozadenant	Parkinson's Disease	[7]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3639).
• [2] Levodopa FDA Label
• [3] ClinicalTrials.gov (NCT00439049) Substance Abuse Pre-Treatment Screening Study
• [4] ClinicalTrials.gov (NCT01646255) Rotigotine Versus Placebo, A Study To Evaluate The Efficacy In Advanced Stage Idiopathic Parkinson's Disease Patients
• [5] ClinicalTrials.gov (NCT00153972) Dopamine Turnover Rate as Surrogate Parameter for Diagnosis of Early Parkinson's Disease
• [6] ClinicalTrials.gov (NCT03959540) Safety and Effectiveness of Opicapone Plus Standard of Care in Elderly Patients With Parkinson's Disease
• [7] ClinicalTrials.gov (NCT01283594) Safety and Efficacy Study of SYN115 in Parkinson's Patients Using Levodopa to Treat End of Dose Wearing Off