Details of the Drug Combinations

General Information of This Drug (ID: DMOBIKY)

Drug Name

Bexarotene DMOBIKY

Synonyms

Bexaroteno; Bexarotenum; Targret; Targretin; Targretyn; Targrexin; Bexarotene [USAN]; Elan brand of bexarotene;Ligand brand of bexarotene; LG 1069; LG100069; LG1069; LG69 compound; LGD 1069; LGD1069; LG-100069; LGD-1069; Targretin (TN); Targretin-gel; Bexarotene (USAN/INN); P-(1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthyl)vinyl)benzoic acid; 3-methyl-TTNEB; 4-(1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethenyl)benzoic acid; 4-(1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl)benzoic acid; 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)ethenyl]benzoic acid; 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)vinyl]benzoic acid; 4-[1-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)ethenyl]benzoic acid; 4-[1-3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthaleneyl)vinyl]benzene carboxylic acid; 9RA

Indication

Disease Entry	ICD 11	Status	REF
Cutaneous T-cell lymphoma	2B01	Approved	[1]
Plasma cell myeloma	2A83.1	Approved	[2]
Primary cutaneous T-cell lymphoma	N.A.	Approved	[2]
Schizoaffective disorder	6A21	Approved	[2]
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Therapeutic Class

Anticancer Agents

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

6 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Bexarotene + Vorinostat	DC3INZG	Vorinostat	Lymphoma	[3]
Bexarotene + Decitabine	DCFQLB8	Decitabine	Leukemia, Myeloid, Acute	[4]
Bexarotene + Capecitabine	DC9T1H5	Capecitabine	Metastatic Triple-Negative Breast Carcinoma	[5]
Erlotinib + Bexarotene	DC6QIZI	Erlotinib	Lung Cancer	[6]
Methotrexate + Bexarotene	DCERZFR	Methotrexate	Primary Cutaneous Anaplastic Large Cell Lymphoma	[7]
Methoxsalen + Bexarotene	DCGKP0J	Methoxsalen	Lymphoma	[8]
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⏷ Show the Full List of 6 DrugCom(s)

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2807).
2	Bexarotene FDA Label
3	ClinicalTrials.gov (NCT00127101) An Investigational Study of a Histone Deacetylase (HDAC) Inhibitor Plus Targretin in Cutaneous T-Cell Lymphoma Patients (0683-016)(TERMINATED)
4	ClinicalTrials.gov (NCT01001143) Intravenous (IV) Decitabine and Oral Bexarotene for Acute Myelogenous Leukemia (AML)
5	ClinicalTrials.gov (NCT04664829) The Role of Bexarotene in Inducing Susceptibility to Chemotherapy in Metastatic TNBC
6	ClinicalTrials.gov (NCT00411632) BATTLE Program: Tarceva and Targretin in Patients With Advanced Non-Small Cell Lung Cancer (NSCLC)
7	ClinicalTrials.gov (NCT01578499) A Phase 3 Trial of Brentuximab Vedotin(SGN-35) Versus Physician's Choice (Methotrexate or Bexarotene) in Participants With CD30-Positive Cutaneous T-Cell Lymphoma (ALCANZA Study)
8	ClinicalTrials.gov (NCT00056056) Ultraviolet Light Therapy Using Methoxsalen With or Without Bexarotene in Treating Patients With Mycosis Fungoides