Details of the Drug Combinations

General Information of This Drug (ID: DMQLT4N)

Drug Name

Brimonidine DMQLT4N

Synonyms

brimonidine; 59803-98-4; Bromoxidine; UK 14,304; 5-Bromo-N-(4,5-dihydro-1H-imidazol-2-yl)-6-quinoxalinamine; 5-Bromo-6-(2-imidazolin-2-ylamino)quinoxaline; UK-14304; AGN 190342; UNII-E6GNX3HHTE; Brimonidine [INN:BAN]; UK 14304; C11H10BrN5; MLS000069370; 6-Quinoxalinamine, 5-bromo-N-(4,5-dihydro-1H-imidazol-2-yl)-; E6GNX3HHTE; CHEMBL844; AGN-190342; BRN 0751629; SMR000058355; CHEBI:3175; LK 14304-18; Brimonidine, 98%; NCGC00016069-09; EN300-50880; DSSTox_RID_80758; Brimonidine (bioerodible, extended release); [3H]brimonidine

Indication

Disease Entry	ICD 11	Status	REF
Ocular hypertension	9C61.01	Approved	[1]
Glaucoma/ocular hypertension	9C61	Phase 3	[2]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

5 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Brinzolamide + Brimonidine	DCES7YX	Brinzolamide	Glaucoma	[3]
Tropicamide + Brimonidine	DCJRD6A	Tropicamide	Intraocular Pressure	[4]
Brinzolamide + Brimonidine	DCVY7EQ	Brinzolamide	Open-Angle Glaucoma	[5]
Azelaic Acid + Brimonidine	DCXKBEB	Azelaic Acid	Acne Rosacea	[6]
Ivermectin + Brimonidine	DCUUCHT	Ivermectin	Rosacea	[7]
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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 520).
2	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
3	ClinicalTrials.gov (NCT00800540) Circadian Ocular Perfusion Pressure and Ocular Blood Flow
4	ClinicalTrials.gov (NCT03139708) The Effect of Brimonidine on Intraocular Pressure When Dilating Routine Patients
5	ClinicalTrials.gov (NCT02339584) Efficacy and Safety of Brinzolamide/Brimonidine Fixed Combination BID Compared to Brinzolamide BID Plus Brimonidine BID in Subjects With Open-Angle Glaucoma (OAG) or Ocular Hypertension (OHT)
6	ClinicalTrials.gov (NCT02147691) Finacea 15% and Brimonidine 0.33% Gel in the Treatment of Rosacea - A Pilot Study
7	ClinicalTrials.gov (NCT02616250) MirvasO Soolantra Association In the Treatment of Moderate to Severe rosaCea.